B. Spear

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PDGF-A promoter and enhancer elements provide efficient and selective antineoplastic gene therapy in multiple cancer types

D. Kaetzel, A. Mishra, A. K. Ormerod, 2009, Cancer Gene Therapy.

The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment.

B. Evers, J. Hundley, P. Angulo, 2012, Anticancer research.

Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response1

A. Simmons, J. Monroe, D. Wiest, 2008, The Journal of Immunology.

Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic mice with elevated hepatic catalase activity.

H. Glauert, B. Spear, V. Nilakantan, 1998, Free radical biology & medicine.

Vitamin E inhibits hepatic NF-kappaB activation in rats administered the hepatic tumor promoter, phenobarbital.

H. Glauert, B. Spear, Karen G. Calfee-Mason, 2002, The Journal of nutrition.

HBV suppresses ZHX2 expression to promote proliferation of HCC through miR‐155 activation

Y. Gong, Zhuanchang Wu, Xiaojia Song, 2018, International journal of cancer.

A device for the simple and rapid transcervical transfer of mouse embryos eliminates the need for surgery and potential post-operative complications.

B. Spear, Michael A. Green, S. Bass, 2009, BioTechniques.

Individual mouse alpha-fetoprotein enhancer elements exhibit different patterns of tissue-specific and hepatic position-dependent activities

B. Spear, T. Ramesh, A. Ellis, 1995, Molecular and cellular biology.

Dietary antioxidants in the prevention of hepatocarcinogenesis: a review.

H. Glauert, B. Spear, Karen G. Calfee-Mason, 2010, Molecular nutrition & food research.

Peroxisome proliferators do not activate the transcription factors AP-1, early growth response-1, or heat shock factors 1 and 2 in rats or hamsters.

M. Cunningham, H. Glauert, B. Spear, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Cell proliferation and apoptosis are altered in mice deficient in the NF-kappaB p50 subunit after treatment with the peroxisome proliferator ciprofibrate.

H. Glauert, E. Konz, B. Spear, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kB activity

L. Leung, Yixin Li, H. Glauert, 1996 .

Increased Liver‐specific Expression of Catalase in Transgenic Mice a

H. Glauert, B. Spear, V. Nilakantan, 1996, Annals of the New York Academy of Sciences.

Alpha-fetoprotein related gene (ARG): a new member of the albumin gene family that is no longer functional in primates.

M. L. Peterson, B. Spear, S. Naidu, 2010, Gene.

Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E.

Y. Gong, Xuetian Yue, Hongxin Ma, 2012, Gastroenterology.

Liver-specific catalase expression in transgenic mice inhibits NF-kappaB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate.

H. Glauert, B. Spear, V. Nilakantan, 1998, Carcinogenesis.

Quantitative Trait Locus Mapping and Identification of Zhx2 as a Novel Regulator of Plasma Lipid Metabolism

Omid Kohannim, A. Lusis, L. Castellani, 2010, Circulation. Cardiovascular genetics.

Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls.

L. Robertson, H. Glauert, Eun Y. Lee, 2002, Toxicology and applied pharmacology.

PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation.

D. Cohen, B. Evers, J. Hundley, 2013, The Journal of surgical research.

Effect of Dietary Selenium on the Promotion of Hepatocarcinogenesis by 3,3′, 4,4′-Tetrachlorobiphenyl and 2,2′, 4,4′, 5,5′-Hexachlorobiphenyl

C. Srinivasan, J. S. Morris, H. Lehmler, 2008, Experimental biology and medicine.

Role of the p50 subunit of NF-kappaB in vitamin E-induced changes in mice treated with the peroxisome proliferator, ciprofibrate.

H. Glauert, Eun Y. Lee, B. Spear, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.

H. Glauert, Eun Y. Lee, B. Spear, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Administered the Peroxisome Proliferator Wy-14,643

H. Glauert, Eun Y. Lee, B. Spear, 2006 .

Effects of vitamin E on the NF-kappaB pathway in rats treated with the peroxisome proliferator, ciprofibrate.

