J. Balthasar

发表

Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy.

V. Yang, Kyuri Lee, M. Shin, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Targeted Delivery of Endosomal Escape Peptides to Enhance Immunotoxin Potency and Anti-cancer Efficacy

Ping Chen, J. Balthasar, J. R. Polli, 2022, The AAPS Journal.

Sorafenib Decreases Tumor Exposure to an Anti-carcinoembryonic Antigen Monoclonal Antibody in a Mouse Model of Colorectal Cancer

J. Balthasar, Veena A. Thomas, 2016, The AAPS Journal.

Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody.

J. Balthasar, L. Abuqayyas, Xiaoyan Zhang, 2013, International journal of pharmaceutics.

FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues

J. Balthasar, T. Li, 2018, Biomolecules.

Antibody pharmacokinetics and pharmacodynamics.

R. Hansen, J. Balthasar, E. Lobo, 2004, Journal of pharmaceutical sciences.

Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling

B. Shin, Yohan Choi, J. Bulitta, 2011, Cancer Chemotherapy and Pharmacology.

Strategies to enhance monoclonal antibody uptake and distribution in solid tumors

J. Balthasar, Brandon M. Bordeau, Brandon M Bordeau, 2021, Cancer biology & medicine.

Pharmacokinetic mAb–mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

J. Balthasar, L. Abuqayyas, 2012, The AAPS Journal.

Special Section on DMPK of Therapeutic Proteins Evaluation of Near Infrared Fluorescent Labeling of Monoclonal Antibodies as a Tool for Tissue Distribution

L. Wienkers, D. Rock, Brooke M. Rock, 2014 .

DMD060319 1906..1913

L. Wienkers, D. Rock, Brooke M. Rock, 2014 .

Development and Evaluation of Competitive Inhibitors of Trastuzumab-HER2 Binding to Bypass the Binding-Site Barrier

Toan D. Nguyen, J. Balthasar, Brandon M. Bordeau, 2022, Frontiers in Pharmacology.

Assessments of antibody biodistribution

J. Balthasar, L. Abuqayyas, P. Glassman, 2015, Journal of clinical pharmacology.

High-performance liquid chromatographic assay for the determination of total and free topotecan in the presence and absence of anti-topotecan antibodies in mouse plasma.

J. Balthasar, Jin Chen, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Inverse targeting of peritoneal tumors: selective alteration of the disposition of methotrexate through the use of anti-methotrexate antibodies and antibody fragments.

H. Fung, J. Balthasar, 1996, Journal of pharmaceutical sciences.

The impact of sialylation linkage‐type on the pharmacokinetics of recombinant butyrylcholinesterases

M. Betenbaugh, C. Chung, J. Cipollo, 2020, Biotechnology and bioengineering.

Immune Complex Therapies for Treatment of Immune Thrombocytopenia

J. Balthasar, R. Deng, 2012 .

Pharmacokinetic effects of 4C9, an anti-FcRn antibody, in rats: implications for the use of FcRn inhibitors for the treatment of humoral autoimmune and alloimmune conditions.

J. Balthasar, Karen Getman, 2005, Journal of Pharmacy and Science.

Monoclonal Antibody Pharmacokinetics and

J. Balthasar, Eq Wang, 2008 .

Investigation of antibody-coated liposomes as a new treatment for immune thrombocytopenia.

J. Balthasar, R. Deng, 2005, International journal of pharmaceutics.

Mechanisms of IVIG action in immune thrombocytopenic purpura.

R. Hansen, J. Balthasar, 2004, Clinical laboratory.

Intravenous Immunoglobulin Mediates an Increase in Anti-Platelet Antibody Clearance via the FcRn Receptor

R. Hansen, J. Balthasar, 2002, Thrombosis and Haemostasis.

Application of pharmacokinetic-pharmacodynamic modeling to predict the kinetic and dynamic effects of anti-methotrexate antibodies in mice.

J. Balthasar, E. Lobo, D. Soda, 2003, Journal of pharmaceutical sciences.

Pharmacokinetics, pharmacodynamics, and platelet binding of an anti-glycoprotein IIb/IIIa monoclonal antibody (7E3) in the rat: a quantitative rat model of immune thrombocytopenic purpura.

