C. Lin

发表

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

H. Rosenkranz, E. ter Haar, B. Day, 1996, Biochemistry.

Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.

K D Paull, K. Paull, E. Hamel, 1992, Cancer research.

Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

E. Hamel, C. Lin, G. Pettit, 1988, Molecular pharmacology.

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.

E. Hamel, C. Lin, G. Pettit, 1989, Biochemistry.

Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.

A. McPhail, K. Lee, E. Hamel, 1993, Journal of medicinal chemistry.

Direct incorporation of guanosine 5'-diphosphate into microtubules without guanosine 5'-triphosphate hydrolysis.

E. Hamel, J. Batra, C. Lin, 1986, Biochemistry.

Glutamate-induced polymerization of tubulin: characteristics of the reaction and application to the large-scale purification of tubulin.

E. Hamel, C. Lin, Chii M. Lin, 1981, Archives of biochemistry and biophysics.

Bivalent ACTH antagonists: influence of peptide and spacer components on potency enhancement.

C. Lin, G. Sarath, R. J. Krueger, 1991, Biochemical pharmacology.

Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers.

R. D'Amato, E. Flynn, E. Hamel, 1996, Biochemistry.

Degradation of di-butyl-phthalate by soil bacteria.

C. Lin, W. Chao, I. Shiung, 2006, Chemosphere.

Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin.

E. Hamel, C. Lin, Chii M. Lin, 1983, Biochemical pharmacology.

Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

T. Liu, E. Hamel, C. Lin, 1989, Biochemistry.

Maytansine inhibits nucleotide binding at the exchangeable site of tubulin.

A. B. Huang, E. Hamel, C. Lin, 1985, Biochemical and biophysical research communications.

Modulation of tubulin-nucleotide interactions by microtubule-associated proteins: polymerization with ribose-modified analogues of guanosine 5'-triphosphate.

E. Hamel, C. Lin, J. Lustbader, 1983, Biochemistry.

Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure. Interactions with tubulin.

E. Hamel, C. Lin, H. Ho, 1988, Biochemical pharmacology.

Anticonvulsant activity of 2- and 3-aminobenzanilides.

C. R. Clark, C. Lin, R. T. Sansom, 1986, Journal of medicinal chemistry.

Anticonvulsant activity of some 4-aminobenzanilides.

C. R. Clark, C. Lin, R. T. Sansom, 1985, Journal of medicinal chemistry.

Effects of organic acids on tubulin polymerization and associated guanosine 5'-triphosphate hydrolysis.

E. Hamel, C. Lin, M. Lowe, 1982, Biochemistry.

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).

P. Giannakakou, D. Kingston, C. Fairchild, 1998, Journal of medicinal chemistry.

Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles.

E. Hamel, C. Lin, C. Lin, 1984, Biochemistry.

Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)-one.

E. Hamel, R. Luduena, J. B. Jiang, 1991, Molecular pharmacology.

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

M. Cushman, E. Hamel, C M Lin, 1992, Journal of medicinal chemistry.

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Ernest Hamel, A. Chakraborti, M. Cushman, 1991, Journal of medicinal chemistry.

Distribution of 64Cu in Saccharomyces cerevisiae: cellular locale and metabolism.

D. Kosman, C. Lin, B. Crawford, 1993, Journal of general microbiology.

Distribution of 64Cu in Saccharomyces cerevisiae: kinetic analyses of partitioning.

D. Kosman, C. Lin, B. Crawford, 1993, Journal of general microbiology.

Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin.

K. Paull, J. Plowman, K. Lee, 1996, Biochemical pharmacology.

Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.

Y. P. Sachdeva, J. Katzenellenbogen, M. Cushman, 1997, Journal of medicinal chemistry.

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

J. Katzenellenbogen, M. Cushman, E. Hamel, 1995, Journal of medicinal chemistry.

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.

K. Paull, S. Kuo, H. Lee, 1993, Journal of medicinal chemistry.

Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.

S. Kuo, A. Mauger, K. Lee, 1997, Journal of medicinal chemistry.

Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, D. Lednicer, K. Lee, 1994, Journal of medicinal chemistry.

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

D. Alberts, E. Hamel, Sheo B. Singh, 1989, Experientia.

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

E. Hamel, L. Jurd, C. Lin, 1992, Journal of medicinal chemistry.

Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.

A. Brossi, E. Hamel, C. Lin, 1990, Journal of medicinal chemistry.

Differential effects of magnesium on tubulin-nucleotide interactions.

A. B. Huang, E. Hamel, C. Lin, 1985, Biochimica et biophysica acta.

Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum.

E. Hamel, G R Pettit, S B Singh, 1988, Journal of natural products.

Characterization of melA: a gene encoding melanin biosynthesis from the marine bacterium Shewanella colwelliana.

D. Stein, W. Fuqua, R. Weiner, 1991, Gene.

Synthesis and biological activity of A-nor-paclitaxel analogues.

D. Kingston, M. Chordia, E. Hamel, 1997, Bioorganic & medicinal chemistry.

Synthesis and properties of sulfhydryl-group-specific reagents containing 125I.

C. Lin, J. A. Frank, R. Krueger, 1991, Analytical biochemistry.

Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.

M. Cushman, E. Hamel, C. Lin, 1993, Journal of medicinal chemistry.

Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, A. Mauger, K. Lee, 1997, Journal of medicinal chemistry.

