B. Frank

发表

A Rapid and Sensitive Radioimmunoassay for the Measurement of Proinsulin in Human Serum

R. Bowsher, J. Wolny, B. Frank, 1992, Diabetes.

In Vitro Activity of Biosynthetic Human Proinsulin: Receptor Binding and Biologic Potency of Proinsulin and Insulin in Isolated Rat Adipocytes

W. Duckworth, B. Frank, D. Peavy, 1984, Diabetes.

Receptor binding and biological activity of specifically labeled [125I]- and [127I]monoiodoinsulin isomers in isolated rat adipocytes.

W. Duckworth, B. Frank, D. Peavy, 1984, Endocrinology.

Biosynthetic Human Proinsulin: Review of Chemistry, in Vitro and in Vivo Receptor Binding, Animal and Human Pharmacology Studies, and Clinical Trial Experience

D. Howey, R. Bowsher, JamesH. Anderson, 1992, Diabetes Care.

The interaction of proinsulin with the insulin-like growth factor-I receptor in human liver, muscle, and adipose tissue.

B. Burguera, R. DiMarchi, J. F. Caro, 1991, The Journal of clinical endocrinology and metabolism.

Binding of proinsulin and proinsulin conversion intermediates to human placental insulin-like growth factor I receptors.

P. Gruppuso, B. Frank, R. Schwartz, 1988, The Journal of clinical endocrinology and metabolism.

In Vivo Deactivation of Proinsulin Action on Glucose Disposal and Hepatic Glucose Production in Normal Man

R. Henry, R. Cohen, J. Olefsky, 1986, Diabetes.

The Effects of Biosynthetic Human Proinsulin on Carbohydrate Metabolism

K. Polonsky, R. Bergenstal, R. Henry, 1984, Diabetes.

Research, Development, Production, and Safety of Biosynthetic Human Insulin

R. Chance, B. Frank, 1993, Diabetes Care.

First direct assay for intact human proinsulin.

J. Sodoyez, J. Sodoyez, B. Frank, 1998, Clinical chemistry.

Highly specific radioimmunoassay for human insulin based on immune exclusion of all insulin precursors.

J. Sodoyez, B. Frank, F. Sodoyez-Goffaux, 1998, Clinical chemistry.

Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites.

K. Polonsky, C. Broelsch, A. Rubenstein, 1990, Endocrinology.

Receptor binding and biological potency of several split forms (conversion intermediates) of human proinsulin. Studies in cultured IM-9 lymphocytes and in vivo and in vitro in rats.

W. Duckworth, B. Frank, D. Peavy, 1985, The Journal of biological chemistry.

Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins.

D. Owens, K. Siddle, S. Luzio, 1989, The Biochemical journal.

Physical studies on proinsulin-association behavior and conformation in solution.

B. Frank, A. J. Veros, 1968, Biochemical and biophysical research communications.

Physical studies on proinsulin. A comparison of the titration behavior of the tyrosine residues in insulin and proinsulin.

B. Frank, A. Pekar, A. J. Veros, 1972, Biochemistry.

A Radioimmunoassay for Circulating Human Proinsulin

S. Shoelson, R. Cohen, P. Blix, 1985, Diabetes.

Fast atom bombardment mass spectrometry of bovine proinsulin.

J. Cottrell, B. Frank, 1985, Biochemical and biophysical research communications.

The preparation and characterization of mono-iodinated photoreactive analogs of insulin.

K. Heidenreich, J. Olefsky, C. Yip, 1985, Biochemical and biophysical research communications.

The effects of biosynthetic human proinsulin on carbohydrate metabolism in non-insulin-dependent diabetes mellitus.

R. Henry, R. Cohen, J. Olefsky, 1987, The New England journal of medicine.

High-performance liquid chromatographic preparation of single-site carrier-free pancreatic polypeptide hormone radiotracers.

B. Frank, K. Willey, M. Beckage, 1983, Journal of chromatography.

Intestinal mucosa is a target tissue for pancreatic polypeptide.

B. Frank, R. Gingerich, J. Kramer, 1986, Endocrinology.

Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia.

K. Polonsky, R. Cohen, A. Rubenstein, 1986, Metabolism: clinical and experimental.

The effects of proinsulin pretreatment on the combined actions of insulin and proinsulin in normal man.

