Jianjun Chen

发表

Design, Synthesis, and Bioevaluation of Novel Enzyme-Triggerable Cell Penetrating Peptide-Based Dendrimers for Targeted Delivery of Camptothecin and Cancer Therapy.

Ruiyao Mai, Bulian Deng, Huiting Zhao, 2022, Journal of medicinal chemistry.

Nanotechnology in retinal drug delivery.

Jianjun Chen, Sibo Jiang, Yesenia Franco, 2018, International journal of ophthalmology.

A Cell Membrane‐Targeting Self‐Delivery Chimeric Peptide for Enhanced Photodynamic Therapy and In Situ Therapeutic Feedback

Zhi-Qiang Yu, Bin Yu, Yun Liu, 2019, Advanced healthcare materials.

A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism

Jin Wang, Jingxuan Chen, Suman Sirimulla, 2019, Drug metabolism reviews.

Versatile Nanodrugs Containing Glutathione and Heme Oxygenase 1 Inhibitors Enable Suppression of Antioxidant Defense System in a Two‐Pronged Manner for Enhanced Photodynamic Therapy

Xian‐Zheng Zhang, Ying Tu, Jingxuan Chen, 2021, Advanced healthcare materials.

Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.

Ruiyao Mai, Bulian Deng, Huiting Zhao, 2022, Journal of medicinal chemistry.

Recent advances in small molecule based cancer immunotherapy.

Wei-En Yuan, Jing Su, Jianjun Chen, 2018, European journal of medicinal chemistry.

Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses.

Jianjun Chen, Jin Liu, Pingzheng Zhou, 2022, Biochemical pharmacology.

Discovery of novel 3-hydroxyandrosta-5,7-Diene-17-Carboxylic acid derivatives as anti-inflammatory bowel diseases (IBD) agents.

Jingxuan Chen, Wei Li, A. Slominski, 2021, European journal of medicinal chemistry.

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.

Shuwen Liu, M. Luo, Ling-Wei Li, 2020, European journal of medicinal chemistry.

Nano-assembly of ursolic acid with platinum prodrug overcomes multiple deactivation pathways in platinum-resistant ovarian cancer.

Zhiqiang Yu, Xuefeng Wang, Jianjun Chen, 2021, Biomaterials science.

Recent progress in histone methyltransferase (G9a) inhibitors as anticancer agents.

Guochao Liao, Bin Yu, Ling-Wei Li, 2019, European journal of medicinal chemistry.

Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment.

Chenyu Zhang, Zhiqiang Yu, Ruiyao Mai, 2020, European journal of medicinal chemistry.

5-arylalkynyl-2-benzoyl thiophene: a novel microtubule inhibitor exhibits antitumor activity without neurological toxicity.

Zichao Yang, Jianjun Chen, Guang Yang, 2022, American journal of cancer research.

Design, synthesis and biological evaluation of benz‐fused five‐membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities

Jianjun Chen, Yao Liu, Jin Liu, 2021, Chemical biology & drug design.

Selective PARP1 Inhibitors, PARP1-based Dual-Target Inhibitors, PROTAC PARP1 Degraders, and Prodrugs of PARP1 Inhibitors for Cancer Therapy.

Jianjun Chen, Weijie Peng, Xiaopeng Peng, 2022, Pharmacological research.

Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity.

Jingxuan Chen, Zichao Yang, Huiting Zhao, 2021, Bioorganic chemistry.

Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia.

Jianjun Chen, Jian Luo, Ting Wu, 2021, European journal of medicinal chemistry.

Discovery of Novel Quinazoline-based KRAS G12C Inhibitors as Potential Anticancer Agents

Jingxuan Chen, Ruiyao Mai, Huiting Zhao, 2022, Bioorganic & Medicinal Chemistry.

Discovery of novel quinazoline-based covalent inhibitors of KRAS G12C with various cysteine-targeting warheads as potential anticancer agents.

Jingxuan Chen, Huiting Zhao, Ling-Wei Li, 2021, Bioorganic chemistry.

Near‐Infrared II Light‐Triggered Robust Carbon Radical Generation for Combined Photothermal and Thermodynamic Therapy of Hypoxic Tumors

Xiqiang Liu, Yuanyuan Yang, Zhiqiang Yu, 2021, Advanced Functional Materials.

Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents.

Zichao Yang, Jianjun Chen, Hui Liao, 2022, European journal of medicinal chemistry.

Discovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening.

Zichao Yang, Ruiyao Mai, Bulian Deng, 2022, European journal of medicinal chemistry.

Synergistic chemotherapy for breast cancer and breast cancer brain metastases via paclitaxel-loaded oleanolic acid nanoparticles.

A. Chen, Jiangbing Zhou, Weiguo Xu, 2020, Molecular Pharmaceutics.

Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents.

Jingxuan Chen, Ling-Wei Li, Jianjun Chen, 2021, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.

Jingxuan Chen, Ling-Wei Li, Jianjun Chen, 2019, European journal of medicinal chemistry.

Discovery of novel 2-aryl-4-bis-amide imidazoles (ABAI) as anti-inflammatory agents for the treatment of inflammatory bowel diseases (IBD).

Jingxuan Chen, Huiting Zhao, Ling-Wei Li, 2022, Bioorganic chemistry.

Discovery of novel CA-4 analogs as dual inhibitors of tubulin polymerization and PD-1/PD-L1 interaction for cancer treatment.

Yao Xiao, Jianjun Chen, Ting Liu, 2020, European journal of medicinal chemistry.

Synthesis of N ‐Carbonyl Acridanes as Highly Potent Inhibitors of Tubulin Polymerization via One‐Pot Copper‐Catalyzed Dual Arylation of Nitriles with Cyclic Diphenyl Iodoniums

Ling-Wei Li, Jianjun Chen, Jin Liu, 2020, Advanced Synthesis & Catalysis.

Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site.

Jing Su, Jing Su, Ling-Wei Li, 2018, European journal of medicinal chemistry.

Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1.

Jianjun Chen, Hao Cao, Yichang Ren, 2020, European journal of medicinal chemistry.

Discovery of Novel Resorcinol Dibenzyl Ethers Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction As Potential Anticancer Agents.

Jin Wang, Yingfeng Tu, Shuwen Liu, 2020, Journal of medicinal chemistry.

Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.

Yao Xiao, W. Pan, Jianjun Chen, 2022, European journal of medicinal chemistry.

Synthesis and Pharmacological Evaluation of Novel Resorcinol Biphenyl Ether Analogs as Small Molecule Inhibitors of PD-1/PD-L1 with Benign Toxicity Profiles for Cancer Treatment.

Jianjun Chen, Ting Liu, Hao Cao, 2021, Biochemical pharmacology.

Recent Advances in the Development of PD-L1 Modulators: Degraders, Downregulators, and Covalent Inhibitors.

Yao Xiao, Jianjun Chen, Hao Cao, 2020, Journal of medicinal chemistry.

Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment.

Yingfeng Tu, Shuwen Liu, Jingxuan Chen, 2020, Journal of medicinal chemistry.

An Overview of HDAC Inhibitors and their Synthetic Routes.

Guochao Liao, Zhiqiang Yu, Jianjun Chen, 2019, Current topics in medicinal chemistry.

An Alkene-Forming Cascade Reaction En Route to 2,2'-Bi(glycerol)

Jianjun Chen, P. Livant, Xiaoxun Li, 2018, Synlett.

Light-Activatable Prodrug and AIEgen Copolymer Nanoparticle for Dual-Drug Monitoring and Combination Therapy.

Xuefeng Wang, Zhiqiang Yu, Wen Ma, 2019, ACS applied materials & interfaces.

pH-Responsive Cross-Linked Low Molecular Weight Polyethylenimine as an Efficient Gene Vector for Delivery of Plasmid DNA Encoding Anti-VEGF-shRNA for Tumor Treatment

Z. Fang, Xiaoshuang Guo, Wei-En Yuan, 2018, Front. Oncol..

Discovery of novel 7,8-dihydropteridine-6(5H)-one-based DNA-PK inhibitors as potential anticancer agents via scaffold hopping strategy.

Yao Xiao, Jianjun Chen, Binbin Cheng, 2022, European journal of medicinal chemistry.

