G. Marshall

发表

The affinities, potencies and efficacies of some benzodiazepine‐receptor agonists, antagonists and inverse‐agonists at rat hippocampal GABAA‐receptors

E. Wong, J. Kemp, G. Woodruff, 1987, British journal of pharmacology.

Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.

J. Kemp, P. Whiting, B. le Bourdellès, 1995, Molecular pharmacology.

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

P D Leeson, J. Kemp, P. Leeson, 1997, Journal of medicinal chemistry.

The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist at the benzodiazepine receptor

S. Iversen, E. Wong, J. Kemp, 1990, British journal of pharmacology.

Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.

H. Broughton, V. Matassa, R. Ball, 1996, Journal of medicinal chemistry.

Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.

S. Iversen, L. Iversen, J. Kemp, 1994, Molecular pharmacology.

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.

J. Kemp, P. Leeson, Brett Williams, 1991, Journal of medicinal chemistry.

A Second Generation of Non‐Peptide Cholecystokinin Receptor Antagonists and Their Possible Therapeutic Potential

J. Kemp, M. Bock, R. M. Dipardo, 1994, Annals of the New York Academy of Sciences.

Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

S. Tye, A. Pike, J. Atack, 2006 .

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

G. Dawson, R. Mckernan, A. Pike, 2004, Journal of medicinal chemistry.

3′‐(Arylmethyl)‐ and 3′‐(Aryloxy)‐3‐phenyl‐4‐hydroxyquinolin‐2(1H)‐ ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor.

J. Kemp, P. Leeson, M. Tricklebank, 2010 .

Second-generation benzodiazepine CCK-B antagonists. Development of subnanomolar analogs with selectivity and water solubility.

J. Kemp, D. Veber, M. Bock, 1994, Journal of medicinal chemistry.

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.

Karen S. Curley, R. Mckernan, J. Atack, 2004, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.

A. Pike, J. Atack, K. Wafford, 2006, Bioorganic & medicinal chemistry letters.

Anxiogenic properties of an inverse agonist selective for α3 subunit‐containing GABAA receptors

G. Dawson, R. Mckernan, J. Atack, 2005 .

Imidazo[1,2-a]pyrimidines as Functionally Selective and Orally Bioavailable GABAAα2/α3 Binding Site Agonists for the Treatment of Anxiety Disorders

Joanna Stanley, A. Pike, J. Atack, 2006 .

Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines.

J. Kemp, P. Leeson, M. Tricklebank, 1993 .

2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the NMDA receptor.

J. Kemp, P. Leeson, A. Foster, 1992, Journal of medicinal chemistry.

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

S. Iversen, L. Iversen, J. Kemp, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Tetramic acids as novel glycine site antagonists

P. Leeson, S. Grimwood, G. Marshall, 1995 .

Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.

J. Kemp, P. Leeson, A. Foster, 1992, Molecular pharmacology.

4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.

J. Kemp, P. Leeson, M. Hudson, 1997, Journal of medicinal chemistry.

Identification of 3,5-dihydro-2-aryl-1H-pyrazolo[3,4-c]quinoline-1,4(2H)-diones as novel high-affinity glycine site N-methyl-D-aspartate antagonists.

L. Bristow, R. Ball, S. Grimwood, 1995, Journal of medicinal chemistry.

3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex.

J. Kemp, P. Leeson, I. Stansfield, 1993, Journal of medicinal chemistry.

High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.

J. Kemp, J. G. Neduvelil, S. Freedman, 1994, Journal of medicinal chemistry.

Synthesis and SAR of diiodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands

P. Leeson, M. Rowley, S. Grimwood, 1996 .

Growth factors regulate the survival and fate of cells derived from human neurospheres

Scott Pollack, Clive N. Svendsen, C. Svendsen, 2001, Nature Biotechnology.

Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.

R. Mckernan, J. Schaeffer, K. Wafford, 2000, The Journal of pharmacology and experimental therapeutics.

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

R. Mckernan, P. Whiting, J. Atack, 2000, Nature Neuroscience.

L‐687,414, a low efficacy NMDA receptor glycine site partial agonist in vitro, does not prevent hippocampal LTP in vivo at plasma levels known to be neuroprotective

J. Kemp, R. Hill, T. Priestley, 1998, British journal of pharmacology.

5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.

H. Broughton, V. Matassa, R. Ball, 1997, Journal of medicinal chemistry.

7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.

G. Dawson, R. Mckernan, A. Pike, 2005, Journal of medicinal chemistry.

Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABAA Receptor Subunit Conferring Atypical Functional Properties

P. Whiting, D. Vassilatis, M. Rigby, 1997, The Journal of Neuroscience.

An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.

G. Dawson, J. Atack, D. O'connor, 2004, Journal of medicinal chemistry.

Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide.

P. Whiting, K. Wafford, G. Marshall, 1999, Molecular pharmacology.

A Pyridazine Series of α2/α3 Subtype Selective GABAA Agonists for the Treatment of Anxiety

S. Tye, A. Pike, J. Atack, 2006 .

Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.

S. Tye, A. Pike, J. Atack, 2006, Journal of medicinal chemistry.

Molecular requirements for recognition at glucoreceptor for insulin release.

C. D. Barry, C D Barry, P. Lacy, 1979, Molecular pharmacology.

Steric mapping of the L-methionine binding site of ATP:L-methionine S-adenosyltransferase.

J. Sufrin, G. Marshall, G R Marshall, 1981, Molecular pharmacology.

The in vivo properties of pagoclone in rat are most likely mediated by 5′-hydroxy pagoclone

G. Dawson, R. Mckernan, J. Atack, 2006, Neuropharmacology.

C5-piperazinyl-1,4-benzodiazepines, water-soluble, orally bioa vailable CCKB/gastrin receptor antagonists

V. Matassa, J. G. Neduvelil, S. Freedman, 1995 .

2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: Functionally selective GABAA α3-subtype agonists

J. Atack, K. Wafford, L. Street, 2006 .

Effect of α Subunit on Allosteric Modulation of Ion Channel Function in Stably Expressed Human Recombinant γ-Aminobutyric AcidA Receptors Determined Using36Cl Ion Flux

C. Adkins, R. Mckernan, J. Atack, 2001 .

Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux.

C. Adkins, R. Mckernan, K. Wafford, 2001, Molecular pharmacology.

Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition

G. Dawson, J. Atack, H. Broughton, 2003 .

The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol

R. Harris, J. Lambert, K. Wafford, 2006, Journal of Pharmacology and Experimental Therapeutics.

Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors.

G. Dawson, R. Mckernan, J. Atack, 2005, British journal of pharmacology.

The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.

R. Harris, J. Lambert, K. Wafford, 2006, The Journal of pharmacology and experimental therapeutics.

Quantitative evaluation of the potencies of GABA‐receptor agonists and antagonists using the rat hippocampal slice preparation

J. Kemp, G. Woodruff, G. Marshall, 1986, British journal of pharmacology.

A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

S. Tye, A. Pike, J. Atack, 2006, Journal of Medicinal Chemistry.

3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

J. Kemp, P. Leeson, C. Moyes, 1993, Journal of medicinal chemistry.

Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801).

J. Kemp, D. Middlemiss, T. Lyle, 1990, Journal of medicinal chemistry.