H. Glauert, B. Spear, Karen G. Calfee-Mason, 2004, Toxicology and applied pharmacology.

Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters.

M. Cunningham, H. Glauert, B. Spear, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Effects of peroxisome proliferators on glutathione and glutathione-related enzymes in rats and hamsters.

M. Cunningham, H. Glauert, B. Spear, 2001, Toxicology and applied pharmacology.

Activation of nuclear factor-κB by the peroxisome proliferator ciprofibrate in H4IIEC3 rat hepatoma cells and its inhibition by the antioxidants N-acetylcysteine and vitamin E

Yixin Li, H. Glauert, B. Spear, 2000 .

Expression of the hydrogen peroxide-generating enzyme fatty acyl CoA oxidase activates NF-kappaB.

H. Glauert, B. Spear, J. Tharappel, 2000, DNA and cell biology.

Role of oil vehicle on hepatic cell proliferation in PCB-treated rats.

H. Lehmler, L. Robertson, H. Glauert, 2011, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.

The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats.

C. Srinivasan, H. Lehmler, L. Robertson, 2007, Toxicology.

Effect of a single dose of polychlorinated biphenyls on hepatic cell proliferation and the DNA binding activity of NF‐κB and AP‐1 in rats

L. Robertson, H. Glauert, Eun Y. Lee, 2003, Molecular carcinogenesis.

Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77).

C. Srinivasan, H. Lehmler, L. Robertson, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Role of oxidative stress in the promoting activities of pcbs.

Subhashish Banerjee, H. Lehmler, L. Robertson, 2008, Environmental toxicology and pharmacology.

Hepatocyte nuclear factor 3 relieves chromatin-mediated repression of the alpha-fetoprotein gene.

M. Barton, A. J. Crowe, B. Spear, 1999, The Journal of biological chemistry.

The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis

M. L. Twaroski, Yixin Li, H. Glauert, 2009, PPAR research.

ReviewArticle The Role of NF-κ Bi n PPARα-Mediated Hepatocarcinogenesis

M. L. Twaroski, Yixin Li, H. Glauert, 2008 .

Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice.

Subhashish Banerjee, H. Lehmler, L. Robertson, 2008, Toxicology and applied pharmacology.

Inhibits Hepatic NF-B Activation in Rats Administered the Hepatic Tumor Promoter , Phenobarbital 1

H. Glauert, B. Spear, Karen G. Calfee-Mason, 2002 .

The alpha-fetoprotein promoter is the target of Afr1-mediated postnatal repression.

M. C. Huang, B. Spear, D. K. Peyton, 2000, Genomics.

Alpha-fetoprotein gene regulation: lessons from transgenic mice.

B. Spear, 1999, Seminars in cancer biology.

Differential activation of hepatic NF-kappaB in rats and hamsters by the peroxisome proliferators Wy-14,643, gemfibrozil, and dibutyl phthalate.

M. Cunningham, H. Glauert, B. Spear, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

The Prorenin Receptor and its Soluble Form Contribute to Lipid Homeostasis

R. Temel, G. Graf, B. Spear, 2020, bioRxiv.

PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors.

A. Buchmann, M. Schwarz, K. Appel, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons

S. Tilghman, B. Spear, 1990, Molecular and cellular biology.

Systemic Par-4 inhibits non-autochthonous tumor growth

V. Rangnekar, S. Qiu, R. Burikhanov, 2011, Cancer biology & therapy.

Cancer resistance in transgenic mice expressing the SAC module of Par-4.

V. Rangnekar, S. Qiu, R. Burikhanov, 2007, Cancer research.

Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131

J. Strominger, D. Wilson, B. Spear, 1985, The Journal of experimental medicine.

Carbohydrate differences in HLA-DR molecules synthesized by alveolar macrophages and blood monocytes.

D. Monos, T. Ferro, M. Kamoun, 2015, The American review of respiratory disease.

Increased liver-specific catalase activity in transgenic mice.

