Khaled R. A. Abdellatif

发表

New indomethacin analogs as selective COX‐2 inhibitors: Synthesis, COX‐1/2 inhibitory activity, anti‐inflammatory, ulcerogenicity, histopathological, and docking studies

Khaled R. A. Abdellatif, Eman K. A. Abdelall, H. A. Elshemy, 2020, Archiv der Pharmazie.

New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.

Emad H M Hassanein, Khaled R. A. Abdellatif, W. A. Fadaly, 2020, Bioorganic chemistry.

Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as Safe Anti-Inflammatory, Analgesic, Antipyretic, Antioxidant Prodrugs

K. Kashfi, L. Keefer, M. Chattopadhyay, 2010, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities

Khaled R. A. Abdellatif, Eman K. A. Abdelall, H. Abdel-Rahman, 2019, BMC Chemistry.

Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.

J. Reisz, Khaled R. A. Abdellatif, Jenna F Dumond, 2011, Journal of medicinal chemistry.

Synthesis of some benzoxazole derivatives and their anti-inflammatory evaluation

Khaled R. A. Abdellatif, A. Mohammedb, 2016 .

Synthesis, Cyclooxygenase Inhibition, Anti‐Inflammatory Evaluation, and Ulcerogenic Liability of New 1,3,5‐Triarylpyrazoline Derivatives Possessing a Methanesulfonyl Pharmacophore

Khaled R. A. Abdellatif, Amany A. Azouz, Wael A. A. Fadaly, 2016, Archiv der Pharmazie.

Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.

Khaled R. A. Abdellatif, Qiao-Hong Chen, M. Chowdhury, 2008, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of new 4-(4-substituted-anilino)quinoline derivatives as anticancer agents

M. Abdelgawad, Khaled R. A. Abdellatif, Eman K. A. Abdelall, 2017, Medicinal Chemistry Research.

Design, synthesis, biological evaluation, and nitric-oxide release studies of a novel series of celecoxib prodrugs possessing a nitric-oxide donor moiety

Khaled R. A. Abdellatif, E. Knaus, Wael Soliman, 2018 .

Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.

Khaled R. A. Abdellatif, Qiao-Hong Chen, M. Chowdhury, 2007, Bioorganic & medicinal chemistry.

3-Methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents

Khaled R. A. Abdellatif, Phoebe F. Lamie, H. Omar, 2016, Journal of enzyme inhibition and medicinal chemistry.

Novel pyrazole-oxadiazole hybrids possessing methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies

Khaled R. A. Abdellatif, Eman K. A. Abdelall, Maha M. Abdel-Fattah, 2022, Journal of Molecular Structure.

Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment

R. B. Bakr, Khaled R. A. Abdellatif, R. Bakr, 2020, Medicinal Chemistry Research.

Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2009, Journal of medicinal chemistry.

New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds.

R. B. Bakr, Khaled R. A. Abdellatif, R. Bakr, 2018, Bioorganic chemistry.

Synthesis, cyclooxygenase inhibition, and anti-inflammatory evaluation of novel diarylheterocycles with a central pyrazole, pyrazoline, or pyridine ring

Khaled R. A. Abdellatif, Eman K. A. Abdelall, Gehan Kamel, 2015, Medicinal Chemistry Research.

Synthesis of novel substituted 4H-chromenes and their antioxidant screening

M. Abdelgawad, Khaled R. A. Abdellatif, H. A. Elshemy, 2013 .

Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities.

Yaser A. Mostafa, Khaled R. A. Abdellatif, D. Zaher, 2019, Bioorganic chemistry.

2,4‐Disubstituted Phenylhydrazonopyrazolone and Isoxazolone Derivatives as Antibacterial Agents: Synthesis, Preliminary Biological Evaluation and Docking Studies

Louise N. Dawe, M. Abdelgawad, P. Georghiou, 2018 .

Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Moshfiqur Rahman, M. Suresh, Khaled R. A. Abdellatif, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of certain 8-quinolyloxy and/or carbocyclic nitrogenous compounds for microbiological testing

M. El-Enany, Khaled R. A. Abdellatif, Madlen B. Labib, 2016 .

Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.

