T. Miyasaka

发表

Synthesis and antitumor activity of 20(S)-camptothecin derivatives: carbamate-linked, water-soluble derivatives of 7-ethyl-10-hydroxycamptothecin.

K. Yamaguchi, S. Sawada, S. Okajima, 1991, Chemical & pharmaceutical bulletin.

Uracil and adenine nucleosides having a 2′,3′-bromovinyl structure: highly versatile synthons for the synthesis of 2′-C- and 3′-C-Branched 2′,3′-Unsaturated Derivatives

T. Miyasaka, Y. Itoh, K. Haraguchi, 1993 .

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

T. Tanaka, K. Nitta, T. Yokokura, 1987, Cancer research.

Uridine 5′-monoselenoacetals as substrates for diastereoselective homolytic C-C bond formation

K. Yamaguchi, T. Miyasaka, K. Haraguchi, 1996 .

Diastereoface selectivity in radical-mediated C-C bond formation of uridine 5′-monoselenoacetals

K. Yamaguchi, T. Miyasaka, K. Haraguchi, 1994 .

Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects.

A. Matsuda, H. Homma, Y. Watanabe, 1992, Journal of medicinal chemistry.

Face selective 6,1′-(1-oxo)ethano bridge formation of uracil nucleosides under hypoiodite reaction conditions

Kazuo T. Nakamura, M. Amano, T. Miyasaka, 1999 .

Synthesis of Anomeric Spiro Uracil Nucleosides with an Orthoester Structure: Stereoselective Cyclization Controlled by the C6-Substituent

Kazuo T. Nakamura, T. Miyasaka, A. Kittaka, 1997 .

Reaction of organometallic reagents with 2'- and 3'-ketouridine derivatives: Synthesis of uracil nucleosides branched at the 2'- and 3'-positions.

H. Hayakawa, Y. Iitaka, K. Yamaguchi, 1987 .

HEPT: From an Investigation of Lithiation of Nucleosides Towards a Rational Design of Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1

R. T. Walker, D. Stuart, D. Stammers, 2000 .

Synthesis of a potential photoaffinity labelling reagent for HIV-1 reverse transcriptase

R. T. Walker, M. Baba, E. Clercq, 1993 .

Synergistic inhibition of human immunodeficiency virus type 1 replication by 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU) and azidothymidine in vitro

R. T. Walker, E. De Clercq, M. Baba, 1991, Antimicrobial Agents and Chemotherapy.

Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT) and recombinant alpha interferon.

R. T. Walker, E. De Clercq, M. Baba, 1991, Antiviral research.

SYNTHESIS AND BIOLOGICAL EVALUATION OF 1'-C-CYANO-PYRIMIDINE NUCLEOSIDES

T. Miyasaka, Y. Itoh, K. Haraguchi, 1996 .

Synthesis and properties of 2'-deoxy-8,2'-methylene-cycloadenosine

A. Matsuda, T. Miyasaka, Hiromichi Tanaka, 1985 .

DNA SEQUENCE RECOGNITION BY NFκB p50 HOMODIMER: STRICT AND OBSCURE RECOGNITION SITES IN THE BINDING SEQUENCE

M. Kurihara, T. Miyasaka, H. Takayama, 2001, Nucleosides, nucleotides & nucleic acids.

Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.

T. Miyasaka, A. Kittaka, K. Ito, 1998, Bioorganic & medicinal chemistry letters.

Vinyl radical-based cyclization of 6-substituted 1-(2-deoxy-D-erythro-pent-1-enofuranosyl)uracils : synthesis of anomeric spiro nucleosides

K. Yamaguchi, T. Miyasaka, A. Kittaka, 1994 .

A lithiation route to C-5 substitution of an imidazole nucleoside and its application to the synthesis of 3-deazaguanosine

A. Matsuda, Masahiro Suzuki, T. Miyasaka, 1986 .

Conversion of guanosine into 2-aminomethylinosine (2-homoguanosine)

A. Matsuda, K. Satoh, T. Miyasaka, 1984 .

Anomeric Manipulation of Nucleosides: Stereospecific Entry to 1′‐C‐ Branched Uracil Nucleosides.

