R. Griffiths

发表

Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.

E. Novellino, T. Liljefors, A. Schousboe, 2001, Journal of medicinal chemistry.

Zolantidine (SK&F 95282) is a potent selective brain‐penetrating histamine H2‐receptor antagonist

R. C. Young, R. Mitchell, C. Ganellin, 1988, British journal of pharmacology.

Kinetic characterization of sulphur-containing excitatory amino acid uptake in primary cultures of neurons and astrocytes

A. Schousboe, R. Griffiths, A. Grieve, 1991, Neurochemistry International.

Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: Kinetic characterisation and analysis of carrier specificity

S. Butcher, R. Griffiths, A. Grieve, 1992, Journal of neuroscience research.

Differential Changes in the Content of Amino Acid Neurotransmitters in Discrete Regions of the Rat Brain Prior to the Onset and During the Course of Homocysteine‐Induced Seizures

R. Griffiths, A. Grieve, I. C. Allen, 1986, Journal of neurochemistry.

A pilot study of orally administered Δ(1)-trans-tetrahydrocannabinol in the management of patients undergoing radiotherapy for carcinoma of the bronchus.

R. Griffiths, B. Davies, J. Graham, 1974, British journal of clinical pharmacology.

A Prototypic Intracellular Calcium Antagonist, TMB‐8, Protects Cultured Cerebellar Granule Cells Against the Delayed, Calcium‐Dependent Component of Glutamate Neurotoxicity

R. Griffiths, A. Grieve, C. Malcolm, 1996, Journal of neurochemistry.

Excitatory amino acid-induced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with elevated, sustained c-fos proto-oncogene expression.

C. Meredith, A. Gorman, P. Rumsby, 1995, Neuroscience letters.

A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.

E. Novellino, T. Rauen, G. Campiani, 2001, Journal of medicinal chemistry.

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists.

R Griffiths, R. C. Young, C R Ganellin, 1988, Journal of medicinal chemistry.

Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells

E. Novellino, A. Schousboe, G. Campiani, 2003, Neurochemistry International.

Cytotoxic actions and effects on intracellular Ca2+ and cGMP concentrations of sulphur‐containing excitatory amino acids in cultured cerebral cortical neurons

A. Schousboe, A. Frandsen, R. Griffiths, 1993, Journal of neuroscience research.

Excitatory-sulphur-amino-acid-evoked neurotransmitter release from synaptosomes and primary neuronal cultures.

R. Griffiths, J. Dunlop, 1990, Biochemical Society transactions.

Modulation by Ionotropic Excitatory Amino Acids and Potassium of (±)‐1‐Aminocyclopentane‐trans‐1,3‐Dicarboxylic Acid‐Stimulated Phosphoinositide Hydrolysis in Mouse Cerebellar Granule Cells

A. Gorman, R. Griffiths, A. Grieve, 1995, Journal of neurochemistry.

Trial of three-day and ten-day courses of amoxycillin in otitis media.

D M Chaput de Saintonge, D F Levine, R Griffiths, 1982, British medical journal.

Excitatory sulphur amino acid-evoked neurotransmitter release from rat brain synaptosome fractions

R. Griffiths, A. Grieve, J. Dunlop, 2005, Journal of Neural Transmission / General Section JNT.

Effect ofl-homocysteine and derivatives on the high-affinity uptake of taurine and GABA into synaptosomes and cultured neurons and astrocytes

A. Schousboe, R. Griffiths, I. C. Allen, 1986, Neurochemical Research.

Mutual Inhibition Kinetic Analysis of γ‐Aminobutyric Acid, Taurine, and β‐Alanine High‐Affinity Transport into Neurons and Astrocytes: Evidence for Similarity Between the Taurine and β‐Alanine Carriers in Both Cell Types

A. Schousboe, O. Larsson, R. Griffiths, 1986 .

Effect of L-homocysteine and derivatives on the high-affinity uptake of taurine and GABA into synaptosomes and cultured neurons and astrocytes.

