A. McKnight

发表

Pharmacological specificity of novel, synthetic, cyclic peptides as antagonists at tachykinin receptors

L. Iversen, J. Maguire, J. Maguire, 1991, British journal of pharmacology.

High-performance liquid chromatography of the neuropeptides: the endogenous opioid peptides.

A. McKnight, H. Kosterlitz, A. Corbett, 1988, Monographs on endocrinology.

trans N -Methyl- N -[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonists

A. McKnight, D. Horwell, V. Sabin, 1997 .

Characterization of opioid peptides in guinea-pig heart and skin.

M. Reinecke, E. Weihe, A. McKnight, 1983, Life sciences.

Opioid peptides and pituitary function.

A. McKnight, H. Kosterlitz, A. Mcknight, 1980, Journal of reproduction and fertility.

Synthesis of enkephalins by guinea-pig striatum in vitro

A. McKnight, J. Hughes, H. Kosterlitz, 1979, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Pharmacological and biochemical aspects of the enkephalins

A. McKnight, J. Hughes, H. Kosterlitz, 1978 .

Incorporation of labelled amino acids into the enkephalins

A. McKnight, J. Hughes, H. Kosterlitz, 1977, FEBS letters.

Effect of gastrin receptor blockade on endocrine cells in rats during achlorhydria.

W. Lorenz, H. Koop, A. McKnight, 1992, Gastroenterology.

The effect of CCKB/gastrin antagonists on stimulated gastric acid secretion in the anaesthetized rat

N. Hayward, G. Woodruff, A. McKnight, 1991, British journal of pharmacology.

The interaction of the NK1 receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences

S. Guard, G. Woodruff, A. McKnight, 1993, British journal of pharmacology.

Evidence that cholecystokinin induces immediate early gene expression in the brainstem, hypothalamus and amygdala of the rat by a CCKA receptor mechanism

A. McKnight, J. Hughes, H. Day, 1994, Neuropharmacology.

Comparison of the effects of [Phe1Ψ(CH2‐NH)Gly2]Nociceptin (1–13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors

D. Lambert, G. Calo’, R. Guerrini, 1999, British journal of pharmacology.

Recent developments in the bioassay of opioids.

A. McKnight, H. Kosterlitz, A. Corbett, 1985, Regulatory peptides. Supplement.

PD 165929 — the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist

R. Jordan, R. A. Lewthwaite, A. McKnight, 1996 .

Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.

R. A. Lewthwaite, G. Woodruff, A. McKnight, 1996, Journal of medicinal chemistry.

Peptoid CCK receptor antagonists: pharmacological evaluation of CCKA, CCKB and mixed receptor antagonists

G. Woodruff, A. McKnight, D. Horwell, 1995, European Journal of Pharmacology.

Cyclic peptides as selective tachykinin antagonists.

D. Veber, J. Maguire, B. Williams, 1993, Journal of medicinal chemistry.

L‐683,877: Pharmacological profile of a novel 5‐HT3 receptor antagonist

N. Newberry, M. Rigby, J. Maguire, 1992 .

Neuroprotective Effect of the χ‐Agonist Enadoline (CI‐977) in Rat Models of Focal Cerebral Ischaemia

N. Hayward, G. Woodruff, A. McKnight, 1993, The European journal of neuroscience.

Characterization of the ORL1 receptor on adrenergic nerves in the rat anococcygeus muscle

A. McKnight, M. Ho, A. Corbett, 2000 .

Selectivities of opioid peptide analogues as agonists and antagonists at the δ‐receptor

A. McKnight, H. Kosterlitz, A. Corbett, 1984 .

THE ACTIONS OF SOME VASOACTIVE POLYPEPTIDES AND THEIR ANTAGONISTS ON THE ANOCOCCYGEUS MUSCLE

J. Gillespie, A. McKnight, A.T. McKNIGHT, 1978, British journal of pharmacology.

PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.

R. A. Lewthwaite, A. McKnight, D. Horwell, 1998, Bioorganic & medicinal chemistry letters.

Characterisation using microphysiometry of CRF receptor pharmacology.