K. Yamaguchi, T. Miyasaka, Y. Itoh, 1994 .

Anomeric manipulation of nucleosides: Stereosepecific entry to 1′- C -branched uracil nucleosides

K. Yamaguchi, T. Miyasaka, Y. Itoh, 1993 .

Photochemical Synthesis of 6-Aryluridines1)

K. Satoh, T. Miyasaka, Hiromichi Tanaka, 1986 .

Synthesis and biological activities of 5-substituted 6-phenylthio and 6-iodouridines, a new class of antileukemic nucleosides.

A. Matsuda, H. Hayakawa, T. Miyasaka, 1983, Chemical & pharmaceutical bulletin.

An Intramolecular Anionic Migration of a Stannyl Group from the 6-Position of 1-(2-Deoxy-d-erythro-pent-1-enofuranosyl)uracil to the 2′-Position: Synthesis of 2′-Substituted 1′,2′-Unsaturated Uridines

Kazuo T. Nakamura, T. Miyasaka, M. Kondo, 2000 .

Nucleoside anomeric radicals via 1,5-translocation: Facile access to anomeric spiro nucleosides

T. Miyasaka, A. Kittaka, Hiromichi Tanaka, 1996 .

Design and Synthesis of a New Fluorescent Tricyclic Nucleoside, 3-.beta.-D-Ribofuranosylpyrazolo[3,2-i]purine

T. Miyasaka, N. Hamamichi, 1994 .

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

R T Walker, R. T. Walker, E. De Clercq, 1989, Journal of medicinal chemistry.

Studies of Heterocyclic Compounds. II. Acetyl Transfer Reactions of 3-Acetoxy-1-acetyl-5-methylpyrazole and the Related Compounds

T. Miyasaka, H. Ochi, K. Arakawa, 1974 .

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

R T Walker, R. T. Walker, E. De Clercq, 1989, Biochemical and biophysical research communications.

The synthesis of octosyl nucleosides based on intramolecular oxyselenation of a conjugated diene

T. Miyasaka, K. Haraguchi, Hiromichi Tanaka, 1998 .

An Unusual Reaction Observed in Sulfonylation and Acylation of 2′,3′-O-Isopropylidenenebularine

H. Hayakawa, K. Yamaguchi, T. Miyasaka, 1989 .

Synthesis of 5-Carbon-Substituted 1-β-D-Ribofuranosylimidazole-4-carboxamides via Lithiation of a Primary Carboxamide

Masahiro Suzuki, T. Miyasaka, Hiromichi Tanaka, 1987 .

FIRST EXCEPTIONS TO THE"IMBACH RULE"FOR β-D-RIBOFURANOSYL NUCLEOSIDES

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1982 .

Synthesis of N-Free 4-Hydroxy-2-thiazoline as an Intermediate in the Hantzsch Thiazole Synthesis

T. Miyasaka, K. Arakawa, H. Ohtsuka, 1972 .

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.

R T Walker, R. T. Walker, S Shigeta, 1992, Journal of medicinal chemistry.

Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.

R T Walker, R. T. Walker, S Shigeta, 2010, Journal of medicinal chemistry.

Lithiation of 5,6-dihydrouridine: a new route to 5-substituted uridines

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1985 .

Enantio- and diastereoselective synthesis of 4′-α-substituted carbocyclic nucleosides

T. Miyasaka, Hiromichi Tanaka, H. Suzuki, 1998 .

Cleavage of cyclic ethers including oxetane and oxolane with a highly nucleophilic species of phenylselenide anion.

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1988 .

Cyclization Reactions of Nucleoside Anomeric Radical with Olefin Tethered on Base: Factors That Induce Anomeric Stereochemistry

Kazuo T. Nakamura, T. Miyasaka, A. Kittaka, 1999 .

