F. Hong

发表

Progress of molecular biology researches in insect flight muscle cell apoptosis

F. Hong, 2011 .

GP96 is a GARP chaperone and controls regulatory T cell functions.

J. Thaxton, Yongliang Zhang, Zihai Li, 2015, The Journal of clinical investigation.

Antifibrotic Activity of Sorafenib in Experimental Hepatic Fibrosis: Refinement of Inhibitory Targets, Dosing, and Window of Efficacy In Vivo

S. Friedman, M. Fiel, F. Hong, 2012, Digestive Diseases and Sciences.

Human immunodeficiency virus (HIV)‐1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein‐1 expression: Implications for the pathogenesis of HIV/hepatitis C virus–induced liver fibrosis

Benjamin K. Chen, Ping Chen, F. Hong, 2010, Hepatology.

In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats.

Zhaoli Sun, Z. Tian, A. Klein, 2003, Gastroenterology.

Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes.

H. Cai, S. Strom, Youhua Liu, 2002, Gastroenterology.

Crucial Role of IL-4/STAT6 in T Cell-Mediated Hepatitis: Up-Regulating Eotaxins and IL-5 and Recruiting Leukocytes

R. Sun, B. Gao, S. Radaeva, 2003, The Journal of Immunology.

Cannabinoid‐2 receptor mediates protection against hepatic ischemia/reperfusion injury

H. Pan, D. Osei-Hyiaman, P. Pacher, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

S. Friedman, G. Moyle, H. Yoneyama, 2016, PloS one.

Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.

G. Chiosis, J. Thaxton, Zihai Li, 2016, Current topics in medicinal chemistry.

Host factors and failure of interferon-alpha treatment in hepatitis C virus.

B. Gao, S. Radaeva, F. Hong, 2004, Hepatology.

Erratum: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

B. Hao, Matthew M. Staron, Zihai Li, 2012, Nature Communications.

blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells

Hong-gang Yu, Yongliang Zhang, Zihai Li, 2016 .

CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells

Hong-gang Yu, Yongliang Zhang, Zihai Li, 2016, Oncoimmunology.

glycoprotein Ib-IX-V complex Heat-shock protein gp96/grp94 is an essential chaperone for the platelet

Aleksandra Stojanovic, Xiaoping Du, Matthew M. Staron, 2012 .

Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.

Aleksandra Stojanovic, Xiaoping Du, Matthew M. Staron, 2011, Blood.

Exploring the Functional Complementation between Grp94 and Hsp90

Zihai Li, D. Gewirth, F. Hong, 2016, PloS one.

A DDX5 S480A Polymorphism Is Associated with Increased Transcription of Fibrogenic Genes in Hepatic Stellate Cells*

S. Friedman, J. Sninsky, D. Mann, 2009, The Journal of Biological Chemistry.

OF DISEASE Host Factors and Failure of Interferon-Treatment in Hepatitis C Virus

B. Gao, S. Radaeva, F. Hong, 2003 .

IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver.

B. Gao, S. Radaeva, F. Hong, 2004, Cellular & molecular immunology.

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

S. Friedman, P. Traber, A. Klyosov, 2013, PloS one.

Additive activation of hepatic NF‐κB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF‐α receptor 1‐independent and ‐dependent mechanisms

Zongyi Hu, T. Liang, S. Fan, 2001 .

Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-xL proteins

Z. Tian, B. Gao, F. Hong, 2002, Oncogene.

Functional linkage of cirrhosis‐predictive single nucleotide polymorphisms of toll‐like receptor 4 to hepatic stellate cell responses

Olivia T. Abar, S. Friedman, J. Sninsky, 2009, Hepatology.

Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways.

S. Fan, R. Sun, B. Gao, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Hydrodynamic Gene Delivery of Interleukin-22 Protects the Mouse Liver from Concanavalin A-, Carbon Tetrachloride-, and Fas Ligand-induced Injury via Activation of Stat3 Interleukin-22 (il-22) Is a Recently Identified T Cell-derived Cytokine Whose Biological Significance Remains Obscure. Previously,

B. Gao, S. Radaeva, F. Hong, 2022 .

Chronic ethanol consumption inhibits hepatic natural killer cell activity and accelerates murine cytomegalovirus-induced hepatitis.

R. Sun, B. Gao, F. Hong, 2006, Alcoholism, clinical and experimental research.

Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.

Zihai Li, D. Gewirth, F. Hong, 2017, Cell reports.

Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration.

X. Shen, B. Gao, G. Kunos, 2000, Biochemical and biophysical research communications.

CNPY2 is a Key Initiator of the PERK-CHOP Pathway of the Unfolded Protein Response

J. Diehl, Zihai Li, C. Davies, 2017, Nature Structural &Molecular Biology.

α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96

G. Chiosis, Zihai Li, D. Gewirth, 2013, The Journal of Biological Chemistry.

Reticulum Chaperone gp 96 : A for Integrin Binding to Endoplasmic I Domain Is Crucial α 7 Helix Region of α Protein Structure and Folding :

G. Chiosis, Zihai Li, D. Gewirth, 2013 .

Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response–dependent destabilization of tumor protein P53

W. Gu, Yizhou Dong, Zihai Li, 2022 .

X4 Human Immunodeficiency Virus Type 1 gp120 Promotes Human Hepatic Stellate Cell Activation and Collagen I Expression through Interactions with CXCR4

Chuanping Si, F. Hong, Y. Saiman, 2012, PloS one.

