S. Singhal

发表

Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin.

Y. Awasthi, S. Awasthi, S. Pikula, 2000, Biochemistry.

Role of Glutathione S-Transferases in Protection against Lipid Peroxidation

Y. Awasthi, S. Awasthi, J. Cheng, 2001, The Journal of Biological Chemistry.

COH-SR4 Reduces Body Weight, Improves Glycemic Control and Prevents Hepatic Steatosis in High Fat Diet-Induced Obese Mice

S. Awasthi, S. Rahbar, S. Singhal, 2013, PloS one.

Novel Anti-cancer Compounds for Developing Combinatorial Therapies to Target Anoikis-Resistant Tumors

S. Awasthi, S. Singhal, L. Nagaprashantha, 2011, Pharmaceutical Research.

RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma

S. Awasthi, S. Singhal, P. Singhal, 2017, Pharmaceutical Research.

Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling.

R. Vatsyayan, L. Prokai, Y. Awasthi, 2010, Biochemistry.

RLIP76, a non-ABC transporter, and drug resistance in epilepsy

Y. Awasthi, S. Awasthi, D. Janigro, 2005, BMC Neuroscience.

Topical 2′-Hydroxyflavanone for Cutaneous Melanoma

V. Tonk, Jihyun Lee, S. Awasthi, 2019, Cancers.

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment.

S. Awasthi, S. Singhal, Shireen Chikara, 2018, Cancer letters.

Prevention of mammary carcinogenesis in MMTV‐neu mice by targeting RLIP

Prakash Kulkarni, R. Salgia, S. Awasthi, 2021, Molecular carcinogenesis.

The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS

D. Armstrong, S. Awasthi, Eranda Wanigasekara, 2008, Analytical and bioanalytical chemistry.

Metastasis of breast tumor cells to brain is suppressed by targeting RLIP alone and in combination with 2'-Hydroxyflavanone.

R. Salgia, S. Awasthi, S. Singhal, 2018, Cancer letters.

2′‐Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76

R. Salgia, S. Awasthi, S. Singhal, 2018, Molecular carcinogenesis.

The sensors and regulators of cell–matrix surveillance in anoikis resistance of tumors

R. Vatsyayan, S. Awasthi, S. Singhal, 2011, International journal of cancer.

Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines.

E. Frenkel, S. Awasthi, R. Sharma, 1993, Cancer letters.

Role of RLIP76 in doxorubicin resistance in lung cancer.

R. Vatsyayan, Y. Awasthi, P. Chaudhary, 2009, International journal of oncology.

Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): A novel link between G‐protein and tyrosine kinase signaling and drug resistance

Y. Awasthi, Rajendra K. Sharma, S. Awasthi, 2003, International journal of cancer.

Chemokines and NSCLC: Emerging role in prognosis, heterogeneity, and therapeutics.

S. Singhal, Saumya S. Srivastava, Arin Nam, 2022, Seminars in cancer biology.

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells

S. Awasthi, S. Rahbar, S. Singhal, 2014, Apoptosis.

1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma.

R. Jove, S. Awasthi, S. Rahbar, 2012, Biochemical pharmacology.

RLIP76 in AED drug resistance

Y. Awasthi, Rajendra K. Sharma, S. Awasthi, 2007, Epilepsia.

RLIP76, a Glutathione-Conjugate Transporter, Plays a Major Role in the Pathogenesis of Metabolic Syndrome

R. Vatsyayan, S. Awasthi, S. Singhal, 2011, PloS one.

RLIP76: a target for kidney cancer therapy.

Y. Awasthi, M. Sahu, S. Awasthi, 2009, Cancer research.

A novel glutathione S-transferase isozyme similar to GST 8-8 of rat and mGSTA4-4 (GST 5.7) of mouse is selectively expressed in human tissues.

S. Srivastava, Y. Awasthi, S. Awasthi, 1994, Biochimica et biophysica acta.

Glutathione S-transferases of mouse liver: sex-related differences in the expression of various isozymes.

M. Saxena, Y. Awasthi, S. Singhal, 1992, Biochimica et biophysica acta.

Purification and characterization of glutathione S-transferases from rat pancreas.

G. Ansari, M. Saxena, Y. Awasthi, 1991, Biochimica et biophysica acta.

Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1.

