B. Steffansen

发表

Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line.

S. Frokjaer, B. Brodin, C. Nielsen, 2001, American journal of physiology. Gastrointestinal and liver physiology.

In vitro solubility, dissolution and permeability studies combined with semi-mechanistic modeling to investigate the intestinal absorption of desvenlafaxine from an immediate- and extended release formulation.

P. Holm, B. Steffansen, F. Franek, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE).

R. Borchardt, H. Ouyang, T. Andersen, 2009, Journal of pharmaceutical sciences.

Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)

B. Brodin, C. Nielsen, L. Saaby, 2013 .

Discovery of Ligands for the Human Intestinal Di‐/Tripeptide Transporter (hPEPT1) Using a QSAR‐Assisted Virtual Screening Strategy

L. Olsen, F. Jørgensen, B. Brodin, 2009, ChemMedChem.

Development of a QSAR Model for Binding of Tripeptides and Tripeptidomimetics to the Human Intestinal Di-/Tripeptide Transporter hPEPT1

L. Olsen, F. Jørgensen, C. Nielsen, 2006, Pharmaceutical Research.

Recent advances in therapeutic applications of human peptide transporters

B. Brodin, C. Nielsen, B. Steffansen, 2005 .

Involvement of Organic Anion Transporting Polypeptide 1a5 (Oatp1a5) in the Intestinal Absorption of Endothelin Receptor Antagonist in Rats

H. Arakawa, I. Tamai, M. Chiba, 2008, Pharmaceutical Research.

Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide.

H. Lennernäs, B. Steffansen, Luise K. Gram, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vitro metabolism and permeation studies in rat jejunum: organic chromium compared to inorganic chromium.

B. Gammelgaard, B. Steffansen, K. Jensen, 1999, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Stability, metabolism and transport of D-Asp(OBzl)-Ala--a model prodrug with affinity for the oligopeptide transporter.

H. Lennernäs, S. Frokjaer, B. Larsen, 1999, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Nonionic surfactants increase digoxin absorption in Caco‐2 and MDCKII MDR1 cells: Impact on P‐glycoprotein inhibition, barrier function, and repeated cellular exposure

R. Holm, C. Nielsen, B. Steffansen, 2018, International journal of pharmaceutics.

Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1.

S. Frokjaer, B. Brodin, C. Nielsen, 2002, Pharmacology & toxicology.

In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1.

S. Frokjaer, F. Jørgensen, B. Brodin, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague‐Dawley rats

C. Bundgaard, R. Holm, C. Nielsen, 2018, International journal of pharmaceutics.

Pyrimidine and nucleoside γ-esters of l-Glu-Sar: Synthesis, stability and interaction with hPEPT1

B. Brodin, B. Steffansen, M. Begtrup, 2005 .

Transport Characteristics of L-Carnosine and the Anticancer Derivative 4-Toluenesulfonylureido-Carnosine in a Human Epithelial Cell Line

C. Supuran, A. Scozzafava, S. Frokjaer, 2002, Pharmaceutical Research.

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line.

S. Frokjaer, B. Brodin, C. Nielsen, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Oligopeptide transporter mediated uptake and transport of D-Asp(OBzl)-Ala, D-Glu(OBzl)-Ala, and D-Ser(Bzl)-Ala in filter-grown Caco-2 monolayers

S. Frokjaer, M. Taub, B. Steffansen, 1998 .

Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU: in vitro efficacy and in vivo gastrointestinal distribution

M. Glavas-Dodov, K. Goracinova, B. Steffansen, 2013, Journal of microencapsulation.

Epidermal growth factor and insulin short-term increase hPepT1-mediated glycylsarcosine uptake in Caco-2 cells.

S. Frokjaer, B. Brodin, C. Nielsen, 2003, Acta physiologica Scandinavica.

Dipeptide Derivatives of AZT: Synthesis, Chemical Stability, Activation in Human Plasma, hPEPT1 Affinity, and Antiviral Activity

C. Pannecouque, R. Moreira, C. Nielsen, 2008, ChemMedChem.

Acyclovir prodrug for the intestinal di/tri-peptide transporter PEPT1: comparison of in vivo bioavailability in rats and transport in Caco-2 cells.

B. Steffansen, M. S. Christensen, A. E. Thomsen, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1.

C. Nielsen, B. Steffansen, M. Begtrup, 2011, Bioorganic & medicinal chemistry letters.

Influence of oligopeptide transporter binding affinity upon uptake and transport of d-Asp(OBzl)-Ala and Asp(OBzl)-Sar in filter-grown Caco-2 monolayers

S. Frokjaer, M. Taub, B. Steffansen, 1997 .

β-Carboxylic acid esterified D-Asp-Ala retains a high affinity for the oligopeptide transporter in Caco-2 monolayers

S. Frokjaer, B. Larsen, M. Taub, 1997 .

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism.

S. Frokjaer, B. Brodin, C. Nielsen, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Bioactivation of morphine-3-propionate, a prodrug of morphine, in tissues from different species

L. Christrup, B. Steffansen, A. Jørgensen, 1997 .

Novel wound models for characterizing ibuprofen release from foam dressings.

B. Steffansen, Sofie P.K. Herping, 2008, International journal of pharmaceutics.

Changes with time after treatment in the concentrations of ivermectin in fresh cow dung and in cow pats aged in the field.

B. Steffansen, C. Sommer, Bente Steffansen, 1993, Veterinary parasitology.

Ivermectin excreted in cattle dung after subcutaneous injection or pour-on treatment: concentrations and impact on dung fauna

J. B. Jespersen, J. Springborg, K. Jensen, 1992 .

The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo.

