L. Canaff

发表

The Retinoblastoma Tumor Suppressor Protein (pRb)/E2 Promoter Binding Factor 1 (E2F1) Pathway as a Novel Mediator of TGFβ-induced Autophagy*

J. Lebrun, J. Korah, L. Canaff, 2015, The Journal of Biological Chemistry.

Calcium-sensing receptor and associated diseases.

G. Hendy, V. Guarnieri, L. Canaff, 2009, Progress in molecular biology and translational science.

Parathyroid Hormone-responsive Smad3-related Factor, Tmem119, Promotes Osteoblast Differentiation and Interacts with the Bone Morphogenetic Protein-Runx2 Pathway*

R. Kitazawa, S. Kitazawa, S. Seino, 2011, The Journal of Biological Chemistry.

Role of Smad3, acting independently of transforming growth factor‐β, in the early induction of Wnt‐β‐catenin signaling by parathyroid hormone in mouse osteoblastic cells

K. Chihara, G. Hendy, T. Sugimoto, 2009, Journal of cellular biochemistry.

Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA.

G. Hendy, I. Kanazawa, L. Canaff, 2012, The Journal of clinical endocrinology and metabolism.

Impaired Transforming Growth Factor-β (TGF-β) Transcriptional Activity and Cell Proliferation Control of a Menin In-frame Deletion Mutant Associated with Multiple Endocrine Neoplasia Type 1 (MEN1)*

G. Hendy, D. Goltzman, H. Kaji, 2012, The Journal of Biological Chemistry.

Menin Is Required for Bone Morphogenetic Protein 2- and Transforming Growth Factor β-regulated Osteoblastic Differentiation through Interaction with Smads and Runx2*

K. Chihara, T. Komori, G. Hendy, 2004, Journal of Biological Chemistry.

Involvement of the Osteoinductive Factors, Tmem119 and BMP-2, and the ER Stress Response PERK–eIF2α–ATF4 Pathway in the Commitment of Myoblastic into Osteoblastic Cells

G. Hendy, I. Kanazawa, Ken-ichiro Tanaka, 2013, Calcified Tissue International.

A hypocalcemic child with a novel activating mutation of the calcium-sensing receptor gene: successful treatment with recombinant human parathyroid hormone.

G. Hendy, D. Cole, M. Geffner, 2006, The Journal of clinical endocrinology and metabolism.

Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells.

K. Chihara, G. Hendy, H. Sowa, 2006, Endocrinology.

Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3.

N. Seidah, G. Hendy, H. Bennett, 1999, Endocrinology.

Differential regulation of PHEX expression in bone and parathyroid gland by chronic renal insufficiency and 1,25-dihydroxyvitamin D3.

G. Hendy, H. Tenenhouse, L. Canaff, 2004, American journal of physiology. Renal physiology.

In vivo regulation of chromogranin A messenger ribonucleic acid in the parathyroid by 1,25-dihydroxyvitamin D: studies in normal rats and in chronic renal insufficiency.

G. Hendy, L. Canaff, J. Fox, 1997, Endocrinology.

Cinacalcet Treatment in an Adolescent With Concurrent 22q11.2 Deletion Syndrome and Familial Hypocalciuric Hypercalcemia Type 3 Caused by AP2S1 Mutation.

O. Mäkitie, M. Välimäki, G. Hendy, 2015, The Journal of clinical endocrinology and metabolism.

Codon Arg15 mutations of the AP2S1 gene: common occurrence in familial hypocalciuric hypercalcemia cases negative for calcium-sensing receptor (CASR) mutations.

G. Hendy, D. Cole, L. Canaff, 2014, The Journal of clinical endocrinology and metabolism.

Calcium Sensing Receptor in Human Colon Carcinoma: Interaction with Ca2+ and 1,25-Dihydroxyvitamin D3

J. Varani, G. Hendy, H. Appelman, 2005, Cancer Research.

Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3).

J. Varani, G. Hendy, H. Appelman, 2005, Cancer research.

Calcium Sensing Receptor in Human Colon Carcinoma: Interaction with Ca and 1,25-Dihydroxyvitamin D3

J. Varani, G. Hendy, H. Appelman, 2005 .

Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins.

M. Tremblay, G. Hendy, R. Day, 2006, Molecular endocrinology.

Calcium-sensing receptor mutations and denaturing high performance liquid chromatography.

