R. Sinha

发表

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.

B. Bay, M. Lazar, C. Newgard, 2012, The Journal of clinical investigation.

Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice

B. Bay, O. Ilkayeva, C. Newgard, 2014, Hepatology.

Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats.

R. Sinha, Vishwa Mohan, Praveen Kumar, 2015, The Journal of endocrinology.

Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.

B. Bay, B. Singh, P. Yen, 2016, Endocrinology.

Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice.

M. Leow, B. Singh, Sujoy Ghosh, 2016, Endocrinology.

Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy

B. Singh, P. Yen, K. Ohba, 2017, Molecular and Cellular Endocrinology.

Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy

B. Bay, B. Singh, S. Sugii, 2018, Autophagy.

Time-restricted feeding reduces high-fat diet associated placental inflammation and limits adverse effects on fetal organ development.

N. M. Godbole, Sangam Rajak, P. Shukla, 2019, Biochemical and biophysical research communications.

Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model

S. Bandyopadhyay, Amrita Pathak, R. Sinha, 2009, International Journal of Developmental Neuroscience.

Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.

P. Yen, R. Sinha, Sherwin Y Xie, 2014, Biochemical and biophysical research communications.

The roles of autophagy and thyroid hormone in the pathogenesis and treatment of NAFLD

P. Yen, R. Sinha, Jin Zhou, 2021, Hepatoma research.

Direct effects of thyroid hormones on hepatic lipid metabolism

B. Singh, P. Yen, R. Sinha, 2018, Nature Reviews Endocrinology.

Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro.

P. Yen, R. Lesmana, R. Sinha, 2018, Methods in molecular biology.

Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.

S. Cook, B. Bay, S. Chothani, 2019, Human molecular genetics.

Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism.

P. Yen, H. Tan, D. Salvatore, 2014, The Journal of clinical endocrinology and metabolism.

Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk

Sangam Rajak, B. Singh, P. Yen, 2020, International journal of molecular sciences.

Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism

B. Singh, P. Yen, R. Sinha, 2014, Trends in Endocrinology & Metabolism.

Estrogen deficiency induces memory loss via altered hippocampal HB-EGF and autophagy.

S. Bandyopadhyay, N. Chattopadhyay, P. Shukla, 2020, The Journal of endocrinology.

Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)

B. Bay, B. Singh, D. Koeberl, 2017, Scientific Reports.

Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease

B. Singh, P. Yen, R. Sinha, 2021, Hepatoma research.

Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells.

B. Singh, P. Yen, A. Lanni, 2016, Biochemical and biophysical research communications.

Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness.

Pratima Gupta, Sangam Rajak, B. Chakravarti, 2022, Biochimica et biophysica acta. Molecular basis of disease.

MTORC1 inhibition drives crinophagic degradation of glucagon

B. Bay, Sangam Rajak, P. Yen, 2021, Molecular metabolism.

Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation

B. Singh, P. Yen, K. Moe, 2016, Cell Death & Disease.

Non-alcoholic fatty liver disease and hypercholesterolemia: Roles of thyroid hormones, metabolites, and agonists.

B. Singh, P. Yen, R. Sinha, 2019, Thyroid : official journal of the American Thyroid Association.

Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet

F. Goglia, P. Yen, F. Cioffi, 2017, Scientific Reports.

Time-restricted feeding ameliorates maternal high-fat diet-induced fetal lung injury.

Alok Kumar, R. Sinha, M. Godbole, 2020, Experimental and molecular pathology.

Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.

B. Singh, Sujoy Ghosh, P. Yen, 2016, Biochemical and biophysical research communications.

Thyroid hormone receptor-α regulates autophagy, mitochondrial biogenesis, and fatty acid utilization in skeletal muscle.

Sheue-yann Cheng, C. R. Han, P. Yen, 2021, Endocrinology.

Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels

Sujoy Ghosh, Han-Ming Shen, P. Yen, 2019, Autophagy.

Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress.

Ashok Kumar, M. Tiwari, A. Balapure, 2006, Carcinogenesis.

Environmental Toxicants and NAFLD: A Neglected yet Significant Relationship

Sangam Rajak, R. Sinha, S. Raza, 2021, Digestive Diseases and Sciences.

β-Adrenergic Agonist and Antagonist Regulation of Autophagy in HepG2 Cells, Primary Mouse Hepatocytes, and Mouse Liver

B. Bay, B. Singh, P. Yen, 2014, PloS one.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Calcium repletion to rats with calcipenic rickets fails to recover bone quality: A calcipenic "memory".

N. Chattopadhyay, S. Gupta, R. Sinha, 2020, Bone.

Purpurin ameliorates alcohol-induced hepatotoxicity by reducing ROS generation and promoting Nrf2 expression.

A. Meena, W. Raza, Sangam Rajak, 2022, Life sciences.

Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy

D. D. De Silva, S. Hernandez-Resendiz, E. Liehn, 2022, Autophagy.

The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts.

