P. Ward

发表

GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors

S. Arkinstall, R. Hagan, I. Beresford, 1994, Neuropeptides.

Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: New tools for investigating neurokinin function

R. Hagan, I. Beresford, S. Ireland, 1991, Neuropeptides.

Potent and highly selective neurokinin antagonists.

J R Brown, J. R. Brown, R. Hagan, 1990, Journal of medicinal chemistry.

Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.

C. Bountra, K. Bunce, P. Ward, 1993, European journal of pharmacology.

ANTIEMETIC ACTIVITY OF NEUROKININ NK1 RECEPTOR ANTAGONISTS IS MEDIATED CENTRALLY IN THE FERRET

K. Bunce, P. Ward, C. Jordan, 1994 .

Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor.

C. Czajkowski, P. Ward, D. Wagner, 2000, Molecular pharmacology.

GSK256066, an Exceptionally High-Affinity and Selective Inhibitor of Phosphodiesterase 4 Suitable for Administration by Inhalation: In Vitro, Kinetic, and In Vivo Characterization

Richard Graham Knowles, R. Williamson, C. Tralau-Stewart, 2011, Journal of Pharmacology and Experimental Therapeutics.

Conversion of kinins and their antagonists into B1 receptor activators and blockers in isolated vessels.

P. Rovero, N. Rhaleb, P. Ward, 1986, European journal of pharmacology.

The activity of GR205171, a potent non-peptide tachykinin NK1 receptor antagonist, in the trigeminovascular system

M. Perren, P. Ward, D. Beattie, 1997, Regulatory Peptides.

Receptors mediating the contractile response to neurokinin agonists in the guinea-pig trachea

S. Ireland, P. Ward, C. Jordan, 1988, Regulatory Peptides.

Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.

A. Mcelroy, R. Hagan, S. Ireland, 1992, Journal of medicinal chemistry.

Potent inhibition of both the acute and delayed emetic responses to cisplatin in piglets treated with GR205171, a novel highly selective tachykinin NK1 receptor antagonist

L. Grélot, A. Bianchi, A. Frugière, 1998, British journal of pharmacology.

The pharmacology of GR203040, a novel, potent and selective non‐peptide tachykinin NK1 receptor antagonist

R. Hagan, F. Marshall, I. Beresford, 1995, British journal of pharmacology.

Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M.

J. Kutok, G. Prestwich, B. Coller, 1992, Biochemistry.

Pharmacology and Clinical Activity of Toreforant, A Histamine H4 Receptor Antagonist

R. Thurmond, L. Karlsson, A. Greenspan, 2017 .

GSK 256066 , An Exceptionally High Affinity and Selective Inhibitor of PDE 4 Suitable for Administration by Inhalation : In vitro , Kinetic and In vivo Characterisation

Richard Graham Knowles, R. Williamson, C. Tralau-Stewart, 2011 .

Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity.

P. Ward, B. Evans, G. Giblin, 1995, Journal of medicinal chemistry.

Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound

M. Congreve, P. Ward, S. Watson, 1996 .

A Non-peptidic photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

C. Fishwick, D. Donnelly, J. Findlay, 1996 .

Characterisation, CNS distribution and function of NK2 receptors studied using potent NK2 receptor antagonists

E. Kawashima, A. Mcelroy, R. Hagan, 1993, Regulatory Peptides.

The broad‐spectrum anti‐emetic activity of the novel non‐peptide tachykinin NK1 receptor antagonist GR203040

Gavin Kilpatrick, J. Gale, P. Ward, 1995, British journal of pharmacology.

GR205171: A novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity

Gavin Kilpatrick, J. Gale, P. Ward, 1996, Regulatory Peptides.

1,4-Benzodiazepin-2-one derived neurokinin-1 receptor antagonists

M. Congreve, P. Ward, A. B. Hawcock, 1997 .

Low molecular weight neurokinin NK2 antagonists

A. Mcelroy, J. Pritchard, R. Hagan, 1993 .

Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor.

A. Mcelroy, R. Hagan, S. Ireland, 1992, Journal of medicinal chemistry.

Improved potency and specificity of Arg-Gly-Asp (RGD) containing peptides as fibrinogen receptor blocking drugs.

P. Ward, E. Hornby, M. Foster, 1993, Thrombosis research.

Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs.

Gavin Kilpatrick, J. Gale, P. Ward, 1996, Oncology.

Inhibition of human platelet aggregation by GR91669, a prototype fibrinogen receptor antagonist.

N. Pike, P. Ward, E. Hornby, 1994, Thrombosis research.

Effect of single point mutations of the human tachykinin NK1 receptor on antagonist affinity.

K. Lundstrom, P. Ward, A. B. Hawcock, 1997, European journal of pharmacology.

Clinical and Preclinical Characterization of the Histamine H4 Receptor Antagonist JNJ-39758979

R. Thurmond, L. Karlsson, A. Greenspan, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Pulmonary pharmacology of DT-TX 30 SE, a potent selective combined thromboxane synthetase inhibitor and receptor antagonist, in guinea pigs.

P. Ward, R. Soyka, C. J. Meade, 1996, Japanese journal of pharmacology.

Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.

Tony W Dean, Michael D. Woodrow, D. Somers, 2009, Bioorganic & medicinal chemistry letters.

Pharmacology and Clinical Activity of Toreforant , a Histamine H 4 Receptor Antagonist

R. Thurmond, L. Karlsson, A. Greenspan, 2017 .

SPIRO-PIPERIDINE NON-PEPTIDE NEUROKININ-1 RECEPTOR ANTAGONISTS

P. Ward, H. G. Davies, S. Watson, 1995 .

NK2 antagonists and the role of NK2 receptors

A. Mcelroy, J. Pritchard, R. Hagan, 1992, Regulatory Peptides.

A novel peptidic tachykinin antagonist which is potent at NK3 receptors

S. Arkinstall, R. Hagan, I. Beresford, 1993, Neuropeptides.

Identification of Benzodiazepine Binding Site Residues in the γ2 Subunit of the γ-Aminobutyric AcidA Receptor

C. Czajkowski, P. Ward, D. Wagner, 2000 .

Paul W Smith, A. Mcelroy, J. Pritchard, 1994 .