D. Segaloff

发表

Ca+2 is an inhibitor of adenylate cyclase in MA-10 Leydig tumor cells.

M. Ascoli, M. Pereira, D. Segaloff, 1988, Endocrinology.

Evidence that the FSH receptor itself is not a calcium channel.

D. Segaloff, E. Shibata, J. Matsuda, 1992, Endocrinology.

Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors.

T. Hébert, Xiuyan Feng, D. Segaloff, 2010, Cellular signalling.

Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity.

D. Segaloff, Y. Xie, H. Wang, 1990, The Journal of biological chemistry.

Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.

P. Donohoue, S. O’Rahilly, G. Yeo, 2003, The Journal of clinical endocrinology and metabolism.

Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism.

A. Latronico, B. Mendonca, G. Ryan, 2007, Fertility and sterility.

Regulatory processes governing the cell surface expression of LH and FSH receptors.

D. Segaloff, 2012, Sub-cellular biochemistry.

Chapter 9 Internalization of peptide hormones and hormone receptors

M. Ascoli, D. Segaloff, 1988 .

On the fates of receptor-bound ovine luteinizing hormone and human chorionic gonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization.

M. Ascoli, D. Segaloff, 1987, Endocrinology.

Bioluminescence Resonance Energy Transfer Studies Reveal Constitutive Dimerization of the Human Lutropin Receptor and a Lack of Correlation between Receptor Activation and the Propensity for Dimerization*

T. Hébert, Xiuyan Feng, D. Segaloff, 2009, Journal of Biological Chemistry.

Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization.

J. Richards, D. Segaloff, H. Wang, 1990, Molecular endocrinology.

The orientation of the lutropin/choriogonadotropin receptor in rat luteal cells as revealed by site-specific antibodies.

D. Segaloff, M. C. Rodríguez, 1990, Endocrinology.

Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.

A. Latronico, D. Segaloff, 1999, American journal of human genetics.

HUMAN GENETICS '99: SEXUAL DEVELOPMENT Naturally Occurring Mutations of the Luteinizing-Hormone Receptor: Lessons Learned about Reproductive Physiology and G Protein-Coupled Receptors

A. Latronico, D. Segaloff, 1999 .

A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty.

Xuebo Liu, A. Abell, A. Latronico, 1998, The Journal of clinical endocrinology and metabolism.

Inhibition of choriogonadotropin-activated steroidogenesis in cultured Leydig tumor cells by the Rp diastereoisomer of adenosine 3',5'-cyclic phosphorothioate.

M. Ascoli, F. Eckstein, M. Pereira, 1987, The Journal of biological chemistry.

Mutational analyses of the extracellular domain of the full-length lutropin/choriogonadotropin receptor suggest leucine-rich repeats 1-6 are involved in hormone binding.

D. Segaloff, D. Thomas, X. Liu, 1996, Molecular endocrinology.

The effect of parainfluenza 3 infection on guinea pig basophil and lung mast cell histamine release.

W. Busse, T. Hirth, F. Graziano, 1989, The American review of respiratory disease.

Characterization of an antiserum to the rat luteal luteinizing hormone/chorionic gonadotropin receptor.

N. Rosemblit, M. Ascoli, D. Segaloff, 1988, Endocrinology.

Certain activating mutations within helix 6 of the human luteinizing hormone receptor may be explained by alterations that allow transmembrane regions to activate Gs.

A. Abell, D. Segaloff, D. Mccormick, 1998, Molecular endocrinology.

Temperature sensitivity of some mutants of the lutropin/choriogonadotropin receptor.

D. Segaloff, J. Jaquette, 1997, Endocrinology.

Temperature Sensitivity of Some Mutants of the Lutropin/Choriogonadotropin Receptor1.

D. Segaloff, J. Jaquette, 1997, Endocrinology.

The Gonadotropin Receptors: Structural Insights Learned from the Cloning of Their cDNAs

D. Segaloff, 1991 .

Regulation of the Differentiated Functions of Leydig Tumor Cells by Epidermal Growth Factor a

M. Ascoli, D. Segaloff, MARIO ASCOLI, 1989, Annals of the New York Academy of Sciences.

The gonadotrophin receptors: insights from the cloning of their cDNAs.

