P. M. Hinkle

P. M. Hinkle, T. Graves, 2003, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Characterization of multidrug-resistant pituitary tumor cells.

P. M. Hinkle, E. Nelson, E J Nelson, 1992, Endocrinology.

Prolactin and secretogranin-II, a marker for the regulated pathway, are secreted in parallel by pituitary GH4C1 cells.

P. M. Hinkle, J. Scammell, E. D. Shanshala, 1992, Endocrinology.

Thyrotropin-releasing hormone-receptor interaction in GH3 pituitary cells.

P. M. Hinkle, D. Lewis, T. Greer, 1980, Endocrinology.

Solubilization of pituitary receptors for thyrotropin-releasing hormone.

P. M. Hinkle, D. Lewis, 1978, Biochimica et biophysica acta.

Regulation of pituitary receptors for thyrotropin-releasing hormone by thyroid hormones.

P. M. Hinkle, M. Perrone, 1978, The Journal of biological chemistry.

Dual Topology of the Melanocortin-2 Receptor Accessory Protein Is Stable

S. Malik, P. M. Hinkle, Z. Maben, 2016, Front. Endocrinol..

Detection of G protein-coupled receptors by immunofluorescence microscopy.

J. Puskás, P. M. Hinkle, 2004, Methods in molecular biology.

Pituitary Ca2+ channels: blockade by conventional and novel Ca2+ antagonists.

P. M. Hinkle, J. Enyeart, S. Sheu, 1987, The American journal of physiology.

Intrinsic tryptophan fluorescence of membranes of GH3 pituitary cells: quenching by thyrotropin-releasing hormone.

G. Fasman, T. Imae, A. Tashjian, 1975, Biochemical and biophysical research communications.

Receptors for thyrotropin-releasing hormone in prolactin producing rat pituitary cells in culture.

A. Tashjian, P. M. Hinkle, 1973, The Journal of biological chemistry.

Characterization of thyroid hormone stimulation of uridine uptake by rat pituitary tumor cells.

P. M. Hinkle, J. Halpern, 1984, Endocrinology.

Thyroid hormone induction of an autocrine growth factor secreted by pituitary tumor cells.

P. M. Hinkle, P. A. Kinsella, 1986, Science.

Activation of MAPK by TRH Requires Clathrin-Dependent Endocytosis and PKC but Not Receptor Interaction with β-Arrestin or Receptor Endocytosis

P. M. Hinkle, R. Yu, J. Smith, 2001 .

Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.

J. Cheung, W. Koch, L. Sklar, 2012, ACS chemical biology.

Receptor Cycling in Pituitary Cells: Biological Consequences of Inhibition of Receptor-Mediated Endocytosis

P. M. Hinkle, J. Halpern, P. A. Kinsella, 1986 .

Signal Transduction and Hormone-dependent Internalization of the Thyrotropin-releasing Hormone Receptor in Cells Lacking Gq and G11 *

P. M. Hinkle, R. Yu, 1999, The Journal of Biological Chemistry.

Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling.

M. Gershengorn, P. M. Hinkle, E. Nelson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.

G. Shulman, J. Boyer, N. Ballatori, 2014, American journal of physiology. Gastrointestinal and liver physiology.

Ca2+-Induced Ca2+ Release in the Pancreatic β-Cell: Direct Evidence of Endoplasmic Reticulum Ca2+ Release

P. M. Hinkle, T. Graves, 2003 .

Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release.

P. M. Hinkle, T. Graves, 2003, Endocrinology.

Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling.

G. Song, P. M. Hinkle, 2005, Molecular endocrinology.

Regulation of thyrotropin-releasing hormone receptors and responses by L-triiodothyronine in dispersed rat pituitary cell cultures.

P. M. Hinkle, K. Goh, Kimberley B. C. Goh, 1982, Endocrinology.

Mechanism of thyroid hormone inhibition of thyrotropin-releasing hormone action.

A. Schonbrunn, P. M. Hinkle, M. Perrone, 1981, Endocrinology.

Relationships between thyroid hormone and glucocorticoid effects in GH3 pituitary cells.

P. M. Hinkle, M. Perrone, T. Greer, 1980, Endocrinology.

The calcium agonist Bay K 8644 stimulates secretion from a pituitary cell line.

