S. Pullen

发表

Signaling and protein associations of a cell permeable CD40 complex in B cells.

M. Kehry, S. Jakes, S. Zoog, 2004, Molecular immunology.

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

Patrick D. Dummer, Chengxiang Qiu, S. Ishibe, 2017, Nature Medicine.

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

D. Kass, H. Bian, S. Weldon, 2019, Proceedings of the National Academy of Sciences.

Early transcription of the ie-1 transregulator gene of Autographa californica nuclear polyhedrosis virus is regulated by DNA sequences within its 5' noncoding leader region

S. Pullen, P. Friesen, 1995, Journal of virology.

A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat

Hong Wang, R. Fryer, Kathleen A. Lincoln, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

Christopher D. Brown, Mingyao Li, B. Voight, 2020, bioRxiv.

A 4 Identification and characterization of positive allosteric modulators of the natriuretic peptide receptor-A

R. Fryer, F. Levy, A. Cataliotti, 2017 .

CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs)

M. Kehry, S. Pullen, J. J. Crute, 1999, The Journal of Biological Chemistry.

CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.

M. Kehry, S. Pullen, J. J. Crute, 1998, Biochemistry.

Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha.

G. W. Peet, M. Kehry, J. Li, 1998, Journal of Biological Chemistry.

5-Aminomethylbenzimidazoles as potent ITK antagonists.

J. Woska, D. Jeanfavre, M. Kashem, 2009, Bioorganic & medicinal chemistry letters.

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells

C. Ahonen, L. Erickson, R. Noelle, 2002, Nature Immunology.

Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent

R. Noelle, M. Kehry, S. Pullen, 2002, European journal of immunology.

Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy

D. Kass, C. Ward, J. Shin, 2022, JCI insight.

Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region.

Daniel R. Albaugh, M. Hao, K. Qian, 2011, Bioorganic & medicinal chemistry letters.

5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).

R. DesJarlais, J. Woska, C. Cywin, 2008, Bioorganic & medicinal chemistry letters.

Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).

B. Tomczuk, R. DesJarlais, D. Ryan, 2008, Bioorganic & medicinal chemistry letters.

High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization.

T. Alber, M. Kehry, R. Ingraham, 1999, Biochemistry.

Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the 1 fibrotic microenvironment in kidney disease progression

Mingyao Li, P. Grandi, C. Hunter, 2022 .

Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies

D. Jonigk, M. Lenter, B. Stierstorfer, 2022, Scientific Reports.

2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket.

J. Woska, M. Kashem, Hidenori Takahashi, 2008, Bioorganic & medicinal chemistry letters.

Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors.

Noel S. Wilson, C. Cywin, G. Roth, 2007, Bioorganic & medicinal chemistry letters.

Three Mechanistically Distinct Kinase Assays Compared: Measurement of Intrinsic ATPase Activity Identified the Most Comprehensive Set of ITK Inhibitors

Mohammed A. Kashem, Richard M. Nelson, Carol Ann Homon, 2007, Journal of biomolecular screening.

The CAGT motif functions as an initiator element during early transcription of the baculovirus transregulator ie-1

S. Pullen, P. Friesen, 1995, Journal of virology.

Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead.

D. Ryan, G. Roth, M. Kashem, 2008, Bioorganic & medicinal chemistry letters.

Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease

Christopher D. Brown, YoSon Park, Chengxiang Qiu, 2018, Nature Medicine.

Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients

R. Urquhart, H. Zimdahl, R. Schmid, 2016, PloS one.

DNA-dependent transregulation by IE1 of Autographa californica nuclear polyhedrosis virus: IE1 domains required for transactivation and DNA binding

S. Rodems, S. Pullen, Steven M. Rodems, 1997, Journal of virology.

The key role of NLRP3 and STING in APOL1-associated podocytopathy.

K. Suszták, Ziyuan Ma, Junnan Wu, 2021, The Journal of clinical investigation.

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

Patrick D. Dummer, Chengxiang Qiu, S. Ishibe, 2017, Nature Medicine.

Discovery of potent, selective chymase inhibitors via fragment linking strategies.

Daniel R. Albaugh, Ming-Hong Hao, M. Hao, 2013, Journal of medicinal chemistry.

Crystallographic analysis of CD40 recognition and signaling by human TRAF2.

J. Holton, T. Alber, M. Kehry, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Emerging therapeutics for the treatment of diabetic nephropathy.

S. Pullen, Jon Hill, J. Brenneman, 2016, Bioorganic & medicinal chemistry letters.

Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design.

G. Roth, Ji Wang, M. Kashem, 2009, Bioorganic & medicinal chemistry letters.

Recombinant IκB Kinases α and β Are Direct Kinases of IκBα*

G. W. Peet, M. Kehry, K. Marcu, 1998, The Journal of Biological Chemistry.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Jordi Villà-Freixa, Peter Sandner, Bernd J. Pichler, 2017, BMC Pharmacology and Toxicology.

A soluble guanylate cyclase activator protects from diabetic nephropathy beyond standard of care in the ZSF1 rat

R. Fryer, Kathleen A. Lincoln, S. Pullen, 2015, BMC Pharmacology and Toxicology.

Structural and biochemical analysis of signal transduction by the TRAF family of adapter proteins.

T. Alber, B. Werneburg, M. Kehry, 1999, Cold Spring Harbor symposia on quantitative biology.

The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease

R. Fryer, M. McHugh, Kathleen A. Lincoln, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision‐cut liver slices

Andre Broermann, G. Birk, B. Stierstorfer, 2021, Pharmacology research & perspectives.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

James C. Campbell, Dong I. Lee, M. Zaccolo, 2017, BMC Pharmacology and Toxicology.

5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).

R. DesJarlais, J. Woska, C. Cywin, 2008, Bioorganic & medicinal chemistry letters.