C. Wright

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Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy

S. Chowdhury, Souvik Sengupta, S. BoseDasgupta, 2011, Molecular biology international.

In vitro antimalarial and cytotoxic activities of semisynthetic derivatives of brusatol

J. Phillipson, I. Toth, D. Warhurst, 1993 .

The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.

G. Besra, C. Lau, S. Gurcha, 2002, Journal of ethnopharmacology.

Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition.

B. Fiebich, C. Wright, O. Olajide, 2013, European journal of medicinal chemistry.

Effects of the anti-malarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay.

Diana Anderson, R. Gopalan, C. Wright, 2011, Toxicology letters.

Artemisia annua as a Traditional Herbal Antimalarial

G. Bodeker, D. Provendier, B. Graz, 2011 .

Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

P. Rasoanaivo, M. Willcox, C. Wright, 2011, Malaria Journal.

Tropical Plants as Sources of Antiprotozoal Agents

J. Phillipson, D. Warhurst, C. Wright, 1993 .

Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

A. D. Forkuo, C. Rynn, C. Wright, 2017, BMC Pharmacology and Toxicology.

Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine

B. Fiebich, C. Wright, O. Olajide, 2013, Evidence-based complementary and alternative medicine : eCAM.

Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death.

W. Wätjen, C. Wright, C. Passreiter, 2015, Phytochemistry.

Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation.

W. Wätjen, C. Wright, A. Kampkötter, 2007, Toxicology.

Phytotherapy used in orissa state, india for treating malaria

S. Parida, V. Kantamreddi, C. Wright, 2009, Phytotherapy research : PTR.

Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.

S. Croft, J. Brown, P. Pollet, 2001, Journal of medicinal chemistry.

In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers.

M. Bibby, R. Wheelhouse, P. Linley, 2004, Journal of natural products.

A microwell cytotoxicity assay using Artemia salina (brine shrimp).

Mahabir P. Gupta, J. Phillipson, M. Anderson, 1993, Planta medica.

Antiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and of some alkaloids isolated from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine.

S. Croft, C. Wright, H. Kendrick, 2001, Journal of ethnopharmacology.

Preliminary investigation of Cyathostemma argenteum, a plant species used in traditional medicine for the treatment of breast cancer

S. Khamis, C. Wright, H. E. Kirkpatrick, 1998 .

Can ethnopharmacology contribute to the development of antimalarial agents?

J. Phillipson, C. Wright, C. Wright, 1991, Journal of ethnopharmacology.

Toward the chemical ecology of medicinal plant use in chimpanzees: The case ofVernonia amygdalina, a plant used by wild chimpanzees possibly for parasite-related diseases

H. Ohigashi, D. Warhurst, D. Allen, 1994, Journal of Chemical Ecology.

Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids

J. Phillipson, D. Warhurst, C. Wright, 1988, Antimicrobial Agents and Chemotherapy.

In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids

P. F. Russell, J. Phillipson, M. Anderson, 1994, Antimicrobial Agents and Chemotherapy.

Natural products and the development of selective antiprotozoal drugs

J. Phillipson, C. Wright, C. Wright, 1990 .

The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.

L. Angenot, C. Bailly, P. Colson, 1998, Biochemistry.

The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites

Juan Aymami, M. Coll, Colin W. Wright, 2002, Nature Structural Biology.

Recent developments in naturally derived antimalarials: cryptolepine analogues

C. Wright, 2007, The Journal of pharmacy and pharmacology.

Synthetic cryptolepine inhibits DNA binding of NF-κB

A. Vollmar, E. Heiss, V. Dirsch, 2007 .

Crystallization and preliminary X-ray analysis of the antimalarial and cytotoxic alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG)2.