N. Chattopadhyay, R. Sinha, S. Chattopadhyay, 2019, Biochemical pharmacology.

MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism

B. Singh, P. Yen, K. Ohba, 2021, Autophagy.

Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD

P. Yen, R. Sinha, 2016, Cell & Bioscience.

Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency.

B. Bay, D. Koeberl, P. Yen, 2016, Journal of hepatology.

Correction: Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance

B. Bay, Chung S. Yang, B. Singh, 2014, PLoS ONE.

Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance

B. Bay, Chung S. Yang, B. Singh, 2014, PloS one.

Autophagy and its Role in Metabolism

R. Sinha, 2012 .

Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing Syntaxin 17 homocysteinylation.

A. Suzuki, B. Singh, P. Yen, 2022, Journal of hepatology.

Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.

Pratima Gupta, Sangam Rajak, B. Singh, 2021, Biochimica et biophysica acta. Molecular basis of disease.

Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells.

Masahito Katsuki, P. Yen, R. Sinha, 2013, Biochemical and biophysical research communications.

Analysis of influenza virus-induced perturbation in autophagic flux and its modulation during Vitamin D3 mediated anti-apoptotic signaling.

T. Dhole, R. Sinha, S. Tiwari, 2020, Virus research.

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis.

S. Cook, S. Albani, S. Chothani, 2019, Gastroenterology.

IL-11 neutralising therapies target hepatic stellate cell-induced liver inflammation and fibrosis in NASH

S. Cook, S. Albani, S. Chothani, 2018, bioRxiv.

Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism.

R. Sinha, C. Chaturvedi, R. Singh, 2018, Biochemical and biophysical research communications.

Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis

Amrita Pathak, A. Pal, R. Sinha, 2012, Experimental Neurology.

Maternal thyroid hormone before the onset of fetal thyroid function regulates reelin and downstream signaling cascade affecting neocortical neuronal migration.

Amrita Pathak, K. Mitra, R. Sinha, 2011, Cerebral cortex.

Hyperthyroidism induces apoptosis in rat liver through activation of death receptor-mediated pathways.

Ashok Kumar, M. Tiwari, T. Koji, 2007, Journal of hepatology.

ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions

Sangam Rajak, R. Sinha, S. Raza, 2022, Frontiers in Cell and Developmental Biology.

Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia.

B. Bay, D. Koeberl, P. Yen, 2017, Molecular genetics and metabolism.

Mechanisms for Thyroid Hormone Action in the CNS

P. Yen, R. Sinha, 2016 .

Loss of ULK1 Attenuates Cholesterogenic Gene Expression in Mammalian Hepatic Cells

Sangam Rajak, B. Singh, Sujoy Ghosh, 2020, Frontiers in Cell and Developmental Biology.

Thyroid Hormones and Thyromimetics: A New Approach to Nonalcoholic Steatohepatitis?

B. Singh, P. Yen, R. Sinha, 2020, Hepatology.

Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development.

Amrita Pathak, A. Pal, R. Sinha, 2010, Biochemical and biophysical research communications.

Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism.

Sangam Rajak, N. Chattopadhyay, R. Sinha, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development

Amrita Pathak, A. Pal, R. Sinha, 2011, Experimental Neurology.

Resveratrol induces insulin gene expression in mouse pancreatic α-cells

W. Han, B. Singh, P. Yen, 2013, Cell & Bioscience.

Molecular signaling network and therapeutic developments in breast cancer brain metastasis

S. Batra, B. Chakravarti, M. Nasser, 2022, Advances in cancer biology - metastasis.

Increased pro-nerve growth factor and p75 neurotrophin receptor levels in developing hypothyroid rat cerebral cortex are associated with enhanced apoptosis.

Ashok Kumar, M. Tiwari, Rajesh Singh, 2006, Endocrinology.

Amniotic fluid stem cells ameliorate cisplatin-induced acute renal failure through induction of autophagy and inhibition of apoptosis

R. Sinha, C. Chaturvedi, S. Nityanand, 2019, Stem Cell Research & Therapy.

Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells.

Ashok Kumar, M. Tiwari, S. Behari, 2007, Carcinogenesis.

Molecular Iodine Induces Caspase-independent Apoptosis in Human Breast Carcinoma Cells Involving the Mitochondria-mediated Pathway*

Ashok Kumar, M. Tiwari, A. Balapure, 2006, Journal of Biological Chemistry.

Multifaceted role of chemokines in solid tumors: from biology to therapy.

Sangam Rajak, B. Chakravarti, N. Chattopadhyay, 2021, Seminars in cancer biology.

Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling

B. Bay, B. Singh, J. Gooding, 2015, Autophagy.

Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library

Yew Chung Tang, P. Tan, Junbo Hu, 2012, BMC Medical Genomics.

Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition*

B. Singh, Sujoy Ghosh, A. Hollenberg, 2015, The Journal of Biological Chemistry.

TH regulates SIRT 1-RICTOR-AKT to activate FOXO 1 1 Hepatic FOXO 1 target genes are co-regulated by thyroid hormone via RICTOR deacetylation and MTORC 2-AKT inhibition *

B. Singh, Sujoy Ghosh, A. Hollenberg, 2015 .

Vitamins and non-alcoholic fatty liver disease: A Molecular Insight⋆.

Sangam Rajak, R. Sinha, Archana Tewari, 2021, Liver research.

Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma

Sangam Rajak, R. Sinha, B. Anjum, 2019, Hepatoma research.

Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis.

B. Singh, P. Yen, R. Sinha, 2017, Endocrine reviews.

Autophagy: A Cellular Guardian against Hepatic Lipotoxicity

R. Sinha, 2023, Genes.

Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging

A. Salmon, B. Singh, P. Yen, 2017, Aging.

FoxO1 Deacetylation Regulates Thyroid Hormone-induced Transcription of Key Hepatic Gluconeogenic Genes*

S. You, B. Singh, P. Yen, 2013, The Journal of Biological Chemistry.

An integrative approach identified genes associated with drug response in gastric cancer.

I. Tan, P. Tan, B. Singh, 2015, Carcinogenesis.

Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells

B. Singh, Sujoy Ghosh, A. Hollenberg, 2016, Autophagy.

Activation of Liver X receptors (LXRs) increases sphingolipid biosynthesis in hepatic cells

B. Singh, P. Yen, R. Sinha, 2016 .

Autophagic protein ULK1 regulates FOXM1 signalling in human hepatoma cells.

Sangam Rajak, Sujoy Ghosh, P. Yen, 2020, Biochemical and biophysical research communications.

Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury.

S. Pradhan, R. Sinha, M. Godbole, 2018, Biochemical and biophysical research communications.

Pharmacological inhibition of CFTR attenuates nonalcoholic steatohepatitis (NASH) progression in mice.

Pratima Gupta, Sangam Rajak, B. Chakravarti, 2023, Biochimica et biophysica acta. Molecular basis of disease.

Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75NTR

Ashok Kumar, M. Tiwari, Ashutosh Shrivastava, 2009, Molecular and Cellular Neuroscience.

Cellular Action of Thyroid Hormone

P. Yen, R. Sinha, 2014 .

Impaired Autophagy Flux is Associated with Proinflammatory Microglia Activation Following Japanese Encephalitis Virus Infection

U. K. Misra, J. Kalita, Alok Kumar, 2020, Neurochemical Research.

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

B. Bay, V. Giguère, B. Singh, 2018, Science Signaling.

Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD

P. Angus, S. Soh, M. Leow, 2018, The Journal of clinical endocrinology and metabolism.

Moderate/subclinical calcium deficiency attenuates trabecular mass, microarchitecture and bone growth in growing rats

N. Chattopadhyay, S. Gupta, R. Sinha, 2021, Biochemistry and biophysics reports.

Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone

B. Singh, P. Yen, R. Sinha, 2018, International journal of molecular sciences.

Adiponectin receptors by increasing mitochondrial biogenesis and respiration promote osteoblast differentiation: Discovery of isovitexin as a new class of small molecule adiponectin receptor modulator with potential osteoanabolic function.

Sangam Rajak, N. Chattopadhyay, M. Siddiqi, 2021, European journal of pharmacology.

Maternal Thyroid Hormone: a Strong Repressor of Neuronal Nitric Oxide Synthase (nnos) in Rat Embryonic Neocortex Short Title: Maternal Thyroxine and Nnos Expression

S. Bandyopadhyay, Amrita Pathak, R. Sinha, 2022 .

ULK1 inhibition attenuates telomerase activity in hepatic cells.

Pratima Gupta, Sangam Rajak, B. Chakravarti, 2022, Biochimica et biophysica acta. Molecular cell research.

Iodine plus n-3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum

A. Pal, R. Sinha, Vishwa Mohan, 2013, British Journal of Nutrition.

Targeting Extracellular RNA Mitigates Hepatic Lipotoxicity and Liver Injury in NASH

Sangam Rajak, B. Chakravarti, R. Sinha, 2023, Cells.

Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.

M. Leow, B. Singh, S. Refetoff, 2017, Thyroid : official journal of the American Thyroid Association.

MTORC1-dependent crinophagy regulates glucagon content in pancreatic α-cells

Sangam Rajak, P. Yen, R. Sinha, 2021, Autophagy.

Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD

P. Yen, R. Sinha, 2016, Cell & Bioscience.

Gossypol enhances the efficacy of sorafenib by trigging autophagy and apoptosis in metastatic lung cancer cells: An upshot of Chou-Talalay combination index process.

A. Meena, Yusuf Hussain, R. Sinha, 2023, Toxicology in vitro : an international journal published in association with BIBRA.

Escin enhanced the efficacy of sorafenib by autophagy‐mediated apoptosis in lung cancer cells

Suaib Luqman, A. Meena, Yusuf Hussain, 2023, Phytotherapy research : PTR.