C. Tsoukas

发表

In Vivo Significance of ITK-SLP-76 Interaction in Cytokine Production

John D Lambris, J. Lambris, J. Grasis, 2010, Molecular and Cellular Biology.

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes

T. Hirano, F. Jirik, T. Kishimoto, 1988, The Journal of experimental medicine.

COSTIMULANT FORHUMANTHYMOCYTES AND TLYMPHOCYTES

T. Hirano, T. Kishimoto, D. Carson, 1988 .

Expression of GTP-binding protein alpha subunits in human thymocytes

P. Kabouridis, C. Tsoukas, S. Escobar, 1995, Molecular and Cellular Biochemistry.

Regulation of expression of interleukin 2 receptors upon triggering of the TCR-CD3 complex on human T lymphocytes.

P. Kabouridis, C. Tsoukas, 1990, Immunological investigations.

Positive Regulation of Itk PH Domain Function by Soluble IP4

A. Andreotti, M. Cooke, Stephen Soonthornvacharin, 2007, Science.

Basis for defective responses of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3 (T3) antibodies.

C. Dinarello, D. Carson, C. Robinson, 1986, The Journal of clinical investigation.

CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation

D. Salomon, S. Todd, C. Tsoukas, 1996, The Journal of experimental medicine.

CD 81 Expressed on H u m a n T h y m o c y t e s Mediates Integrin Act ivat ion and Interleukin 2-d e p e n d e n t Prol iferation

D. Salomon, S. Todd, C. Tsoukas, 2022 .

Regulation of Epstein‐Barr virus infection by recombinant interferons. Selected sensitivity to interferon‐γ

D. Carson, S. Fong, J. Vaughan, 1985, European journal of immunology.

Bacterial Superantigens Bypass Lck-Dependent T Cell Receptor Signaling by Activating a Gα11-Dependent, PLC-β-Mediated Pathway

A. Rahman, J. McCormick, J. Madrenas, 2006 .

Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway.

A. Rahman, J. McCormick, J. Madrenas, 2006, Immunity.

Pleckstrin Homology Domain by Phosphatidylinositol 3-Kinase and the Tec Tec Kinase Signaling in T Cells Is Regulated

K. Ching, L. Berg, C. Tsoukas, 2013 .

Tec Kinase Signaling in T Cells Is Regulated by Phosphatidylinositol 3-Kinase and the Tec Pleckstrin Homology Domain1

K. Ching, L. Berg, C. Tsoukas, 2001, The Journal of Immunology.

Cellular requirements for pokeweed mitogen-induced autoantibody production rheumatoid arthritis.

D. Carson, S. Fong, J. Vaughan, 1980, Journal of immunology.

1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone.

S. Manolagas, C. Tsoukas, D. Provvedini, 1984, Science.

Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain.

K. Ching, T. Kawakami, C. Tsoukas, 1999, Journal of immunology.

Domain Complexes: Role of the Pleckstrin Homology Emt/Itk Associates with Activated TCR

K. Ching, T. Kawakami, C. Tsoukas, 1999 .

The role of the T3 molecular complex on human T lymphocyte-mediated cytotoxicity.

D. Carson, J. Vaughan, C. Tsoukas, 1985, Advances in experimental medicine and biology.

Cholera toxin inhibits resting human T cell activation via a cAMP-independent pathway.

D. Anderson, C. Tsoukas, 1989, Journal of immunology.

1 alpha,25-Dihydroxyvitamin D3-binding macromolecules in human B lymphocytes: effects on immunoglobulin production.

S. Manolagas, L. Deftos, C. Tsoukas, 1986, Journal of immunology.

Interactions of 1,25-dihydroxyvitamin D3 and the immune system

S. Manolagas, C. Tsoukas, D. Provvedini, 1985, Molecular and Cellular Endocrinology.

Characterization of recirculating lymphocytes in rheumatoid arthritis patients: selective deficiency of natural killer cells in thoracic duct lymph.

R. Fox, S. Fong, J. Vaughan, 1984, Journal of immunology.

Selective lymphocyte deficiency in seronegative rheumatoid arthritis.