P. M. Hinkle, J. Enyeart, J. J. Enyeart, 1984, Biochemical and Biophysical Research Communications - BBRC.

Interaction of dihydropyridine Ca2+ agonist Bay K 8644 with normal and transformed pituitary cells.

P. M. Hinkle, T. Aizawa, J. Enyeart, 1986, The American journal of physiology.

A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss)

D. I. Våge, Patricia I. M. Silva, S. Omholt, 2016, Scientific Reports.

Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

R. Gross, Dianqing Wu, J. Bidlack, 1999 .

Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids.

R. Gross, J. Bidlack, J. McLaughlin, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Dihydropyridine Ca2+ antagonists: potent inhibitors of secretion from normal and transformed pituitary cells.

P. M. Hinkle, T. Aizawa, J. Enyeart, 1985, The American journal of physiology.

Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor.

P. M. Hinkle, R. Yu, 1997, Molecular pharmacology.

Cadmium uptake and toxicity via voltage-sensitive calcium channels.

K. Osterhoudt, P. M. Hinkle, P. A. Kinsella, 1987, The Journal of biological chemistry.

Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation

G. Song, B. W. Jones, P. M. Hinkle, 2007, Proceedings of the National Academy of Sciences.

A novel TRH analog, Glp–Asn–Pro–d-Tyr–d-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2

P. M. Hinkle, J. A. Kelly, K. O’boyle, 2008, Neuroscience Letters.

Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s.

R. Dores, P. M. Hinkle, J. Angleson, 2011, General and comparative endocrinology.

Calcium responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone and somatostatin in phospholipase css3 knockout mice.

P. M. Hinkle, T. Graves, D. Wu, 2001, Molecular endocrinology.

Opposite Effects of the Melanocortin-2 (MC2) Receptor Accessory Protein MRAP on MC2 and MC5 Receptor Dimerization and Trafficking*

P. M. Hinkle, J. Sebag, 2009, The Journal of Biological Chemistry.

Activation of protein kinase C increases Ca2+ sensitivity of secretory response of GH3 pituitary cells.

P. M. Hinkle, A. Haymes, 1993, The American journal of physiology.

Epidermal growth factor decreases thyroid hormone receptors and attenuates thyroid hormone responses in GH4C1 cells.

H. Kaji, P. M. Hinkle, 1987, Endocrinology.

Cellular Uptake of Lead Is Activated by Depletion of Intracellular Calcium Stores*

P. M. Hinkle, L. Kerper, Laura E. Kerper, 1997, The Journal of Biological Chemistry.

Differential effects of thyrotropin-releasing hormone, vasoactive intestinal peptide, phorbol ester, and depolarization in GH4C1 rat pituitary cells.

P. M. Hinkle, T. Aizawa, P. M. Hinkle, 1985, Endocrinology.

Calcium channel agonists and antagonists: effects of chronic treatment on pituitary prolactin synthesis and intracellular calcium.

A. Zavacki, P. M. Hinkle, C. Bancroft, 1988, Molecular endocrinology.

Fluorescence methods to assess multidrug resistance in individual cells

N. Zinkin, P. M. Hinkle, E. Nelson, 1998, Cancer Chemotherapy and Pharmacology.

Prolactin synthesis in cultured pituitary cells is chloride-dependent.

R. Day, P. M. Hinkle, 1988, Journal of Biological Chemistry.

Attenuation of thyroid hormone action by 1,25-dihydroxyvitamin D3 in pituitary cells.

H. Kaji, P. M. Hinkle, 1989, Endocrinology.

Subcellular trafficking of the TRH receptor: effect of phosphorylation.

B. W. Jones, P. M. Hinkle, 2009, Molecular endocrinology.

Receptors for thyrotropin-releasing hormone on rat lactotropes and thyrotropes.

P. M. Hinkle, R. Yu, R. Ashworth, 1998, Thyroid : official journal of the American Thyroid Association.

Pituitary TRH Receptors a

P. M. Hinkle, 1989, Annals of the New York Academy of Sciences.

Thyrotropin-releasing hormone rapidly stimulates a biphasic secretion of prolactin and growth hormone in GH4C1 rat pituitary tumor cells.

P. M. Hinkle, T. Aizawa, 1985, Endocrinology.

Lead uptake in brain capillary endothelial cells: activation by calcium store depletion.

P. M. Hinkle, L. Kerper, 1997, Toxicology and applied pharmacology.

Global functions of extracellular, transmembrane and cytoplasmic domains of organic solute transporter β-subunit.

