M. Kosaka

发表

Intracellular delivery of proteins into mammalian living cells by polyethylenimine-cationization.

M. Sakaguchi, M. Namba, M. Miyazaki, 2005, Journal of bioscience and bioengineering.

Protein transduction assisted by polyethylenimine-cationized carrier proteins.

M. Sakaguchi, M. Namba, N. Huh, 2005, Journal of biochemistry.

‘Crystal lattice engineering,’ an approach to engineer protein crystal contacts by creating intermolecular symmetry: Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines

H. Yamaguchi, R. Kuroki, M. Seno, 2007, Protein science : a publication of the Protein Society.

Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups.

M. Seno, H. Yamada, J. Futami, 2001, Biochemistry.

Reaction mechanism of tetrathionate hydrolysis based on the crystal structure of tetrathionate hydrolase from Acidithiobacillus ferrooxidans

K. Kamimura, T. Kanao, T. Tamada, 2020, Protein science : a publication of the Protein Society.

Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form.

J. Folkman, M. Seno, H. Yamada, 1996, Growth factors.

Crystallization and preliminary X-ray diffraction analysis of tetrathionate hydrolase from Acidithiobacillus ferrooxidans.

J. Takada, R. Kuroki, K. Kamimura, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Insertional‐fusion of basic fibroblast growth factor endowed ribonuclease 1 with enhanced cytotoxicity by steric blockade of inhibitor interaction

M. Seno, J. Futami, M. Kosaka, 2004, FEBS letters.

Recombinant human pancreatic ribonuclease produced in E. coli: importance of the amino-terminal sequence.

M. Seno, H. Yamada, J. Futami, 1995, Biochemical and biophysical research communications.

Intracellular delivery of glutathione S-transferase-fused proteins into mammalian cells by polyethylenimine-glutathione conjugates.

M. Sakaguchi, N. Huh, M. Seno, 2008, Journal of biochemistry.

Transient cell proliferation with polyethylenimine-cationized N-terminal domain of simian virus 40 large T-antigen.

M. Seno, J. Futami, M. Kitazoe, 2008, Journal of bioscience and bioengineering.

Nucleotide sequence encoding human pancreatic ribonuclease.

M. Seno, H. Yamada, J. Futami, 1994, Biochimica et biophysica acta.

Purification and characterization of a recombinant human cripto-1 protein.

M. Desantis, C. Bianco, D. Salomon, 1998, Growth factors.

BALB/c 3T3 cells co-expressing FGF-2 and soluble FGF receptor acquire tumorigenicity.

M. Seno, H. Yamada, K. Igarashi, 1998, Cytokine.

Optimum modification for the highest cytotoxicity of cationized ribonuclease.

M. Seno, J. Futami, T. Maeda, 2002, Journal of biochemistry.

Uniformly cationized protein efficiently reaches the cytosol of mammalian cells.

J. Futami, H. Murata, M. Kosaka, 2012, Bioconjugate chemistry.

An S-alkylating reagent with positive charges as an efficient solubilizer of denatured disulfide-containing proteins.

H. Yamada, T. Imoto, M. Seno, 1994, Journal of biochemistry.

Denatured and reversibly cationized p53 readily enters cells and simultaneously folds to the functional protein in the cells.

M. Sakaguchi, N. Huh, M. Seno, 2006, Biochemistry.