P. Chytil

发表

Micelle-forming HPMA copolymer conjugates of ritonavir bound via a pH-sensitive spacer with improved cellular uptake designed for enhanced tumor accumulation.

V. Šubr, T. Etrych, S. Filippov, 2016, Journal of materials chemistry. B.

Fluorescence Imaging as a Tool in Preclinical Evaluation of Polymer-Based Nano-DDS Systems Intended for Cancer Treatment

T. Etrych, O. Janoušková, P. Chytil, 2019, Pharmaceutics.

Nanotherapeutics with suitable properties for advanced anticancer therapy based on HPMA copolymer‐bound ritonavir via pH‐sensitive spacers

T. Etrych, O. Janoušková, D. Machová, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester.

K. Ulbrich, P. Štěpánek, T. Etrych, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice.

K. Ulbrich, H. Maeda, T. Etrych, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Doxorubicin release is not a prerequisite for the in vitro cytotoxicity of HPMA-based pharmaceuticals: in vitro effect of extra drug-free GlyPheLeuGly sequences.

K. Ulbrich, V. Šubr, T. Etrych, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy.

K. Ulbrich, L. Kovář, T. Etrych, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Novel star HPMA-based polymer conjugates for passive targeting to solid tumors

K. Ulbrich, T. Etrych, B. Říhová, 2011, Journal of drug targeting.

N-(2-Hydroxypropyl)methacrylamide-Based Polymer Conjugates with pH-Controlled Activation of Doxorubicin. I. New Synthesis, Physicochemical Characterization and Preliminary Biological Evaluation

K. Ulbrich, T. Etrych, T. Mrkvan, 2008 .

Interaction of spin-labeled HPMA-based nanoparticles with human blood plasma proteins - the introduction of protein-corona-free polymer nanomedicine.

D. Weitz, I. Raška, T. Etrych, 2018, Nanoscale.

Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins

D. Svergun, T. Etrych, A. Gruzinov, 2020, Pharmaceutics.

Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid.

H. Maeda, T. Etrych, M. Haratake, 2019, Molecular pharmaceutics.

Comparison of the pharmacological and biological properties of HPMA copolymer‐pirarubicin conjugates: A single‐chain copolymer conjugate and its biodegradable tandem‐diblock copolymer conjugate

K. Ulbrich, H. Maeda, T. Etrych, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Improved Tumor-Specific Drug Accumulation by Polymer Therapeutics with pH-Sensitive Drug Release Overcomes Chemotherapy Resistance

T. Etrych, T. Mueller, K. Mäder, 2016, Molecular Cancer Therapeutics.

Nanotherapeutics shielded with a pH responsive polymeric layer.

K. Ulbrich, V. Šubr, T. Etrych, 2015, Physiological research.

Preclinical Evaluation of Linear HPMA-Doxorubicin Conjugates with pH-Sensitive Drug Release: Efficacy, Safety, and Immunomodulating Activity in Murine Model

K. Ulbrich, L. Kovář, T. Etrych, 2009, Pharmaceutical Research.

HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy

T. Etrych, B. Říhová, M. Šírová, 2021, Pharmaceutics.

Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II: impact of release rate on biodistribution.

K. Ulbrich, T. Etrych, T. Mueller, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin.

K. Ulbrich, H. Maeda, T. Etrych, 2016, Molecular pharmaceutics.

HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases

K. Ulbrich, H. Maeda, T. Etrych, 2016, Targeted Oncology.

Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage.

K. Ulbrich, H. Maeda, T. Etrych, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Structural Design and Synthesis of Polymer Prodrugs

T. Etrych, P. Chytil, L. Kostka, 2017 .

The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel

T. Etrych, B. Říhová, M. Šírová, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Binding of HSA to Macromolecular pHPMA Based Nanoparticles for Drug Delivery: An Investigation Using Fluorescence Methods.

G. Winter, T. Etrych, S. Filippov, 2018, Langmuir.

Synthesis and Properties of Star HPMA Copolymer Nanocarriers Synthesised by RAFT Polymerisation Designed for Selective Anticancer Drug Delivery and Imaging.

K. Ulbrich, T. Etrych, O. Janoušková, 2015, Macromolecular bioscience.

New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting.

K. Ulbrich, T. Etrych, T. Mrkvan, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study.

K. Ulbrich, D. Svergun, P. Štěpánek, 2013, Biomacromolecules.

Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization.

T. Etrych, Jun Fang, Hideaki Nakamura, 2020, Acta biomaterialia.

Nanotherapeutics with anthracyclines: methods of determination and quantification of anthracyclines in biological samples.

T. Etrych, O. Janoušková, E. Koziolová, 2015, Physiological research.

Hydrolytically Degradable Polymer Micelles for Anticancer Drug Delivery to Solid Tumors

K. Ulbrich, T. Etrych, P. Chytil, 2012 .

Synthesis of HPMA Copolymers Containing Doxorubicin Bound via a Hydrazone Linkage. Effect of Spacer on Drug Release and in vitro Cytotoxicity

K. Ulbrich, T. Etrych, B. Říhová, 2002 .

Polymer-Based Drug-Free Therapeutics for Anticancer, Anti-Inflammatory, and Antibacterial Treatment.

T. Etrych, M. Pechar, P. Chytil, 2021, Macromolecular bioscience.

Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: Comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties.

T. Etrych, B. Říhová, O. Janoušková, 2020, Journal of controlled release : official journal of the Controlled Release Society.

High-affinity HPMA copolymers with tailored N-acetyllactosamine presentation discriminate between galectins.