H. Glauert, B. Spear, V. Nilakantan, 1996, DNA and cell biology.

A Nonimmunoglobulin Transgene and the Endogenous Immunoglobulin μ Gene Are Coordinately Regulated by Alternative RNA Processing during B-Cell Maturation

E. C. Snow, R. Seipelt, B. Spear, 1998, Molecular and Cellular Biology.

Effect of vitamin E on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-κB after treatment with phenobarbital.

H. Glauert, B. Spear, J. Tharappel, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lymphocyte function-associated antigen 1 (LFA-1) and natural killer (NK) cell activity: LFA-1 is not necessary for all killer: target cell interactions.

D. Wilson, J. Taylor, B. Spear, 1987, Cellular immunology.

Antigenic changes in gp70 associated with the adult variant of Gross murine leukemia virus, WB91.

K. Klyczek, J. Pozsgay, K. Blank, 1986, Microbial pathogenesis.

Evidence for the role of class I and class II HLA antigens in the lytic function of a cloned line of human natural killer cells.

D. Wilson, S. Raab, B. Spear, 1985, Journal of immunology.

ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA

Xuetian Yue, Hongxin Ma, Lifen Gao, 2014, Oncotarget.

The Neuronal Voltage-Gated Sodium Channel, Scn8a, Is Essential for Postnatal Maturation of Spinal, but Not Oculomotor, Motor Units

J. D. Porter, J. Brueckner, E. Kasarskis, 1996, Experimental Neurology.

Zinc fingers and homeoboxes 2 is required for diethylnitrosamine‐induced liver tumor formation in C57BL/6 mice

T. Hinds, Jieyun Jiang, Mei Xu, 2022, bioRxiv.

Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats.

H. Lehmler, L. Robertson, H. Glauert, 2005, The Journal of nutrition.

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

Jieyun Jiang, B. Spear, K. Creasy, 2016, Gene expression.

Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-kappaB.

H. Glauert, B. Spear, J. Tharappel, 2008, Toxicology and applied pharmacology.

Endogenous and transfected mouse alpha-fetoprotein genes in undifferentiated F9 cells are activated in transient heterokaryons

B. Spear, A. Ellis, Brett T. Spear, 1995, Somatic cell and molecular genetics.

Position-dependent activity of alpha -fetoprotein enhancer element III in the adult liver is due to negative regulation.

B. Spear, T. Ramesh, D. K. Peyton, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The mouse alpha-albumin (afamin) promoter is differentially regulated by hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β.

B. Spear, Hui Ren, Hua Liu, 2011, DNA and cell biology.

Elongation of Very Long Chain Fatty Acids Like- 3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression

Jieyun Jiang, B. Spear, K. Creasy, 2022, bioRxiv.

N-Aryl benzenesulfonamide inhibitors of [3H]-thymidine incorporation and β-catenin signaling in human hepatocyte-derived Huh-7 carcinoma cells.

D. Watt, Wen Zhang, Chunming Liu, 2015, Bioorganic & medicinal chemistry letters.

ZBTB20 is a sequence-specific transcriptional repressor of alpha-fetoprotein gene

Jia-wei Wu, Xiao Guo, Zhifang Xie, 2015, Scientific Reports.

The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha‐fetoprotein regulator 2

A. Dobierzewska, B. Spear, L. Morford, 2007, Hepatology.

Nonsurgical embryo transfer device compared with surgery for embryo transfer in mice.

B. Spear, Kendra H Steele, Barbara J. Stone, 2013, Journal of the American Association for Laboratory Animal Science : JAALAS.

Pericentral activity of alpha‐fetoprotein enhancer 3 and glutamine synthetase upstream enhancer in the adult liver are regulated by β‐catenin in mice

B. Spear, Erica L Clinkenbeard, J. E. Butler, 2012, Hepatology.

Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15.

M. Meisler, W. Jang, D. Burgess, 1995, Genomics.

Mouse alpha-fetoprotein gene 5' regulatory elements are required for postnatal regulation by raf and Rif

B. Spear, 1994, Molecular and cellular biology.

Zhx2 and Zbtb20: novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer.