A convenient method for the selective acylation of guanine nucleosides

A. Matsuda, K. Watanabe, T. Miyasaka, 1986 .

Synthesis and Optical Properties of 2'-Deoxy-8, 2'-methanoguanosine

A. Matsuda, T. Miyasaka, Kazuyuki Watanabe, 1989 .

First Evident Generation of Purin-2-yllithium: Lithiation of an 8-Silyl-Protected 6-Chloropurine Riboside as a Key Step for the Synthesis of 2-Carbon-Substituted Adenosines†

H. Hayakawa, T. Miyasaka, H. Kumamoto, 1999 .

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.

Richard T. Walker, David I. Stuart, Robert M. Esnouf, 1996, Journal of medicinal chemistry.

Radical-mediated furanose ring reconstruction from 2′,3′-seco-uridine

T. Miyasaka, S. Shibuya, T. Yokomatsu, 2001 .

Radical-initiated 1,2-acyloxy migration which generates a nucleoside anomeric radical

Kazuo T. Nakamura, T. Miyasaka, Y. Itoh, 1995 .

THE CONFIGURATION AT THE ANOMERIC CARBON OF THE ETHYNYLATED PRODUCTS OF 2,3,5-TRI-O-BENZOYL-D-RIBOFURANOSYL BROMIDE WITH MERCURIC AND CUPROUS PHENYLETHYNYLIDES

T. Miyasaka, N. Hamamichi, K. Arakawa, 1976 .

SYNTHESIS OF 1-β-(3-PHENYLPYRAZOL-4-YL)-D-RIBOFURANOSIDE, A C-NUCLEOSIDE

T. Miyasaka, N. Hamamichi, K. Arakawa, 1974 .

Intramolecular Radical Reactions of 5′-O-Modified 2′,3′-Didehydro-2′,3′-Dideoxyuridine Derivatives

K. Yamaguchi, T. Miyasaka, A. Kittaka, 1996 .

A New Entry to 2-Substituted Purine Nucleosides Based on Lithiation-Mediated Stannyl Transfer of 6-Chloropurine Nucleosides

S. Shuto, H. Hayakawa, T. Miyasaka, 1997 .

Synthesis of CPT‐11 (Irinotecan Hydrochloride Trihydrate)

S. Sawada, T. Yokokura, T. Miyasaka, 1996, Annals of the New York Academy of Sciences.

Synthesis and antitumor activity of 20(S)-camptothecin derivatives: A-ring modified and 7,10-disubstituted camptothecins.

S. Sawada, K. Nokata, T. Furuta, 1991, Chemical & pharmaceutical bulletin.

Chemical modification of an antitumor alkaloid camptothecin: synthesis and antitumor activity of 7-C-substituted camptothecins.

S. Sawada, K. Nokata, T. Yokokura, 1991, Chemical & pharmaceutical bulletin.

Characterization of human taurine transporter expressed in insect cells using a recombinant baculovirus.

T. Hisatsune, S. Kaminogawa, M. Shimizu, 2001, Protein expression and purification.

A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).

S Shigeta, H. Hayakawa, M. Baba, 1991, Journal of medicinal chemistry.

Hept Derivatives: 6-Benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442)

R. T. Walker, M. Baba, E. Clercq, 1995 .

REACTION OF URACIL NUCLEOSIDES WITH 1-METHYLIMIDAZOLE IN THE PRESENCE OF PHOSPHORYL CHLORIDE : A CONVENIENT METHOD FOR THE SYNTHESIS OF 4-SUBSTITUTED PYRIMIDIN-2 (1H)-ONE NUCLEOSIDES

A. Matsuda, T. Miyasaka, K. Obi, 1985 .

Direct C-8 lithiation of naturally-occurring purine nucleosides. A simple method for the synthesis of 8-carbon-substituted purine nucleosides

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1987 .

A Ribonolactone-Based Approach to the Synthesis of 1′-Carbon-Substituted Thymine Ribonucleosides

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1994 .

Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).

R T Walker, R. T. Walker, S Shigeta, 1991, Journal of medicinal chemistry.