Interleukin 22 (IL‐22) plays a protective role in T cell‐mediated murine hepatitis: IL‐22 is a survival factor for hepatocytes via STAT3 activation

R. Sun, B. Gao, S. Radaeva, 2004, Hepatology.

Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.

Z. Tian, B. Gao, S. Radaeva, 2002, The Journal of clinical investigation.

Hepatic stellate cells express functional CXCR4: Role in stromal cell–derived factor‐1α–mediated stellate cell activation

Ritu Agarwal, A. Branch, M. Schwartz, 2009, Hepatology.

Tumor necrosis factor α attenuates interferon‐α signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy

B. Gao, F. Hong, V. Nguyen, 2001 .

Host factors and failure of interferon‐α treatment in hepatitis C virus

B. Gao, S. Radaeva, F. Hong, 2004 .

The Regulation of the Unfolded Protein Response and Its Roles in Tumorigenesis and Cancer Therapy

Zihai Li, F. Hong, Jordan Morreall, 2019, Cancer Drug Discovery and Development.

Interferon-α activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes

H. Cai, S. Strom, Youhua Liu, 2002 .

Phosphorylated nerve growth factor-induced clone B (NGFI-B) translocates from the nucleus to mitochondria of stressed rat cardiomyocytes and induces apoptosis

F. Hong, Z. Rui, Qian Lingjia, 2012, Stress.

Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway

Dianqing Wu, Matthew M. Staron, Zihai Li, 2013, Proceedings of the National Academy of Sciences.

Interleukin‐22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

B. Gao, F. Hong, D. Feng, 2012, Hepatology.

Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease

Zhigang Tian, Bin Gao, Z. Tian, 2004, Hepatology.

GP96 is a GARP chaperone and controls regulatory T cell functions.

J. Thaxton, Yongliang Zhang, Zihai Li, 2015, The Journal of clinical investigation.

Erratum: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

B. Hao, Matthew M. Staron, Zihai Li, 2012, Nature Communications.

IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1.

Won Ho Kim, Bin Gao, B. Gao, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Chaperone gp96-independent Inhibition of Endotoxin Response by Chaperone-based Peptide Inhibitors*

Zihai Li, Bei Liu, F. Hong, 2012, The Journal of Biological Chemistry.

IL‐10 attenuates IFN‐α‐activated STAT1 in the liver: involvement of SOCS2 and SOCS3

B. Gao, F. Hong, V. Nguyen, 2000 .

Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: differential regulation by acute ethanol via a protein kinase C-dependent mechanism.

J. Chen, B. Gao, F. Hong, 2000, The Biochemical journal.

Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis.

Yongliang Zhang, Zihai Li, X. Ouyang, 2014, Cancer research.

CNPY2 Contributes to Liver Oncogenesis by Promoting UPR-dependent destabilization of p53.

W. Gu, Yizhou Dong, Zihai Li, 2022, Hepatology.

STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury.

S. Fan, B. Gao, S. Radaeva, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism.

T. Liang, S. Fan, B. Gao, 2005, Cellular & molecular immunology.

The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain*

Zihai Li, D. Gewirth, Bei Liu, 2012, The Journal of Biological Chemistry.

GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development.

Yongliang Zhang, Zihai Li, Bill X. Wu, 2016, Advances in cancer research.

High expression of endoplasmic reticulum chaperone grp94 is a novel molecular hallmark of malignant plasma cells in multiple myeloma

Sandeep Jain, C. Wallace, Bei Liu, 2015, Journal of Hematology & Oncology.

Characterization of the Grp94/OS-9 chaperone-lectin complex.

M. Cosgrove, Zihai Li, D. Gewirth, 2014, Journal of molecular biology.

Frontline Science: HIV infection of Kupffer cells results in an amplified proinflammatory response to LPS

A. Branch, Adeeb H. Rahman, M. Stevenson, 2017, Journal of leukocyte biology.

IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3.

X. Shen, B. Gao, F. Hong, 2000, FEBS letters.

Tumor necrosis factor alpha attenuates interferon alpha signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy.

B. Gao, F. Hong, V. Nguyen, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90

Hongyu Zhao, O. Ohara, H. Hirano, 2017, PloS one.

Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease

Z. Tian, R. Veech, B. Gao, 2004 .

gp96-Independent Inhibition of Endotoxin Response By Chaperone-Based Peptide Inhibitors CHAPERONE-BASED INHIBITORS AGAINST LPS

M. Noman, Zihai Li, Bei Liu, 2012 .

Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.

Zihai Li, D. Gewirth, F. Hong, 2017, Cell reports.

Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.

Aleksandra Stojanovic, Xiaoping Du, Matthew M. Staron, 2011, Blood.

Characterization of the Grp94/OS-9 chaperone-lectin complex.

M. Cosgrove, Zihai Li, D. Gewirth, 2014, Journal of Molecular Biology.