V. Křen, T. Etrych, L. Elling, 2020, Biomacromolecules.

Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system.

K. Ulbrich, D. Svergun, P. Štěpánek, 2012, Biomacromolecules.

Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers

V. Křen, N. Abrescia, A. Ardá, 2021, International journal of molecular sciences.

Polymeric anticancer drugs with pH-controlled activation.

K. Ulbrich, T. Etrych, B. Říhová, 2004, International journal of pharmaceutics.

Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting.

K. Ulbrich, T. Etrych, T. Mrkvan, 2008, Journal of controlled release : official journal of the Controlled Release Society.

HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity.

K. Ulbrich, T. Etrych, B. Říhová, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Glycopolymers for Efficient Inhibition of Galectin-3: In Vitro Proof of Efficacy Using Suppression of T Lymphocyte Apoptosis and Tumor Cell Migration.

V. Křen, T. Etrych, L. Bumba, 2020, Biomacromolecules.

Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system

K. Ulbrich, P. Štěpánek, J. Putaux, 2012 .

Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3

V. Křen, T. Etrych, L. Bumba, 2018, Journal of Nanobiotechnology.

Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells

K. Ulbrich, V. Šubr, L. Kovář, 2010, Tumor Biology.

Fluorescence optical imaging in anticancer drug delivery.

T. Etrych, T. Mueller, O. Janoušková, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction.

Michael Y. Gerner, K. Ulbrich, A. Wang, 2019, Biomacromolecules.

HPMA Copolymer-Drug Conjugates with Controlled Tumor-Specific Drug Release.

K. Ulbrich, T. Etrych, E. Koziolová, 2018, Macromolecular bioscience.

Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification.

K. Ulbrich, T. Etrych, T. Mrkvan, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Antibody-targeted Polymer–doxorubicin Conjugates with pH-controlled Activation

K. Ulbrich, T. Etrych, B. Říhová, 2004, Journal of drug targeting.

HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery

T. Etrych, P. Chytil, L. Kostka, 2021, Journal of personalized medicine.

ReviewHPMA Copolymer-Based Nanomedicines in Controlled Drug DeliveryPetr Chytil

T. Etrych, P. Chytil, L. Kostka, 2021 .

Glycopolymers Decorated with 3-O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin-3.

V. Křen, T. Etrych, L. Bumba, 2022, Journal of medicinal chemistry.

N-(2-Hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation.

K. Ulbrich, V. Šubr, T. Etrych, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effective doxorubicin‐based nano‐therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging

T. Etrych, L. Šefc, V. Kolářová, 2018, Journal of controlled release : official journal of the Controlled Release Society.

HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study.

K. Ulbrich, H. Maeda, T. Etrych, 2018, International journal of pharmaceutics.

Influence of molar mass, dispersity, and type and location of hydrophobic side chain moieties on the critical micellar concentration and stability of amphiphilic HPMA-based polymer drug carriers

T. Etrych, S. Filippov, C. Papadakis, 2017, Colloid and Polymer Science.

Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity.

K. Ulbrich, T. Etrych, T. Mrkvan, 2005, Journal of controlled release : official journal of the Controlled Release Society.

A tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging.

W. Cai, T. Etrych, T. Barnhart, 2017, Nanoscale.

Intended and Unintended Targeting of Polymeric Nanocarriers: The Case of Modified Poly(glycerol adipate) Nanoparticles.

T. Etrych, J. Kressler, T. Mueller, 2018, Macromolecular bioscience.

The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia.

K. Ulbrich, T. Etrych, B. Říhová, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Polymer donors of nitric oxide improve the treatment of experimental solid tumours with nanosized polymer therapeutics

T. Etrych, B. Říhová, M. Šírová, 2017, Journal of drug targeting.

The comparison of in vivo properties of water-soluble HPMA-based polymer conjugates with doxorubicin prepared by controlled RAFT or free radical polymerization.

K. Ulbrich, T. Etrych, B. Říhová, 2015, Physiological research.

Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting.

K. Ulbrich, T. Etrych, J. Strohalm, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A Novel Approach to Increase the Stability of Liposomal Containers via In Prep Coating by Poly[N -(2-Hydroxypropyl)Methacrylamide] with Covalently Attached Cholesterol Groups

K. Ulbrich, T. Etrych, L. Kováčik, 2018 .

Macromolecular pHPMA-Based Nanoparticles with Cholesterol for Solid Tumor Targeting: Behavior in HSA Protein Environment.

D. Svergun, T. Etrych, A. Kikhney, 2018, Biomacromolecules.

Micellar and Antibody-Targeted Polymer Therapeutics

K. Ulbrich, L. Kovář, T. Etrych, 2010 .

Glycan-decorated HPMA copolymers as high-affinity lectin ligands

V. Křen, T. Etrych, L. Bumba, 2017 .

Biodegradable Micellar HPMA-Based Polymer-Drug Conjugates with Betulinic Acid for Passive Tumor Targeting.

K. Ulbrich, T. Etrych, Y. Skorik, 2016, Biomacromolecules.

The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia.

K. Ulbrich, T. Etrych, B. Říhová, 2016, Journal of controlled release : official journal of the Controlled Release Society.

The same drug but a different mechanism of action: comparison of free doxorubicin with two different N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugates in EL-4 cancer cell line.

K. Ulbrich, L. Kovář, T. Mrkvan, 2007, Bioconjugate chemistry.

New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting.

T. Etrych, T. Mrkvan, B. Říhová, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines

T. Etrych, M. Filipová, M. Pechar, 2024, European Polymer Journal.