F. Debart

发表

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

B. Coutard, E. Decroly, B. Canard, 2013, Antiviral research.

Use of MALDI–TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides

J. Imbach, J. Vasseur, F. Morvan, 2002, Analytical and bioanalytical chemistry.

Gymnotic delivery and gene silencing activity of reduction-responsive siRNAs bearing lipophilic disulfide-containing modifications at 2'-position.

J. Bertrand, J. Vasseur, F. Debart, 2018, Bioorganic & medicinal chemistry.

Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

B. Coutard, Priscila Sutto-Ortiz, E. Decroly, 2022, Journal of medicinal chemistry.

Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5′ Caps

S. Jaffrey, A. Rentmeister, J. Vasseur, 2019, Chembiochem : a European journal of chemical biology.

Binding of the methyl donor SAM to MERS-CoV 2'-O-methyltransferase nsp16 promotes the recruitment of the allosteric activator nsp10

E. Decroly, B. Canard, J. Vasseur, 2016 .

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

E. Decroly, B. Canard, J. Vasseur, 2021, bioRxiv.

Metallophyte wastes and polymetallic catalysis: a promising combination in green chemistry. The illustrative synthesis of 5′-capped RNA

C. Grison, J. Vasseur, Y. Thillier, 2013 .

Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N⁷)-methyl transferase.

E. Decroly, B. Canard, J. Vasseur, 2012, RNA.

Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.

J. Vasseur, Y. Thillier, F. Debart, 2013, Bioorganic & medicinal chemistry.

From Anionic to Cationic α‐Anomeric Oligodeoxynucleotides

J. Vasseur, F. Morvan, F. Debart, 2010, Chemistry & biodiversity.

A versatile post-synthetic method on a solid support for the synthesis of RNA containing reduction-responsive modifications.

J. Vasseur, F. Debart, Christelle Dupouy, 2016, Organic & biomolecular chemistry.

Synthesis, binding, nuclease resistance and cellular uptake properties of 2'-O-acetalester-modified oligonucleotides containing cationic groups.

J. Bertrand, J. Vasseur, F. Debart, 2015, Bioorganic & medicinal chemistry.

Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers

J. Bertrand, J. Vasseur, F. Debart, 2020, Molecules.

Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

B. Coutard, J. Contreras, E. Decroly, 2017, Antiviral Research.

Bisubstrate Strategies to Target Methyltransferases

J. Vasseur, F. Debart, Rostom Ahmed‐Belkacem, 2022, European Journal of Organic Chemistry.

Synthesis of Adenine Dinucleosides 2′,5′-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2′-O -Methyltransferases

Priscila Sutto-Ortiz, E. Decroly, J. Vasseur, 2019, European Journal of Organic Chemistry.

Modified Oligoribonucleotides: Synthesis and Preliminary Evaluation of α-RNA

C. Chaix, B. Rayner, J. Imbach, 1993 .

FTIR and UV Spectroscopy Studies of Triplex Formation Between Pyrimidine Methoxyethylphosphoramidates α- Oligodeoxynucleotides and ds DNA Targets

E. Taillandier, J. Vasseur, M. Naval, 2002, Journal of biomolecular structure & dynamics.

Toward high yield synthesis of peptide-oligonucleotide chimera through a disulfide bridge: a simplified method for oligonucleotide activation.

E. Vivés, B. Lebleu, A. Thierry, 2005, Bioorganic & medicinal chemistry letters.

Conjugation of Small Molecules to RNA Using a Reducible Disulfide Linker Attached at the 2′-OH Position through a Carbamate Function

J. Vasseur, F. Debart, Christelle Dupouy, 2019, European Journal of Organic Chemistry.

A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome

E. Decroly, B. Canard, J. Vasseur, 2022, Nucleic acids research.

Oligonucleosides: Synthesis of a Novel Methylhydroxylamine-Linked Nucleoside Dimer and Its Incorporation into Antisense Sequences.

P. D. Cook, J. Vasseur, F. Debart, 1992 .

Optimization of hybridizing abilities and nuclease resistance in the design of chimeric α-anomeric oligodeoxynucleotides containing β-anomeric gaps

B. Rayner, J. Imbach, F. Debart, 1994 .

Esterase-triggered fluorescence of fluorogenic oligonucleotides.

