G. Roma

发表

Acid‐catalysed Hydrolysis and Benzodiazepine‐like Properties of 5‐(Dialkylamino)‐ and 5‐(Alkylthio)‐substituted 8‐Chloro‐6‐phenyl‐6H‐[1,2,4]triazolo[4,3‐a][1,5]benzodiazepines in Mice

A. Cagnotto, S. Caccia, M. Ghia, 1998, The Journal of pharmacy and pharmacology.

Effect of 2-(1-piperazinyl)-4H-pyrido[1,2-a]pyrimidin-4-one (AP155) on human platelets in vitro.

G. Leoncini, G. Roma, M. G. Signorello, 1997, Biochemical pharmacology.

Coumarin, chromone, and 4(3H)-pyrimidinone novel bicyclic and tricyclic derivatives as antiplatelet agents: synthesis, biological evaluation, and comparative molecular field analysis.

G. Leoncini, A. Carotti, A. Carrieri, 2003, Bioorganic & medicinal chemistry.

Synthesis and anti-platelet activity of some 2-(dialkylamino)chromones

G. Leoncini, M. Maresca, G. Roma, 1988 .

1,5-benzodiazepines. Part XIII. Substituted 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines and 4H-imidazo[1,2-a][1,5]benzodiazepin-5-amines as analgesic, anti-inflammatory and/or antipyretic agents with low acute toxicity.

V. Ballabeni, E. Barocelli, G. Grossi, 2002, European journal of medicinal chemistry.

1,5-Benzodiazepines. Part XII. Synthesis and biological evaluation of tricyclic and tetracyclic 1,5-benzodiazepine derivatives as nevirapine analogues.

M. Marongiu, M. Mura, G. Grossi, 2001, European journal of medicinal chemistry.

1,8-Naphthyridines IV. 9-substituted N,N-dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3-a][1, 8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities.

G Roma, M. Ghia, F. Mattioli, 2000, European journal of medicinal chemistry.

1,5‐Benzodiazepines. Part 12. Synthesis and Biological Evaluation of Tricyclic and Tetracyclic 1,5‐Benzodiazepine Derivatives as Nevirapine Analogues.

M. Marongiu, M. Mura, G. Grossi, 2002 .

1,5-Benzodiazepines. XI: 5-(Dialkylamino) or 5-(alkylthio) substituted 8-chloro-6-phenyl-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepines with anticonvulsant activity

M. Ghia, G. Brambilla, G. Grossi, 1993 .

1,5-Benzodiazepines. X. Dialkylamino substituted 1,5-benzodiazepine and [1,2,4]triazolo [4,3-a][1,5] benzodiazepine derivatives with inhibitory activity on PAF-induced platelet aggregation.

G. Leoncini, M. Maresca, G. Grossi, 1992, Farmaco.

1,5-Benzodiazepines IX. A new route to substituted 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines with analgesic and/or anti-inflammatory activities

M. Ghia, F. Mattioli, G. Grossi, 1991 .

1,5-Benzodiazepines VIII Novel 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine derivatives with analgesic or anti-inflammatory activity

M. Ghia, E. Mereto, G. Grossi, 1990 .

1,8-Naphthyridines v. novel N-substituted 5-amino-N,N-diethyl-9-isopropyl [1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides, as potent anti-inflammatory and/or analgesic agents completely devoid of acute gastrolesivity.

V. Ballabeni, E. Barocelli, G. Grossi, 2005, European journal of medicinal chemistry.

Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site.

P. Fossa, G. Leoncini, L. Mosti, 2007, Journal of medicinal chemistry.

Synthesis and in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)coumarins.

G. Leoncini, G. Grossi, G. Roma, 2004, European journal of medicinal chemistry.

Pyran derivatives. Part XXI. Antiproliferative and cytotoxic properties of novel N-substituted 4-aminocoumarins, their benzo-fused derivatives, and some related 2-aminochromones.

C. Marzano, F. Bordin, F. Baccichetti, 2003, Farmaco.

[Chemistry and pharmacology of pyrane derivatives. XVII. Synthesis of substituted 2-(dialkylamino)-3-formylchromones and their tricyclic derivatives].

G. Roma, M. Mazzei, A. Balbi, 1989, Farmaco.

Synthesis, antiplatelet activity and comparative molecular field analysis of substituted 2-amino-4H-pyrido[1,2-a]pyrimidin-4-ones, their congeners and isosteric analogues.