A. Schousboe, R. Griffiths, I. C. Allen, 1986, Neurochemical research.

Cysteine sulphinate (CSA) as an excitatory amino acid transmitter candidate in the mammalian central nervous system

R. Griffiths, 1990, Progress in Neurobiology.

Characterization of the receptor-mediated sulphur amino acid-evoked release of [3H]d-aspartate from primary cultures of cerebellar granule cells

A. Schousboe, R. Griffiths, A. Grieve, 1990, Neurochemistry International.

NMDA receptor‐mediated cGMP synthesis in primary cultures of mouse cerebellar granule cells appears to involve neuron‐astrocyte communication with NO operating as the intercellular messenger

A. Schousboe, R. Griffiths, A. Grieve, 1996, Journal of neuroscience research.

Preliminary evaluation of an in vitro test for assessment of excitotoxicity by measurement of early gene (c-fos mRNA) levels.

C. Williams, C. Meredith, R. Griffiths, 2000, Toxicology in vitro : an international journal published in association with BIBRA.

Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1‐receptor antagonist with negligible ability to penetrate the central nervous system

R Griffiths, R. Griffiths, E A Brown, 1986, British journal of pharmacology.

Binding of [3H]muscimol to calf cerebrocortical synaptic membranes and the effects of sulphur-containing convulsant and non-convulsant compounds

R. Griffiths, J. Egbuta, 1987, Neurochemical Research.

Homocysteine-induced alterations in extracellular amino acids in rat hippocampus

S. Butcher, R. Griffiths, L. Kendall, 1992, Neurochemistry International.

Synergistic inhibition of [3H]muscimol binding to calf-brain synaptic membranes in the presence of L-homocysteine and pyridoxal 5'-phosphate. A possible mechanism for homocysteine-induced seizures.

D. Williams, I. Dewhurst, R. Griffiths, 1983, European journal of biochemistry.

Hippocampal Electrical Activity and γ‐Aminobutyrate Metabolism in Brain Tissue Following Administration of Homocysteine

I. Dewhurst, R. Griffiths, R. G. Morris, 1983, Journal of neurochemistry.

Enzyme studies in cystathionine-β-synthase deficiency: A possible effect of elevated intracellular levels of homocystine in kinetic studies

F. Hemraj, R. Griffiths, 1978, Journal of Inherited Metabolic Disease.

Stimulation of γ‐[3H]Aminobutyric Acid Release from Cultured Mouse Cerebral Cortex Neurons by Sulphur‐Containing Excitatory Amino Acid Transmitter Candidates: Receptor Activation Mediates Two Distinct Mechanisms of Release

A. Schousboe, R. Griffiths, A. Grieve, 1991, Journal of neurochemistry.

Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-d-aspartate receptors

A. Gorman, R. Griffiths, 1994, Neuroscience.

Neuronal and glial plasma membrane carrier-mediated uptake of l-homocysteate is not selectively blocked by β-p-chlorophenylglutamate

H. J. Olverman, R. Griffiths, A. Grieve, 1992, Neuroscience Letters.

Neuronal and glial plasma membrane carrier-mediated uptake of L-homocysteate is not selectively blocked by beta-p-chlorophenylglutamate.

H. J. Olverman, R. Griffiths, A. Grieve, 1992, Neuroscience letters.

Sulphur‐Containing Amino Acids Modulate Noradrenaline Release from Hippocampal Slices

S. Gassó, R. Griffiths, E. Rodríguez-Farré, 1997, Journal of neurochemistry.

A double inhibition kinetic analysis of [3H]-muscimol binding to the gamma-aminobutyric acid receptor on calf brain synaptic membranes. Further studies on the mechanism of homocysteine-induced seizures.

R. Griffiths, J. Egbuta, 1985, Biochemical pharmacology.

l-Homocysteine enhances pyridoxal 5′-phosphate-induced seizures in the rat

R. Griffiths, I. C. Allen, 1984 .

An approach to the design of brain-penetrating histaminergic agonists

R Griffiths, R. C. Young, R. Mitchell, 1993 .