M. Ascoli, D. Segaloff, 1992, Oxford reviews of reproductive biology.

Differential Regulation of Human and Mouse Myometrial Contractile Activity by FSH as a Function of FSH Receptor Density

K. Lamping, B. Mitchell, D. Segaloff, 2016, Biology of reproduction.

Signaling through FSH receptors on human umbilical vein endothelial cells promotes angiogenesis.

D. Duffy, D. Segaloff, Rongbin Guan, 2014, The Journal of clinical endocrinology and metabolism.

Thyroid-Stimulating Hormone/Luteinizing Hormone/Follicle-Stimulating Hormone Receptors

M. Ascoli, D. Mizrachi, D. Segaloff, 2004 .

Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist

C. McArdle, R. Millar, C. Newton, 2011, Proceedings of the National Academy of Sciences.

Hormone-binding properties and glycosylation pattern of a recombinant form of the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor expressed in mammalian cells.

D. Segaloff, D. Thomas, 1994, Endocrinology.

Evidence for the Direct Involvement of Transmembrane Region 6 of the Lutropin/Choriogonadotropin Receptor in Activating Gs *

A. Abell, D. Segaloff, 1997, The Journal of Biological Chemistry.

Heterodimerization between the lutropin and follitropin receptors is associated with an attenuation of hormone-dependent signaling.

Xiuyan Feng, D. Segaloff, Rongbin Guan, 2013, Endocrinology.

Inhibition of gonadotropin-responsive adenylate cyclase in MA-10 Leydig tumor cells by epidermal growth factor.

M. Ascoli, M. Pereira, D. Segaloff, 1988, The Journal of biological chemistry.

A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization.

T. Hébert, Xiuyan Feng, D. Segaloff, 2009, Cellular signalling.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Stephen P. H. Alexander, Leigh A. Stoddart, Kalyan C. Tirupula, 2021, British journal of pharmacology.

Expression and Localization of Luteinizing Hormone Receptor in the Female Mouse Reproductive Tract

Meiling Zheng, D. Segaloff, B. V. Voorhis, 2001 .

Deletion of fetoplacental Fshr inhibits fetal vessel angiogenesis in the mouse placenta

D. Segaloff, J. Stilley, 2018, Molecular and Cellular Endocrinology.

The lutropin/choriogonadotropin receptor, a 2002 perspective.

M. Ascoli, F. Fanelli, D. Segaloff, 2002, Endocrine reviews.

Multiple luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic acid transcripts.

M. Ascoli, D. Segaloff, H. Wang, 1991, Endocrinology.

Structure of the lutropin/choriogonadotropin receptor.

R. Sprengel, M. Ascoli, K. Nikolics, 1990, Recent progress in hormone research.

On the structure of the luteinizing hormone/chorionic gonadotropin receptor.

M. Ascoli, D. Segaloff, 1989, Endocrine reviews.

Characterization of the desensitized state of Leydig tumor cells.

M. Ascoli, D. Puett, D. Segaloff, 1981, Biochimica et biophysica acta.

Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.

P. Seeburg, R. Sprengel, M. Köhler, 1989, Science.

Glycoprotein hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

S. Costagliola, M. Gershengorn, A. Themmen, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA.

P. Seeburg, R. Sprengel, K. Nikolics, 1990, Molecular endocrinology.

FSH Receptor (FSHR) Expression in Human Extragonadal Reproductive Tissues and the Developing Placenta, and the Impact of Its Deletion on Pregnancy in Mice1

A. Al-Hendy, S. England, P. Kirby, 2014, Biology of reproduction.

The lutropin/choriogonadotropin receptor ... 4 years later.

M. Ascoli, D. Segaloff, 1993, Endocrine reviews.

The dynamics of the steroidogenic response of perifused Leydig tumor cells to human chorionic gonadotropin, ovine luteinizing hormone, cholera toxin, and adenosine 3',5'-cyclic monophosphate.