D. Carson, S. Fong, J. Vaughan, 1981, Arthritis and rheumatism.

Inheritance of immunoglobulin M rheumatoid-factor idiotypes.

D. Carson, S. Fong, J. Vaughan, 1980, The Journal of clinical investigation.

Physiology and pathology of rheumatoid factors

D. Carson, S. Slovin, S. Fong, 2005, Springer Seminars in Immunopathology.

Different populations of rheumatoid factor idiotypes induced by two polyclonal B cell activators, pokeweed mitogen and Epstein--Barr virus.

D. Carson, S. Slovin, S. Fong, 1981, Clinical immunology and immunopathology.

D. Carson, S. Fong, J. Vaughan, 1981, Clinical immunology and immunopathology.

Infection of human thymocytes by Epstein-Barr virus

J. Lambris, G. Rhodes, J. Lamberti, 1991, The Journal of experimental medicine.

1α,25‐Dihydroxyvitamin D3 receptors in human thymic and tonsillar lymphocytes

S. Manolagas, C. Tsoukas, R. Sobol, 1987 .

The antiproliferative effect of calcitriol on human peripheral blood mononuclear cells.

S. Manolagas, L. Deftos, C. Tsoukas, 1986, The Journal of clinical endocrinology and metabolism.

Thoracic duct drainage in rheumatoid arthritis.

D. Carson, R. Fox, J. Vaughan, 1984, Clinical and experimental immunology.

Inhibition of interleukin-1 production by 1,25-dihydroxyvitamin D3.

S. Manolagas, C. Dinarello, S. Escobar, 1989, The Journal of clinical endocrinology and metabolism.

TCR/CD3-Induced Activation and Binding of Emt/Itk to Linker of Activated T Cell Complexes: Requirement for the Src Homology 2 Domain1

K. Ching, T. Kawakami, J. Grasis, 2000, The Journal of Immunology.

Homology 2 Domain Complexes : Requirement for the Src Emt / Itk to Linker of Activated T Cell TCR / CD 3-Induced Activation and Binding of TsoukasKawakami ,

K. Ching, T. Kawakami, J. Grasis, 2000 .

Activation of heterotrimeric GTP-binding proteins upon TCR/CD3 engagement.

K. Ching, C. Tsoukas, J. Stanners, 2000, Methods in molecular biology.

Interaction between G Proteins and Tyrosine Kinases upon T Cell Receptor·CD3-mediated Signaling (*)

P. Kabouridis, C. Tsoukas, J. Stanners, 1995, The Journal of Biological Chemistry.

Impairment in T-lymphocyte responses during early infection with the human immunodeficiency virus

D. Richman, J. McCutchan, S. Spector, 1989, Journal of Clinical Immunology.

Regulation of Immune Responsiveness In Vivo by Disrupting an Early T-Cell Signaling Event Using a Cell-Permeable Peptide

John D Lambris, J. Lambris, M. Croft, 2013, PloS one.

Expression of EBV/C3d receptors on T cells: biological significance.

John D Lambris, J. Lambris, C. Tsoukas, 1993, Immunology today.

T cell proliferation induced by anti‐cd3 antibodies: requirement for a t‐t cell interaction

J. Vaughan, C. Tsoukas, J. Bentin, 1988, European journal of immunology.

The role of the T3 molecular complex in antigen recognition and subsequent activation events.

D. Carson, J. Vaughan, C. Tsoukas, 1984, Immunology today.

Effects of monoclonal antibodies against lymphocyte surface antigens on interleukin 2 excretion by Epstein-Barr virus-specific human T-cell hybridomas.

D. Carson, J. Vaughan, C. Tsoukas, 1984, Cellular immunology.

Interaction between Epstein‐Barr virus and a T cell line (HSB‐2) via a receptor phenotypically distinct from complement receptor type 2

John D Lambris, J. Lambris, J. Hedrick, 1992, European journal of immunology.

Activation of resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes.

D. Carson, J. Vaughan, C. Tsoukas, 1985, Journal of immunology.

Lymphotoxin. A review and analysis.