DIVERGENT AND STEREOCONTROLLED APPROACH TO THE SYNTHESIS OF URACIL NUCLEOSIDES BRANCHED AT THE ANOMERIC POSITION

T. Miyasaka, Y. Itoh, K. Haraguchi, 1995 .

A Ribonolactone-Based Approach to the Synthesis of 1′-Carbon- Substituted Thymine Ribonucleosides.

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1995 .

Stannyl migration from the base to the sugar portion of 1′,2′-unsaturated uridine: the first example of substitution at the 2′-position

T. Miyasaka, A. Kittaka, H. Kumamoto, 1998 .

Electrophilic addition to 4-thio furanoid glycal: a highly stereoselective entry to 2′-deoxy-4′-thio pyrimidine nucleosides

Kazuo T. Nakamura, T. Miyasaka, K. Haraguchi, 1998 .

Radical-Mediated Cyclization of A 6-Chloro-9-(2-Deoxy--d erythro-pent-1-enofuranosyl)-8-(2,2-dibromovinyl) purine

Kazuo T. Nakamura, T. Miyasaka, A. Kittaka, 1996 .

Divergent and Stereocontrolled Approach to the Synthesis of Uracil Nucleosides Branched at the Anomeric Position.

T. Miyasaka, Y. Itoh, K. Haraguchi, 1995 .

A simple and general entry to 5-substituted uridines based on the regioselective lithiation controlled by a protecting group in the sugar moiety

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1987 .

Selenoxide Elimination for the Synthesis of Unsaturated Sugar Uracil Nucleosides.

T. Miyasaka, Y. Itoh, K. Haraguchi, 1992 .

Effect of human serum on the in vitro anti-HIV-1 activity of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives as related to their lipophilicity and serum protein binding.

R. T. Walker, M. Baba, M. Yamamoto, 1993, Biochemical pharmacology.

Cleavage of a nucleosidic oxetane with carbanions: synthesis of a highly promising candidate for anti-HIV agents — a phosphonate isostere of AZT 5′-phosphate

T. Miyasaka, K. Haraguchi, Hiromichi Tanaka, 1989 .

Facile synthesis of 2′-deoxy-2′-arylthiouridines

A. Matsuda, T. Miyasaka, 1983 .

Selenoxide elimination for the synthesis of unsaturated-sugar uracil nucleosides

T. Miyasaka, Y. Itoh, K. Haraguchi, 1991 .

Preparation and reactions of 2′- and 3′-vinyl bromides of uracil-nucleosides: versatile synthons for anti-hiv agents

T. Miyasaka, Y. Itoh, K. Haraguchi, 1991 .

A lithiation approach to cordycepin analogues variously substituted at the C-8 position

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1989 .

Allylic Substitution of 3‘,4‘-Unsaturated Nucleosides: Organosilicon-Based Stereoselective Access to 4‘-C-Branched 2‘,3‘-Didehydro-2‘,3‘-dideoxyribonucleosides

K. Yamaguchi, T. Miyasaka, Y. Itoh, 1996 .

LITHIATION-STANNYLATION CHEMISTRY OF NUCLEOSIDES

H. Hayakawa, T. Miyasaka, H. Kumamoto, 1999 .

Stannyl Migration from the Base to the Sugar Portion of 1′,2′‐Unsaturated Uridine: The First Example of Substitution at the 2′‐Position.

T. Miyasaka, A. Kittaka, H. Kumamoto, 1998 .

Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.

R T Walker, R. T. Walker, S Shigeta, 1992, Journal of medicinal chemistry.

Reactions Of 2′-Deoxy-2′-halouridines and O 2,2′-Cyclouridine with Lithium Dialkylamides: Formation of 1′,2′-Unsaturated Derivatives

K. Yamaguchi, T. Miyasaka, A. Kittaka, 1992 .

Diethylaminosulfur Trilfluoride (DAST) as a Fluorinating Agent of Pyrimidine Nucleosides Having a 2', 3'-Vicinal Diol System

H. Hayakawa, K. Yamaguchi, T. Miyasaka, 1990 .

Dynamic aspects in the LDA lithiation of an arabinofuranosyl derivative of 4-ethoxy-2-pyrimidinone: Regioselective entry to both C-5 and C-6 substitutions

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1990 .