J. Pous, M. Coll, C. Wright, 2002, Acta crystallographica. Section D, Biological crystallography.

Structure of the tetraphenyl borate complex of the indoloquinoline alkaloid cryptolepine

R. Palmer, C. Wright, J. Lisgarten, 1999 .

In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine

D. Mancama, A. D. Forkuo, K. Annan, 2017, Malaria Journal.

Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

A. D. Forkuo, C. Rynn, C. Wright, 2017, BMC Pharmacology and Toxicology.

Levels in Severe and Uncomplicated Malaria in Relation to Reactive Oxygen Species amongst Ghanaian Children View project

D. Mancama, A. D. Forkuo, K. Annan, 2017 .

Metabolism of cryptolepine and 2‐fluorocryptolepine by aldehyde oxidase

J. Stell, R. Wheelhouse, C. Wright, 2012, The Journal of pharmacy and pharmacology.

Anti‐inflammatory properties of cryptolepine

C. Wright, A. Ajayi, O. Olajide, 2009, Phytotherapy research : PTR.

Plant Derived Antimalarial Agents: New Leads and Challenges

C. Wright, 2005, Phytochemistry Reviews.

Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action.

S. Croft, S. Parapini, D. Taramelli, 2005, Journal of medicinal chemistry.

In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots

J. Phillipson, D. Warhurst, D. Allen, 1992 .

Recent developments in research on terrestrial plants used for the treatment of malaria.

C. Wright, 2010, Natural product reports.

Prenylated flavonoid derivatives from the bark of Erythrina addisoniae.

W. Wätjen, C. Wright, R. Rohrig, 2008, Journal of natural products.

Investigation of Indian Diospyros Species for Antiplasmodial Properties

V. Kantamreddi, C. Wright, 2007, Evidence-based complementary and alternative medicine : eCAM.

Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone

P. F. Russell, J. Phillipson, D. Warhurst, 2000, Phytotherapy research : PTR.

Antiprotozoal activities of Centipeda minima

J. Phillipson, D. Warhurst, C. Wright, 1994 .

Selective antiprotozoal activity of some Strychnos alkaloids

L. Angenot, J. Phillipson, M. Tits, 1994 .

InVitro Antiplasmodial, Antiamoebic, andCytotoxic Activities ofa Series ofBisbenzylisoquin oline Alkaloids

M. Anderson, C. Wright, 1994 .

Quassinoids Exhibit Greater Selectivity Against Plasmodium Falciparum Than Against Entamoeba Histolytica, Giardia Intestinalis Or Toxoplasma Gondii In Vitro

J. Phillipson, H. R. Chang, M. Anderson, 1993, The Journal of eukaryotic microbiology.

Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico).

J. Phillipson, M. Heinrich, D. Warhurst, 1992, Journal of ethnopharmacology.

ANTIAMOEBIC ACTIVITY OF INDOLE ANALOGUES OF EMETINE WITH IN‐VITRO POTENCY GREATER THAN THAT OF EMETINE

L. Angenot, J. Phillipson, J. Quetin-Leclercq, 1990 .

A review of antimycobacterial natural products

C. Wright, S. Newton, C. Lau, 2000, Phytotherapy research : PTR.

Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection.

S. Y. Gbedema, M. Bayor, K. Annan, 2015, Journal of ethnopharmacology.

1. Medicinal plants against protozoal diseases

J. Phillipson, C. Wright, 1991 .

Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta

S. Gibbons, F. Fallah, C. Wright, 2003, Phytotherapy research : PTR.

Evaluation of Some Egyptian Plant Species for in vitro Antimycobacterial and Cytotoxic Activities

M. Bibby, C. Wright, N. Shoeib, 2003 .

Plants as sources of antimalarial drugs, Part 6: Activities of Simarouba amara fruits.

J. Phillipson, D. Warhurst, M. Gupta, 1988, Journal of ethnopharmacology.

Antiprotozoal Agents from Plant Sources

J. Phillipson, C. Wright, C. Wright, 1991, Planta medica.

Antiplasmodial compounds from Cassia siamea stem bark extract

J. Ashidi, C. Wright, P. Houghton, 2008, Phytotherapy research : PTR.

Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.

S. Croft, I. Scowen, W. Abraham, 2002, Journal of natural products.

Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus.