Moshfiqur Rahman, M. Suresh, Khaled R. A. Abdellatif, 2010, Bioorganic & medicinal chemistry letters.

Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors.

M. El-Magd, Khaled R. A. Abdellatif, Y. A. Elshaier, 2019, Bioorganic chemistry.

New pyrazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies.

Khaled R. A. Abdellatif, Eman K. A. Abdelall, Phoebe F. Lamie, 2019, Bioorganic chemistry.

Design, synthesis, cyclooxygenase inhibition and biological evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing amino/methanesulfonyl pharmacophore.

Khaled R. A. Abdellatif, Wael A. A. Fadaly, 2017, Bioorganic chemistry.

Synthesis and antimicrobial evaluation of certain purine, benzothiazole and thiazole systems substituted with dialkylaminoalkyl-o-cresols

M. El-Enany, Khaled R. A. Abdellatif, O. El-Badry, 2015 .

Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS.

A. Belal, Khaled R. A. Abdellatif, Noha H Amin, 2020, Bioorganic chemistry.

Synthesis and Anticancer Activity of Some New Pyrazolo[3,4-d]pyrimidin-4-one Derivatives

M. Abdelgawad, R. B. Bakr, R. Ahmed, 2014, Molecules.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2008, Bioorganic & medicinal chemistry.

Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors

Mohamed Alfateh Badawy, Khaled R. A. Abdellatif, Eman K. A. Abdelall, 2021, RSC advances.

Synthesis, cyclooxygenase inhibition, and anti-inflammatory evaluation of novel diarylheterocycles with a central pyrazole, pyrazoline, or pyridine ring

Khaled R. A. Abdellatif, Eman K. A. Abdelall, Gehan Kamel, 2015, Medicinal Chemistry Research.

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.

M. Abdelgawad, Khaled R. A. Abdellatif, Madlen B. Labib, 2015, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.

M. Abdelgawad, Khaled R. A. Abdellatif, H. A. Elshemy, 2016, Bioorganic chemistry.

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Synthesis, characterization and biological evaluation of novel 4′-fluoro-2′-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents

S. Salama, Khaled R. A. Abdellatif, H. A. Elshemy, 2015, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment

R. B. Bakr, Khaled R. A. Abdellatif, R. Bakr, 2020 .

Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies.

J. Reisz, Khaled R. A. Abdellatif, S. King, 2010, Organic & biomolecular chemistry.

Design , Synthesis and biological evaluation of some novel indole derivatives as selective COX-2 inhibitors

Khaled R. A. Abdellatif, Ahmed A. Hefny, Noha H Amin, 2017 .

Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.

Khaled R. A. Abdellatif, Qiao-Hong Chen, M. Chowdhury, 2008, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel thiohydantoin derivatives as antiproliferative agents: A combined experimental and theoretical assessments

A. Khodair, Khaled R. A. Abdellatif, M. Awad, 2022, Journal of Molecular Structure.

Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies.

Khaled R. A. Abdellatif, Eman K. A. Abdelall, Madlen B. Labib, 2020, Bioorganic chemistry.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: synthesis, nitric oxide release studies and anti-inflammatory activities.

Khaled R. A. Abdellatif, M. Chowdhury, Ying Dong, 2008, Bioorganic & medicinal chemistry.

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,5-diarylpyrazole derivatives

Khaled R. A. Abdellatif, Gehan Kamel, Waleed A M Ali, 2016, Journal of enzyme inhibition and medicinal chemistry.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2008, Bioorganic & medicinal chemistry.

Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues.

A. Belal, Khaled R. A. Abdellatif, H. Omar, 2013, Bioorganic & medicinal chemistry letters.

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1-phenylpyrazolo[3,4-d]pyrimidine derivatives

Khaled R. A. Abdellatif, Amany A. Azouz, R. Bakr, 2016, Journal of enzyme inhibition and medicinal chemistry.

Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of new 1‐[4‐methane(amino)sulfonylphenyl)]‐5‐[4‐(aminophenyl)]‐3‐trifluoromethyl‐1H‐pyrazoles

Khaled R. A. Abdellatif, M. Chowdhury, E. Knaus, 2008 .