REGIOSELECTIVITY IN THE LITHIATION OF URIDINE. EFFECT OF THE SUGAR PROTECTING GROUPS

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1985 .

Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

R T Walker, R. T. Walker, M. Baba, 1991, Journal of medicinal chemistry.

Stereoselective synthesis of 4′-C-branched 2,′3′-didehydro-2′-dideoxy nucleosides based on SnCl4-promoted allylic rearrangement

T. Miyasaka, Y. Itoh, K. Haraguchi, 1992 .

Lithiation Chemistry of Uridine Derivatives: Access to a New Anti-HIV-1 Lead

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1993 .

Synthesis of 6-Methyluridine via Palladium-Catalyzed Cross-Coupling Between A 6-Iodouridine Derivative and Tetramethylstannane

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1992 .

Regioselectivity in the Lithiation of Uridine. Effect of the Sugar Protecting Groups.

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1986 .

A SIMPLIFIED SYNTHESIS OF 8-SUBSTITUTED PURINE NUCLEOSIDES VIA LITHIATION OF 6-CHLORO-9-(2, 3-O-ISOPROPYLIDENE-β-D-RIBOFURANOSYL) PURINE

A. Matsuda, H. Hayakawa, T. Miyasaka, 1983 .

“Umpulong” of reactivity at the C-6 position of uridine: a simple and general method for 6-substituted uridines

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1982 .

Introduction of 6-formylcytidine into a Myb binding sequence.

A. Sarai, S. Ishii, T. Yasukawa, 1999, Nucleosides and Nucleotides.

1,5-Translocation Strategy for Nucleoside Anomeric Radicals

T. Miyasaka, A. Kittaka, Hiromichi Tanaka, 1997 .

Synthesis of some analogues of 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine (hept) which have different types of acyclic structures

R. T. Walker, M. Baba, E. Clercq, 1992 .

Nucleosidic enol esters: A versatile tool for the synthesis of 3′-carbon-substituted nucleosides

T. Miyasaka, Y. Itoh, K. Haraguchi, 1991 .

Lithiation of Uracilnucleosides and its Application to the Synthesis of a New Class of Anti-HIV-1 Acyclonucleosides

Erik De Clercq, Richard T. Walker, R. T. Walker, 1991 .

Diethylaminosulfur Trifluoride (DAST) as a Fluorinating Agent of Pyrimidine Nucleosides Having a 2′,3′-Vicinal Diol System.

H. Hayakawa, K. Yamaguchi, T. Miyasaka, 1991 .

Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro

S Shigeta, E. De Clercq, M. Baba, 1994, Antimicrobial Agents and Chemotherapy.

Regiospecific C-alkylation of uridine: a simple route to 6-alkyluridines

T. Miyasaka, Hiromichi Tanaka, I. Nasu, 1980 .

Addition of carbon radicals to 4′,5′-unsaturated uracilnucleosides by the use of organoselenium reagents: A new stereoselective entry to CC bond formation at the 5′-position

T. Miyasaka, K. Haraguchi, Hiromichi Tanaka, 1990 .

Pummerer Rearrangement of Selenium-Containing Uracil Nucleosides

T. Miyasaka, K. Haraguchi, Hiromichi Tanaka, 1992 .

Stereoselective Synthesis of 4′‐C‐Branched 2′,3′‐Didehydro‐2′,3′‐ dideoxy Nucleosides Based on SnCl4‐Promoted Allylic Rearrangement.

T. Miyasaka, Y. Itoh, K. Haraguchi, 1992 .

Design and Synthesis of Regioisomeric Analogues of a Specific Anti-HIV-1 Agent 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

Erik De Clercq, Richard T. Walker, R. T. Walker, 1994 .