Xiaoping Zhou, G. Hendy, A. Scillitani, 2008, Journal of molecular endocrinology.

Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3).

J. Varani, G. Hendy, H. Appelman, 2005, Cancer research.

Novel homozygous inactivating mutation of the calcium-sensing receptor gene (CASR) in neonatal severe hyperparathyroidism-lack of effect of cinacalcet.

G. Hendy, D. Cole, L. Canaff, 2014, Bone.

Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.

G. Hendy, U. Kumar, M. Grant, 2006, Human molecular genetics.

Activin inhibits pituitary prolactin expression and cell growth through Smads, Pit-1 and menin.

G. Hendy, D. Devost, J. Lebrun, 2004, Molecular endocrinology.

The Proinflammatory Cytokine, Interleukin-6, Up-regulates Calcium-sensing Receptor Gene Transcription via Stat1/3 and Sp1/3*

Xiaoping Zhou, G. Hendy, L. Canaff, 2008, Journal of Biological Chemistry.

Glial Cells Missing‐2 (GCM2) transactivates the calcium‐sensing receptor gene: effect of a dominant‐negative GCM2 mutant associated with autosomal dominant hypoparathyroidism

Xiaoping Zhou, G. Hendy, D. Cole, 2009, Human mutation.

Osteoblast Menin Regulates Bone Mass in Vivo*

T. Clemens, S. Komarova, G. Hendy, 2014, The Journal of Biological Chemistry.

Increased prevalence of the GCM2 polymorphism, Y282D, in primary hyperparathyroidism: analysis of three Italian cohorts.

C. Marcocci, F. Cetani, G. Hendy, 2014, The Journal of clinical endocrinology and metabolism.

Expression of PTH1R constructs in LLC-PK1 cells: protein nuclear targeting is mediated by the PTH1R NLS.

G. Hendy, A. Hodsman, E. Patterson, 2007, Bone.

Role of menin in bone development.

G. Hendy, H. Kaji, L. Canaff, 2009, Advances in experimental medicine and biology.

Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells.

R. Kitazawa, S. Seino, T. Komori, 2012, Bone.

Menin interacts with β-catenin in osteoblast differentiation.

S. Seino, G. Hendy, H. Kaji, 2011, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Cellular Functions ofMenin

G. Hendy, H. Kaji, L. Canaff, 2009 .

Cellular functions of menin.

G. Hendy, H. Kaji, L. Canaff, 2009, Advances in experimental medicine and biology.

CDC73 mutations and parafibromin immunohistochemistry in parathyroid tumors: clinical correlations in a single-centre patient cohort

M. Carella, E. Maiello, M. Bisceglia, 2012, Cellular Oncology.

Functional characterization of calcium-sensing receptor codon 227 mutations presenting as either familial (benign) hypocalciuric hypercalcemia or neonatal hyperparathyroidism.

J. Chudek, A. Więcek, G. Hendy, 2005, The Journal of clinical endocrinology and metabolism.

Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia.

E. Brown, G. Hendy, D. Cole, 2002, The Journal of clinical endocrinology and metabolism.

An acceptor splice site mutation in the calcium‐sensing receptor (CASR) gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

G. Hendy, D. Cole, L. Canaff, 2001, Human mutation.

Secretory granule targeting of atrial natriuretic peptide correlates with its calcium-mediated aggregation.

G. Thibault, L. Canaff, V. Brechler, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Advances in Brief Cell Cycle Regulation of Menin Expression 1

G. Hendy, D. Goltzman, H. Kaji, 1999 .

Cell Cycle Regulation of Menin Expression 1

G. Hendy, D. Goltzman, H. Kaji, 1999 .

1,25(OH)(2)D(3) stimulates Mg2+ uptake into MDCT cells: modulation by extracellular Ca2+ and Mg2+.

G. Hendy, L. Dai, G. Ritchie, 2001, American journal of physiology. Renal physiology.

1,25(OH)2D3 stimulates Mg uptake into MDCT cells: modulation by extracellular Ca and Mg

G. Hendy, Hyung-Sub Kang, G. Ritchie, 2001 .

1,25(OH) 2 D 3 stimulates Mg 2 1 uptake into MDCT cells: modulation by extracellular Ca 2 1 and Mg 2 1

G. Hendy, Hyung-Sub Kang, L. Dai, 2001 .

Rabbit calcium-sensing receptor (CASR) gene: chromosome location and evidence for related genes

R. Korstanje, G. Hendy, P. Martin-DeLeon, 1999, Cytogenetic and Genome Research.

Genetic Deletion of Menin in Mouse Mesenchymal Stem Cells: An Experimental and Computational Analysis

D. Pasini, Meisam Asgari, D. Goltzman, 2022, JBMR plus.

Genetic variation at the calcium-sensing receptor (CASR) locus: implications for clinical molecular diagnostics.