C. Tsoukas, W. Rosenau, 1976, The American journal of pathology.

Inducible T cell tyrosine kinase (ITK): structural requirements and actin polymerization.

K. Ching, J. Grasis, C. Tsoukas, 2006, Advances in experimental medicine and biology.

Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization.

K. Ching, T. Kawakami, J. Grasis, 2001, Trends in immunology.

Release of lymphokines after Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans.

C. Dinarello, D. Carson, S. Fong, 1986, Journal of immunology.

Expression of CR2/EBV receptors on human thymocytes detected by monoclonal antibodies

John D Lambris, J. Lambris, C. Tsoukas, 1988, European journal of immunology.

Lymphocyte mitogenesis induced by monoclonal antibodies to the T3 complex. Differential modulation by human IgG.

John D Lambris, J. Lambris, D. Carson, 1984, Cellular immunology.

Lysis of autologous Epstein-Barr virus-infected B cells by cytotoxic T lymphocytes of rheumatoid arthritis patients.

D. Carson, S. Slovin, R. Fox, 1982, Clinical immunology and immunopathology.

Molecular interactions in human T-cell-mediated cytotoxicity to Epstein-Barr virus. I. Blocking of effector cell function by monoclonal antibody OKT3.

D. Carson, R. Fox, S. Fong, 1982, Cellular immunology.

Inducible T Cell Tyrosine Kinase Regulates Actin-Dependent Cytoskeletal Events Induced by the T Cell Antigen Receptor1

J. Grasis, C. Tsoukas, C. D. Browne, 2003, The Journal of Immunology.

Induced by the T Cell Antigen Receptor Actin-Dependent Cytoskeletal Events Inducible T Cell Tyrosine Kinase Regulates

J. Grasis, C. Tsoukas, C. D. Browne, 2003 .

Effect of ultraviolet irradiation on selected host cell proteins including Ro/SS-A and Epstein-Barr virus in cultured lymphoblastoid cell lines.

M. Newkirk, C. Tsoukas, 1992, Journal of autoimmunity.

Interleukins and Interferons during EBV Infection

D. Carson, J. Vaughan, C. Tsoukas, 1987 .

Characterization of Epstein-Barr virus-specific T-cell hybridomas derived from infectious mononucleosis.

D. Carson, J. Vaughan, C. Tsoukas, 1985, Clinical immunology and immunopathology.

Phytohemagglutinin binds to the 20‐kDa molecule of the T3 complex

D. Carson, G. Rhodes, J. Vaughan, 1985, European journal of immunology.

Frequencies of Epstein-Barr virus-inducible IgM anti-IgG B lymphocytes in normal children and children with juvenile rheumatoid arthritis.

T. Moore, D. Carson, S. Fong, 1982, Arthritis and rheumatism.

Solid-phase selection of human T lymphocyte subpopulations using monoclonal antibodies.

J. E. Rose, D. Carson, R. Fox, 1981, Journal of immunological methods.

Fractionation of human lymphocyte subpopulations on immunoglobulin coated Petri dishes.

J. E. Rose, D. Carson, R. Fox, 1981, Journal of immunological methods.

Lymphotoxin A RevieL and Analysis

C. Tsoukas, W. Rosenau, 2007 .

1,25-Dihydroxyvitamin D3 receptors in lymphocytes from patients with rheumatoid arthritis.

S. Manolagas, J. Vaughan, D. Werntz, 1986, The Journal of laboratory and clinical medicine.

Distribution of antibodies against denatured collagen in AIDS risk groups and homosexual AIDS patients suggests a link between autoimmunity and the immunopathogenesis of AIDS.

G. Hoffmann, C. Tsoukas, M. Grant, 1990, Journal of immunology.

The role of calcium in the lethal hit of T lymphocyte-mediated cytolysis.

M. Gately, E. Martz, C. Tsoukas, 1982, Advances in experimental medicine and biology.

Release of lymphokines after infection with Epstein Barr virus in vitro. II. A monocyte-dependent inhibitor of interleukin 1 downregulates the production of interleukin 2 and interferon-gamma in rheumatoid arthritis.

