H. Forsman

发表

The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor loop.

Tudor I. Oprea, T. Oprea, A. Karlsson, 2013, Biochimica et biophysica acta.

Allosteric receptor modulation uncovers an FFAR2 antagonist as a positive orthosteric modulator/agonist in disguise

C. Dahlgren, H. Forsman, Simon Lind, 2021, bioRxiv.

Structural changes of the ligand and of the receptor alters the receptor preference for neutrophil activating peptides starting with a formylmethionyl group.

C. Dahlgren, H. Forsman, F. Boulay, 2015, Biochimica et biophysica acta.

A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1.

Tudor I. Oprea, T. Oprea, C. Dahlgren, 2012, Biochemical pharmacology.

Data describing expression of formyl peptide receptor 2 in human articular chondrocytes

H. Forsman, I. Gjertsson, C. Jonsson, 2020, Data in brief.

Formyl peptide receptor 2 orchestrates mucosal protection against Citrobacter rodentium infection

S. Lindén, H. Forsman, M. Padra, 2019, Virulence.

The Host Defense Peptide LL-37 Selectively Permeabilizes Apoptotic Leukocytes

K. Brown, D. Davidson, S. Teneberg, 2008, Antimicrobial Agents and Chemotherapy.

Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated Functions.

C. Dahlgren, H. Forsman, Simon Lind, 2020, ACS pharmacology & translational science.

Signals Generated by Neutrophil Receptors for Danger Molecules Transactivate Allosterically Modulated FFA2R: Distinct response patterns are mediated by modulators recognized by different allosteric receptor sites

C. Dahlgren, H. Forsman, Simon Lind, 2022, bioRxiv.

Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

I. Mårtensson, M. Reth, Kathrin Kläsener, 2022, The Journal of experimental medicine.

Lack of Receptor for Advanced Glycation End Products Leads to Less Severe Staphylococcal Skin Infection but More Skin Abscesses and Prolonged Wound Healing

R. Pullerits, H. Forsman, Abukar Ali, 2018, The Journal of infectious diseases.

Phenol-Soluble Modulin α Peptide Toxins from Aggressive Staphylococcus aureus Induce Rapid Formation of Neutrophil Extracellular Traps through a Reactive Oxygen Species-Independent Pathway

A. Karlsson, C. Urban, C. Dahlgren, 2017, Frontiers in immunology.

GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists.

C. Dahlgren, Thor C. Møller, H. Forsman, 2022, Biochimica et biophysica acta. Molecular cell research.

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis.

M. Bouvier, H. Franzyk, K. Jennbacken, 2020, Biochimica et biophysica acta. Molecular cell research.

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis

M. Bouvier, H. Franzyk, K. Jennbacken, 2020, bioRxiv.

The putative Gαq-inhibiting pepducin P4Pal10 distinctly modulates function of the Gαi-coupled receptors FPR2 and FFA2R in neutrophils

C. Dahlgren, H. Forsman, Simon Lind, 2019, bioRxiv.

Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949.

R. Holmdahl, C. Dahlgren, P. Olofsson, 2019, Biochemical pharmacology.

Staphylococcus aureus–Derived PSMα Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate β-Arrestin Recruitment and Chemotaxis

K. Jennbacken, C. Dahlgren, Thor C. Møller, 2019, The Journal of Immunology.

Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949

R. Holmdahl, C. Dahlgren, P. Olofsson, 2019, bioRxiv.

Allosteric receptor modulation of FFA2R turns natural agonists into potent activators of the superoxide generating neutrophil NADPH-oxidase

C. Dahlgren, H. Forsman, L. Björkman, 2018, bioRxiv.

Formyl Peptide Receptors in Mice and Men: Similarities and Differences in Recognition of Conventional Ligands and Modulating Lipopeptides.

C. Dahlgren, H. Forsman, Malene Winther, 2018, Basic & clinical pharmacology & toxicology.

Neutrophil priming that turns natural FFA2R agonists into potent activators of the superoxide generating NADPH‐oxidase

C. Dahlgren, H. Forsman, L. Björkman, 2018, Journal of leukocyte biology.

Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question

C. Dahlgren, H. Forsman, J. Bylund, 2017, PloS one.

FPR2 signaling without &bgr;‐arrestin recruitment alters the functional repertoire of neutrophils

C. Dahlgren, H. Forsman, Jalal Lomei, 2017, Biochemical pharmacology.

Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists.