J. Olefsky, P. Wallace, H. Glauber, 1986, The Journal of clinical endocrinology and metabolism.

Differences in the cellular processing of AspB10 human insulin compared with human insulin and LysB28ProB29 human insulin.

W. Duckworth, R. Chance, J. Fawcett, 1999, Metabolism: clinical and experimental.

The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes.

J. Licinio, K. Polonsky, A. Cherrington, 1987, The Journal of clinical endocrinology and metabolism.

Characteristics of binding of a low affinity, noncooperative insulin [( LeuB25]insulin) to IM-9 lymphocytes.

J. Olefsky, A. Green, A. Rubenstein, 1983, Endocrinology.

Degradation products of insulin generated by hepatocytes and by insulin protease.

W. Duckworth, J. Liepnieks, M. Ryan, 1988, The Journal of biological chemistry.

Isolation of insulin degradation products from endosomes derived from intact rat liver.

W. Duckworth, B. Posner, J. Bergeron, 1988, The Journal of biological chemistry.

Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.

Bruce H. Frank, Theodore Karrison, K. Polonsky, 1986, The Journal of clinical investigation.

Biochemical and clinical implications of proinsulin conversion intermediates.

S. Shoelson, R. Cohen, A. Rubenstein, 1985, The Journal of clinical investigation.

Structure of a protein in a kinetic trap

Shai N. Gozani, Bruce H. Frank, S. Gozani, 1995, Nature Structural Biology.

Synthesis of a Fast-Acting Insulin Based on Structural Homology with Insulin-Like Growth Factor I,

D. Brems, J. Mayer, R. DiMarchi, 1992 .

Insulin Analog Formulation installations

Henry A. Havel, Bruce H. Frank, Diane Lee Bakaysa, 1995 .

Stability of Insulin Lispro in Insulin Infusion Systems

B. Zinman, L. Janis, T. Strack, 1997, Diabetes Care.

Differences in the nature of the interaction of insulin and proinsulin with zinc.

T. L. Coombs, B. Frank, P. T. Grant, 1972, The Biochemical journal.

Interaction of zing with proinsulin

B. Frank, A. J. Veros, 1970 .

Immunologic Aspects of Human Proinsulin Therapy

N. Fineberg, S. Fineberg, J. Galloway, 1988, Diabetes.

Characterization and Use in Immunoradiometric Assay of Monoclonal Antibodies Directed Against Human Proinsulin

K. Siddle, C. Hales, B. Frank, 1987, Diabetes.

In Vitro Characterization of Biosynthetic Human Proinsulin

J. Olefsky, B. Frank, D. A. Podlecki, 1984, Diabetes.

Comparative 2D NMR studies of the Phe B24 → Leu mutant human insulin

E. O’Shea, D. Nguyen, S. Shoelson, 1988 .

Isolation and characterization of a genetic variant of bovine proinsulin.

R. Chance, B. Frank, A. Pekar, 2009, International journal of peptide and protein research.

Characterization of the Receptor Binding Properties of Monoiodoinsulin Isomers and the Identification of Different Insulin Receptor Specificities in Hepatic and Extrahepatic Tissues

J. Olefsky, T. Ciaraldi, H. Horikoshi, 1983, Diabetes.

Conversion of biosynthetic human proinsulin to partially cleaved intermediates by collagenase proteinases adsorbed to isolated rat adipocytes.

W. Duckworth, J. Liepnieks, F. Hamel, 1988, The Biochemical journal.

Two routes for producing human insulin utilizing recombinant DNA technology.

R. Chance, B. Frank, 1983, MMW, Munchener medizinische Wochenschrift.

Insulin and Proinsulin Conformation in Solution

B. Frank, A. Pekar, A. J. Veros, 1972, Diabetes.

PROINSULIN IN HUMAN SERUM: PROBLEMS IN MEASUREMENT AND INTERPRETATION

K. Siddle, K. Docherty, C. Hales, 1984, Clinical endocrinology.

Human Insulin Analogs with Rapid Onset and Short Duration of Action

R. DiMarchi, H. B. Long, B. Frank, 1992 .

Differential binding of monoiodinated insulins to muscle and liver derived receptors and activation of the receptor kinase.