R. Hansen, J. Balthasar, 2001, The Journal of pharmacology and experimental therapeutics.

IVIG effects on autoantibody elimination

R. Hansen, J. Balthasar, 2004, Allergy.

Cell Penetrating Peptides Conjugated to Anti-Carcinoembryonic Antigen "Catch-and-Release" Monoclonal Antibodies Alter Plasma and Tissue Pharmacokinetics in Colorectal Cancer Xenograft Mice.

J. Balthasar, J. R. Polli, 2022, Bioconjugate chemistry.

High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths.

Shaolian Zhou, L. Benincosa, Xue Wang, 2019, Analytical chemistry.

Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Predicting the Effects of Anti-FcRn Therapy on the Disposition of Endogenous IgG in Humans.

J. Balthasar, T. Li, 2019, Journal of pharmaceutical sciences.

Investigation of the role of FcγR and FcRn in mAb distribution to the brain.

J. Balthasar, L. Abuqayyas, 2013, Molecular pharmaceutics.

Physiologically based pharmacokinetic model for topotecan in mice

D. Shah, J. Balthasar, 2011, Journal of Pharmacokinetics and Pharmacodynamics.

Mathematical modeling of topotecan pharmacokinetics and toxicodynamics in mice

J. Balthasar, Jin Chen, Q. Lu, 2007, Journal of Pharmacokinetics and Pharmacodynamics.

Effects of intravenous immunoglobulin on platelet count and antiplatelet antibody disposition in a rat model of immune thrombocytopenia.

R. Hansen, J. Balthasar, 2002, Blood.

Evaluation of combined bevacizumab and intraperitoneal carboplatin or paclitaxel therapy in a mouse model of ovarian cancer

D. Shah, J. Veith, R. Bernacki, 2011, Cancer Chemotherapy and Pharmacology.

Pharmacokinetic and pharmacodynamic optimization of intraperitoneal chemotherapy.

H. Fung, J. Balthasar, 1996, Life sciences.

Evaluation of Near IR Fluorescent Labeling of mAbs as a Tool for Tissue Distribution

D. Rock, Brooke M. Rock, J. Balthasar, 2014 .

Highly sensitive high-performance liquid chromatographic assay for methotrexate in the presence and absence of anti-methotrexate antibody fragments in rat and mouse plasma.

J. Balthasar, E. Lobo, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Application of knockout mouse models to investigate the influence of FcγR on the tissue distribution and elimination of 8C2, a murine IgG1 monoclonal antibody.

J. Balthasar, L. Abuqayyas, 2012, International journal of pharmaceutics.

Pharmacokinetic/pharmacodynamic modeling of IVIG effects in a murine model of immune thrombocytopenia.

J. Balthasar, R. Deng, 2007, Journal of pharmaceutical sciences.

Mechanisms of intravenous immunoglobulin action in immune thrombocytopenic purpura.

J. Balthasar, Feng Jin, 2005, Human immunology.

Sensitive high performance liquid chromatographic assay for assessment of doxorubicin pharmacokinetics in mouse plasma and tissues.

B. Shin, V. Yang, J. Balthasar, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The Capsular Polysaccharide of Acinetobacter baumannii Is an Obstacle for Therapeutic Passive Immunization Strategies

T. Russo, J. Beanan, R. Olson, 2017, Infection and Immunity.

Predicting the effects of 8C2, a monoclonal anti-topotecan antibody, on plasma and tissue disposition of topotecan

D. Shah, J. Balthasar, 2014, Journal of Pharmacokinetics and Pharmacodynamics.

Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies

W. Jusko, Yanguang Cao, J. Balthasar, 2013, Journal of Pharmacokinetics and Pharmacodynamics.

Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling.

Shiew-Mei Huang, Filippos Kesisoglou, Johannes G Khinast, 2019, Journal of pharmaceutical sciences.

