R. Carling

发表

Heat capacities of NaNO3 and KNO3 from 350 to 800 K

Robert W. Carling, R. Carling, 1983 .

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

P D Leeson, J. Kemp, P. Leeson, 1997, Journal of medicinal chemistry.

Cellular basis for bimatoprost effects on human conventional outflow.

W. Stamer, S. Pettit, R. Carling, 2010, Investigative ophthalmology & visual science.

A Heat Pump and Thermal Storage System for Solar Heating and Cooling Based on the Reaction of Calcium Chloride and Methanol Vapor

F. C. Brown, R. W. Mar, R. W. Carling, 1980 .

Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers

Desmond O'Connor, G. Dawson, J. Atack, 2004 .

Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist

Sandra M. Sanabria-Bohórquez, G. Bormans, K. Van Laere, 2011, Journal of psychopharmacology.

4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.

P. Leeson, A. Foster, S. Grimwood, 1992, Journal of medicinal chemistry.

Synthesis of medium ring ethers. Part 2. Synthesis of the fully saturated carbon skeleton of Laurencia non-terpenoid ether metabolites containing seven-, eight- and nine-membered rings

A. Holmes, J. S. Clark, R. Carling, 1992 .

Synthetic methodology for the preparation of trans- and cis-2,9-disubstituted oxonanes

A. Holmes, R. Carling, N. Curtis, 1989 .

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.

J. Kemp, P. Leeson, Brett Williams, 1991, Journal of medicinal chemistry.

Synthesis of medium ring ethers. Part 3. Disproof of the proposed 2,8-disubstituted oxocane structure for gloeosporone. Synthesis of pseudo-gloeosporone

A. Holmes, D. Sartor, J. S. Clark, 1992 .

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II.

G. Meneses‐Lorente, M. Rigby, K. Tsao, 2006, Bioorganic & medicinal chemistry letters.

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

G. Dawson, S. Tye, R. Mckernan, 2006, Journal of Pharmacology and Experimental Therapeutics.

The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products.

S. Pettit, R. Carling, C. Cornell, 2008, Pharmacology & therapeutics.

Studies on the synthesis of gloeosporone - synthesis of the proposed 2,8-disubstituted oxocane structure

A. Holmes, R. Carling, 1986 .

Synthesis of Medium Ring Ethers. Part 13. Disproof of the Proposed 2,8‐ Disubstituted Oxocane Structure for Gloeosporone. Synthesis of pseudo‐ Gloeosporone.

A. Holmes, D. Sartor, J. S. Clark, 1992 .

Synthesis of iminomethano-dibenzo[a,e]cyclooctenes by transannular formation and cleavage of isoxazolidines

P. Leeson, R. Carling, 1988 .

A new synthesis of eight-membered lactones containing a 5,6-double bond

A. Holmes, R. Carling, 1986 .

A Second Generation Prostanoid Receptor Antagonist Acting at Multiple Receptor Subtypes.

M. Lawrence, L. Waterbury, S. Pettit, 2020, ACS pharmacology & translational science.

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

G. Dawson, R. Mckernan, A. Pike, 2004, Journal of medicinal chemistry.

Microstructural changes in coal during low temperature ashing

R. Allen, R. Carling, J. Vandersande, 1986 .

Synthetic Methodology for the Preparation of trans- and cis-2,9-Disubstituted Oxonanes.

A. Holmes, R. Carling, N. Curtis, 1990 .

Synthesis of Medium Ring Ethers. Part 2. Synthesis of the Fully Saturated Carbon Skeleton of Laurencia Non‐Terpenoid Ether Metabolites Containing Seven‐, Eight‐ and Nine‐Membered Rings.

A. Holmes, J. S. Clark, R. Carling, 1992 .

Direct conversion of N-methoxy-N-methylamides (Weinreb amides) to ketones via a nonclassical Wittig reaction.

R. Carling, John A. Murphy, T. McGuire, 2005, Organic letters.

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.

Karen S. Curley, R. Mckernan, J. Atack, 2004, Bioorganic & medicinal chemistry letters.

3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

G. Dawson, P. Leeson, R. Mckernan, 2004 .

3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

G. Dawson, P. Leeson, R. Mckernan, 2004, Journal of medicinal chemistry.

Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines.

J. Kemp, P. Leeson, M. Tricklebank, 1993 .

2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the NMDA receptor.

J. Kemp, P. Leeson, A. Foster, 1992, Journal of medicinal chemistry.

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.