G. Leoncini, A. Carotti, G. Grossi, 2000, Bioorganic & medicinal chemistry.

Psychopharmacological study with K 8409, a 1H-naphtho[2,1-b]pyran 3-dialkylamino substituted derivative.

M. Galante, G. Roma, A. Cuttica, 1979, Il Farmaco; edizione scientifica.

1,2‐Fused pyrimidines. III. Derivatives of 12H‐pyrido[1′,2′:1,2]pyrimido[4,5‐b]quinoline, a novel heterocyclic system

G. Roma, M. Mazzei, A. Balbi, 1987 .

1,5-Benzodiazepine tricyclic derivatives exerting anti-inflammatory effects in mice by inhibiting interleukin-6 and prostaglandinE(2)production.

L. Diomede, A. Cagnotto, T. Mennini, 2001, Pharmacological research.

Synthesis of (E)- and (Z)-29-methylidyne-2,3-oxidosqualene derivatives as inhibitors of liver and yeast oxidosqualene cyclase

F. Viola, P. Milla, M. Ceruti, 2002 .

1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity.

V. Ballabeni, E. Barocelli, S. Bertoni, 2008, European journal of medicinal chemistry.

1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoid of acute gastrolesivity.

V. Ballabeni, E. Barocelli, S. Bertoni, 2010, European journal of medicinal chemistry.

1,8-Naphthyridines VI. Synthesis and anti-inflammatory activity of 5-(alkylamino)-N,N-diethyl[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides with a new substitution pattern on the triazole ring.

F. Mattioli, D. Piras, G. Grossi, 2008, European journal of medicinal chemistry.

1,2-fused pyrimidines. VI. Substituted 2-amino-4H-pyrido[1,2-a]pyrimidin-4-ones with antiplatelet activity.

G. Leoncini, G. Roma, M. Di Braccio, 1993, Farmaco.

Mechanisms involved in the antiplatelet activity of 8-methyl-4-(1-piperazinyl)-7-(3-pyridinylmethoxy)-2H-1-benzopyran-2-one (RC414).

G. Leoncini, G. Grossi, G. Roma, 2004, Biochemical pharmacology.

Some 2-(dialkylamino) substituted chromenylium salts

G. Roma, M. Mazzei, E. Sottofattori, 1981 .

Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study

M. Gallicchio, C. Dianzani, M. Collino, 2006, Journal of Inflammation.

Pyran derivatives. XX. 2-Aminochromone benzo-fused derivatives with antiproliferative properties.

C. Marzano, F. Bordin, G. Grossi, 1998, Farmaco.

Pyran Derivatives. Part 20. 2‐Aminochromone Benzo‐Fused Derivatives with Antiproliferative Properties.

C. Marzano, F. Bordin, G. Grossi, 1999 .

Pyran derivatives XIX. (Dialkylamino) substituted 1-benzopyranones and naphthopyranones with platelet antiaggregating activity.

G. Leoncini, M. Poggi, G. Roma, 1995, Il Farmaco.

1,2-Fused pyrimidines. VII: 3-(dialkylamino)-1H-pyrimido[1,2-a]quinolin-1-ones and 2-(dialkylamino)-4H-pyrimido[2,1-a]isoquinolin-4-ones as antiplatelet compounds

G. Leoncini, G. Roma, M. D. Braccio, 1995 .

Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases

F. Viola, P. Milla, M. Ceruti, 2003, Lipids.

New 1,5-benzodiazepine compounds: activity at native GABAA receptors

A. Cupello, M. Robello, G. Grossi, 2010, Neuroscience.

1,2-fused pyrimidines. V. Synthesis of 1-alkyl or phenyl-2H-dipyrido-[1,2-a:2′,3′-d]pyrimidine-2,5(1H)-diones

G. Grossi, G. Roma, M. D. Braccio, 1992 .

1,8-Naphthyridines. Part 8. Novel 5-Aminoimidazo[1,2-a][1,8]naphthyridine-6-carboxamide and 5-Amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamide Derivatives Showing Potent Analgesic or Antiinflammatory Activity, Respectively, and Completely Devoid of Acute Gastrolesivity.

V. Ballabeni, E. Barocelli, S. Bertoni, 2010 .

1,8-Naphthyridines. III. N,N-dialkyl-5-chloro[1,2,4]-triazolo[4,3-a][1,8]naphthyridine-6-carboxa mides with anti-inflammatory activity.

M. Ghia, F. Mattioli, G. Grossi, 2010, Farmaco.