D. Smart, A. McKnight, C. Rossant, 1999, European journal of pharmacology.

Characterization of CCK receptors in a novel smooth muscle preparation from the guinea‐pig stomach by use of the selective antagonists CI‐988, L‐365,260 and devazepide

G. Woodruff, A. McKnight, S. Boyle, 1993, British journal of pharmacology.

Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference

Sally Loomis, A. McKnight, L. Singh, 2001, Psychopharmacology.

Proenkephalin- and prodynorphin- derived opioid peptides in guinea-pig heart

E. Weihe, A. McKnight, H. Kosterlitz, 1985, Neuropeptides.

Increase in potencies of opioid peptides after peptidase inhibition.

A. McKnight, H. Kosterlitz, A. Corbett, 1983, European journal of pharmacology.

Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain.

C. Evans, J. Barchas, A. McKnight, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for Two Types of Tachykinin Receptors on Cholinergic Neurons of the Guinea Pig Ileum Myenteric Plexus a

S. Watson, S. Guard, A. McKnight, 1991, Annals of the New York Academy of Sciences.

Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices

D. Lambert, D. Rowbotham, D. Smart, 1996, British journal of pharmacology.

Orphanin FQ inhibits capsaicin‐induced thermal nociception in monkeys by activation of peripheral ORL1 receptors

K. Rice, M. Ko, J. Woods, 2002, British journal of pharmacology.

Opioid Peptides and Sensory Function

A. McKnight, H. Kosterlitz, A. Mcknight, 1981 .

Bombesin Receptors as a Novel Anti-Anxiety Therapeutic Target: BB1 Receptor Actions on Anxiety through Alterations of Serotonin Activity

H. Anisman, Z. Merali, A. McKnight, 2006, The Journal of Neuroscience.

Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

A. McKnight, H. Kosterlitz, A. Corbett, 1982, Nature.

k‐Binding and Degradation of [3H]Dynorphin A (1–8) and [3H]Dynorphin A (1–9) in Suspensions of Guinea Pig Brain Membranes

A. McKnight, H. Kosterlitz, M. Gillan, 1985, Journal of neurochemistry.

Adverse effects of tris hydrochloride, a commonly used buffer in physiological media.

J. Gillespie, A. McKnight, A. Mcknight, 1976, The Journal of physiology.

THE EFFECT OF ETHANOL ON INHIBITORY AND MOTOR RESPONSES IN THE RAT AND RABBIT ANOCOCCYGEUS AND THE BOVINE RETRACTOR PENIS MUSCLES

J. Gillespie, A. McKnight, J. C. Hunter, 1982, British journal of pharmacology.

Reduction by gabapentin of K+‐evoked release of [3H]‐glutamate from the caudal trigeminal nucleus of the streptozotocin‐treated rat

A. McKnight, N. Andrews, Y. Maneuf, 2004, British journal of pharmacology.

75 years of opioid research: the exciting but vain quest for the Holy Grail

Graeme Henderson, G. Henderson, A. McKnight, 2006, British journal of pharmacology.

The orphan opioid receptor and its endogenous ligand--nociceptin/orphanin FQ.

G. Henderson, A. McKnight, A. Mcknight, 1997, Trends in pharmacological sciences.

Development of NK-2 selective antagonists

J. Maguire, B. Williams, A. McKnight, 1988, Regulatory Peptides.

Rational design of high affinity tachykinin NK1 receptor antagonists.

S. Guard, A. McKnight, S. Boyle, 1994, Bioorganic & medicinal chemistry.

Pharmacological specificity of synthetic peptides as antagonists at tachykinin receptors

L. Iversen, J. Maguire, A. Foster, 1988, Regulatory Peptides.

Multiple Receptors and Binding Sites for Tachykinins

L. Iversen, A. Foster, B. Williams, 1987 .

Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices.

