J. Hadfield

发表

Tubulin as a Target for Anticancer Drugs: Agents which Interact with the Mitotic Spindle

N. Lawrence, A. Jordan, A. McGown, 1998 .

Tubulin and microtubules as targets for anticancer drugs.

John A Hadfield, A. McGown, Alan T McGown, 2003, Progress in cell cycle research.

Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature.

D. J. Edwards, J. Hadfield, S. Ducki, 2011, Organic & biomolecular chemistry.

Antimitotic activity of diaryl compounds with structural features resembling combretastatin A‐4

J. Hadfield, Krzysztof Aleksandrzak Alan T McGown, 1998, Anti-cancer drugs.

Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.

N. Lawrence, A. McGown, J. Hadfield, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and anticancer activities of 4-oxobenzopyrano[2,3-d]pyrimidines.

A. McGown, J. Hadfield, P. J. Perry, 1999, Anti-cancer drugs.

Isoflavones inhibit intestinal epithelial cell proliferation and induce apoptosis in vitro

C. Potten, C. Booth, A. McGown, 1999, British Journal of Cancer.

Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin

S. Botchway, G. M. Greetham, A. Parker, 2014 .

Microwave-Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents

P. Ragazzon, J. Hadfield, A. Ragazzon-Smith, 2018, Letters in Organic Chemistry.

Functional comparison of annexin V analogues labeled indirectly and directly with iodine-124.

P. Julyan, A. Reader, A. Watson, 2005, Nuclear medicine and biology.

The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo.

D. Crowther, M. Lind, N. Thatcher, 1989, Biochemical pharmacology.

The interaction with tubulin of a series of stilbenes based on combretastatin A-4.

G. Pettit, J. Woods, A. McGown, 1995, British Journal of Cancer.

Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle

N. Lawrence, A. Jordan, A. McGown, 1998, Medicinal research reviews.

Biochemistry of topoisomerase I and II inhibition by anthracenyl-amino acid conjugates.

J. S. Macpherson, J. Cummings, J. Smyth, 1995, Biochemical pharmacology.

Facile synthesis and biological evaluation of chrysin derivatives

P. Ragazzon, J. Hadfield, H. Foster, 2021, Journal of Chemical Research.

Time-resolved nanosecond fluorescence lifetime imaging and picosecond infrared spectroscopy of combretastatin A-4 in solution and in cellular systems

S. Botchway, G. M. Greetham, A. Parker, 2012 .

Synthesis of Cytotoxic Pyrrolo[1,2-a]-benzimidazol-1-ones

J. Hadfield, V. H. Pavlidis, J. Roffey, 1995 .

Potent antimitotic and cell growth inhibitory properties of substituted chalcones.

N. Lawrence, A. McGown, J. Hadfield, 1998, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.

Jan Balzarini, John A Hadfield, Andrea Brancale, 2007, Journal of medicinal chemistry.

The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.

N. Lawrence, A. McGown, J. Hadfield, 2003, Bioorganic & medicinal chemistry letters.

Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?

N. Lawrence, A. McGown, J. Hadfield, 2003, Organic & biomolecular chemistry.

PREPARATION OF NATURALLY OCCURRING ANTHRAQUINONES

B. Fox, J. Hadfield, X.G. Zhang, 1996 .

Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle

N. Lawrence, A. Jordan, A. McGown, 1998, Medicinal research reviews.

Spirodienones. Part 5. The synthesis and reactions of N-sulphonylcyclohexadienimines

J. Hadfield, V. H. Pavlidis, I. Coutts, 1985 .

Novel syntheses of cis and trans isomers of combretastatin A-4.

N. Lawrence, A. McGown, J. Hadfield, 2001, The Journal of organic chemistry.

Expanding the scope of the Babler–Dauben oxidation: 1,3-oxidative transposition of secondary allylic alcohols

Steven B. Rossington, J. Hadfield, J. Wilkinson, 2016 .

Reaction of Baylis–Hillman products with Swern and Dess–Martin oxidants

N. Lawrence, A. McGown, J. Hadfield, 2001 .

Synthesis and evaluation of double bond substituted combretastatins.

N. Lawrence, A. McGown, J. Hadfield, 2005, European journal of medicinal chemistry.

A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone

A. McGown, J. Hadfield, J. Butler, 2000 .

Synthesis and anticancer activity of fluorinated analogues of combretastatin A-4

N. Lawrence, A. McGown, J. Hadfield, 2003 .

Fluorescence lifetime imaging of E-combretastatin uptake and distribution in live mammalian cells.

S. Botchway, A. Parker, A. McGown, 2012, European journal of cancer.

Novel syntheses of cis and trans isomers of combretastatin A-4.