L. Zhai, T. Theander, A. Kharazmi, 1997, The Journal of infectious diseases.

Passive diffusion of drug substances: the concepts of flux and permeability

B. Brodin, C. Nielsen, B. Steffansen, 2010 .

Imidazole‐4‐acetic acid, a new lead structure for interaction with the taurine transporter in outer blood‐retinal barrier cells

B. Steffansen, Jacob Krall, Sophie Valembois, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Erythromycin prodrugs: kinetics of hydrolysis of erythromycin and various erythromycin 2'-esters in aqueous solution and human plasma

B. Steffansen, H. Bundgaard, 1989 .

Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in‐vitro kinetic parameters for the prediction of clinically relevant drug–drug interactions

N. Rapin, B. Steffansen, H. Vestergaard, 2012, The Journal of pharmacy and pharmacology.

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs.

I. Sylte, K. Luthman, F. Jørgensen, 2005, Bioorganic & medicinal chemistry.

Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption.

S. Frokjaer, B. Brodin, C. Nielsen, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa.

R. Borchardt, H. Ouyang, T. Andersen, 2009, Journal of pharmaceutical sciences.

Pharmacokinetics of intravitreal 5-fluorouracil prodrugs in silicone oil: experimental studies in pigs.

M. la Cour, B. Steffansen, E. Scherfig, 2005, Acta ophthalmologica Scandinavica.

Intraocular drug delivery. In vitro release studies of 5-fluorouracil from N1-alkoxycarbonyl prodrugs in silicone oil

P. Ashton, B. Steffansen, A. Buur, 1996 .

Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC): Relevance to oral drug absorption.

R. Holm, C. Nielsen, B. Steffansen, 2019, International journal of pharmaceutics.

Transporters in Drug Development

Y. Sugiyama, B. Steffansen, Yuichi Sugiyama, 2013, AAPS Advances in the Pharmaceutical Sciences Series.

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Christel A. S. Bergström, P. Artursson, C. Nielsen, 2020, Pharmaceutics.

Membrane Transporters in ADME

B. Brodin, C. Nielsen, B. Steffansen, 2013 .

In Vitro Kinetic Characterization of Transporter-Mediated Permeability

B. Steffansen, Anne Sophie Grandvuinet, 2013 .

Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media.

S. Frokjaer, B. Brodin, C. Nielsen, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Human peptide transporters: therapeutic applications

S. Frokjaer, F. Jørgensen, B. Brodin, 2002 .

Stability and in vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter.

H. Lennernäs, S. Frokjaer, P. Veski, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Model prodrugs designed for the intestinal peptide transporter. A synthetic approach for coupling of hydroxy-containing compounds to dipeptides.

C. Nielsen, B. Steffansen, M. Begtrup, 2001, European Journal of Pharmaceutical Sciences.

Estimating Intestinal Absorption of Inorganic and Organic Selenium Compounds by in Vitro Flux and Biotransformation Studies in Caco-2 Cells and ICP-MS Detection

C. Gabel‐Jensen, B. Gammelgaard, B. Steffansen, 2011, Biological Trace Element Research.

The permeation of acamprosate is predominantly caused by paracellular diffusion across Caco-2 cell monolayers: A paracellular modelling approach.

Christel A. S. Bergström, C. Nielsen, S. Neuhoff, 2019, Molecular pharmaceutics.

SGLT1-Mediated Transport in Caco-2 Cells Is Highly Dependent on Cell Bank Origin.

C. Nielsen, B. Steffansen, Maria L. Pedersen, 2017, Journal of pharmaceutical sciences.

Interactions between organic anions on multiple transporters in Caco-2 cells.

B. Steffansen, Anne Sophie Grandvuinet, 2011, Journal of pharmaceutical sciences.

The Effect of β-Turn Structure on the Permeation of Peptides Across Monolayers of Bovine Brain Microvessel Endothelial Cells

R. Borchardt, S. Frokjaer, G. Knipp, 1997, Pharmaceutical Research.

The effect of beta-turn structure on the permeation of peptides across monolayers of bovine brain microvessel endothelial cells.

R. Borchardt, S. Frokjaer, G. Knipp, 1997, Pharmaceutical research.

Interaction between fed gastric media (Ensure Plus®) and different hypromellose based caffeine controlled release tablets: comparison and mechanistic study of caffeine release in fed and fasted media versus water using the USP dissolution apparatus 3.

Per Holm, P. Holm, Frank Larsen, 2014, International journal of pharmaceutics.

Carrier-mediated transport kinetics

B. Brodin, C. Nielsen, B. Steffansen, 2010 .

Impact of transporters in oral absorption: a case study of in vitro and in vivo organic anion absorption.

B. Steffansen, Luise K. Gram, G. M. Rist, 2009, Molecular pharmaceutics.

Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa.

R. Borchardt, H. Ouyang, T. Andersen, 2009, Journal of pharmaceutical sciences.

Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters.

C. Supuran, A. Scozzafava, D. Vullo, 2006, Bioorganic & medicinal chemistry.

Simulating kinetic parameters in transporter mediated permeability across Caco-2 cells. A case study of estrone-3-sulfate.

N. Rapin, B. Steffansen, K. Rolsted, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Delivery aspects of small peptides and substrates for peptide transporters.

S. Frokjaer, C. Nielsen, B. Steffansen, 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Design, Synthesis, and Evaluation of Tripeptidic Promoieties Targeting the Intestinal Peptide Transporter hPEPT1

C. Nielsen, J. Christensen, B. Steffansen, 2007, ChemMedChem.

New insights into the carrier-mediated transport of estrone-3-sulfate in the Caco-2 cell model.

L. Gustavsson, B. Steffansen, Anne Sophie Grandvuinet, 2013, Molecular pharmaceutics.