D. Lambert, E. Okuda‐Ashitaka, S. Ito, 1998, European journal of pharmacology.

Identification of nociceptin in human cerebrospinal fluid: comparison of levels in pain and non-pain states

D. Lambert, D. Rowbotham, D. Smart, 1998, Pain.

Rat central ORL-1 receptor uncouples from adenylyl cyclase during membrane preparation

D. Lambert, D. Smart, R. Hirst, 1998, Neuroscience Letters.

Conformationally constrained tachykinin analogs which are selective ligands for the eledoisin binding site.

D. Veber, R. Freidinger, J. Maguire, 1986, Molecular pharmacology.

Rational design of high affinity tachykinin NK2 receptor antagonists.

S. Guard, A. McKnight, S. Boyle, 1994, Bioorganic & medicinal chemistry.

A novel series of non‐quaternary oxadiazoles acting as full agonists at muscarinic receptors

L. Iversen, N. Newberry, J. Maguire, 1990, British journal of pharmacology.

Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase

A. McKnight, Y. Maneuf, Yannick P Maneuf, 2001, British journal of pharmacology.

Tissue Content of Opioid Peptides in the Myenteric Plexus‐Longitudinal Muscle of Guinea‐Pig Small Intestine

A. McKnight, A. Corbett, Hans W. Kosterlitz, 1988, Journal of neurochemistry.

Pre‐incubation of guinea‐pig myenteric plexus with β‐funaltrexamine: discrepancy between binding assays and bioassays

A. McKnight, H. Kosterlitz, A. Corbett, 1985, British journal of pharmacology.

Acute and persistent effects of β-funaltrexamine on the binding and agonist potencies of opioids in the myenteric plexus of the guinea-pig ileum

A. McKnight, H. Kosterlitz, A. Corbett, 1984, Neuropeptides.

Effects of electrical stimulation on teh enkephalinsin guinea-pig small intestine

A. McKnight, H. Kosterlitz, A. Corbett, 1980 .

Comparison of in vitro potencies in pharmacological and binding assays after inhibition of peptidases reveals that dynorphin (1-9) is a potent kappa-agonist.

A. McKnight, H. Kosterlitz, A. Corbett, 1982, Life sciences.

ENKEPHALIN PRECURSORS FROM GUINEA-PIG MYENTERIC PLEXUS

A. McKnight, H. Kosterlitz, A. Corbett, 1980 .

Hamster vas deferens contains δ-opioid receptors

M. Marcoli, A. McKnight, H. Kosterlitz, 1984, Neuropeptides.

Tetraethylammonium facilitates the stimulation-evoked loss of the enkephalins from the myenteric plexus of guinea-pig ileum

A. McKnight, H. Kosterlitz, A. Corbett, 1981, Proceedings of the Royal Society of London. Series B. Biological Sciences.

INHIBITION OF THEIR BREAKDOWN AND RELEASE OF ENDOGENOUS OPIOID PEPTIDES FROM THE MYENTERIC PLEXUS-LONGITUDINAL MUSCLE OF THE GUINEA-PIG ILEUM

A. McKnight, A. Corbett, 1981 .

[3H]-dynorphin A (1-9): binding characteristics and degradation profile in brain homogenates.

A. McKnight, H. Kosterlitz, L. Robson, 1983, Life sciences.

Dynorphin and dynorphin are ligands for the kappa-subtype of opiate receptor.

A. McKnight, H. Kosterlitz, A. Corbett, 1982, Nature.

Pharmacological studies on the "orphan" opioid receptor in central and peripheral sites.

J. Menzies, A. McKnight, A. Corbett, 1998, Canadian journal of physiology and pharmacology.

The opioid receptors in the hamster vas deferens are of the δ-type

M. Marcoli, A. McKnight, H. Kosterlitz, 1985, Neuropharmacology.

Radioligands for probing opioid receptors.

A. McKnight, H. Kosterlitz, A. Corbett, 1984, Journal of receptor research.

Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor.