C. Burant, M. Buse, M. Treutelaar, 1988, Biochemical and biophysical research communications.

Developing rat brain binds monoiodinated insulin isomers similarly to other extrahepatic target tissues

M. Raizada, F. Boyd, B. Frank, 1985, Brain Research.

Structural studies of a crystalline insulin analog complex with protamine by atomic force microscopy.

M. Ward, C. Yip, M. Brader, 2000, Biophysical journal.

A novel protein cross-linking reaction in stressed Neutral Protamine Hagedorn formulations of insulin.

R. Beavis, B. Frank, M. Defelippis, 1999, Journal of pharmaceutical sciences.

NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition.

S. Shoelson, M. Weiss, L. Neuringer, 1990, Biochemistry.

Self-Association Properties of Monomeric Insulin Analogs Under Formulation Conditions

D. Flora, R. Chance, B. Frank, 1998, Pharmaceutical Research.

Preparation of a microcrystalline suspension formulation of Lys(B28)Pro(B29)-human insulin with ultralente properties.

G. D. Smith, J. Radziuk, S. Pye, 1999, Journal of pharmaceutical sciences.

Preparation and characterization of a cocrystalline suspension of [LysB28,ProB29]-human insulin analogue.

J. Radziuk, S. Pye, B. Frank, 1998, Journal of pharmaceutical sciences.

Crystalline L-asparaginase from Escherichia coli B. II. Physical properties, subunits, and reconstitution behavior.

B. Frank, A. Pekar, P. Ho, 1970, The Journal of biological chemistry.

Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin.

J. M. Beals, E. Ciszak, J. Beals, 1995, Structure.

Glucagon structure and function. I. Purification and properties of bovine glucagon and monodesmidoglucagon.

B. Frank, A. Pekar, W. Bromer, 1972, The Journal of biological chemistry.

Improved insulin stability through amino acid substitution.

D. Brems, L. K. Green, H. B. Long, 1992, Protein engineering.

Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design.

S. Shoelson, M. Weiss, B. Frank, 1991, Biochemistry.

Biosynthetic human insulin and proinsulin have additive but not synergistic effects on total body glucose disposal.

R. Henry, R. Cohen, J. Olefsky, 1984, The Journal of clinical endocrinology and metabolism.

Physical stress testing of insulin suspensions and solutions.

B. Frank, D. Shnek, M. A. Bell, 1998, Journal of pharmaceutical sciences.

Insulin Secretion and Clearance: Comparison After Oral and Intravenous Glucose

K. Polonsky, M. Miller, J. Galloway, 1987, Diabetes.

Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.

K. Polonsky, E. van Cauter, J. Galloway, 1988, The New England journal of medicine.

Human proinsulin standards

L. Thim, R. Cohen, A. Rubenstein, 1984, Diabetologia.

Insulin self-association and the relationship to pharmacokinetics and pharmacodynamics.

R. Chance, B. Frank, M. Defelippis, 2001, Critical reviews in therapeutic drug carrier systems.

Stability of U-10 and U-50 dilutions of insulin lispro.

B. Frank, S. M. Storms, M. Stickelmeyer, 2000, Diabetes technology & therapeutics.

Activation Energy of Deuterium-Hydrogen Exchange in Amides

I. M. Klotz, B. Frank, 1964 .

Binding of ethidium bromide to double-stranded ribonucleic acid.

R. J. Douthart, R. Douthart, B. Frank, 1973, Biochemistry.

Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH.

B. Frank, A. Pekar, 1972, Biochemistry.

Structural and morphological characterization of ultralente insulin crystals by atomic force microscopy: evidence of hydrophobically driven assembly.

M. Ward, C. Yip, M. Brader, 1998, Biophysical journal.

Chemical, Physical, and Biologic Properties of Biosynthetic Human Insulin

J. A. Hoffmann, R. Chance, B. Frank, 1981, Diabetes Care.

LYS(B28)PRO(B29)-HUMAN INSULIN

J. M. Beals, E. Ciszak, G. D. Smith, 1996 .

Altering the association properties of insulin by amino acid replacement.

B H Frank, D. Brems, R. DiMarchi, 1992, Protein engineering.

Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics.

M. Karplus, E. O’Shea, D. Nguyen, 1989, Biochemistry.

The degradation of monoiodotyrosyl insulin isomers by insulin protease.

W. Duckworth, M. Ryan, B. Frank, 1984, Endocrinology.

A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers.