Synthesis of 6-aroyluridine from uridine via regiospecific lithiation.

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1981 .

Allosteric Inhibitors against HIV-1 Reverse Transcriptase: Design and Synthesis of MKC-442 Analogues Having an Ω-Functionalized Acyclic Structure

D. Stuart, A. Hopkins, D. Stammers, 1998, Antiviral chemistry & chemotherapy.

Synthesis and Anti‐HIV Activity of 2‐, 3‐, and 4‐Substituted Analogues of 1‐((2‐Hydroxyethoxy)methyl)‐6‐(phenylthio)thymine (HEPT).

R. T. Walker, M. Baba, E. Clercq, 1991 .

Synthesis of 6-alkynylated uridines

T. Miyasaka, K. Haraguchi, Hiromichi Tanaka, 1986 .

Introduction of an Azido Group to the C-6 Position of Uridine by the Use of a 6-Iodouridine Derivative

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1985 .

Lithiation of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine: synthesis of 6-substituted 2'-deoxyuridines

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1985 .

Desulfurizative stannylation of uracil derivatives

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1985 .

The Reaction of 6-Phenylthiouridine with Sulfur Nucleophiles : A Simple and Regiospecific Preparation of 6-Alkylthiouridines and 6-Alkylthiouridylic Acids

A. Matsuda, H. Hayakawa, T. Miyasaka, 1983 .

A NOVEL AND REGIOSPECIFIC ROUTE TO 5-ACYLURIDINES VIA AN AMIDE α-ANION DERIVED FROM 5,6-DIHYDROURIDINE

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1982 .

A facile and regiospecific preparation of 6-alkyluridines.

H. Hayakawa, T. Miyasaka, H. Tanaka, 1980, Nucleic acids symposium series.

Highly potent and selective inhibition of HIV-1 replication by 6-phenylthiouracil derivatives.

R. T. Walker, E. De Clercq, R. Pauwels, 1992, Antiviral research.

Photochemical intramolecular nitrene insertion of 6-azidouridine derivatives

K. Satoh, Y. Iitaka, K. Yamaguchi, 1987 .

Lithiation-mediated CC silyl and stannyl migrations observed in 6-chloro-9-(β-d-ribofuranosyl)purine

H. Hayakawa, T. Miyasaka, H. Kumamoto, 1995 .

LITHIATION OF AN IMIDAZOLE NUCLEOSIDE AT THE C-5 POSITION. SYNTHESIS OF 3-DEAZAGUANOSINE FROM URIDINE

A. Matsuda, T. Miyasaka, Hiromichi Tanaka, 1985 .

A SIMPLIFIED SYNTHESIS OF 8-SUBSTITUTED PURINE NUCLEOSIDES VIA LITHIATION OF 6-CHLORO-9-(2,3-O-ISOPROPYLIDENE-β-D-RIBOFURANOSYL)PURINE

A. Matsuda, H. Hayakawa, T. Miyasaka, 1983 .

Nucleosidic Enol Esters: A Versatile Tool for the Synthesis of 3′- Carbon-Substituted Nucleosides.

T. Miyasaka, Y. Itoh, K. Haraguchi, 1991 .

1,5‐Translocation Strategy for Nucleoside Anomeric Radicals.

T. Miyasaka, A. Kittaka, Hiromichi Tanaka, 1998 .

Tandem Radical Cyclization-Oxygenation of 6-(2,2-Di-bromovinyl)-1-(2-deoxy-d-erytho-pent-1-enofuranosyl)-uracil: Synthesis of Anomeric Spiro Nucleosides Having Arabino and Ribo Configurations

Kazuo T. Nakamura, T. Miyasaka, A. Kittaka, 1996 .

Addition of Carbon Radicals to 4′,5′-Unsaturated Uracil Nucleosides by the Use of Organoselenium Reagents: A New Stereoselective Entry to C-C Bond Formation at the 5′-Position.