Understanding Inter-Individual Variability in Monoclonal Antibody Disposition

J. Balthasar, Veena A. Thomas, 2019, Antibodies.

Development and Validation of an Enzyme Linked Immunosorbent Assay for the Quantification of Carcinoembryonic Antigen in Mouse Plasma

V. Yang, J. Balthasar, S. Urva, 2009, Journal of immunoassay & immunochemistry.

Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeys

J. Balthasar, P. Glassman, Yang Chen, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Mechanistic considerations for the use of monoclonal antibodies for cancer therapy

J. Balthasar, P. Glassman, 2014, Cancer biology & medicine.

Pharmacokinetic/pharmacodynamic modeling of the effects of intravenous immunoglobulin on the disposition of antiplatelet antibodies in a rat model of immune thrombocytopenia.

R. Hansen, J. Balthasar, 2003, Journal of pharmaceutical sciences.

A GPIIb/IIIa bioreactor for specific treatment of immune thrombocytopenic purpura, an autoimmune disease. Preparation, in vitro characterization, and preliminary proof-of-concept animal studies.

V. Yang, Emel Emregul, Allan E. David, 2005, Journal of biomedical materials research. Part A.

Physiologically-based modeling of monoclonal antibody pharmacokinetics in drug discovery and development.

Joseph P Balthasar, J. Balthasar, P. Glassman, 2019, Drug metabolism and pharmacokinetics.

Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry.

Shichen Shen, Joseph P Balthasar, Jun Qu, 2017, Mass spectrometry reviews.

Investigation of the Influence of Nephropathy on Monoclonal Antibody Disposition: A Pharmacokinetic Study in a Mouse Model of Diabetic Nephropathy

F. Engler, J. Balthasar, B. Zheng, 2014, Pharmaceutical Research.

Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice

Joseph P. Balthasar, J. Balthasar, Amit Garg, 2007, Journal of Pharmacokinetics and Pharmacodynamics.

Pharmacodynamic modeling of chemotherapeutic effects: Application of a transit compartment model to characterize methotrexate effects in vitro

Evelyn D. Lobo, Joseph P. Balthasar, J. Balthasar, 2008, AAPS PharmSci.

Investigation of the Influence of Nephropathy on Monoclonal Antibody Disposition: A Pharmacokinetic Study in a Mouse Model of Diabetic Nephropathy

F. Engler, J. Balthasar, B. Zheng, 2013, Pharmaceutical Research.

Strategies for improving the functionality of an affinity bioreactor.

V. Yang, Emel Emregul, Allan E. David, 2005, International journal of pharmaceutics.

Pharmacokinetics , Pharmacodynamics , and Platelet Binding of an Anti-Glycoprotein IIb / IIIa Monoclonal Antibody ( 7 E 3 ) in the Rat : A Quantitative Rat Model of Immune Thrombocytopenic Purpura

R. Hansen, J. Balthasar, 2001 .

Mechanisms of ADC Toxicity and Strategies to Increase ADC Tolerability

J. Balthasar, Brandon M Bordeau, T. D. Nguyen, 2023, Cancers.

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

J. Balthasar, Yang Chen, 2012, The AAPS Journal.

Comparison of the effects of antibody-coated liposomes, IVIG, and anti-RBC immunotherapy in a murine model of passive chronic immune thrombocytopenia.

J. Balthasar, R. Deng, 2007, Blood.

Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effects of FcRn Inhibitors in Mice, Rats, and Monkeys.

J. Balthasar, T. Li, 2019, Journal of pharmaceutical sciences.

Antibody Dependent Enhancement of Acinetobacter baumannii Infection in a Mouse Pneumonia Model

T. Russo, J. Beanan, R. Olson, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Effects of Calibration Approaches on the Accuracy for LC–MS Targeted Quantification of Therapeutic Protein

Tao Ji, Jun Qu, Bo An, 2014, Analytical chemistry.

Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis.

Joseph P Balthasar, Jun Qu, Xiao-tao Duan, 2012, Journal of chromatography. A.

High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrometry.

Joseph P Balthasar, Jun Qu, Xiao-tao Duan, 2012, Analytical chemistry.

