F. Falchi

发表

Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia.

R. Ravazzolo, A. Cavalli, L. Goldoni, 2018, Cell chemical biology.

Structure-based design of small-molecule protein – protein interaction modulators : the story

Maurizio Recanatini, Fabiana Caporuscio, Federico Falchi, 2014 .

N‐[2‐Methyl‐5‐(triazol‐1‐yl)phenyl]pyrimidin‐2‐amine as a Scaffold for the Synthesis of Inhibitors of Bcr‐Abl

E. Crespan, I. Filippi, G. Maga, 2011, ChemMedChem.

Protein Dynamics of the HIF-2α PAS-B Domain upon Heterodimerization and Ligand Binding

M. Recanatini, Matteo Masetti, F. Falchi, 2014, PloS one.

Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.

A. Cavalli, S. Minucci, G. Di Stefano, 2017, ACS chemical biology.

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.

A. Cavalli, M. Radi, E. Crespan, 2017, Journal of medicinal chemistry.

Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.

Maria Paola Costi, A. Cavalli, M. Bolognesi, 2017, European journal of medicinal chemistry.

Targeting the Protein Tunnels of the Urease Accessory Complex: A Theoretical Investigation

M. Recanatini, S. Ciurli, Matteo Masetti, 2020, Molecules.

Chalcone-based carbamates for Alzheimer's disease treatment.

A. Cavalli, F. Belluti, A. Bisi, 2017, Future medicinal chemistry.

Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.

M. Recanatini, L. Altucci, A. Nebbioso, 2014, ACS medicinal chemistry letters.

Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

F. Baldanti, M. Radi, S. Zanoli, 2011, ChemMedChem.

Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication

G. Alvisi, G. Palù, A. Loregian, 2020, Viruses.

Divide et Impera: Identification of Small-Molecule Inhibitors of HCMV Replication Interfering with Dimerization of DNA Polymerase Processivity Factor UL44

G. Alvisi, G. Palù, A. Loregian, 2020, bioRxiv.

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents.

M. Radi, E. Crespan, G. Maga, 2008, Bioorganic & medicinal chemistry letters.

Radial access for percutaneous coronary procedure: relationship between operator expertise and complications

N. Ferrara, A. Petronio, F. Falchi, 2018, Clinical and experimental emergency medicine.

Protein Tunnels: The Case of Urease Accessory Proteins.

A. Cavalli, M. Recanatini, S. Ciurli, 2017, Journal of chemical theory and computation.

Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A.

M. Recanatini, G. Di Stefano, M. Roberti, 2016, Organic & biomolecular chemistry.

Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication.

U. Dietrich, M. Radi, S. Zanoli, 2011, Current medicinal chemistry.

Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti‐HIV Agents

C. Tintori, C. Brullo, E. Crespan, 2013, ChemMedChem.

Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors.

M. Recanatini, R. Buonfiglio, Matteo Masetti, 2015, European journal of medicinal chemistry.

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.

A. Cavalli, V. Andrisano, F. Belluti, 2015, Bioorganic & medicinal chemistry letters.

N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds.

Fabrizio Manetti, Maurizio Botta, Silvia Schenone, 2008, Bioorganic & medicinal chemistry letters.

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.

G. Biamonti, M. Radi, C. Tintori, 2015, Journal of medicinal chemistry.

Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr‐Abl T315I Mutant: from Docking False Positives to ATP‐Noncompetitive Inhibitors

Fabrizio Manetti, Maurizio Botta, Marco Radi, 2010, ChemMedChem.

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.

F. Baldanti, M. Radi, G. Maga, 2012, Bioorganic & medicinal chemistry letters.

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

A. Cavalli, S. Minucci, G. Di Stefano, 2020, Journal of medicinal chemistry.

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.

A. Cavalli, S. Minucci, G. Di Stefano, 2019, European journal of medicinal chemistry.

Fyn kinase in brain diseases and cancer: the search for inhibitors.

F. Musumeci, C. Brullo, S. Schenone, 2011, Current medicinal chemistry.

Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach.

S. Rampelli, S. Turroni, P. Brigidi, 2021, Journal of medicinal chemistry.

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives

A. Cavalli, N. Pedemonte, M. Roberti, 2022, Journal of medicinal chemistry.

Structure-Based Virtual Screening Allows the Identification of Efficient Modulators of E-Cadherin-Mediated Cell–Cell Adhesion

A. Cavalli, Chiara Vettraino, Tommaso Prosdocimi, 2019, International journal of molecular sciences.

Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.

G. Maga, M. Botta, M. Witvrouw, 2008, Journal of medicinal chemistry.

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.

E. Dreassi, G. Maga, S. Schenone, 2009, European journal of medicinal chemistry.

Development of a multisite model for Ni(II) ion in solution from thermodynamic and kinetic data

Andrea Cavalli, Maurizio Recanatini, Matteo Masetti, 2017, J. Comput. Chem..

Review Special FocuS: computational chemiStRy

Federico Falchi, F. Falchi, 2014 .

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.

A. Cavalli, M. Bolognesi, R. Brun, 2015, Journal of medicinal chemistry.

Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5

M. Recanatini, N. Pedemonte, E. Romeo, 2023, Journal of medicinal chemistry.

A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation.

M. Radi, F. Musumeci, C. Zamperini, 2012, Bioorganic & medicinal chemistry letters.

3D QSAR Models Built on Structure‐Based Alignments of Abl Tyrosine Kinase Inhibitors

Fabrizio Manetti, Maurizio Botta, Silvia Schenone, 2009, ChemMedChem.

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin‐Based Derivatives

A. Cavalli, V. Andrisano, F. Belluti, 2016, ChemMedChem.

Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification.

Andrea Armirotti, Andrea Cavalli, Federico Falchi, 2016, Analytical chemistry.

Structure-based design of small-molecule protein-protein interaction modulators: the story so far.

M. Recanatini, F. Falchi, F. Caporuscio, 2014, Future medicinal chemistry.