K. Siminovitch, G. Hendy, D. Cole, 2007, Clinical biochemistry.

Smad7 inhibits differentiation and mineralization of mouse osteoblastic cells.

S. Seino, G. Hendy, T. Sugimoto, 2012, Endocrine journal.

Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia.

W. Simonds, G. Hendy, S. Marx, 2005, Human molecular genetics.

Inactivation of Menin, the Product of the Multiple Endocrine Neoplasia Type 1 Gene, Inhibits the Commitment of Multipotential Mesenchymal Stem Cells into the Osteoblast Lineage*

Toru Yamaguchi, Kohei Miyazono, Hiroshi Kaji, 2003, Journal of Biological Chemistry.

Calcium-Sensing Receptor Gene: Regulation of Expression

G. Hendy, L. Canaff, 2016, Front. Physiol..

Calcium-sensing receptor, proinflammatory cytokines and calcium homeostasis.

G. Hendy, L. Canaff, 2016, Seminars in cell & developmental biology.

Calcium-sensing Receptor Gene Transcription Is Up-regulated by the Proinflammatory Cytokine, Interleukin-1β

G. Hendy, L. Canaff, 2005, Journal of Biological Chemistry.

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

G. Hendy, J. Lebrun, D. Goltzman, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Menin and TGF-beta superfamily member signaling via the Smad pathway in pituitary, parathyroid and osteoblast.

G. Hendy, J. Lebrun, H. Sowa, 2005, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Parathyroid hormone signaling via Gαs is selectively inhibited by an NH2‐terminally truncated Gαs: Implications for pseudohypoparathyroidism

G. Hendy, H. Jüppner, M. Bastepe, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Human Calcium-sensing Receptor Gene

G. Hendy, L. Canaff, 2002, The Journal of Biological Chemistry.

Alterations in the Sensing and Transport of Phosphate and Calcium by Differentiating Chondrocytes*

G. Hendy, J. Henderson, Hanlong Liu, 2001, The Journal of Biological Chemistry.

The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma

J. Lebrun, Jun Tian, L. Canaff, 2015, BMC Cancer.

Transforming Growth Factor-beta Regulation of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration

J. Lebrun, M. Hachim, L. Canaff, 2017, Scientific Reports.

Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes

Morag Park, J. Lebrun, Jimin Guo, 2014, Breast Cancer Research.

Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes

Morag Park, J. Lebrun, Jimin Guo, 2014, Breast Cancer Research.

Mutations of the calcium‐sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia

G. Hendy, L. Canaff, L. D’Souza-Li, 2000, Human mutation.

Calcium-sensing receptor (CASR) mutations in hypercalcemic states: studies from a single endocrine clinic over three years.

L. Muscarella, G. Hendy, A. Scillitani, 2010, The Journal of clinical endocrinology and metabolism.

Identification and functional characterization of a novel mutation in the calcium-sensing receptor gene in familial hypocalciuric hypercalcemia: modulation of clinical severity by vitamin D status.

G. Hendy, J. Vrbíková, D. Goltzman, 2007, The Journal of clinical endocrinology and metabolism.

CASRdb: calcium‐sensing receptor locus‐specific database for mutations causing familial (benign) hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia

G. Hendy, L. Canaff, L. D’Souza-Li, 2004, Human mutation.

The CASR gene: alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: structure and ligand binding sites.

G. Hendy, D. Cole, L. Canaff, 2013, Best practice & research. Clinical endocrinology & metabolism.

Recurrent familial hypocalcemia due to germline mosaicism for an activating mutation of the calcium-sensing receptor gene.