Design, synthesis of new anti-inflammatory agents with a pyrazole core: COX-1/COX-2 inhibition assays, anti-inflammatory, ulcerogenic, histopathological, molecular Modeling, and ADME studies.

Khaled R. A. Abdellatif, Eman K. A. Abdelall, H. A. Elshemy, 2021 .

Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.

Khaled R. A. Abdellatif, Eman K. A. Abdelall, Madlen B. Labib, 2019, Bioorganic chemistry.

Non-acidic 1,3,4-trisubstituted-pyrazole derivatives as lonazolac analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.

Khaled R. A. Abdellatif, Gehan Kamel, Waleed A M Ali, 2018, Bioorganic chemistry.

Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore

Khaled R. A. Abdellatif, Mohammed T. Elsaady, S. Abdel-Aziz, 2016, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX‐2 Inhibitors

M. Abdelgawad, Khaled R. A. Abdellatif, Madlen B. Labib, 2017, Archiv der Pharmazie.

Design , synthesis , molecular docking and cytotoxicity evaluation of some novel 5-arylidene-3-( substituted phenyl )-2-( p-tolylamino )-4-imidazolones

A. Khodair, Khaled R. A. Abdellatif, Mohammed T. Elsaady, 2017 .

A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.

Khaled R. A. Abdellatif, S. Kaufman, Zhangjian Huang, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: a search for novel nitric oxide donor anti-inflammatory agents.

Khaled R. A. Abdellatif, M. Chowdhury, Ying Dong, 2008, Bioorganic & medicinal chemistry.

Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study.

Khaled R. A. Abdellatif, Eman K. A. Abdelall, H. A. Elshemy, 2022, Bioorganic chemistry.

Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies.

Khaled R. A. Abdellatif, Eman K. A. Abdelall, H. A. Elshemy, 2021, Bioorganic chemistry.

Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.

M. Abdel-Latif, Khaled R. A. Abdellatif, H. A. Elshemy, 2017, Bioorganic chemistry.

Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2010, Bioorganic & medicinal chemistry letters.

1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents.

Khaled R. A. Abdellatif, H. A. Elshemy, Amany A Azoz, 2015, Bioorganic chemistry.

Synthesis of new rofecoxib analogs of expected anti-inflammatory activity

M. Abdelgawad, N. Helmy, Khaled R. A. Abdellatif, 2013 .

New 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents.

Khaled R. A. Abdellatif, Wael A. A. Fadaly, 2017, Bioorganic chemistry.

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.

Khaled R. A. Abdellatif, Eman K. A. Abdelall, Gehan Kamel, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing an aminosulphonyl pharmacophore

M. Abdelgawad, Khaled R. A. Abdellatif, H. A. Elshemy, 2015, Archives of pharmacal research.

Moshfiqur Rahman, M. Suresh, Khaled R. A. Abdellatif, 2010, Bioorganic & medicinal chemistry letters.

Design, Synthesis and Cytotoxicity Evaluation of New 3, 5-Disubstituted-2-Thioxoimidazolidinones.

A. Khodair, T. Fujimura, S. Kawamoto, 2018, Anti-cancer agents in medicinal chemistry.

Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2010, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of new 4-(4-substituted-anilino)quinoline derivatives as anticancer agents

M. Abdelgawad, Khaled R. A. Abdellatif, Eman K. A. Abdelall, 2017, Medicinal Chemistry Research.

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW PYRROLOAZEPINES WITH POTENTIAL AND SELECTIVE ANTITUMOR ACTIVITY.

M. Abdelgawad, A. Belal, Khaled R. A. Abdellatif, 2016, Acta poloniae pharmaceutica.

Design, synthesis and pharmacological evaluation of novel pyrrolizine derivatives as potential anticancer agents.

El‐Shaimaa A. Arafa, A. Abdelazeem, A. Gouda, 2014, Bioorganic chemistry.

Vicinal diaryl pyrazole with tetrazole/urea scaffolds as selective angiotensin converting enzyme‐1/cyclooxygenase‐2 inhibitors: Design, synthesis, anti‐hypertensive, anti‐fibrotic, and anti‐inflammatory

Fares E. M. Ali, Khaled R. A. Abdellatif, Ali H El-Bahrawy, 2024, Drug development research.