Lauren D Hagler

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting.

H. Chan, Jianjun Cheng, S. Zimmerman, 2016, Journal of the American Chemical Society.

Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors.

S. Butcher, M. Tonelli, J. Vergara, 2020, Biochemistry.

Versatile Target-Guided Screen for Discovering Bidirectional Transcription Inhibitors of a Trinucleotide Repeat Disease.

J. Vergara, S. Zimmerman, Lauren D Hagler, 2021, ACS medicinal chemistry letters.

Structural basis for targeting T:T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA.

C. Chien, S. Zimmerman, Cheng-Chung Chang, 2020, Journal of the American Chemical Society.

A comprehensive thermodynamic model for RNA binding by the Saccharomyces cerevisiae Pumilio protein PUF4

D. Herschlag, W. Greenleaf, Inga Jarmoskaite, 2021, Nature Communications.

Assessing the feasibility and stability of uracil base flipping in RNA–small molecule complexes using molecular dynamics simulations

S. Zimmerman, Lauren D Hagler, Philip A. Kocheril, 2020, Canadian Journal of Chemistry.

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

H. Chan, S. Zimmerman, A. Kalsotra, 2019, Proceedings of the National Academy of Sciences.

Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking

S. Butcher, S. Zimmerman, E. Montemayor, 2019, Acta crystallographica. Section F, Structural biology communications.

Development of novel macrocyclic small molecules that target CTG trinucleotide repeats.

S. Zimmerman, Lauren D Hagler, Juyeon Lee, 2019, Bioorganic & medicinal chemistry.