Stabilization of the colchicine-binding activity of tubulin by organic acids.

E. Hamel, C. Lin, 1981, Biochimica et biophysica acta.

Tubulin-dependent biochemical assay for the antineoplastic agent taxol and application to measurement of the drug in serum.

E. Hamel, C. Lin, D. Johns, 1982, Cancer treatment reports.

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

R. D'Amato, J. Folkman, E. Flynn, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Interactions of taxol, microtubule-associated proteins, and guanine nucleotides in tubulin polymerization.

E. Hamel, C M Lin, E Hamel, 1981, The Journal of biological chemistry.

Microtubule assembly with the guanosine 5'-diphosphate analogue 2',3'-dideoxyguanosine 5'-diphosphate.

E. Hamel, C. Lin, A. D. del Campo, 1983, Biochemistry.

Interrelationships of tubulin-GDP and tubulin-GTP in microtubule assembly.

E. Hamel, C. Lin, C. Lin, 1987, Biochemistry.

Guanosine 5'-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly.

E. Hamel, C. Lin, C. Lin, 1984, The Journal of biological chemistry.

Effects of inhibitors of tubulin polymerization on GTP hydrolysis.

E. Hamel, C M Lin, E Hamel, 1981, The Journal of biological chemistry.

Copper uptake in wild type and copper metallothionein-deficient Saccharomyces cerevisiae. Kinetics and mechanism.

D. Kosman, C. Lin, C. Lin, 1990, The Journal of biological chemistry.

Effects of pH on tubulin-nucleotide interactions.

A B Huang, A. B. Huang, E. Hamel, 1986, Archives of biochemistry and biophysics.

Deoxyguanosine nucleotide analogues: potent stimulators of microtubule nucleation with reduced affinity for the exchangeable nucleotide site of tubulin.

E. Hamel, C. Lin, J. Lustbader, 1984, Biochemistry.

Interactions of a new antimitotic agent, NSC-181928, with purified tubulin.

E. Hamel, C. Lin, 1982, Biochemical and biophysical research communications.

N-iodoacetyltyramine: preparation and use in 125I labeling by alkylation of sulfhydryl groups.

C. Lin, K. Mihal, R. Krueger, 1989, Analytical biochemistry.

Introduction of sulfhydryl groups into proteins at carboxyl sites.

C. Lin, K. Mihal, R. Krueger, 1990, Biochimica et biophysica acta.

Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra.

T. Konoshima, E. Hamel, M. Kozuka, 1995, Journal of Natural Products.

Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.

S. Kuo, A. Mauger, K. Lee, 1994, Journal of medicinal chemistry.

Two new cytotoxic chalcones from Calythropsis aurea.

M. Boyd, R. Shoemaker, G. Cragg, 1993, Journal of natural products.

Tubulin polymerization with ATP is mediated through the exchangeable GTP site.

C. Duanmu, E. Hamel, C. Lin, 1986, Biochimica et biophysica acta.

Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.

K. Lee, E. Hamel, C. Lin, 1993, Journal of medicinal chemistry.

Reexamination of the role of nonhydrolyzable guanosine 5'-triphosphate analogues in tubulin polymerization: reaction conditions are a critical factor for effective interactions at the exchangeable nucleotide site.

E. Hamel, C. Lin, 1990, Biochemistry.

Interactions of tubulin with guanine nucleotides that have paclitaxel-like effects on tubulin assembly: 2',3'-dideoxyguanosine 5'-[alpha,beta-methylene]triphosphate, guanosine 5'-[alpha,beta-methylene]triphosphate, and 2',3'-dideoxyguanosine 5'-triphosphate.

E. Hamel, C. Lin, Z. Getahun, 1995, Archives of biochemistry and biophysics.

Stability of tubulin polymers formed with dideoxyguanosine nucleotides in the presence and absence of microtubule-associated proteins.

E. Hamel, C. Lin, A. D. del Campo, 1984, The Journal of biological chemistry.

Highly variable effects of beryllium and beryllium fluoride on tubulin polymerization under different reaction conditions: comparison of assembly reactions dependent on microtubule-associated proteins, glycerol, dimethyl sulfoxide, and glutamate.

P. Skehan, S. Kenney, E. Hamel, 1991, Archives of biochemistry and biophysics.

Modulation of tubulin-nucleotide interactions by metal ions: comparison of beryllium with magnesium and initial studies with other cations.

P. Skehan, S. Kenney, E. Hamel, 1992, Archives of biochemistry and biophysics.

Nucleotide interconversions in microtubule protein preparations, a significant complication for accurate measurement of GTP hydrolysis in the presence of adenosine 5'-(beta, gamma-imidotriphosphate).

E. Hamel, J. Batra, C. Lin, 1987, Biochemistry.

Inhibition of tubulin polymerization with ribose-modified analogs of GDP and GTP. Reduced inhibition with microtubule-associated proteins and magnesium.

E. Hamel, C. Lin, C. Lin, 1984, Biochimica et biophysica acta.

Interaction of tubulin with ribose-modified analogs of GTP and GDP: evidence for two mutually exclusive exchangeable nucleotide binding sites.

E. Hamel, C. Lin, 1981, Proceedings of the National Academy of Sciences of the United States of America.