Pharmacodynamics of in Vivo Nitroglycerin Tolerance in Normal Conscious Rats: Effects of Dose and Dosing Protocol

H. Fung, J. Balthasar, E. Wang, 2004, Pharmaceutical Research.

Application of Pharmacodynamic Modeling for Designing Time-Variant Dosing Regimens to Overcome Nitroglycerin Tolerance in Experimental Heart Failure

John Anthony Bauer, J. Bauer, H. Fung, 1997, Pharmaceutical Research.

Pharmacokinetic and Pharmacodynamic Considerations for the Use of Monoclonal Antibodies in the Treatment of Bacterial Infections

J. Balthasar, Shun Xin Wang-Lin, 2018, Antibodies.

Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens

J. Balthasar, P. Glassman, 2017, mAbs.

Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics.

J. Canty, Shaolian Zhou, R. Young, 2018, Analytical chemistry.

PK/TD modeling for prediction of the effects of 8C2, an anti-topotecan mAb, on topotecan-induced toxicity in mice.

Dhaval K Shah, Joseph P Balthasar, D. Shah, 2014, International journal of pharmaceutics.

Application of anti-methotrexate Fab fragments for the optimization of intraperitoneal methotrexate therapy in a murine model of peritoneal cancer.

J. Balthasar, E. Lobo, 2005, Journal of pharmaceutical sciences.

Half-Life Extension and Biodistribution Modulation of Biotherapeutics via Red Blood Cell Hitch-Hiking with Novel Anti-Band 3 Single-Domain Antibodies

Toan D. Nguyen, J. Balthasar, Yu Zhang, 2022, International journal of molecular sciences.

Transient Inhibition of Trastuzumab-Tumor Binding to Overcome the "Binding-Site Barrier" and Improve the Efficacy of a Trastuzumab-Gelonin Immunotoxin.

Ping Chen, J. Balthasar, Brandon M Bordeau, 2022, Molecular cancer therapeutics.

Transient Competitive Inhibition Bypasses the Binding Site Barrier to Improve Tumor Penetration of Trastuzumab and Enhance T-DM1 Efficacy

J. Balthasar, Yujie Yang, Brandon M Bordeau, 2021, Cancer Research.

Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies

J. Balthasar, P. Glassman, 2016, Journal of Pharmacokinetics and Pharmacodynamics.

AAPS Workshop Report: Strategies to Address Therapeutic Protein–Drug Interactions during Clinical Development

Steven W. Martin, Shiew-Mei Huang, R. Evers, 2011, The AAPS Journal.

Physiologically based pharmacokinetic model for T84.66: a monoclonal anti-CEA antibody.

Joseph P Balthasar, Victor C Yang, V. Yang, 2010, Journal of pharmaceutical sciences.

Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies

J. Balthasar, P. Glassman, 2016, Journal of Pharmacokinetics and Pharmacodynamics.

Target mediated disposition of T84.66, a monoclonal anti-CEA antibody

J. Balthasar, S. Urva, 2010, mAbs.

Pharmacokinetic-pharmacodynamic modeling of methotrexate-induced toxicity in mice.

Joseph P Balthasar, Evelyn D Lobo, J. Balthasar, 2003, Journal of pharmaceutical sciences.

Development and Validation of Enzyme‐Linked Immunosorbent Assays for Quantification of Anti‐Methotrexate IgG and Fab in Mouse and Rat Plasma

J. Balthasar, Z. Tayab, 2004, Journal of immunoassay & immunochemistry.

Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer

J. Balthasar, L. Abuqayyas, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Investigation of the Influence of Protein-Losing Enteropathy on Monoclonal Antibody Pharmacokinetics in Mice

J. Balthasar, T. Li, Yujie Yang, 2017, The AAPS Journal.

Investigation of the Influence of FcRn on the Distribution of IgG to the Brain

Joseph P. Balthasar, J. Balthasar, Amit Garg, 2009, The AAPS Journal.