Inhibition by excitatory sulphur amino acids of the high-affinityl-glutamate transporter in synaptosomes and in primary cultures of cortical astrocytes and cerebellar neurons

A. Schousboe, R. Griffiths, A. Grieve, 1989, Neurochemical Research.

Comparison of the cardiovascular effects of the novel 5-HT(1B/1D) receptor agonist, SB 209509 (VML251), and sumatriptan in dogs.

A. A. Parsons, F. King, A. Hunter, 1997, Journal of cardiovascular pharmacology.

Excitatory amino acid-induced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with elevated, sustained c-fos protoncogene expression

C. Meredith, A. Gorman, P. Rumsby, 1995, Neuroscience Letters.

Possible role for the FosB/JunD AP‐1 transcription factor complex in glutamate‐mediated excitotoxicity in cultured cerebellar granule cells

R. Griffiths, Kate Lidwell, 2000, Journal of neuroscience research.

Mutual inhibition kinetic analysis of gamma-aminobutyric acid, taurine, and beta-alanine high-affinity transport into neurons and astrocytes: evidence for similarity between the taurine and beta-alanine carriers in both cell types.

A. Schousboe, O. Larsson, R. Griffiths, 1986, Journal of neurochemistry.

The enolization of 4, 5‐dehydromuscarone

K. Bowden, R. Griffiths, A. Beckett, 1976, The Journal of pharmacy and pharmacology.

Oxmetidine: clinical pharmacological studies with a new H2-receptor antagonist.

R. Hunt, R. Griffiths, W. L. Burland, 1982, Gut.

L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters.

A. Gorman, R. Griffiths, A. Grieve, 1994, Biochemical pharmacology.

Chapter 6 Excitatory amino acid receptors

R. Griffiths, 1997 .

Neuroactive Sulphur Amino Acids Evoke a Calcium‐Dependent Transmitter Release from Cultured Neurones That Is Sensitive to Excitatory Amino Acid Receptor Antagonists

A. Schousboe, R. Griffiths, A. Grieve, 1989, Journal of neurochemistry.

Association of c‐fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neurons

A. Schousboe, C. Meredith, A. Frandsen, 1997, Journal of neuroscience research.

Endothelin‐1 Increases Arachidonic Acid Release in C6 Glioma Cells Through a Potassium‐Modulated Influx of Calcium

D. Williams, L. O’Neill, R. Griffiths, 1996, Journal of neurochemistry.

Improvements in an in-vitro assay for excitotoxicity by measurement of early gene (c-fos mRNA) levels

A. Schousboe, G. Campiani, D. Williams, 2005, Archives of Toxicology.

Glutamate toxicity in primary cerebellar cultures from mouse brain is unaffected by changes in cGMP levels.

R. Griffiths, A. Grieve, C. Malcolm, 1996, NeuroReport.

Cimetidine-a clinical and pharmacokinetic study.

J. Webster, G. Hawksworth, P. Brunt, 1981, British journal of clinical pharmacology.

Simultaneous measurement by HPLC of the excitatory amino acid transmitter candidates homocysteate and homocysteine sulphinate supports a predominant astrocytic localisation

R. Griffiths, A. Grieve, 1992, Neuroscience Letters.

Sulphur-containing excitatory amino acid-evoked Ca2+-independent release of d-[3H]aspartate from cultured cerebellar granule cells: The role of glutamate receptor activation coupled to reversal of the acidic amino acid plasma membrane carrier

A. Schousboe, R. Griffiths, A. Grieve, 1992, Neuroscience.

Differential Mechanisms of Glutamate-Stimulated Perturbations in the Kinetics of c-fos mRNA Induction Are Associated with Maturation of Cerebellar Granule Cells in Primary Culture

C. Meredith, R. Griffiths, A. Grieve, 2004, Neurochemical Research.

The biochemistry and pharmacology of excitatory sulphur-containing amino acids.

R. Griffiths, 1993, Biochemical Society transactions.

Cysteine sulphinic acid as candidate endogenous EAA ligand.

R. Griffiths, J. Dunlop, 1991, Trends in pharmacological sciences.

Sustained c-fos expression is associated with excitotoxicity during the development of neuronal cells in vitro.

A. Schousboe, C. Meredith, A. Gorman, 1996, Biochemical Society transactions.