C. Dinarello, D. Carson, S. Fong, 1986, Journal of immunology.

Leukoplasmapheresis for myasthenia gravis. Acetylcholine receptor antibody production.

J. Lindstrom, S. Fong, J. Vaughan, 1982, Archives of neurology.

Selective induction of autoantibody secretion in human bone marrow by Epstein Barr virus.

D. Carson, S. Fong, J. Vaughan, 1982, Journal of immunology.

1,25-dihydroxyvitamin D3 receptors in human leukocytes.

S. Manolagas, L. Deftos, S C Manolagas, 1983, Science.

Membrane antigen on Epstein--Barr virus-infected human B cells recognized by a monoclonal antibody.

D. Carson, S. Slovin, J. Vaughan, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Cellular receptors for lymphotoxin: correlation of binding and cytotoxicity in sensitive and resistant target cells.

J. Baxter, C. Tsoukas, W. Rosenau, 1976, Journal of immunology.

Effect of levamisole on pokeweed mitogen stimulation of immunoglobulin production in vitro.

D. Carson, S. Fong, J. Vaughan, 1981, Immunopharmacology.

Itk: The Rheostat of the T Cell Response

J. Grasis, C. Tsoukas, Juris A. Grasis, 2011, Journal of signal transduction.

Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript.

S. K. Sinha, J. Lambris, S. Todd, 1993, Journal of immunology.

Age-associated changes in Epstein-Barr virus-induced human lymphocyte autoantibody responses.

D. Carson, S. Fong, J. Vaughan, 1981, Journal of immunology.

Simultaneous suppression of allogeneic cytolytic activity and stimulation of lectin-dependent cytolytic activity by con A.

E. Martz, C. Tsoukas, 1978, Cellular immunology.

Molecular interactions in human T cell-mediated cytotoxicity to EBV II. Monoclonal antibody OKT3 inhibits a post-killer-target recognition/adhesion step.

D. Carson, S. Fong, J. Vaughan, 1982, Journal of immunology.

Navigating the leukocyte signaling maze guided by Ariadne's thread

G. Koretzky, A. Altman, C. Tsoukas, 2009, Nature Immunology.

In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase

Amy H. Andreotti, Constantine D. Tsoukas, A. Andreotti, 2012, Journal of signal transduction.

Inhibition of TCR/CD3‐mediated signaling by a mutant of the hematopoietically expressed G16 GTP‐binding protein

Jie Zhou, P. Kabouridis, C. Tsoukas, 1998, European journal of immunology.

Human T cell hybridomas specific for Epstein Barr virus-infected B lymphocytes.

A. Altman, D. Carson, J. Vaughan, 1983, Journal of immunology.

A Conserved Motif in the ITK PH-Domain Is Required for Phosphoinositide Binding and TCR Signaling but Dispensable for Adaptor Protein Interactions

K. Sauer, T. Zal, S. Rigaud, 2012, PloS one.

Evidence for multiple sites of interaction in C3 for complement receptor type 2 (C3d/EBV receptor, CD21)

John D Lambris, J. Lambris, J. Alsenz, 1991, European journal of immunology.

EBV induces proliferation of immature human thymocytes in an IL-2-mediated response.

S. Todd, C. Tsoukas, 1996, Journal of immunology.

T lymphocyte-mediated cytotoxicity against autologous EBV-genome-bearing B cells.

S. Ferrone, D. Carson, S. Slovin, 1981, Journal of immunology.

Structural and functional characteristics of the CD3 (T3) molecular complex on human thymocytes.

D. Carson, J. Vaughan, C. Tsoukas, 1987, Journal of immunology.

References and Notes Supporting Online Material Materials and Methods Som Text Figs. S1 to S7 References a Common Variant in the Fto Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

M. Jarvelin, D. Melzer, L. Ferrucci, 2022 .

M. Jarvelin, L. Ferrucci, E. Zeggini, 2022 .

Regulation of immunoglobulin secretion by factor H of human complement.

John D Lambris, G. Inghirami, G. Tsokos, 1985, Immunology.