A. McKnight, H. Kosterlitz, A. Corbett, 1984, British journal of pharmacology.

[3H]-dynophin A (1–8): Degradation profile and binding characteristics in brain homogenates

A. McKnight, H. Kosterlitz, L. Robson, 1985, Neuropeptides.

Gabapentin inhibits the substance P-facilitated K+-evoked release of [3H]glutamate from rat caudal trigeminal nucleus slices

A. McKnight, J. Hughes, Y. Maneuf, 2001, Pain.

L-687,306: a functionally selective and potent muscarinic M1 receptor agonist.

L. Iversen, N. Newberry, S. Freedman, 1992, European journal of pharmacology.

Identification and characterisation of functional bombesin receptors in human astrocytes.

J. Skepper, Ian C B Marshall, D. Smart, 2002, European journal of pharmacology.

Inhibition by nociceptin of the light‐evoked release of ACh from retinal cholinergic neurones

M. Neal, A. McKnight, S. Paterson, 1997, British journal of pharmacology.

Prolonged Changes in Neurochemistry of Dopamine Neurones After Chronic Ethanol Consumption

A. McKnight, J. Hughes, H. Little, 2000, Pharmacology Biochemistry and Behavior.

Brain temperature and the neuroprotective action of enadoline and dizocilpine in the gerbil model of global ischaemia.

N. Hayward, G. Woodruff, A. McKnight, 1993, European journal of pharmacology.

Synthesis and characterization of all four isomers of the muscarinic agonist 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane].

J. Salamone, J. Springer, J. Hirshfield, 1987, Journal of medicinal chemistry.

Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle.

A. McKnight, M. Ho, A. Corbett, 2000, British journal of pharmacology.

Comparison of the ORL1 receptor‐mediated inhibition of noradrenaline release in human and rat neocortical slices

J. Zentner, A. Rominger, T. Feuerstein, 2002, British journal of pharmacology.

Effect of gastrin-releasing peptide on rat hippocampal extracellular GABA levels and seizures in the audiogenic seizure-prone DBA/2 mouse

A. McKnight, L. Singh, N. Andrews, 2000, Brain Research.

Calcitonin gene-related peptide-mediated increase in K+-induced [3H]-dopamine release from rat caudal striatal slices

A. McKnight, Y. Maneuf, 2001, Neuroscience Letters.

L‐689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors

S. Freedman, R. Hargreaves, S. Patel, 1992, British journal of pharmacology.

Characterisation of tachykinin receptors using selectivity of agonists and antagonists: Evidence for an NK-4 type

L. Iversen, J. Maguire, B. Williams, 1988, Regulatory Peptides.

The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design

G. Woodruff, A. McKnight, K. Meecham, 1994 .

Activation of the cloned human NK3 receptor in Chinese Hamster Ovary cells characterized by the cellular acidification response using the Cytosensor microphysiometer

R. Jordan, D. Smart, A. McKnight, 1998, British journal of pharmacology.

The Rational Development of Small Molecule Tachykinin NK3 Receptor Selective Antagonists ‐ The Utilization of a Dipeptide Chemical Library in Drug Design.

G. Woodruff, A. McKnight, K. Meecham, 1995 .

The opioid receptors in the hamster vas deferens are of the delta-type.

M. Marcoli, A. McKnight, H. Kosterlitz, 1985, Neuropharmacology.

PD 165929 - The First High Affinity Non-Peptide Neuromedin-B (NMB) Receptor Selective Antagonist.

R. Jordan, R. A. Lewthwaite, A. McKnight, 1997 .

Kappa‐opioid receptor agonists increase locomotor activity in the monoamine‐depleted rat model of parkinsonism

A. Crossman, G. Woodruff, A. McKnight, 1998, Movement disorders : official journal of the Movement Disorder Society.

In vitro characterization of Ac-RYYRWK-NH2, Ac-RYYRIK-NH2 and [Phe1CΨ(CH2-NH)Gly2] nociceptin(1-13)NH2 at rat native and recombinant ORL1 receptors

A. McKnight, M. Ho, J. Nicholson, 2001, Neuropeptides.

Nociceptin hyperpolarises neurones in the rat ventromedial hypothalamus

A. McKnight, Kevin Lee, J. Nicholson, 1997, Neuroscience Letters.