M. Weiss, B. Frank, Q. Hua, 2002, Biochemistry.

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.

M. Weiss, S. H. Wang, B. Frank, 1996, Journal of molecular biology.

Crystalline L-asparaginase from Escherichia coli B. I. Purification and chemical characterization.

J. L. Bobbitt, B. Frank, L. D. Boeck, 1970, The Journal of biological chemistry.

Basolateral and apical binding, internalization, and degradation of insulin by cultured kidney epithelial cells.

R. Rabkin, B. Frank, C. Yagil, 1989, The American journal of physiology.

High performance liquid chromatographic analysis of insulin degradation products from a cultured kidney cell line.

W. Duckworth, J. Liepnieks, R. Rabkin, 1988, Endocrinology.

Insulin binding, internalization, and degradation by a cultured kidney cell line.

R. Rabkin, U. Ehmann, B. Frank, 1988, The American journal of physiology.

Receptor Binding Properties of Monoiodotyrosyl Insulin Isomers Purified by High Performance Liquid Chromatography

W. Duckworth, B. Frank, D. Peavy, 1983, Diabetes.

Insulin degradation products from perfused rat kidney.

W. Duckworth, J. Liepnieks, R. Rabkin, 1989, The American journal of physiology.

DEUTERIUM--HYDROGEN EXCHANGE IN AMIDE N--H GROUPS.

I. M. Klotz, B. Frank, 1965, Journal of the American Chemical Society.

Internalization and catabolism of insulin by an established renal cell line.

R. Rabkin, B. Frank, C. Yagil, 1988, The American journal of physiology.

Ionic strength effects on the stability and conformation of Penicillium chrysogenum mycophage double stranded RNA.

R. Douthart, B. Frank, J. P. Burnett, 1975, Nucleic acids research.

Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans.

B H Frank, K. Polonsky, T. Karrison, 1988, The American journal of physiology.

Catalysis by Imidazole of Deuterium-Hydrogen Exchange in Amide N-H Groups

B. Frank, Irving M. Klotz, 1962, Science.

Quantitative study of insulin secretion and clearance in normal and obese subjects.

B H Frank, K. Polonsky, E. van Cauter, 1988, The Journal of clinical investigation.

Human Proinsulin-Specific Antigenic Determinants Identified by Monoclonal Antibodies

O. Madsen, D. Steiner, B. Frank, 1984, Diabetes.

A sensitive radioimmunoassay for human proinsulin, with sequential use of antisera to C-peptide and insulin.

D. Porte, W. Ward, B. Frank, 1986, Clinical chemistry.

Structure and Dynamics of a Protein Assembly.1H-NMR Studies of the 36 kDaR6Insulin Hexamer

A. Stern, E. Jacoby, M. Weiss, 1996 .

Structure and dynamics of a protein assembly. 1H-NMR studies of the 36 kDa R6 insulin hexamer.

A. Stern, E. Jacoby, M. Weiss, 1996, Journal of molecular biology.

Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites.

W. Duckworth, J. Liepnieks, M. Rosner, 1989, Biochemistry.

Differences in renal metabolism of insulin and cytochrome c.

R. Rabkin, B. Frank, J. Herrman, 1988, The American journal of physiology.

Effect of experimental diabetes on insulin binding by renal basolateral membranes.

R. Roth, R. Rabkin, B. Frank, 1986, Kidney international.

Equilibrium denaturation of insulin and proinsulin.

D. Brems, B. Frank, P. L. Brown, 1990, Biochemistry.

The Limitations to and Valid Use of C-Peptide as a Marker of the Secretion of Insulin

K. Polonsky, T. Karrison, W. Pugh, 1986, Diabetes.

Scintigraphic distribution of 123 I labelled proinsulin, split conversion intermediates and insulin in rats

J. Sodoyez, B. Frank, F. Sodoyez-Goffaux, 1988, Diabetologia.

HEART RATE, SHEAR STRESS, ATHEROGENESIS AND PLAQUE RUPTURE : IS THERE A LINK ?

R. DiMarchi, R. Chance, J. Radziuk, 1998 .

A Sensitive Radioimmunoassayfor Human Proinsulin,with SequentialUse of Antiserato C-Peptideand Insulin

W. Ward, B. Frank, T. Paquette, 1986 .