M. Ascoli, D. Puett, D. Segaloff, 1981, Endocrinology.

N-linked carbohydrates on G protein-coupled receptors: mapping sites of attachment and determining functional roles.

D. Segaloff, D. Davis, 2002, Methods in enzymology.

The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction.

D. Segaloff, X. Liu, T. Rozell, 1997, Molecular endocrinology.

Disruption of potential sites for N-linked glycosylation does not impair hormone binding to the lutropin/choriogonadotropin receptor if Asn-173 is left intact.

D. Segaloff, X. Liu, D. Davis, 1993, The Journal of biological chemistry.

Diseases associated with mutations of the human lutropin receptor.

D. Segaloff, 2009, Progress in molecular biology and translational science.

Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.

R. Sprengel, R. Cone, D. Segaloff, 1990, Molecular endocrinology.

Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess.

G. Stamp, M. Poutanen, I. Huhtaniemi, 2010, Endocrinology.

Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix.

F. Fanelli, A. Latronico, D. Segaloff, 2000, The Journal of clinical endocrinology and metabolism.

A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor.

A. Latronico, D. Segaloff, B. Mendonca, 1998, Molecular endocrinology.

Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism.

E. Pinto, B. V. Van Voorhis, Xiuyan Feng, 2007, The Journal of clinical endocrinology and metabolism.

Follicle stimulating hormone receptor mutations and reproductive disorders.

D. Segaloff, Y. Tao, 2009, Progress in molecular biology and translational science.

Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function.

D. Segaloff, X. Liu, D. Davis, 1995, Molecular endocrinology.

Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor.

M. Ascoli, D. Segaloff, H. Wang, 1991, Endocrinology.

Intrinsic Differences in the Response of the Human Lutropin Receptor Versus the Human Follitropin Receptor to Activating Mutations*

F. Fanelli, Xiuyan Feng, G. Ryan, 2007, Journal of Biological Chemistry.

Regulation of the LH/CG Receptor by Gonadotropins

J. Richards, M. Ascoli, D. Segaloff, 1992 .

The 5'-flanking region of the rat luteinizing hormone/chorionic gonadotropin receptor gene confers Leydig cell expression and negative regulation of gene transcription by 3',5'-cyclic adenosine monophosphate.

M. Ascoli, S. Nelson, D. Segaloff, 1992, Molecular endocrinology.

Epidermal growth factor activates steroid biosynthesis in cultured Leydig tumor cells without affecting the levels of cAMP and potentiates the activation of steroid biosynthesis by choriogonadotropin and cAMP.

M. Ascoli, D. Segaloff, J. Euffa, 1987, The Journal of biological chemistry.

Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA.

M. Ascoli, D. Segaloff, H. Wang, 1991, The Journal of biological chemistry.

LutropinEhoriogonadotropin Receptor (LHR) Gene Transcription in the Follitropin-Stimulated Induction of the LHR in Granulosa Cells

D. Segaloff, Hong-zhen Shi, 1995 .

O-103. Structure of the LH receptor and signal transduction

D. Segaloff, 1997 .

Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.

D. Segaloff, Y. Tao, 2004, The Journal of clinical endocrinology and metabolism.

Association of gonadotropin receptor precursors with the protein folding chaperone calnexin.

D. Segaloff, Y. Chai, T. Rozell, 1998, Endocrinology.

Intracellular retention of mutant gonadotropin receptors results in loss of hormone binding activity of the follitropin receptor but not of the lutropin/choriogonadotropin receptor.

D. Segaloff, H. Wang, X. Liu, 1995, Molecular endocrinology.

Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor.

M. Conti, D. Segaloff, H. Shinozaki, 2003, The Journal of clinical endocrinology and metabolism.

Spontaneous fertility in a male patient with testotoxicosis despite suppression of FSH levels.

A. Latronico, B. Mendonca, D. Macedo, 2018, Human reproduction.

Revisiting and questioning functional rescue between dimerized LH receptor mutants.

D. Segaloff, Rongbin Guan, Meilin Zhang, 2012, Molecular endocrinology.

Constitutive activity of the lutropin receptor and its allosteric modulation by receptor heterodimerization.

