Shizhen Zhu

发表

Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology

Choong Yong Ung, C. Ung, Shizhen Zhu, 2016, International journal of molecular sciences.

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification.

Richard A. Young, R. Young, A. Look, 2018, Cancer discovery.

Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.

A. Look, B. Neel, D. Fisher, 2010, Developmental cell.

Gene utility recapitulates chromosomal aberrancies in advanced stage neuroblastoma

C. Ung, Shizhen Zhu, K. Yeo, 2022, Computational and structural biotechnology journal.

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.

Hu Li, A. Look, C. Ung, 2017, Cell reports.

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

D. Neuberg, A. Look, J. Kutok, 2012, Cancer cell.

A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

M. Parker, Z. Nagy, O. Sangfelt, 2021, Oncogene.

K-ras/PI3K-Akt Signaling Is Essential for Zebrafish Hematopoiesis and Angiogenesis

Z. Gong, B. C. Low, Shizhen Zhu, 2008, PloS one.

A Knowledge-Based Discovery Approach Couples Artificial Neural Networks With Weight Engineering to Uncover Immune-Related Processes Underpinning Clinical Traits of Breast Cancer

C. Ung, Hu Li, Shizhen Zhu, 2022, Frontiers in Immunology.

Using zebrafish for studying Rho GTPases signaling in vivo.

B. C. Low, Shizhen Zhu, 2012, Methods in molecular biology.

Zebrafish Model of Neuroblastoma Metastasis.

Shizhen Zhu, K. Yeo, T. Levee, 2021, Journal of visualized experiments : JoVE.

Yupingfeng formula inhibits lung cancer metastasis via modulating NK cells in a mouse model

Shizhen Zhu, Haiyan Si, C. Yao, 2019 .

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

Andrew C. Wood, Nazneen Rahman, Sharon J. Diskin, 2015, Nature.

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

A. Look, J. Epstein, Shuning He, 2016, eLife.

Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health

C. Ung, D. Billadeau, Hu Li, 2023, Frontiers in Cell and Developmental Biology.

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

D. Neuberg, A. Look, M. Harris, 2011, The Journal of experimental medicine.

Neuroblastoma and Its Zebrafish Model.

Shizhen Zhu, A. Thomas Look, 2016, Advances in experimental medicine and biology.

Zebrafish as a Neuroblastoma Model: Progress Made, Promise for the Future

Shizhen Zhu, K. Yeo, Shuai Li, 2021, Cells.

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

A. Look, T. Tao, G. Qing, 2021, Cancer Research.

GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma

Hu Li, A. Look, C. Ung, 2021, Cancer Research.

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Hu Li, D. Neuberg, A. Look, 2017, Cancer cell.

Unraveling Neuroblastoma Pathogenesis with the Zebrafish

A. Look, Shizhen Zhu, Erin N. Dankert, 2018, Cell cycle.

Mosaic zebrafish transgenesis for functional genomic analysis of candidate cooperative genes in tumor pathogenesis.

C. Ung, Shizhen Zhu, Xiaoling Zhang, 2015, Journal of visualized experiments : JoVE.

Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.

A. Look, J. Epstein, A. Padmanabhan, 2010, Human molecular genetics.

Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

M. Fischer, A. Oberthuer, M. Parker, 2019, Cancer research.

Machine Learning-Assisted Network Inference Approach to Identify a New Class of Genes that Coordinate the Functionality of Cancer Networks

Cheng Zhang, Choong Yong Ung, Hu Li, 2017, Scientific Reports.

RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling.

Z. Gong, V. Korzh, B. C. Low, 2006, Cellular signalling.

Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State

R. Young, J. Joung, J. Maris, 2023, bioRxiv.

Title: c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification Authors:

R. Young, A. Look, Beisi Xu, 2017 .

Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer

Fei Zhang, Shizhen Zhu, C. Yao, 2021, Mediators of inflammation.

Network Biology-Inspired Machine Learning Features Predict Cancer Gene Targets and Reveal Target Coordinating Mechanisms

Hu Li, Shizhen Zhu, Cristina Correia, 2023, Pharmaceuticals.

Machine Learning-Assisted Network Inference Approach to Identify a New Class of Genes that Coordinate the Functionality of Cancer Networks

Hu Li, C. Ung, Mehrab Ghanat Bari, 2017, Scientific Reports.

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

R. Young, J. Joung, J. Maris, 2023, The Journal of clinical investigation.

Supplemental Methods PCR analysis on genomic translocations Genomic

R. Young, A. Look, Beisi Xu, 2017 .

SPIN-AI: A Deep Learning Model That Identifies Spatially Predictive Genes

Hu Li, C. Ung, Shizhen Zhu, 2023, Biomolecules.

The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma

A. Look, T. Tao, S. Baserga, 2017, Oncogene.

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Hu Li, D. Neuberg, A. Look, 2017, Cancer cell.

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

A. Look, J. Epstein, Shuning He, 2016, eLife.