W. V. Christian, P. M. Hinkle, 2017, The Biochemical journal.

Purification of a stimulator of microtubule assembly from bovine thyroid.

B. Berk, P. M. Hinkle, 1981, The Journal of biological chemistry.

Thyrotropin (TSH)-releasing hormone stimulates TSH beta promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C.

J. Weck, M. Shupnik, P. M. Hinkle, 1996, Molecular endocrinology.

EFFORTS DIRECTED TOWARD AN UNDERSTANDING OF THE BIOSYNTHESIS OF THE HYPOTHALAMIC-RELEASING HORMONES

P. Andrews, J. Dixon, P. M. Hinkle, 1980 .

A macromolecule which gives rise to thyrotropin releasing-hormone.

J. Dixon, P. M. Hinkle, J. Rupnow, 1979, Biochemical and biophysical research communications.

Detection in Living Cells of Ca2+-dependent Changes in the Fluorescence Emission of an Indicator Composed of Two Green Fluorescent Protein Variants Linked by a Calmodulin-binding Sequence

A. Persechini, Valerie A. Romoser, Patricia M. Hinkle, 1997, The Journal of Biological Chemistry.

Characterization of the calcium response to thyrotropin-releasing hormone in lactotrophs and GH cells

P. M. Hinkle, E. Nelson, R. Ashworth, 1996, Trends in Endocrinology & Metabolism.

Pituitary thyrotropin-releasing hormone receptors: local anesthetic effects on binding and responses.

W. J. Phillips, P. M. Hinkle, J. Enyeart, 1989, Molecular endocrinology.

Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs.

P. M. Hinkle, R. Ashworth, P. M. Hinkle, 1996, Endocrinology.

Central Hypothyroidism Due to a TRHR Mutation Causing Impaired Ligand Affinity and Transactivation of Gq

L. Pardo, J. Moreno, P. M. Hinkle, 2017, The Journal of clinical endocrinology and metabolism.

Desensitization, Trafficking, and Resensitization of the Pituitary Thyrotropin-Releasing Hormone Receptor

B. W. Jones, Austin U. Gehret, P. M. Hinkle, 2012, Front. Neurosci..

Dimerization and Phosphorylation of Thyrotropin-releasing Hormone Receptors Are Modulated by Agonist Stimulation*

Chang-Cheng Zhu, P. M. Hinkle, Laurie B. Cook, 2002, The Journal of Biological Chemistry.

Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides

P. M. Hinkle, A. Sattin, A.Eugene Pekary, 2002, Brain Research.

Desensitization of Thyrotropin-releasing Hormone Receptor-mediated Responses Involves Multiple Steps*

P. M. Hinkle, R. Yu, 1997, The Journal of Biological Chemistry.

Characteristics of the Ca2+ spike and oscillations induced by different doses of thyrotropin-releasing hormone (TRH) in individual pituitary cells and nonexcitable cells transfected with TRH receptor complementary deoxyribonucleic acid.

P. M. Hinkle, E. Nelson, 1994, Endocrinology.

Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels.

M. Gershengorn, G. Sempowski, P. M. Hinkle, 1992, Molecular endocrinology.

Rapid Turnover of Calcium in the Endoplasmic Reticulum during Signaling

P. M. Hinkle, R. Yu, 2000, The Journal of Biological Chemistry.

Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.

C. Abboud, K. Rosell, T. Obrig, 2001, Blood cells, molecules & diseases.

Misfolded growth hormone causes fragmentation of the Golgi apparatus and disrupts endoplasmic reticulum-to-Golgi traffic.

P. M. Hinkle, P. Dannies, T. Graves, 2001, Journal of cell science.

Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides*

R. Neubig, K. Griendling, M. Ghosh, 2003, Journal of Biological Chemistry.

Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.

R. Neubig, K. Griendling, M. Ghosh, 2003, The Journal of biological chemistry.

Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides.

P. M. Hinkle, P. A. Kinsella, 1984, The Journal of biological chemistry.

Promoter Activity by Two Distinct Mechanisms Involving Calcium Influx Through L Type Ca*+ Channels and Protein Kinase C

M. Shupnik, P. M. Hinkle, Jennifer Week, 1996 .

Pituitary thyrotropin-releasing hormone (TRH) receptors: effects of TRH, drugs mimicking TRH action, and chlordiazepoxide.

