John B. Lees-Shepard

发表

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva

V. Kaartinen, D. Goldhamer, Sean J. Stoessel, 2018, Nature Communications.

Stem cells and heterotopic ossification: Lessons from animal models.

D. Goldhamer, John B. Lees-Shepard, 2018, Bone.

Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

A. Murphy, K. Schutz, A. Economides, 2021, bioRxiv.

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice

D. Goldhamer, K. Bouchard, Sean J. Stoessel, 2021, bioRxiv.

Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

D. Goldhamer, Sean J. Stoessel, John B. Lees-Shepard, 2018, eLife.

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

A. Murphy, E. Goebel, A. Economides, 2020, eLife.

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva

V. Kaartinen, D. Goldhamer, Sean J. Stoessel, 2018, Nature Communications.

Lysosomal degradation of ACVR1-Activin complexes negatively regulates signaling of Activins and Bone Morphogenetic Proteins

Krunal Patel, S. Hatsell, John B. Lees-Shepard, 2024, bioRxiv.

How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva

S. Hatsell, John B. Lees-Shepard, K. N. Hart, 2024, Biomolecules.