D. Segaloff, 2010, Methods in enzymology.

Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor

A. Latronico, D. Segaloff, 2007, Molecular and Cellular Endocrinology.

The Formation of a Salt Bridge Between Helices 3 and 6 Is Responsible for the Constitutive Activity and Lack of Hormone Responsiveness of the Naturally Occurring L457R Mutation of the Human Lutropin Receptor*

F. Fanelli, D. Mizrachi, D. Segaloff, 2005, Journal of Biological Chemistry.

Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7.

D. Mizrachi, D. Segaloff, Y. Tao, 2002, Molecular endocrinology.

Pleiotropic effects of substitutions of a highly conserved leucine in transmembrane helix III of the human lutropin/choriogonadotropin receptor with respect to constitutive activation and hormone responsiveness.

K. Nakamura, F. Fanelli, D. Segaloff, 2001, Molecular endocrinology.

Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III.

A. Abell, K. Nakamura, D. Segaloff, 2000, Molecular endocrinology.

Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain

D. Segaloff, J. Jaquette, 2002, Molecular and Cellular Endocrinology.

Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone Stimulation.

G. Chrousos, R. Guan, Q. Fan, 2016, Molecular endocrinology.

An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.

Francesca Fanelli, F. Fanelli, Xiuyan Feng, 2008, Endocrinology.

Multiple elements and protein factors coordinate the basal and cyclic adenosine 3',5'-monophosphate-induced transcription of the lutropin receptor gene in rat granulosa cells.

H. Shi, D. Segaloff, S. Chen, 1999, Endocrinology.

The inositol phosphate/diacylglycerol pathway in MA-10 Leydig tumor cells. Activation by arginine vasopressin and lack of effect of epidermal growth factor and human choriogonadotropin.

O. Pignataro, M. Ascoli, D. Segaloff, 1989, The Journal of biological chemistry.

Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor-mediated hormone internalization.

D. Segaloff, Y. Xie, K. Collison, 1992, Molecular endocrinology.

Removal of the surface-bound human choriogonadotropin results in the cessation of hormonal responses in cultured Leydig tumor cells.

M. Ascoli, D. Segaloff, 1981, The Journal of biological chemistry.

Truncation of the cytoplasmic tail of the lutropin/choriogonadotropin receptor prevents agonist-induced uncoupling.

M. Ascoli, J. Sánchez-Yagüe, D. Segaloff, 1992, The Journal of biological chemistry.

Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects.

D. Segaloff, Y. Tao, 2005, The Journal of clinical endocrinology and metabolism.

FSH Actions and Pregnancy: Looking Beyond Ovarian FSH Receptors.

D. Segaloff, J. Stilley, 2018, Endocrinology.

Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity.

D. Segaloff, Y. Tao, 2003, Endocrinology.

A role for increased lutropin/choriogonadotropin receptor (LHR) gene transcription in the follitropin-stimulated induction of the LHR in granulosa cells.

H. Shi, D. Segaloff, 1995, Molecular endocrinology.

Luteinizing hormone receptor appearance in cultured porcine granulosa cells requires continual presence of follicle-stimulating hormone.

L. Limbird, D. Segaloff, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Identification of an SAS (Sp1c adjacent site)-like element in the distal 5'-flanking region of the rat lutropin receptor gene essential for cyclic adenosine 3',5'-monophosphate responsiveness.

D. Segaloff, S. Chen, X. Liu, 2001, Endocrinology.

A novel cyclic adenosine 3',5'-monophosphate-responsive element involved in the transcriptional regulation of the lutropin receptor gene in granulosa cells.

D. Segaloff, S. Chen, X. Liu, 2000, Molecular endocrinology.

Glycoprotein hormone receptors in GtoPdb v.2023.1

S. Costagliola, A. Themmen, G. Vassart, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Constitutive and Agonist-dependent Self-association of the Cell Surface Human Lutropin Receptor*

D. Segaloff, Y. Tao, N. B. Johnson, 2004, Journal of Biological Chemistry.

Intracellularly located misfolded glycoprotein hormone receptors associate with different chaperone proteins than their cognate wild-type receptors.

D. Mizrachi, D. Segaloff, 2004, Molecular endocrinology.