T. Miyasaka, K. Haraguchi, Hiromichi Tanaka, 1990 .

STEREOSELECTIVE SYNTHESIS OF 1'-C-BRANCHED URACIL NUCLEOSIDES FROM URIDINE

T. Miyasaka, Y. Itoh, K. Haraguchi, 1995 .

Radical-Mediated Cyclization of a 6-Chloro-9-(2-deoxy-D-erythro-pent-1- enofuranosyl)-8-(2,2-dibromovinyl)purine.

Kazuo T. Nakamura, T. Miyasaka, A. Kittaka, 1997 .

Electrophilic Addition to 4‐Thio Furanoid Glycal: A Highly Stereoselective Entry to 2′‐Deoxy‐4′‐thio Pyrimidine Nucleosides.

Kazuo T. Nakamura, T. Miyasaka, K. Haraguchi, 1998 .

Introduction of 5-Formyl-2′-deoxyuridine into a κB Site: Critical Discrimination of a Base Structure in the Major Groove by NFκB p50 Homodimer

Kazuo T. Nakamura, T. Miyasaka, A. Kittaka, 1999 .

A Simple and General Entry to 5-Substituted Uridines Based on the Regioselective Lithiation Controlled by a Protecting Group in the Sugar Moiety.

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1987 .

Preparation of γ- and δ-Phenylselenenyl Alcohols via Ring Cleavage of Oxetane and Oxolane

T. Miyasaka, K. Haraguchi, Hiromichi Tanaka, 1989 .

Synthesis of 3-(β-D-ribofuranosyl)pyrazolo[3,2-i]-purine derivatives and their cytotoxic activities

T. Miyasaka, N. Hamamichi, 1993 .

Synthesis of 2-Alkynylcordycepins and Evaluation of Their Vasodilating Activity

A. Matsuda, H. Hayakawa, T. Miyasaka, 1998 .

Cleavage of a Nucleosidic Oxetane with Carbanions: Synthesis of a Highly Promising Candidate for Anti-HIV Agents. A Phosphonate Isoster of AZT 5′-Phosphate.

T. Miyasaka, K. Haraguchi, Hiromichi Tanaka, 1989 .

Preparation and Reactions of 2′- and 3′-Vinyl Bromides of Uracil Nucleosides: Versatile Synthons for anti-HIV Agents.

T. Miyasaka, Y. Itoh, K. Haraguchi, 1992 .

Introduction of an alkyl group into the sugar portion of uracilnucleosides by the use of gilman reagents

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1990 .

A Lithiation Approach to Cordycepin Analogues Variously Substituted at the C-8 Position.

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1989 .

Preparation of 8-Chloropurine Nucleosides Through the Reaction Between their C-8 Lithiated Species and p-Toluenesulfonyl Chloride

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1988 .

Allylic Substitution of 3′,4′‐Unsaturated Nucleosides: Organosilicon‐ Based Stereoselective Access to 4′‐C‐Branched 2′,3′‐Didehydro‐2′,3′‐ dideoxyribonucleosides.

K. Yamaguchi, T. Miyasaka, Y. Itoh, 1996 .

Lithiation—Stannylation Chemistry of Nucleosides

H. Hayakawa, T. Miyasaka, H. Kumamoto, 1999 .

Stereoselective Synthesis of 4'-α-Alkylcarbovir Derivatives Based on an Asymmetric Synthesis or Chemoenzymatic Procedure

M. Baba, K. Yamaguchi, T. Miyasaka, 1999 .

Antitumor activity of a new camptothecin derivative, SN-22, against various murine tumors.

K. Nitta, T. Yokokura, T. Miyasaka, 1987, Journal of pharmacobio-dynamics.

Synthesis and antitumor activity of 20(S)-camptothecin derivatives. A-ring-substituted 7-ethylcamptothecins and their E-ring-modified water-soluble derivatives.

T. Yaegashi, S. Sawada, T. Furuta, 1994, Chemical & pharmaceutical bulletin.

[Antitumor activity of new derivatives of camptothecin].