B. Rayner, F. Debart, N. Lamb, 1997, Bioconjugate chemistry.

Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing

J. Vasseur, F. Debart, Christelle Dupouy, 2018, Beilstein journal of organic chemistry.

Lipophilic 2′‐O‐Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery

G. Sczakiel, J. Bertrand, J. Vasseur, 2016, Chembiochem : a European journal of chemical biology.

Direct Synthesis of Partially Modified 2′‐O‐Pivaloyloxymethyl RNAs by a Base‐Labile Protecting Group Strategy and their Potential for Prodrug‐Based Gene‐Silencing Applications

G. Sczakiel, J. Vasseur, F. Debart, 2014, Chembiochem : a European journal of chemical biology.

Identification of the m6Am methyltransferase PCIF1 reveals the location and functions of m6Am in the transcriptome

L. Aravind, E. Greer, S. Jaffrey, 2018, bioRxiv.

Identiﬁcation of the m 6 Am Methyltransferase PCIF1 Reveals the Location and Functions of m 6 Am in the Transcriptome

L. Aravind, E. Greer, S. Jaffrey, 2018 .

Resource Identification of the m 6 Am Methyltransferase PCIF 1 Reveals the Location and Functions of m 6 Am in the Transcriptome Graphical Abstract Highlights

L. Aravind, E. Greer, S. Jaffrey, 2019 .

Highly Stable DNA Triplexes Formed with Cationic Phosphoramidate Pyrimidine α‐Oligonucleotides

F. Heitz, J. Vasseur, F. Debart, 2005 .

Cationic phosphoramidate alpha-oligonucleotides efficiently target single-stranded DNA and RNA and inhibit hepatitis C virus IRES-mediated translation.

B. Lebleu, I. Robbins, J. Vasseur, 2003, Nucleic acids research.

Efficient guanidination of the phosphate linkage towards cationic phosphoramidate oligonucleotides

J. Vasseur, F. Debart, T. Michel, 2003 .

α-OLIGONUCLEOTIDES WITH ANIONIC PHOSPHODIESTER AND CATIONIC PHOSPHORAMIDATE LINKAGES ENHANCED STABILITY OF DNA TRIPLE HELIX

J. Vasseur, F. Ehrenmann, F. Debart, 2001, Nucleosides, nucleotides & nucleic acids.

Chiral and steric effects in the efficient binding of alpha-anomeric deoxyoligonucleoside N-alkylphosphoramidates to ssDNA and RNA.

B. Rayner, J. Vasseur, M. Naval, 1999, Nucleic acids research.

Efficient solid-phase chemical synthesis of 5'-triphosphates of DNA, RNA, and their analogues.

M. Manoharan, T. Lavergne, J. Vasseur, 2010, Organic letters.

Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus

I. Gutsche, D. Chevret, J. Vasseur, 2022, The Journal of biological chemistry.

Ecological catalysis and phytoextraction: Symbiosis for future

C. Grison, J. Vasseur, Y. Thillier, 2014 .

Synthesis, DNA binding properties and biological evaluation of novel oligo-meta-benzamides related to netropsin

C. Paoletti, J. Balzarini, E. Clercq, 1991 .

Intermolecular radical CC bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides

P. D. Cook, J. Vasseur, F. Debart, 1992 .

2-Amino-α-2'-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate α-oligodeoxynucleotides with RNA target

J. Vasseur, M. Naval, F. Debart, 2002 .

Efficient and Stereoselective Synthesis of 3′-Deoxy 3′ -C-Branched-Chain Substituted Thymidine

F. Debart, Y. Sanghvi, A. D. Mesmaeker, 1994 .

Oligonucleosides: synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences

P. D. Cook, J. Vasseur, F. Debart, 1992 .

mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

B. Coutard, E. Decroly, B. Canard, 2015, Journal of Virology.

Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

B. Rayner, F. Debart, J. Imbach, 1990 .

Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

B. Coutard, E. Decroly, B. Canard, 2016, Journal of Virology.

Solid‐Phase Synthesis of Oligonucleotide 5′‐(α‐P‐Thio)triphosphates and 5′‐(α‐P‐Thio)(β,γ‐methylene)triphosphates

J. Vasseur, C. Sallamand, Y. Thillier, 2015 .

Assessment of new 2'-O-acetalester protecting groups for regular RNA synthesis and original 2'-modified proRNA.

T. Lavergne, J. Vasseur, F. Debart, 2009, Bioorganic & medicinal chemistry letters.

A base-labile group for 2'-OH protection of ribonucleosides: a major challenge for RNA synthesis.