P. M. Hinkle, E. D. Shanshala, 1989, Molecular endocrinology.

Measurement of intracellular cadmium with fluorescent dyes. Further evidence for the role of calcium channels in cadmium uptake.

P. M. Hinkle, E. Nelson, E. D. Shanshala, 1992, The Journal of biological chemistry.

Thyroid and brain microtubules: a comparison.

B. Berk, P. M. Hinkle, 1980, The Journal of biological chemistry.

Receptor-binding affinities and biological activities of analogs of thyrotropin-releasing hormone in prolactin-producing pituitary cells in culture.

A. Tashjian, P. M. Hinkle, E. Woroch, 1974, The Journal of biological chemistry.

Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish

R. Cone, P. M. Hinkle, J. Sebag, 2013, Science.

Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers

P. M. Hinkle, J. Sebag, 2007, Proceedings of the National Academy of Sciences.

Osmotic regulation of prolactin secretion. Possible role of chloride.

R. Day, P. M. Hinkle, 1988, The Journal of biological chemistry.

Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity.

P. M. Hinkle, M. Fliss, C. Bancroft, 1999, Molecular endocrinology.

Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein.

P. M. Hinkle, Laurie B. Cook, 2004, The Biochemical journal.

Phosphorylation of the Endogenous Thyrotropin-releasing Hormone Receptor in Pituitary GH3 Cells and Pituitary Tissue Revealed by Phosphosite-specific Antibodies*

G. Song, B. W. Jones, P. M. Hinkle, 2007, Journal of Biological Chemistry.

Ostα−/− mice are not protected from western diet‐induced weight gain

N. Ballatori, Sadie G. Wheeler, C. Hammond, 2015, Physiological reports.

Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes from GH4C1 rat pituitary tumor cells.

W. J. Phillips, P. M. Hinkle, 1984, Proceedings of the National Academy of Sciences of the United States of America.

β-Subunit of the Ostα-Ostβ Organic Solute Transporter Is Required Not Only for Heterodimerization and Trafficking but Also for Function*

N. Ballatori, W. V. Christian, P. M. Hinkle, 2012, The Journal of Biological Chemistry.

Epidermal growth factor decreases the concentration of thyrotropin-releasing hormone (TRH) receptors and TRH responses in pituitary GH4C1 cells.

P. M. Hinkle, E. D. Shanshala, Z. Yan, 1991, Endocrinology.

Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool. Demonstration using controlled expression of TRH receptors by adenovirus mediated gene transfer.

M. Gershengorn, P. M. Hinkle, E. Falck-Pedersen, 1994, The Journal of biological chemistry.

Cadmium toxicity in rat pheochromocytoma cells: studies on the mechanism of uptake.

P. M. Hinkle, M. Osborne, 1994, Toxicology and applied pharmacology.

Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone

K. Tipton, D. Gregg, P. M. Hinkle, 2007, Neuropharmacology.

Binding and internalization of epidermal growth factor by rat pituitary tumor cells

P. M. Hinkle, J. Halpern, 1983, Molecular and Cellular Endocrinology.

Saturable, stereospecific transport of 3,5,3'-triiodo-L-thyronine and L-thyroxine into GH4C1 pituitary cells.

P. M. Hinkle, Z. Yan, Z. Yan, 1993, The Journal of biological chemistry.

Transient dopaminergic inhibition of prolactin release from hybrid cells derived by fusion of normal rat pituitary and GH4C1 tumor cells.

R. Day, P. M. Hinkle, 1988, Endocrinology.

Thyroliberin action in pituitary cells is not inhibited by pertussis toxin.

E. Hewlett, M. Gershengorn, P. M. Hinkle, 1986, The Biochemical journal.

Adenylyl cyclase and cyclic nucleotide phosphodiesterases in GH-Strains of rat pituitary cells.

A. Tashjian, P. M. Hinkle, 1977, Endocrinology.

siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor.

Austin U. Gehret, P. M. Hinkle, 2013, ACS chemical biology.

Studies on the biological activity of triiodothyronine sulfate.

F. B. Davis, M. Kung, J. Roth, 1992, The Journal of clinical endocrinology and metabolism.

Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.