K. Nitta, T. Yokokura, T. Miyasaka, 1987, Gan to kagaku ryoho. Cancer & chemotherapy.

A SELECTIVE ONE-STEP INTRODUCTION OF HYDROXYLIC FUNCTIONS AT THE C-5 AND C-7 POSITIONS OF 20(S)-CAMPTOTHECIN, AN ALKALOID HAVING ANTITUMOR ACTIVITY

S. Sawada, K. Nokata, T. Miyasaka, 1981 .

Diazaquinomycin A, a new antifolate antibiotic, inhibits thymidylate synthase.

S. Ōmura, H. Tanaka, T. Miyasaka, 1985, The Journal of antibiotics.

A convenient method for the synthesis of 6-enaminopurine derivatives by catalytic hydrogenation of 6-cyanomethylenepurines

T. Miyasaka, N. Hamamichi, 1985 .

Antitumor Activity of 7-Ethyl-10-(4-(l-piperidino)-l-piperidino)carbonyloxy- camptothecin, a Novel Water-soluble Derivative of Camptothecin, against

T. Yokokura, T. Miyasaka, T. Kunimoto, 1987 .

Action of 7-ethylcamptothecin on tumor cells and its disposition in mice.

S. Sawada, T. Furuta, T. Yokokura, 1987, Cancer treatment reports.

Palladium-catalyzed cross-coupling of 2-iodoadenosine with terminal alkynes: synthesis and biological activities of 2-alkynyladenosines.

A. Matsuda, T. Miyasaka, H. Machida, 1985, Chemical & pharmaceutical bulletin.

PALLADIUM-CATALYZED CROSS-COUPLING OF 2-IODOADENOSINE WITH TERMINAL ALKYNES: SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 2-ALKYNYLADENOSINES

A. Matsuda, T. Miyasaka, H. Machida, 1985 .

The synthesis of 6-C-substituted 9-methoxymethylpurine derivatives

T. Miyasaka, N. Hamamichi, 1990 .

Studies of heterocyclic compounds. VIII. Synthesis and tautomerism of 2-hydroxypyrazolo(1,5-a)pyridine.

T. Miyasaka, H. Ochi, K. Arakawa, 1976 .

STUDIES OF HETEROCYCLIC COMPOUNDS. VIII. SYNTHESIS AND TAUTOMERISM OF 2-HYDROXYPYRAZOLO(1,5-A)PYRIDINE

T. Miyasaka, H. Ochi, K. Arakawa, 1976 .

Studies of Heterocyclic Compounds. I. Structures of Acetylated Products of 3-Methylpyrazol-5-one

T. Miyasaka, H. Ochi, K. Arakawa, 1974 .

STUDIES OF HETEROCYCLIC COMPOUNDS. VII. THE REACTIONS OF 5,6‐DIHYDROTHIAZOLO(2,3‐B)THIAZOLIUM SALTS WITH CARBANIONS

T. Miyasaka, K. Arakawa, H. Ohtsuka, 1976 .

Studies of Heterocyclic Compouds. XII. Structures of Acetylated Products of 5-Hydroxy-4-(2-hydroxyethyl)-3-methylpyrazole

T. Miyasaka, H. Ochi, K. Arakawa, 1977 .

STUDIES OF HETEROCYCLIC COMPOUNDS PART 1, STRUCTURES OF ACETYLATED PRODUCTS OF 3-METHYLPYRAZOL-5-ONE

T. Miyasaka, H. Ochi, K. Arakawa, 1974 .

Studies of Heterocyclic Compounds. V. Synthesis of 5,6-Dihydrothiazolo-[2,3-b] thiazolium Salts and Their Reactions with Amines. A New Synthesis of 2-Aminothiazoles

T. Miyasaka, H. Toyofuku, K. Arakawa, 1975 .

A New Entry to 2‐Substituted Purine Nucleosides Based on Lithiation‐Mediated Stannyl Transfer of 6‐Chloropurine Nucleosides.

S. Shuto, H. Hayakawa, T. Miyasaka, 1998 .