Anne-Sophie Cornec

发表

Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies

J. Trojanowski, V. Lee, Amos B. Smith, 2014, Journal of medicinal chemistry.

Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies.

J. Trojanowski, V. Lee, A. Brancale, 2021, Journal of medicinal chemistry.

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.

J. Trojanowski, V. Lee, Michael J. James, 2018, Bioorganic & Medicinal Chemistry Letters.

brain-penetrant enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.

Virginia M. Y. Lee, J. Trojanowski, Amos B. Smith, 2018 .

Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies

J. Trojanowski, V. Lee, Amos B. Smith, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine.

J. Trojanowski, V. Lee, Amos B. Smith, 2015, Bioorganic & medicinal chemistry letters.

Rod-like conjugated molecules with ethynylene linkage and pyridazines moieties: synthesis and light emitting properties

Anne-Sophie Cornec, Y. Ramondenc, C. Hadad, 2010 .

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer’s and Other Neurodegenerative Diseases

J. Trojanowski, V. Lee, Amos B. Smith, 2017, Journal of medicinal chemistry.

One “Click” to Access Push–Triazole–Pull Fluorophores Incorporating a Pyrimidine Moiety: Structure–Photophysical Properties Relationships

Anne-Sophie Cornec, Y. Ramondenc, G. Dupas, 2013 .

Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro.

Amos B. Smith, C. Caffrey, K. Brunden, 2020, ACS infectious diseases.

Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists.

J. Trojanowski, V. Lee, A. Brancale, 2014, ACS medicinal chemistry letters.

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

J. Trojanowski, V. Lee, Amos B. Smith, 2018, Molecular Neurodegeneration.

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

J. Trojanowski, V. Lee, Amos B. Smith, 2018, Molecular Neurodegeneration.

Microtubule-Stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal New Structure–Activity Insights

Virginia M. Y. Lee, A. Brancale, Amos B. Smith, 2022, Journal of medicinal chemistry.

Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies

J. Trojanowski, V. Lee, Amos B. Smith, 2016, The Journal of Pharmacology and Experimental Therapeutics.