Chunhong Ma, B. Spear, M. Peterson, 2011, Seminars in cancer biology.

Evolutionary Analysis of the Zinc Finger and Homeoboxes Family of Proteins Identifies Multiple Conserved Domains and a Common Early Chordate Ancestor

J. Smith, B. Spear, M. Peterson, 2020, Genome biology and evolution.

Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2

Jieyun Jiang, B. Spear, Erica L Clinkenbeard, 2019, Mammalian Genome.

Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver

Jieyun Jiang, B. Spear, K. Creasy, 2017, The Journal of Biological Chemistry.

Characterization of the ETnII-α endogenous retroviral element in the BALB/cJ Zhx2Afr1 allele

B. Spear, M. Peterson, S. Perincheri, 2007, Mammalian Genome.

Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation

L. Jin, A. Dobierzewska, B. Spear, 2006, Cellular and Molecular Life Sciences CMLS.

Hereditary persistence of alpha-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene.

B. Spear, M. Peterson, S. Perincheri, 2005, Proceedings of the National Academy of Sciences of the United States of America.

FoxA Proteins Regulate H19 Endoderm Enhancer E1 and Exhibit Developmental Changes in Enhancer Binding In Vivo

Lingyun Long, B. Spear, 2004, Molecular and Cellular Biology.

Striking differences between the mouse and the human α-fetoprotein enhancers

Lingyun Long, B. Spear, J. Davidson, 2004 .

The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development.

Lingyun Long, B. Spear, Michael A Green, 2009, Developmental biology.

A sensitive lacZ-based expression vector for analyzing transcriptional control elements in eukaryotic cells.

S. Moulder, B. Spear, S. Wang, 1995, DNA and cell biology.

Role of Oxidative Stress in Peroxisome Proliferator-Mediated Carcinogenesis

H. Glauert, B. Spear, M. O'Brien, 2005, Critical reviews in toxicology.

Hepatocyte Nuclear Factor 3 Relieves Chromatin-mediated Repression of the α-Fetoprotein Gene*

M. Barton, Kathleen C. Lee, A. J. Crowe, 1999, The Journal of Biological Chemistry.

The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 (FOXA).

B. Spear, Mei‐Chuan Huang, K. Li, 2002, DNA and cell biology.

Effect of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) on hepatocyte proliferation and apoptosis in mice deficient in the p50 subunit of the transcription factor NF-kappaB.

L. Robertson, H. Glauert, Eun Y. Lee, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

M. Meisler, D. Burgess, Julie M. Jones, 1995, Nature Genetics.

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

B. Spear, M. Peterson, Alexandra N. Nail, 2020, Gene.

Normal intestinal epithelial cell differentiation in the absence of p21 and p27: new insights from old knock-out mice

B. Spear, J. E. Butler, 2008, Cancer biology & therapy.

Autophagic flux modulation by Wnt/β-catenin pathway inhibition in hepatocellular carcinoma

D. Watt, Chunming Liu, Jieyun Jiang, 2019, PloS one.

Effects of Cigarette Smoke on the Activation of Oxidative Stress-Related Transcription Factors in Female A/J Mouse Lung

Parvaneh Espandiari, C. Gairola, P. Espandiari, 2010, Journal of toxicology and environmental health. Part A.

Targeting the Wnt/β-Catenin Signaling Pathway in Liver Cancer Stem Cells and Hepatocellular Carcinoma Cell Lines with FH535

Malay Shah, K. Esser, Xiping Zhang, 2014, PloS one.

An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors.

C. Zhan, D. Watt, B. Evers, 2019, Journal of medicinal chemistry.

Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways.

B. Spear, R. Gedaly, Changguo Chen, 2014, Anticancer research.

Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kappaB activity.

L. Leung, H. Glauert, B. Spear, 1997, Carcinogenesis.

A device for the simple and rapid transcervical transfer of mouse embryos eliminates the need for surgery and potential post-operative complications.

B. Spear, Michael A. Green, S. Bass, 2009, BioTechniques.