H. Franzyk, C. Dahlgren, H. Forsman, 2017, Journal of medicinal chemistry.

Syddansk Universitet The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 ( GPR 43 ) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

S. Pandey, T. Ulven, H. Forsman, 2016 .

The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

S. Pandey, C. Dahlgren, T. Ulven, 2016, Molecular and Cellular Biology.

The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2 Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase*

Ji Ming Wang, A. Karlsson, H. Franzyk, 2016, The Journal of Biological Chemistry.

Formylated MHC Class Ib Binding Peptides Activate Both Human and Mouse Neutrophils Primarily through Formyl Peptide Receptor 1

Ji Ming Wang, C. Dahlgren, H. Forsman, 2016, PloS one.

The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse neutrophils.

Ji Ming Wang, H. Franzyk, C. Dahlgren, 2016, Biochemical pharmacology.

A pepducin designed to modulate P2Y2R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk mechanism.

Tudor I. Oprea, T. Oprea, C. Dahlgren, 2016, Biochimica et biophysica acta.

The proteolytically stable peptidomimetic Pam-(Lys-βNSpe)6-NH2 selectively inhibits human neutrophil activation via formyl peptide receptor 2.

H. Franzyk, C. Dahlgren, P. Heegaard, 2015, Biochemical pharmacology.

P2Y2 receptor signaling in neutrophils is regulated from inside by a novel cytoskeleton-dependent mechanism.

Tudor I. Oprea, T. Oprea, A. Karlsson, 2015, Experimental cell research.

A neutrophil inhibitory pepducin derived from FPR1 expected to target FPR1 signaling hijacks the closely related FPR2 instead

C. Dahlgren, H. Forsman, A. Welin, 2015, FEBS letters.

Binding Domain of Gelsolin 2 Selective Peptides Descending from a PIP Profile of Formyl Peptide Receptor 2 Structural Characterization and Inhibitory

H. Forsman, F. Boulay, M. Rabiet, 2012 .

Structural Characterization and Inhibitory Profile of Formyl Peptide Receptor 2 Selective Peptides Descending from a PIP2-Binding Domain of Gelsolin

C. Dahlgren, H. Forsman, F. Boulay, 2012, The Journal of Immunology.

Receptor-Dependent and -Independent Immunomodulatory Effects of Phenol-Soluble Modulin Peptides from Staphylococcus aureus on Human Neutrophils Are Abrogated through Peptide Inactivation by Reactive Oxygen Species

C. Dahlgren, H. Forsman, J. Bylund, 2012, Infection and Immunity.

The anionic amphiphile SDS is an antagonist for the human neutrophil formyl peptide receptor 1.

F. Thorén, C. Dahlgren, H. Forsman, 2010, Biochemical pharmacology.

Tumour necrosis factor (TNF)‐α primes murine neutrophils when triggered via formyl peptide receptor‐related sequence 2, the murine orthologue of human formyl peptide receptor‐like 1, through a process involving the type I TNF receptor and subcellular granule mobilization

C. Dahlgren, H. Forsman, J. Bylund, 2008, Immunology.

Lipoxin A4 Metabolites/Analogues from Two Commercial Sources have No Effects on TNF‐α‐mediated Priming or Activation through the Neutrophil Formyl Peptide Receptors

C. Dahlgren, H. Forsman, 2009, Scandinavian journal of immunology.

The PAR4-derived pepducin P4Pal10 lacks effect on neutrophil GPCRs that couple to Gαq for signaling but distinctly modulates function of the Gαi-coupled coupled FPR2 and FFAR2.

C. Hesse, C. Dahlgren, H. Forsman, 2020, Biochemical pharmacology.

Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation mechanism

C. Dahlgren, H. Forsman, Simon Lind, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In Vitro

A. Karlsson, C. Dahlgren, H. Forsman, 2013, PloS one.

Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE mutations

Xiaodong Zhao, C. Dahlgren, Wenyan Li, 2019, BMC Pediatrics.

Allosteric receptor modulation uncovers an FFA2R antagonist as a positive orthosteric modulator/agonist in disguise.

C. Dahlgren, H. Forsman, Simon Lind, 2021, Cellular signalling.

Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in neutrophils.