N. Lawrence, A. McGown, J. Hadfield, 2001, The Journal of organic chemistry.

Cytotoxic michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone

N. Lawrence, A. McGown, J. Hadfield, 2001 .

Isolation of aurantiamide acetate from Arisaema erubescens.

N. Lawrence, A. McGown, J. Hadfield, 1996, Planta medica.

Synthesis of cytotoxic furonaphthoquinones: Regiospecific synthesis of diodantunezone and 2-ethylfuronaphthoquinones.

J. Hadfield, P. J. Perry, V. H. Pavlidis, 1997 .

Synthesis of water-soluble sugar derivatives of combretastatin A-4

J. Woods, A. McGown, B. Fox, 1995 .

Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization

Kathrin M Scherer, Roger H Bisby, Stanley W Botchway, 2014, Journal of biomedical optics.

The Synthesis of (E) and (Z)-Combretastatins A-4 and a Phenanthrene from Combretum caffrum

N. Lawrence, A. McGown, J. Hadfield, 1999 .

Linked parallel synthesis and MTT bioassay screening of substituted chalcones.

N. Lawrence, A. McGown, J. Hadfield, 2001, Journal of combinatorial chemistry.

A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.

A. Parker, P. Ragazzon, J. Hadfield, 2020, Bioorganic & medicinal chemistry.

Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.

Steven B. Rossington, J. Hadfield, Nicholas Hirst, 2012, Bioorganic & medicinal chemistry letters.

Isolation of paeonol from Arisaema erubescens.

N. Lawrence, A. McGown, J. Hadfield, 1995, Planta medica.

Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies

H. Kitchener, I. Hampson, L. Hampson, 2009, British Journal of Cancer.

Comparison of different busulfan analogues for depletion of hematopoietic stem cells and promotion of donor-type chimerism in murine bone marrow transplant recipients.

M. Dawson, A. McGown, J. Down, 2000, Cancer research.

Tubulin-binding dibenz[c,e]oxepines: Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents.

Steven B. Rossington, K. Williams, S. Shnyder, 2017, Bioorganic & medicinal chemistry.

Syntheses of Combretastatin A‐4 and Related Stilbenes by Using Aqueous Conditions

P. Ragazzon, J. Hadfield, N. Barnes, 2021, ChemistrySelect.

Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4

John A. Hadfield, Alan T. McGown, D. Hastings, 1999, European Journal of Nuclear Medicine.

Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation

Kathrin M Scherer, Roger H Bisby, Stanley W Botchway, 2015, Journal of biomedical optics.

Isolation of E-1-(4'-Hydroxyphenyl)-but-1-en-3-one from Scutellaria barbata.

N. Lawrence, A. McGown, J. Hadfield, 1996, Planta medica.

Synthesis and cell growth inhibitory properties of substituted (E)-1-phenylbut-1-en-3-ones

N. Lawrence, A. McGown, J. Hadfield, 1997 .

Fluorescence lifetime imaging of

S. Botchway, A. Parker, A. McGown, 2018 .

The suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump: an HPLC-dynamic FAB study.

N. Thatcher, M. Dawson, A. McGown, 1993, Journal of pharmaceutical and biomedical analysis.

Efficient regiospecific synthesis of two cytotoxic furonaphthoquinones, 5,7-dimethoxy-4,9-dihydronaphtho[2,3-b]furan-4,9-dione and 5,6,7-trimethoxy-4,9-dihydronaphtho[2,3-b]furan-4,9-dione

J. Hadfield, P. J. Perry, V. H. Pavlidis, 1995 .

Molecular modeling of the interaction of anthracenyl-amino acid topoisomerase inhibitors with the DNA sequence d(CGTACG)

J. Cummings, J. Smyth, A. McGown, 1996, Anti-cancer drugs.

An elimination–rearrangement of ribulose-1,5-bisphosphate with implications for riboflavin biosynthesis

J. Hadfield, D. Crout, 1987 .

Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides.

J. Woods, A. McGown, B. Fox, 1993, Bioorganic & medicinal chemistry.

PREPARATION AND EVALUATION OF DIARYLALKYNES AS ANTITUMOUR AGENTS

A. McGown, J. Hadfield, 1998 .

The interaction of chalcones with tubulin.

N. Lawrence, A. McGown, J. Hadfield, 2000, Anti-cancer drug design.

Tubulin-binding dibenz[c,e]oxepines: Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents.

Steven B. Rossington, S. Shnyder, J. Hadfield, 2017, Bioorganic & medicinal chemistry.

Synthesis and anticancer activity of fluorinated analogues of combretastatin A-4

N. Lawrence, A. McGown, J. Hadfield, 2003 .

ChemInform Abstract: Potent Antimitotic and Cell Growth Inhibitory Properties of Substituted Chalcones.

Alex Kendall, N. Lawrence, A. McGown, 1998 .