P. M. Hinkle, Laurie B. Cook, 2004, Endocrinology.

Evidence for conformational restrictions within the active site of acyl papains which influence the rates of hydrolysis

J. Kirsch, P. M. Hinkle, 1970 .

Regions of Melanocortin 2 (MC2) Receptor Accessory Protein Necessary for Dual Topology and MC2 Receptor Trafficking and Signaling*

P. M. Hinkle, J. Sebag, 2009, Journal of Biological Chemistry.

Regulation of L-type voltage-gated calcium channels by epidermal growth factor.

P. M. Hinkle, E. Nelson, A. Haymes, 1993, Endocrinology.

Activation of protein kinase C reduces L-type calcium channel activity of GH3 pituitary cells.

Y. Kwan, R. Kass, J. P. Arena, 1992, The American journal of physiology.

Thyrotropin‐Releasing Hormone Action in Pituitary Cells

H. Kaji, P. M. Hinkle, 1989 .

Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.

J. Casnellie, H. Kaji, P. M. Hinkle, 1988, The Journal of biological chemistry.

Dihydropyridine modulators of voltage-sensitive Ca2+ channels specifically regulate prolactin production by GH4C1 pituitary tumor cells.

P. M. Hinkle, J. Enyeart, S. Sheu, 1987, The Journal of biological chemistry.

Evidence for an active step in thyroid hormone transport to nuclei: drug inhibition of L-125I-triiodothyronine binding to nuclear receptors in rat pituitary tumor cells.

P. M. Hinkle, J. Halpern, 1982, Endocrinology.

Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane*

S. Malik, P. M. Hinkle, Z. Maben, 2015, The Journal of Biological Chemistry.

Regulation of G Protein–Coupled Receptor Signaling: Specific Dominant-Negative Effects of Melanocortin 2 Receptor Accessory Protein 2

P. M. Hinkle, J. Sebag, 2010, Science Signaling.

Structure and function of the melanocortin2 receptor accessory protein (MRAP)

P. M. Hinkle, J. Sebag, 2009, Molecular and Cellular Endocrinology.

Corrigendum to “A novel TRH analog, Glp–Asn–Pro–d-Tyr–d-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2” [Neurosci. Lett. 431 (2007) 26–30]

P. M. Hinkle, J. A. Kelly, K. O’boyle, 2008, Neuroscience Letters.

Endocrine Effects of Calcium Channel Agonists and Antagonists in a Pituitary Cell System

R. Day, P. M. Hinkle, J. Enyeart, 1988 .

Regulation of thyroid hormone receptors and responses by thyrotropin-releasing hormone in GH4C1 cells.

H. Kaji, P. M. Hinkle, 1987, Endocrinology.

Evidence for a thyrotropin-releasing hormone inhibitor in the pineal gland.

K. Knigge, J. Vriend, P. M. Hinkle, 1980, Endocrinology.

Rapid temperature-dependent transformation of the thyrotropin-releasing hormone-receptor complex in rat pituitary tumor cells.

P. M. Hinkle, P. A. Kinsella, 1982, Journal of Biological Chemistry.

Inhibition of L-type calcium-channel activity by thapsigargin and 2,5-t-butylhydroquinone, but not by cyclopiazonic acid.

R. Kass, P. M. Hinkle, T. Benson, 1994, The Biochemical journal.

Thyroid hormone action in pituitary cells. Differences in the regulation of thyrotropin-releasing hormone receptors and growth hormone synthesis.

P. M. Hinkle, M. Perrone, T. Greer, 1979, Journal of Biological Chemistry.

Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein.

C. Haskell-Luevano, P. M. Hinkle, J. Sebag, 2011, European journal of pharmacology.

β-Arrestin Mediates Desensitization and Internalization but Does Not Affect Dephosphorylation of the Thyrotropin-releasing Hormone Receptor*

B. W. Jones, Patricia M. Hinkle, P. M. Hinkle, 2005, Journal of Biological Chemistry.

Solubilization and characterization of pituitary thyrotropin-releasing hormone receptors.

W. J. Phillips, P. M. Hinkle, 1989, Molecular pharmacology.

Role of Helix 8 of the Thyrotropin-Releasing Hormone Receptor in Phosphorylation by G Protein-Coupled Receptor Kinase

B. W. Jones, Austin U. Gehret, P. M. Hinkle, 2010, Molecular Pharmacology.

Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.

G. Shulman, J. Boyer, N. Ballatori, 2014, American journal of physiology. Gastrointestinal and liver physiology.