C. Dahlgren, H. Forsman, Simon Lind, 2020, Biochimica et biophysica acta. Molecular cell research.

Interdependent Allosteric FFA2R Modulators Synergistically Induce Functional Selective Activation and Desensitization in Neutrophils

C. Dahlgren, H. Forsman, Simon Lind, 2019, bioRxiv.

The Allosterically Modulated Free Fatty Acid Receptor 2 is Transactivated by an Increase in the Cytosolic Concentration of Calcium Ions

C. Dahlgren, H. Forsman, Yanling Wu, 2022, bioRxiv.

Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis.

K. Brown, A. Karlsson, M. Magnusson, 2011, Arthritis and rheumatism.

CFP-10 from Mycobacterium tuberculosis Selectively Activates Human Neutrophils through a Pertussis Toxin-Sensitive Chemotactic Receptor

Tudor I. Oprea, T. Oprea, A. Karlsson, 2014, Infection and Immunity.

G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions

C. Dahlgren, H. Forsman, Simon Lind, 2022, Immunological reviews.

Neutrophil recruitment to inflamed joints can occur without cellular priming

A. Karlsson, C. Dahlgren, H. Forsman, 2019, Journal of leukocyte biology.

IL-4 Protects the Mitochondria Against TNFα and IFNγ Induced Insult During Clearance of Infection with Citrobacter rodentium and Escherichia coli

S. Lindén, Harvey R. Fernandez, H. Forsman, 2015, Scientific Reports.

Phenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic arthritis

F. Götz, C. Dahlgren, R. Pullerits, 2022, Communications Biology.

Turning chemoattractant receptors on and off with conventional ligands and allosteric modulators: recent advances in formyl peptide receptor signaling and regulation

C. Dahlgren, H. Forsman, J. Bylund, 2014 .

The ketone body acetoacetate activates human neutrophils through FFA2R

C. Dahlgren, H. Forsman, Simon Lind, 2022, bioRxiv.

Multiple ligand recognition sites in free fatty acid receptor 2 (FFA2R) direct distinct neutrophil activation patterns.

C. Dahlgren, H. Forsman, Simon Lind, 2021, Biochemical pharmacology.

The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

Xin Xie, T. Ulven, H. Forsman, 2021, Journal of Innate Immunity.

The two formyl peptide receptors differently regulate GPR84-mediated neutrophil NADPH-oxidase activity

Xin Xie, T. Ulven, H. Forsman, 2020, bioRxiv.

Multiple ligand recognition sites in free fatty acid receptor 2 (FFAR2) direct distinct neutrophil activation patterns

C. Dahlgren, H. Forsman, Simon Lind, 2020, bioRxiv.

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex

R. Holmdahl, C. Dahlgren, P. Olofsson, 2020, Journal of leukocyte biology.

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex

R. Holmdahl, C. Dahlgren, P. Olofsson, 2020, bioRxiv.

Structure–Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect Function

H. Franzyk, C. Dahlgren, H. Forsman, 2019, ACS Omega.

Regis Dieckmann, C. Dahlgren, H. Forsman, 2018, Biochimica et biophysica acta. Molecular cell research.

Reactivation of Gαi‐coupled formyl peptide receptors is inhibited by Gαq‐selective inhibitors when induced by signals generated by the platelet‐activating factor receptor

E. Kostenis, C. Dahlgren, H. Forsman, 2017, Journal of leukocyte biology.

Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria.

C. Dahlgren, H. Forsman, Malene Winther, 2016, Biochemical pharmacology.

Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4

C. Dahlgren, H. Forsman, Malene Winther, 2016, Data in brief.

A Pepducin Derived from the Third Intracellular Loop of FPR2 Is a Partial Agonist for Direct Activation of This Receptor in Neutrophils But a Full Agonist for Cross-Talk Triggered Reactivation of FPR2

C. Dahlgren, H. Forsman, J. Bylund, 2014, PloS one.

A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide.

Tudor I. Oprea, T. Oprea, C. Müller, 2014, Experimental cell research.

Antibacterial Activity of Pepducins, Allosterical Modulators of Formyl Peptide Receptor Signaling

Tudor I. Oprea, T. Oprea, C. Dahlgren, 2014, Antimicrobial Agents and Chemotherapy.