Thomas Lavergne, Jean-Jacques Vasseur, T. Lavergne, 2008, Chemistry.

STEP-BY-STEP CONTROL BY MALDI-TOF MS OF AN OLIGONUCLEOTIDE SYNTHESIS ON STANDARD CPG SOLID-SUPPORT

J. Imbach, J. Vasseur, F. Debart, 2001, Nucleosides, Nucleotides & Nucleic Acids.

Effect of DNA Modifications on DNA Processing by HIV-1 Integrase and Inhibitor Binding

Y. Pommier, D. Corey, D. Jerina, 2006, Journal of Biological Chemistry.

Synthesis and structure of methylene(dimethylhydrazo) linked thymidine dimer and their utility as antisense oligonucleotides

P. D. Cook, J. Vasseur, F. Debart, 1993 .

Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides

P. D. Cook, J. Vasseur, F. Debart, 1992 .

5-Propynylamino α-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic α-oligonucleotides

Gaëlle Deglane, J. Vasseur, F. Morvan, 2007 .

Synthesis and base-pairing properties of the nuclease-resistant α-anomeric dodecaribonucleotide α-[r(UCUUAACCCACA)]

G. Degols, B. Rayner, J. Imbach, 1992 .

Anomeric inversion (from β to α) in methylphosphonate oligonucleosides enhances their affinity for DNA and RNA

B. Rayner, J. Vasseur, F. Debart, 1998 .

High Affinity Of Backbone-Modified α-Anomeric Oligodeoxynucleottoes For Dna And Rna Targets

B. Rayner, J. Vasseur, J. Bologna, 1998 .

Synthesis andbase-pairing properties ofthenuclease- resistant ot-anomeric dodecaribonucleo

G. Degols, B. Rayner, F. Debart, 1992 .

A new route to oligodeoxynucleoside phosphoramidates (PNH2)

B. Rayner, F. Debart, A. Laurent, 1997 .

Impact of the Guanidinium Group on Hybridization and Cellular Uptake of Cationic Oligonucleotides

E. Vivés, I. Barvík, B. Lebleu, 2006, Chembiochem : a European journal of chemical biology.

Chimeric alpha‐beta oligonucleotides as antisense inhibitors of reverse transcription

J. Toulmé, C. Boiziau, B. Rayner, 1995, FEBS letters.

DNA Triple Helix Formation by N-Alkylphosphoramidate α-Oligonucleosides

B. Rayner, J. Vasseur, M. Naval, 1999 .

A New Route to Oligodeoxynucleoside Phosphoramidates (P-NH2).

B. Rayner, F. Debart, A. Laurent, 1997 .

Chemical modifications to improve the cellular uptake of oligonucleotides.

H. Moulton, B. Lebleu, Gaëlle Deglane, 2007, Current topics in medicinal chemistry.

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

B. Canard, J. Vasseur, S. Priet, 2012, PLoS pathogens.

A 2',2'-disulfide-bridged dinucleotide conformationally locks RNA hairpins.

J. Vasseur, F. Debart, F. Beltran, 2018, Organic & biomolecular chemistry.

FTIR and UV Spectroscopy Studies of Triplex Formation Between α-Oligonucleotides with Non-Ionic Phoshoramidate Linkages and DNA Targets

E. Taillandier, J. Vasseur, F. Debart, 2003, Journal of biomolecular structure & dynamics.

Efficient Release of Base‐Sensitive Oligonucleotides from Solid Supports using Fluoride Ions

T. Lavergne, J. Vasseur, F. Debart, 2009 .

First insights into the structural features of Ebola virus methyltransferase activities

A. Desmyter, B. Coutard, E. Decroly, 2021, Nucleic acids research.

The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation

B. Coutard, E. Decroly, B. Canard, 2020, Journal of Virology.

X-ray structure and activities of an essential Mononegavirales L-protein domain

E. Decroly, G. Paesen, J. Grimes, 2015, Nature Communications.

The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure.

T. Lavergne, P. Herdewijn, J. Vasseur, 2013, Organic & biomolecular chemistry.

Synthesis and preliminary evaluation of pro-RNA 2'-O-masked with biolabile pivaloyloxymethyl groups in an RNA interference assay.

