W. Howson

发表

The effects of adenosine triphosphate and related purines on arterial resistance vessels in vitro and in vivo.

M. Parsons, E. M. Taylor, P. Wright, 1989, European journal of pharmacology.

Phosphinic acid analogues of GABA are antagonists at the GABAB receptor in the rat anococcygeus

A. J. Sellers, W. Howson, J. Hills, 1991, British journal of pharmacology.

A comparison of the relative activities of a number of GABAB antagonists in the isolated vas deferens of the rat

W. Howson, J. Hills, M. M. Larkin, 1991, British journal of pharmacology.

3‐Aminopropylphosphinic acid—a potent, selective GABAB receptor agonist in the guinea‐pig ileum and rat anococcygeus muscle

R. Dolle, M. Parsons, W. Howson, 1989, British journal of pharmacology.

PD 165929 — the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist

R. Jordan, R. A. Lewthwaite, A. McKnight, 1996 .

An SAR study for the non-peptide substance P receptor (NK1) antagonist, CP-96,345.

S. Guard, W. Howson, K. Watling, 1992 .

Absorption of Cam-2445, and NK1 neurokinin receptor antagonist: in vivo, in situ, and in vitro evaluations.

O. H. Chan, B. H. Stewart, H. L. Schmid, 1996, Journal of pharmaceutical sciences.

Design and synthesis of a series of combined vasodilator/beta-adrenoceptor antagonists based on 6-arylpyridazinones.

E. M. Taylor, W. Howson, D. R. Reavill, 1988, Journal of medicinal chemistry.

Ring-opening of N-tosyl aziridines by 2-lithiodithianes

J. Sweeney, W. Howson, H. Osborn, 1995 .

A practical alternative to sulfonyl activation of aziridines: Ring-opening of N-diphenylphosphinoyl aziridines by carbon nucleophiles

J. Sweeney, W. Howson, H. Osborn, 1994 .

Rational design of high affinity tachykinin NK1 receptor antagonists.

S. Guard, A. McKnight, S. Boyle, 1994, Bioorganic & medicinal chemistry.

The design of polar β-turn dipeptide mimetics

D. Horwell, W. Howson, D. Naylor, 1995 .

Rational design of high affinity tachykinin NK2 receptor antagonists.

S. Guard, A. McKnight, S. Boyle, 1994, Bioorganic & medicinal chemistry.

Two novel, potent and selective histamine H3 receptor agonists

M. Parsons, W. Howson, Michael E. Parsons, 1992 .

Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)

M. Parsons, E. M. Taylor, W. Howson, 1988 .

Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity

W. Howson, J. Mistry, M. Broekman, 1993 .

Synthesis and biological evaluation of 3-amino-2-(4-chlorophenyl)1,1-difluoropropyl phosphonic acid

G. Blackburn, W. Howson, M. Broekman, 1991 .

Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs.

S. Menon, D. Woods, W. Howson, 2016, Bioorganic & medicinal chemistry letters.

Synthesis of (±)-3-amino-2-(4-chlorophenyl)propanesulfonic acid (Saclofen)

R. Dolle, W. Howson, Chun-Sing Li, 1991 .

Electrophysiological characterization of potent agonists and antagonists at pre‐ and postsynaptic GABAB receptors on neurones in rat brain slices

M. Lacey, G. Seabrook, W. Howson, 1990, British journal of pharmacology.

Alanine scan and N-methyl amide derivatives of Ac-bombesin[7-14]. Development of a proposed binding conformation at the neuromedin B (NMB) and gastrin releasing peptide (GRP) receptors.

S. Osborne, D. Horwell, W. Howson, 2009, International journal of peptide and protein research.

Structure-activity requirements of bombesin for gastrin-releasing peptide- and neuromedin B-preferring bombesin receptors in rat brain.

S. Guard, W. Howson, K. Watling, 1993, European journal of pharmacology.

Evaluation of a Targeted Prodrug Strategy to Enhance Oral Absorption of Poorly Water-Soluble Compounds

O. H. Chan, B. H. Stewart, H. L. Schmid, 1998, Pharmaceutical Research.

Model studies on the active site of cytochrome P-450 : an FeII–porphyrin carrying a strapped thiolate ligand

A. Hamilton, A. Battersby, W. Howson, 1982 .

The GABAB Receptor Profile of a Series of Phosphinic Acids: Agonist and Antagonist Activity in a Range of Peripheral Tissues

W. Howson, J. Hills, 1992 .

Subpopulations of GABA-mediated synaptic potentials in slices of rat dorsal striatum are differentially modulated by presynaptic GABAB receptors

M. Lacey, G. Seabrook, W. Howson, 1991, Brain Research.

The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design

G. Woodruff, A. McKnight, K. Meecham, 1994 .

The Rational Development of Small Molecule Tachykinin NK3 Receptor Selective Antagonists ‐ The Utilization of a Dipeptide Chemical Library in Drug Design.

G. Woodruff, A. McKnight, K. Meecham, 1995 .

The design of dipeptide helical mimetics: the synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes.

H. Willems, D. Horwell, W. Howson, 1996, Bioorganic & medicinal chemistry.

The development of a high affinity NK3 receptor antagonist

D. Horwell, W. Howson, M. Pritchard, 1995 .

The design of a dipeptide library for screening at peptide receptor sites

D. Rees, D. Horwell, W. Howson, 1993 .

PD 165929 - The First High Affinity Non-Peptide Neuromedin-B (NMB) Receptor Selective Antagonist.

R. Jordan, R. A. Lewthwaite, A. McKnight, 1997 .

The design of dipeptide helical mimetics, Part I: the synthesis of 1,6-disubstituted indanes

H. Willems, D. Rees, D. Horwell, 1995 .

Design and synthesis of a series of glycerol-derived receptor mediated calcium entry (RMCE) blockers

T. Rink, K. Cassidy, R. Dolle, 1990 .

Synthesis of (±)-3-Amino-2-(4-chlorophenyl)propanesulfonic acid (Saclofen)

R. Dolle, W. Howson, C. Li, 1991 .