C. Pannecouque, S. Apers, N. Hermans, 2010, Planta medica.

Alstonia species: are they effective in malaria treatment?

J. Phillipson, D. Warhurst, D. Allen, 1993, Journal of ethnopharmacology.

Cajachalcone: An Antimalarial Compound from Cajanus cajan Leaf Extract

P. Houghton, J. Ashidi, O. Ogbole, 2013, Journal of parasitology research.

Screening Indian Plant Species for Antiplasmodial Properties – Ethnopharmacological Compared with Random Selection

V. Kantamreddi, C. Wright, 2012, Phytotherapy research : PTR.

CRYPTOLEPINE AND DEVELOPMENT OF NEW ANTIMALARIAL AGENTS

C. Wright, 2010 .

Critical Evaluation of the DNA-methyl Green Assay : Application to Some indole alkaloids

L. Angenot, J. Quetin-Leclercq, C. Wright, 1996 .

Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae).

O. Olubiyi, F. V. van Heerden, C. Wright, 2017, Bioorganic & medicinal chemistry.

Medicinal plants in tropical medicine. 1. Medicinal plants against protozoal diseases.

J. Phillipson, C. Wright, 1991, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Ancient Chinese Methods Are Remarkably Effective for the Preparation of Artemisinin-Rich Extracts of Qing Hao with Potent Antimalarial Activity

P. Linley, R. Brun, S. Wittlin, 2010, Molecules.

Artemisia annua as a herbal tea for malaria.

V. Sharma, M. Willcox, J. Ferreira, 2006, African journal of traditional, complementary, and alternative medicines : AJTCAM.

Traditional antimalarials and the development of novel antimalarial drugs.

C. Wright, C. Wright, 2005, Journal of ethnopharmacology.

Bioactivity and cytotoxicity profiling of strictosamide and vincosamide, anthelmintic epimers from Sarcocephalus latifolius (Smith) Bruce leaf.

C. Wright, A. Fatokun, S. Aderibigbe, 2020, Journal of ethnopharmacology.

Recent Advances in the Chemistry and Pharmacology of Cryptolepine.

S. Shnyder, C. Wright, 2021, Progress in the chemistry of organic natural products.

Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

A. Isaksson, R. Larsson, P. Nygren, 2009, Investigational New Drugs.

Searching for new treatments of malaria

C. Wright, 2015 .

Correlation of Hyperforin Content of Hypericum Perforatum(St John’s Wort) Extracts with Their Effects On Alcohol Drinking in C57Bl/6J Mice: A Preliminary Study

A. G. Smith, C. Wright, B. Grayson, 2003, Journal of psychopharmacology.

Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer

E. Winzeler, D. V. van Schalkwyk, J. Cockcroft, 2022, Frontiers in Pharmacology.

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.

A. Fairlamb, S. Y. Gbedema, D. Muñoz-Torrero, 2015, Bioorganic & medicinal chemistry.

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.

S. Y. Gbedema, D. Muñoz-Torrero, M. Taylor, 2014, Bioorganic & medicinal chemistry letters.

Antiprotozoal agents from plant sources.

J. Phillipson, C. Wright, 1991, Planta medica.

A methanolic extract of Zanthoxylum bungeanum modulates secondary metabolism regulator genes in Aspergillus flavus and shuts down aflatoxin production

A. Malinen, T. Yli-Mattila, C. Wright, 2022, Scientific Reports.

Seasonal Variation in Bromophenol Content of Polysiphonia lanosa

M. Bibby, P. Linley, G. Blunden, 2006 .

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

D. Muñoz-Torrero, M. Taylor, J. Kelly, 2016, Bioorganic & medicinal chemistry.

Huprines as a new family of dual acting trypanocidal–antiplasmodial agents

P. Camps, D. Muñoz-Torrero, M. Taylor, 2011, Bioorganic & medicinal chemistry.

Synthetic cryptolepine inhibits DNA binding of NF-kappaB.