Pharmacokinetic and pharmacodynamic effects of high-dose monoclonal antibody therapy in a rat model of immune thrombocytopenia

J. Balthasar, Z. Tayab, Feng Jin, 2005, The AAPS Journal.

Sorafenib Decreases Tumor Exposure to an Anti-carcinoembryonic Antigen Monoclonal Antibody in a Mouse Model of Colorectal Cancer

J. Balthasar, Veena A. Thomas, 2016, The AAPS Journal.

Pharmacokinetic mAb–mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

J. Balthasar, L. Abuqayyas, 2012, The AAPS Journal.

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Prediction of Monoclonal Antibody Tumor Disposition

F. Schweser, H. Grimm, J. Balthasar, 2022, International journal of molecular sciences.

Physiologically Based Modeling of the Pharmacokinetics of "Catch-and-Release" Anti-Carcinoembryonic Antigen Monoclonal Antibodies in Colorectal Cancer Xenograft Mouse Models.

F. Engler, J. Balthasar, J. R. Polli, 2019, Journal of pharmaceutical sciences.

Use of an Anti-Vascular Endothelial Growth Factor Antibody in a Pharmacokinetic Strategy to Increase the Efficacy of Intraperitoneal Chemotherapy

Beom Soo Shin, Dhaval K Shah, Joseph P Balthasar, 2009, Journal of Pharmacology and Experimental Therapeutics.

“Catch-and-Release” Anti-Carcinoembryonic Antigen Monoclonal Antibody Leads to Greater Plasma and Tumor Exposure in a Mouse Model of Colorectal Cancer

F. Engler, J. Balthasar, J. R. Polli, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Development and validation of an enzyme-linked immunosorbent assay for the quantification of gelonin in mouse plasma

F. Engler, J. Balthasar, 2016, Journal of immunoassay & immunochemistry.

Application of a catenary PBPK model to predict the disposition of "catch and release" anti-PCSK9 antibodies.

J. Balthasar, P. Glassman, 2016, International journal of pharmaceutics.

Utilization of antidrug antibody fragments for the optimization of intraperitoneal drug therapy: studies using digoxin as a model drug.

H. Fung, J. Balthasar, 1994, The Journal of pharmacology and experimental therapeutics.

AN ELISA FOR QUANTIFICATION OF T84.66, A MONOCLONAL ANTI-CEA ANTIBODY, IN MOUSE PLASMA

Joseph P Balthasar, Victor C Yang, V. Yang, 2009, Journal of immunoassay & immunochemistry.

Bioequivalence and Bioequivalency Testing

J. Balthasar, 2004 .

Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

F. Theil, L. Khawli, J. Balthasar, 2012, The AAPS Journal.

Prediction of drug bioavailability in humans using immobilized artificial membrane phosphatidylcholine column chromatography and in vitro hepatic metabolic clearance.

B. Shin, S. Yoo, J. Balthasar, 2009, Biomedical chromatography : BMC.

Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer

J. Balthasar, L. Abuqayyas, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

Daniela Bumbaca, F. Theil, L. Khawli, 2012, The AAPS Journal.

PK/TD modeling for prediction of the effects of 8C2, an anti-topotecan mAb, on topotecan-induced toxicity in mice.

D. Shah, J. Balthasar, 2014, International journal of pharmaceutics.

Development and Characterization of High‐Affinity Anti‐Topotecan IgG and Fab Fragments

J. Balthasar, Jin Chen, 2010 .

High-affinity rabbit antibodies directed against methotrexate: production, purification, characterization, and pharmacokinetics in the rat.

H. Fung, J. Balthasar, 1995, Journal of pharmaceutical sciences.

Payload-binding Fab fragments increase the therapeutic index of MMAE antibody-drug conjugates.

J. Balthasar, J. R. Polli, Ping Chen, 2023, Molecular cancer therapeutics.

Sensitive high performance liquid chromatographic assay for assessment of doxorubicin pharmacokinetics in mouse plasma and tissues.

B. Shin, V. Yang, J. Balthasar, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Application of a catenary PBPK model to predict the disposition of "catch and release" anti-PCSK9 antibodies.

J. Balthasar, P. Glassman, 2016, International journal of pharmaceutics.