Discovery of pomalidomide-based PROTACs for selective degradation of histone deacetylase 8.

Zichao Yang, Ruiyao Mai, Bulian Deng, 2022, European journal of medicinal chemistry.

Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment.

Jianjun Chen, Peihua Kuang, Xiaopeng Peng, 2020, European journal of medicinal chemistry.

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects.

Jianjun Chen, Jin Liu, Yichang Ren, 2022, Journal of medicinal chemistry.

Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities.

Jianjun Chen, Yuxi Wang, Yichang Ren, 2021, Journal of medicinal chemistry.

Recent Advances in c-Jun N-terminal Kinase (JNK) Inhibitors.

W. Qi, M. Luo, Jianjun Chen, 2020, Current medicinal chemistry.

Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanoma

Ting Yu, Bulian Deng, Jianjun Chen, 2023, Journal of enzyme inhibition and medicinal chemistry.

X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.

Zichao Yang, Jianjun Chen, Yuxi Wang, 2023, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities.

Ling-Wei Li, Yuyu Fang, Jianjun Chen, 2021, Bioorganic & medicinal chemistry.

Design, synthesis, and bioevaluation of imidazo [1,2-a] pyrazine derivatives as tubulin polymerization inhibitors with potent anticancer activities.

Yuxi Wang, Zichao Yang, Ruiyao Mai, 2022, Bioorganic & medicinal chemistry.

Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities.

Jingxuan Chen, Ling-Wei Li, Jianjun Chen, 2020, Organic letters.

Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy.

Jianjun Chen, Shuanghu Wang, Yiyu Lu, 2023, Journal of medicinal chemistry.

Bifunctional small molecules targeting PD-L1/CXCL12 as dual immunotherapy for cancer treatment

Jianjun Chen, Ting Liu, Hao Cao, 2023, Signal Transduction and Targeted Therapy.

Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation.

Zichao Yang, Jianjun Chen, Shumin Cai, 2023, European journal of medicinal chemistry.

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

Jianjun Chen, Xiaopeng Peng, Weiming Chen, 2023, Acta pharmaceutica Sinica. B.

Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents.

Ling-Wei Li, Jianjun Chen, Ting Liu, 2023, Journal of medicinal chemistry.

Discovery of conformationally constrained c-Abl inhibitors with potential neuroprotective effects against Parkinson's disease.

Jiajie Zhang, Zichao Yang, Tingting Zhang, 2023, Bioorganic & medicinal chemistry.

HDAC-targeting epigenetic modulators for cancer immunotherapy.

Jianjun Chen, Jin Liu, Binbin Cheng, 2024, European journal of medicinal chemistry.

Small molecules targeting selected histone methyltransferases (HMTs) for cancer treatment: Current progress and novel strategies.

Jianjun Chen, Xiaopeng Peng, Zhihao Hu, 2023, European journal of medicinal chemistry.

Recent Progress in DNA Damage Response-Targeting PROTAC Degraders.

Jianjun Chen, Binbin Cheng, Xiaopeng Peng, 2024, Journal of medicinal chemistry.

Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.

Jingxuan Chen, Ling-Wei Li, Jianjun Chen, 2022, Journal of medicinal chemistry.

Recent progress in the development of hypoxia-inducible factor 2α (HIF-2α) modulators: Inhibitors, agonists, and degraders (2009–2024)

Jianjun Chen, Jin Liu, Binbin Cheng, 2024, European Journal of Medicinal Chemistry.

Discovery of novel resorcinol biphenyl ether-based macrocyclic small molecules as PD-1/PD-L1 inhibitors with favorable pharmacokinetics for cancer immunotherapy.

Zichao Yang, Ling-Wei Li, Jianjun Chen, 2023, Bioorganic chemistry.

Rhizoaspergillin A and Rhizoaspergillinol A, including a Unique Orsellinic Acid–Ribose–Pyridazinone-N-Oxide Hybrid, from the Mangrove Endophytic Fungus Aspergillus sp. A1E3

Jianjun Chen, Guangying Chen, Binbin Wu, 2023, Marine drugs.

Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy.

Jianjun Chen, Jian-Feng Xiao, Jin Liu, 2024, Journal of medicinal chemistry.