T. Lavergne, G. Sczakiel, J. Vasseur, 2011, The Journal of organic chemistry.

First evaluation of acyloxymethyl or acylthiomethyl groups as biolabile 2'-O-protections of RNA.

J. Vasseur, F. Debart, C. Baraguey, 2006, Organic letters.

FTO controls reversible m6Am RNA methylation during snRNA biogenesis

J. Mauer, S. Jaffrey, L. Pellizzoni, 2019, Nature Chemical Biology.

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

Olivier Elemento, Samie R. Jaffrey, Jean-Jacques Vasseur, 2016, Nature.

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome.

Jean-Jacques Vasseur, Samie R Jaffrey, Sara Zaccara, 2019, Molecular cell.

The RNA demethylase FTO targets m6Am in snRNA to establish distinct methyl isoforms that influence splicing

J. Mauer, S. Jaffrey, L. Pellizzoni, 2018, bioRxiv.

Structure and conformation of the duplex consensus 5'-splice site d[(CpApGpGpTpApApGpT).(ApCpTpTpApCpCpTpG)] deduced from high field 1H-NMR of the non-exchangeable and imino protons.

J. Lown,, D. Chang, R. Pon, 1987, Journal of biomolecular structure & dynamics.

Structure and conformation of the duplex consensus acceptor exon:intron junction d[(CpTpApCpApGpGpT). (ApCpCpTpGpTpApG)] deduced from high-field 1H-NMR of non-exchangeable and imino protons.

J. Lown,, D. Chang, B. Rayner, 1986, Journal of biomolecular structure & dynamics.

1H and 31P-NMR assignments of the non-exchangeable protons of the consensus acceptor exon:intron junction d(CpTpApCpApGpGpT).

J. Lown,, D. Chang, B. Rayner, 1986, Journal of biomolecular structure & dynamics.

Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10

E. Decroly, B. Canard, J. Vasseur, 2016, Journal of Virology.

Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates

V. Larue, O. Pellegrini, C. Condon, 2013, Proceedings of the National Academy of Sciences.

The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

B. Coutard, E. Decroly, G. Paesen, 2018, Nucleic acids research.

Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

I. Ulitsky, J. Vasseur, R. Dikstein, 2017, eLife.

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Eric Rivals, E. Crapez, J. Vialaret, 2020, Nature Communications.

Carson C. Thoreen, Lucas Philippe, J. Vasseur, 2017, Nucleic acids research.

Innovative Chemistry for Synthesis of Regular RNA, 5′-Triphosphate RNA, or 5′-Capped RNA

J. Vasseur, F. Morvan, Y. Thillier, 2014 .

The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

P. Rigaux, Nina Ysebaert, Priscila Sutto-Ortiz, 2021, PLoS pathogens.

AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.

Priscila Sutto-Ortiz, E. Decroly, P. Shi, 2023, Antiviral research.

Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

Priscila Sutto-Ortiz, E. Decroly, B. Canard, 2020, European Journal of Medicinal Chemistry.

Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

D. Missé, B. Coutard, S. Nisole, 2022, Nucleic acids research.

mRNA maturation in giant viruses: variation on a theme

J. Claverie, C. Abergel, S. Priet, 2015, Nucleic acids research.

Direct Access to Unique C‐5’‐acyl Modified Nucleosides through Liebeskind‐Srogl Cross Coupling Reaction

M. Smietana, J. Vasseur, F. Debart, 2021, European Journal of Organic Chemistry.

Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

B. Coutard, E. Decroly, A. Delpal, 2023, European Journal of Medicinal Chemistry.

Facile access to 4'-(N-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14.

E. Decroly, A. Delpal, B. Canard, 2022, Organic & biomolecular chemistry.

Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.

E. De Clercq, C. Paoletti, J. Balzarini, 1989, Journal of medicinal chemistry.

Carson C. Thoreen, Lucas Philippe, J. Vasseur, 2018, Nucleic acids research.

Chemical Synthesis of RNA with Base‐Labile 2′‐O‐(Pivaloyloxymethyl)‐Protected Ribonucleoside Phosphoramidites

T. Lavergne, J. Vasseur, F. Debart, 2010, Current protocols in nucleic acid chemistry.

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

B. Coutard, E. Decroly, B. Canard, 2013, Antiviral research.

Supplemental Information Identification of the mAm Methyltransferase PCIF1 Reveals the Location and Functions of mAm in the Transcriptome

S. Jaffrey, S. Zaccara, F. Debart, 2019 .