G. Hendy, D. Cole, L. Canaff, 2003, The Journal of clinical endocrinology and metabolism.

Menin Inactivation Leads to Loss of Transforming Growth Factor β Inhibition of Parathyroid Cell Proliferation and Parathyroid Hormone Secretion

R. Kitazawa, S. Kitazawa, K. Chihara, 2004, Cancer Research.

Novel Glial Cells Missing-2 (GCM2) variants in parathyroid disorders

F. Cetani, A. Scillitani, D. Goltzman, 2022, European journal of endocrinology.

Identification and Functional Characterization of Three NoLS (Nucleolar Localisation Signals) Mutations of the CDC73 Gene

M. Copetti, V. Pazienza, M. Carella, 2013, PloS one.

Extracellular Calcium-sensing Receptor Is Expressed in Rat Hepatocytes

G. Hendy, L. Canaff, P. Watson, 2001, The Journal of Biological Chemistry.

Extracellular Mg2(+)- and Ca2(+)-sensing in mouse distal convoluted tubule cells.

G. Hendy, F. Jirik, L. Dai, 1998, Kidney international.

Cell cycle regulation of menin expression.

G. Hendy, D. Goltzman, H. Kaji, 1999, Cancer research.

CDC73 mutations and parafibromin immunohistochemistry in parathyroid tumors: clinical correlations in a single-centre patient cohort

M. Carella, E. Maiello, M. Bisceglia, 2012, Cellular Oncology.

Mg2+/Ca2+sensing inhibits hormone-stimulated Mg2+ uptake in mouse distal convoluted tubule cells.

G. Hendy, L. Dai, G. Ritchie, 1998, American journal of physiology. Renal physiology.

sensing inhibits hormone-stimulated Mg uptake in mouse distal convoluted tubule cells

G. Hendy, L. Dai, G. Ritchie, 1998 .

Effect of Menin Deletion in Early Osteoblast Lineage on the Mineralization of an In Vitro 3D Osteoid-like Dense Collagen Gel Matrix

G. Hendy, S. Nazhat, D. Goltzman, 2022, Biomimetics.

Involvement of the Osteoinductive Factors, Tmem119 and BMP-2, and the ER Stress Response PERK–eIF2α–ATF4 Pathway in the Commitment of Myoblastic into Osteoblastic Cells

G. Hendy, I. Kanazawa, Ken-ichiro Tanaka, 2014, Calcified Tissue International.

Analysis of molecular mechanisms controlling neuroendocrine cell specific transcription of the chromogranin A gene.

R. Rehfuss, G. Hendy, A. Mouland, 1998, Endocrinology.

Homozygous Calcium-Sensing Receptor Polymorphism R544Q Presents as Hypocalcemic Hypoparathyroidism

R. Domingues, G. Hendy, J. L. Gleason, 2018, The Journal of clinical endocrinology and metabolism.

Functional analysis of a type 1 parathyroid hormone receptor intracellular tail mutant [KRK(484-6)AAA]: effects on second messenger generation and cellular targeting.

G. Hendy, A. Hodsman, E. Patterson, 2010, Bone.

Peptide hormone precursor processing: getting sorted?

G. Hendy, H. Bennett, L. Canaff, 1999, Molecular and Cellular Endocrinology.

Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1beta. Role of the NF-kappaB PATHWAY and kappaB elements.

G. Hendy, L. Canaff, 2005, The Journal of biological chemistry.

UKCCCR guidelines for the use of cell lines in cancer research

T. Thangarajah, M. Hattori, N. Saitou, 1999, Cytogenetic and Genome Research.

Clinical Craniofacial Dysmorphologies

M. Murshed, L. Canaff, Geoffrey, 2011 .

The three common polymorphisms p.A986S, p.R990G and p.Q1011E in the calcium sensing receptor (CASR) are not associated with chronic pancreatitis.

P. Bugert, C. Férec, D. Goltzman, 2021, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Transforming Growth Factor-beta Regulation of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration

J. Lebrun, M. Hachim, L. Canaff, 2017, Scientific Reports.

Impaired Transforming Growth Factor- (TGF-) Transcriptional Activity and Cell Proliferation Control of a Menin In-frame Deletion Mutant Associated with Multiple

L. Canaff, D. Goltzman, Hiroshi Kaji, 2012 .

Impaired Transforming Growth Factor-β (TGF-β) Transcriptional Activity and Cell Proliferation Control of a Menin In-frame Deletion Mutant Associated with Multiple Endocrine Neoplasia Type 1 (MEN1)*

G. Hendy, D. Goltzman, H. Kaji, 2012, The Journal of Biological Chemistry.