R. Mckernan, J. Atack, K. Wafford, 2005, Journal of medicinal chemistry.

3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

J. Kemp, P. Leeson, C. Moyes, 1993, Journal of medicinal chemistry.

Fragmentation of nitrone triflates to 9-membered rings.

M. Mahesh, R. Carling, John A. Murphy, 2007, Organic letters.

Synthesis of pyrido[2,3-d]pyridazines and pyrazino[2,3-d]-pyridazines—novel classes of GABAA receptor benzodiazepine binding site ligands

R. Lewis, R. Carling, S. Bourrain, 2006 .

Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists

J. Kemp, P. Leeson, I. Stansfield, 1993 .

Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.

J. Kemp, P. Leeson, A. Foster, 1992, Molecular pharmacology.

Characterization of the binding of [3H]L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes.

P. Leeson, A. Foster, S. Grimwood, 1992, Molecular pharmacology.

4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.

J. Kemp, P. Leeson, M. Hudson, 1997, Journal of medicinal chemistry.

Thermophysics of alkali and related azides II. Heat capacities of potassium, rubidium, cesium, and thallium azides from 5 to 350 K,

E. Westrum, R. Carling, E. F. Westrum, 1978 .

Heat capacity investigation of dopant effects on the magnetic disordering temperature in Fe3O4

R. Carling, 1979 .

Hydrogen bonding. II. Complex fluoride salts of arylammonium ions

R. Carling, K. Harmon, Susan L. Madeira, 1974 .

HYDROGEN BONDING PART 2, COMPLEX FLUORIDE SALTS OF ARYLAMMONIUM IONS

R. Carling, K. Harmon, Susan L. Madeira, 1974 .

Thermophysics of alkali and related azides I. Heat capacity of NaN3 from 5 to 350 K

E. Westrum, R. Carling, 1976 .

Thermodynamics of the monohydrogen difluorides V. Melting thermodynamics of NH4HF2

E. Westrum, R. Carling, 1976 .

The calcium chloride—ethanol system

R. W. Mar, R. Carling, 1981 .

A review of the chemical and physical properties of molten alkali nitrate salts and their effect on materials used for solar central receivers

R. W. Bradshaw, R. Bradshaw, R. W. Carling, 1987 .

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

R. Mckernan, P. Whiting, J. Atack, 2000, Nature Neuroscience.

4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.

P. Leeson, M. Rowley, S. Patel, 1999, Bioorganic & medicinal chemistry letters.

7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.

G. Dawson, R. Mckernan, A. Pike, 2005, Journal of medicinal chemistry.

An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.

G. Dawson, J. Atack, D. O'connor, 2004, Journal of medicinal chemistry.

1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.

P. Leeson, A. Pike, C. Moyes, 1999, Journal of medicinal chemistry.

Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.

S. Tye, A. Pike, J. Atack, 2006, Journal of medicinal chemistry.

FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug.

R. Vitale, P. Amodeo, G. Marino, 2018, ACS chemical neuroscience.

Dissociation pressures and enthalpies of reaction in MgCl2 · nH2O and CaCl2 · nNH3☆

R. Carling, 1981 .

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.

M. Rigby, K. Tsao, F. Murray, 2006, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

A. Pike, J. Atack, K. Wafford, 2006 .

2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: Functionally selective GABAA α3-subtype agonists

J. Atack, K. Wafford, L. Street, 2006 .

Imidazo[1,2-a]pyrazin-8-ones, Imidazo[1,2-d][1,2,4]triazin-8-ones and Imidazo[2,1-f][1,2,4]triazine-8-ones as α2/α3 Subtype Selective GABAA Agonists for the Treatment of Anxiety.

A. Pike, J. Atack, K. Wafford, 2006 .

Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone.

R. Carling, R. Kobylecki, C. Smith, 1982, Journal of medicinal chemistry.

Multitargeting of selected prostanoid receptors provides agents with enhanced anti‐inflammatory activity in macrophages

L. Marnett, P. Kingsley, R. Carling, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Anticonvulsant activity of glycine-site NMDA antagonists: 1. 2-Carboxyl prodrugs of 5,7-dichlorokynurenic acid

P. Leeson, R. Carling, K. Moore, 1993 .

Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel.

E. Wong, P. Leeson, R. Carling, 1990, Journal of Medicinal Chemistry.

In vivo studies validating multitargeting of prostanoid receptors for achieving superior anti‐inflammatory effects

M. Ni, R. Carling, J. Martos, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.