Reactivation of Desensitized Formyl Peptide Receptors by Platelet Activating Factor: A Novel Receptor Cross Talk Mechanism Regulating Neutrophil Superoxide Anion Production

A. Karlsson, C. Dahlgren, H. Forsman, 2013, PloS one.

What Formyl Peptide Receptors, if Any, Are Triggered by Compound 43 and Lipoxin A4?

C. Dahlgren, H. Forsman, K. Önnheim, 2011, Scandinavian journal of immunology.

A methodological approach to studies of desensitization of the formyl peptide receptor: Role of the read out system, reactive oxygen species and the specific agonist used to trigger neutrophils.

C. Movitz, C. Dahlgren, H. Forsman, 2010, Journal of immunological methods.

Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library.

C. Dahlgren, H. Forsman, E. Nordling, 2011, Biochemical pharmacology.

Negative regulation of Toll‐like receptor signaling plays an essential role in homeostasis of the intestine

A. Biswas, Koichi S. Kobayashi, H. Tlaskalova-Hogenova, 2011, European journal of immunology.

The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics.

H. Franzyk, H. Forsman, J. Bylund, 2018, Current pharmaceutical design.

The FPR2-induced rise in cytosolic calcium in human neutrophils relies on an emptying of intracellular calcium stores and is inhibited by a gelsolin-derived PIP2-binding peptide

C. Dahlgren, H. Forsman, 2010, BMC Cell Biology.

The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis

P. Chambon, M. Lagerquist, C. Ohlsson, 2014, Arthritis Research & Therapy.

Porphyromonas gingivalis Produce Neutrophil Specific Chemoattractants Including Short Chain Fatty Acids

Otto Savolainen, C. Dahlgren, H. Forsman, 2021, Frontiers in Cellular and Infection Microbiology.

An increase in the cytosolic concentration of free calcium ions activates the neutrophil NADPH-oxidase provided that the free fatty acid receptor 2 has been allosterically modulated.

C. Dahlgren, H. Forsman, Simon Lind, 2023, Cellular signalling.

The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist.

A. Karlsson, C. Dahlgren, H. Forsman, 2008, Glycobiology.

The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels.

C. Dahlgren, H. Forsman, J. Bylund, 2009, Cell calcium.

The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil GPCRs

C. Dahlgren, H. Forsman, Simon Lind, 2023, PloS one.

The Subcellular Localization of the Receptor for Platelet-Activating Factor in Neutrophils Affects Signaling and Activation Characteristics

H. Forsman, K. Önnheim, E. Andréasson, 2013, Clinical & developmental immunology.

Antibacterial Activity of Pepducins, Allosterical Modulators of

Tudor I. Oprea, C. Dahlgren, H. Forsman, 2014 .

Receptor Signaling Allosterical Modulators of Formyl Peptide Antibacterial Activity of Pepducins

Tudor I. Oprea, C. Dahlgren, H. Forsman, 2014 .

Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA–Encoded Cytochrome b

C. Dahlgren, H. Forsman, Simon Lind, 2019, The Journal of Immunology.

AZ2158 is a more potent formyl peptide receptor 1 inhibitor than the commonly used peptide antagonists in abolishing neutrophil chemotaxis.

C. Dahlgren, H. Forsman, L. Björkman, 2023, Biochemical pharmacology.

Larixol is not an inhibitor of Gαi containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide receptors.

Linda Bergqvist, H. Forsman, L. Björkman, 2023, Biochemical pharmacology.

Larixol is not an inhibitor of Gαi containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide receptors

Linda Bergqvist, H. Forsman, L. Björkman, 2023, bioRxiv.

Mitocryptides from Human Mitochondrial DNA–Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties

C. Dahlgren, H. Forsman, Simon Lind, 2018, The Journal of Immunology.

Function and regulation of GPR84 in human neutrophils

C. Dahlgren, H. Forsman, L. Björkman, 2023, British journal of pharmacology.

A neutrophil inhibitory pepducin derived from FPR1 expected to target FPR1 signaling hijacks the closely related FPR2 instead

C. Dahlgren, H. Forsman, A. Welin, 2015, FEBS letters.

Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis.

K. Brown, A. Karlsson, M. Magnusson, 2011, Arthritis and rheumatism.

Ultra‐high static magnetic fields cause immunosuppression through disrupting B‐cell peripheral differentiation and negatively regulating BCR signaling

Y. Jing, Lu Yang, Danqing Kang, 2023, MedComm.