A. Vollmar, E. Heiss, V. Dirsch, 2007, Bioorganic & medicinal chemistry.

In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.

P. F. Russell, J. Phillipson, M. Anderson, 2000, Journal of natural products.

Genomewide Expression Profiling of Cryptolepine-Induced Toxicity in Saccharomyces cerevisiae

B. Piña, Marta Rojas, Colin W. Wright, 2008, Antimicrobial Agents and Chemotherapy.

New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley & Dendly)

N. Sarma, Y. Murthy, P. Parameswaran, 2010 .

Phytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a malaysian plant used traditionally for the treatment of breast cancer

I. Scowen, P. Cooper, M. Bibby, 2004, Phytotherapy research : PTR.

Determination of anti-giardial activity in vitro by means of soluble formazan production.

J. Phillipson, D. Warhurst, C. Wright, 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

X-ray Crystallographic Structure of the Potent Antiplasmodial Compound 2,7-Dibromocryptolepine Acetic Acid Solvate

J. Pitts, R. Palmer, C. Wright, 2008 .

Antileishmanial activity of cryptolepine analogues and apoptotic effects of 2,7-dibromocryptolepine against Leishmania donovani promastigotes

S. Sundar, V. Prajapati, C. Wright, 2012, Parasitology Research.

Antiplasmodial Activities Of Sesquiterpene Lactones From Eupatorium Semialatum

J. Castillo, N. Filipowicz, C. Wright, 2002, Zeitschrift für Naturforschung C - A Journal of Biosciences.

Antiplasmodial Principles from Cassia nigricans.

J. Okogun, U. Inyang, C. Wright, 2005 .

The Evaluation of Selected Ghanaian Medicinal Plants for Cytotoxic Activities

M. Bayor, R. Phillips, S. Shnyder, 2008 .

A Cytotoxic Diterpenoid from Croton Membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

R. Wheelhouse, M. Bayor, R. Phillips, 2008 .

Alkaloids from Narcissus cantabricus

C. Codina, J. Phillipson, C. Wright, 1995 .

Evaluation of 43 species of Congolese medicinal plants used traditionally for the treatment of schistosomiasis leading to the isolation of an anti-schistosomal phaeophytin from Pseudolachnostylis maprouneifolia Pax.

J. Keiser, C. Wright, Cécile Häberli, 2023, Journal of ethnopharmacology.

Anthelmintic activity and non-cytotoxicity of phaeophorbide-a isolated from the leaf of Spondias mombin L.

C. Wright, A. Fatokun, I. O. Ademola, 2021, Journal of ethnopharmacology.

An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside Against Cancer and Non-cancer Cells

P. Linley, R. Phillips, Simon J. Allison, 2021, Planta Medica.

Chapter 28 – Antiprotozoal natural products

C. Wright, 2009 .

Complete NMR Assignments of Tubulosine

C. Wright, V. S. S. Kantamreddi, 2012, Natural product communications.

Evaluation of Alangium lamarckii Bark for Antiplasmodial and Cytotoxic Constituents and Isolation of a Novel Tubulosine Analogue

S. Shnyder, C. Wright, Gemma Marston, 2018, Natural Product Communications.

Machine learning enhances prediction of plants as potential sources of antimalarials

M. Howes, E. Lucas, D. Silvestro, 2023, Frontiers in Plant Science.

Antimalarial Activity of Cryptolepine and Some Other Anhydronium Bases

L. Angenot, J. Phillipson, J. Quetin-Leclercq, 1996 .

Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer

R. Klopfleisch, I. Martincorena, D. Adams, 2023, Genome Biology.

Alkaloids from Cephaelis dichroa

Mahabir P. Gupta, J. Phillipson, C. Wright, 1993 .

Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death

C. Wright, C. Passreiter, A. Kulawik, 2015 .

Antileishmanial activity of cryptolepine analogues and apoptotic effects of 2,7-dibromocryptolepine against Leishmania donovani promastigotes

S. Sundar, V. Prajapati, C. Wright, 2012, Parasitology Research.