G. Zhu

发表

Targeting serine/threonine protein kinase B/Akt and cell-cycle checkpoint kinases for treating cancer.

Qun Li, G. Zhu, 2002, Current topics in medicinal chemistry.

Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.

V. Stoll, Eric F. Johnson, X. Liu, 2007, Bioorganic & medicinal chemistry.

The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo.

Eric F. Johnson, X. Liu, V. Giranda, 2008, Anticancer research.

Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks

Eric F. Johnson, X. Liu, V. Giranda, 2008, Molecular Cancer Research.

Synthesis, biological activity, and conformational analysis of four seco-D-15,19-bisnor-1alpha,25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20.

R. Bouillon, A. Verstuyf, G. Zhu, 1999, Journal of medicinal chemistry.

Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.

V. Stoll, Eric F. Johnson, X. Liu, 2006, Bioorganic & medicinal chemistry letters.

Conformationally restricted mimics of vitamin D rotamers

A. Norman, W. Okamura, Thong Vu, 2001, Steroids.

ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors

P. Ellis, X. Liu, V. Giranda, 2009, Clinical Cancer Research.

A facile and general synthesis of 2,4‐Di‐ and 2,4,7‐trisubstituted thieno[2,3‐c]pyridines

G. Zhu, S. Boyd, W. GunawardanaIndrani, 2008 .

SCANDIUM-MEDIATED OPENING OF AZIRIDINE CARBOXYLATES : A FACILE SYNTHESIS OF ARYL SUBSTITUTED TRYPTOPHANS

G. Zhu, Y. Bennani, J. Freeman, 1998 .

Synthesis of CD-ring modified 1alpha,25-dihydroxy vitamin D analogues: C-ring analogues

R. Bouillon, A. Verstuyf, P. D. Clercq, 1996 .

11-fluoro-1α-hydroxyvitamin D3: The quest for experimental evidence of the folded vitamin D conformation

P. D. Clercq, G. Zhu, D. Haver, 1994 .

Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.

V. Stoll, Eric F. Johnson, X. Liu, 2006, Bioorganic & medicinal chemistry letters.

Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.

L. Kifle, K. Marsh, G. Zhu, 2001, Journal of medicinal chemistry.

Synthesis of Vitamin D (Calciferol)

W. Okamura, G. Zhu, 1995 .

Synthesis of Vitamin D (Calciferol)

W. Okamura, G. Zhu, 1995 .

Synthesis of CD‐Ring Modified 1α,25‐Dihydroxy Vitamin D Analogues: C‐Ring Analogues.

R. Bouillon, A. Verstuyf, P. D. Clercq, 1996 .

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.

Eric F. Johnson, X. Liu, V. Giranda, 2006, Bioorganic & medicinal chemistry.

Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.

Eric F. Johnson, X. Liu, V. Giranda, 2010, Journal of medicinal chemistry.

Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways

Eric F. Johnson, X. Liu, V. Giranda, 2009, Molecular Cancer Research.

ABT-888 , an OrallyActive Poly ( ADP-Ribose ) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in PreclinicalTumorModels

Eric F. Johnson, T. DeWeese, X. Liu, 2007 .

Synthesis and mode of action of (125)I- and (3)H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression.

G. Zhu, S. Boyd, G. Okasinski, 2002, The Journal of organic chemistry.

Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer.

P. Ellis, Eric F. Johnson, X. Liu, 2012, Bioorganic & medicinal chemistry.

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Eric F. Johnson, T. DeWeese, X. Liu, 2007, Clinical Cancer Research.

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.

Eric F. Johnson, X. Liu, V. Giranda, 2008, Bioorganic & medicinal chemistry.

Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.

Eric F. Johnson, X. Liu, V. Giranda, 2008, Bioorganic & medicinal chemistry letters.

Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.

Eric F. Johnson, X. Liu, V. Giranda, 2009, Journal of medicinal chemistry.

Intramolecular Diels-Alder Reaction of 8-Trifluoromethyl-1,3,8-Nona-Trienes: An Access to Angular Trifluoromethylated Hydrindenes

P. D. Clercq, Guo-Dong Zhu, G. Zhu, 2010 .

Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.

V. Stoll, Eric F. Johnson, X. Liu, 2006, Bioorganic & medicinal chemistry letters.

Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.

Eric F. Johnson, X. Liu, V. Giranda, 2006, Bioorganic & medicinal chemistry letters.

Discovery and SAR of Oxindole—Pyridine-Based Protein Kinase B/Akt Inhibitors for Treating Cancers.

G. Zhu, Gui‐Dong Zhu, 2006 .

Rationale for the combination of veliparib with platinum-based chemotherapy.

Eric F. Johnson, T. Penning, E. DiGiammarino, 2015 .

Biological Activity of CD‐Ring Modified 1α,25‐Dihydroxyvitamin D Analogues: C‐Ring and Five‐Membered D‐Ring Analogues

M. Haussler, C. Mathieu, R. Bouillon, 2000 .

Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naïve Patients With Obsessive-Compulsive Disorder

Ping Li, Qiang Hu, Sufang Li, 2018, Front. Neurosci..

Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.

V. Stoll, G. Gintant, Eric F. Johnson, 2007, Journal of medicinal chemistry.

Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.

K. Longenecker, T. Penning, Y. Tong, 2021, ACS medicinal chemistry letters.

Chemistry and design: structural biology of vitamin D action

D. Feldman, W. Okamura, G. Zhu, 1997 .

Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.

Eric F. Johnson, X. Liu, V. Giranda, 2009, Journal of medicinal chemistry.