G. Ansari, V. Thiviyanathan, Y. Awasthi, 2000, Chemico-biological interactions.

Modulation of doxorubicin cytotoxicity by ethacrynic acid

S. Srivastava, Shivendra V. Singh, Y. Awasthi, 1996, International journal of cancer.

Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein.

S. Srivastava, E. Frenkel, M. Saxena, 1994, The Journal of clinical investigation.

Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa.

S. Srivastava, Y. Awasthi, P. Zimniak, 1999, Archives of biochemistry and biophysics.

Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil.

S. Srivastava, Y. Awasthi, S. Awasthi, 2000, Biochemical and biophysical research communications.

Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.

S. Awasthi, Sharda P. Singh, S. Singhal, 2015, Toxicology and applied pharmacology.

Glutathione-Conjugate Transport by RLIP76 Is Required for Clathrin-Dependent Endocytosis and Chemical Carcinogenesis

Sumihiro Suzuki, R. Vatsyayan, Y. Awasthi, 2011, Molecular Cancer Therapeutics.

Two distinct 4-hydroxynonenal metabolizing glutathione S-transferase isozymes are differentially expressed in human tissues.

Y. Awasthi, S. Awasthi, Sharda P. Singh, 2001, Biochemical and biophysical research communications.

Role of glutathione S-transferase 8-8 in allylamine resistance of vascular smooth muscle cells in vitro.

P. Boor, T. Zhao, S. Awasthi, 1999, Toxicology and applied pharmacology.

The role of human glutathione S-transferases hGSTA1-1 and hGSTA2-2 in protection against oxidative stress.

T. Zhao, Y. Awasthi, S. Awasthi, 1999, Archives of biochemistry and biophysics.

The role of glutathione S-transferases as a defense against reactive electrophiles in the blood vessel wall.

P. Boor, M. B. Trent, N. He, 1998, Toxicology and applied pharmacology.

Rat GST 8-8 is expressed predominantly in myeloid origin cells infiltrating the gravid uterus.

C. Yallampalli, Y. Awasthi, S. Awasthi, 1997, The international journal of biochemistry & cell biology.

Purification and characterization of glutathione S-transferases of rat uterus.

C. Yallampalli, S. Awasthi, S. Singhal, 1996, The international journal of biochemistry & cell biology.

Purification and characterization of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme from bovine pulmonary microvessel endothelial cells.

Y. Awasthi, S. Awasthi, P. Zimniak, 1996, Biochimica et biophysica acta.

Several closely related glutathione S-transferase isozymes catalyzing conjugation of 4-hydroxynonenal are differentially expressed in human tissues.

D. Petersen, Y. Awasthi, S. Awasthi, 1994, Archives of biochemistry and biophysics.

Purification and characterization of human muscle glutathione S-transferases: evidence that glutathione S-transferase zeta corresponds to a locus distinct from GST1, GST2, and GST3.

Y. Awasthi, A. Haque, R. Sharma, 1991, Archives of biochemistry and biophysics.

Comparative studies on the effect of butylated hydroxyanisole on glutathione and glutathione S-transferases in the tissues of male and female CD-1 mice.

S. Srivastava, M. Saxena, Y. Awasthi, 1993, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Independent segregation of glutathione S-transferase and fatty acid ethyl ester synthase from pancreas and other human tissues.

Y. Awasthi, A. Haque, R. Sharma, 1991, The Biochemical journal.

Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse glutathione S-transferase mGSTA4-4 (GST 5.7).

S. Srivastava, Y. Awasthi, S. Awasthi, 1994, The Journal of biological chemistry.

Characterization of a novel α-class anionic glutathione S-transferase isozyme from human liver

Y. Awasthi, Rajendra K. Sharma, S. Singhal, 1990 .

Characterization of two novel subunits of the α-class glutathione S-transferases of human liver

M. Saxena, Y. Awasthi, S. Singhal, 1993 .

Characterization of a novel glutathione S-transferase isoenzyme from mouse lung and liver having structural similarity to rat glutathione S-transferase 8-8.

M. Saxena, Y. Awasthi, S. Singhal, 1991, The Biochemical journal.

Glutathione S-transferases of human skin: qualitative and quantitative differences in men and women.

H. Mukhtar, M. Saxena, Y. Awasthi, 1993, Biochimica et biophysica acta.

M. Saxena, Y. Awasthi, S. Awasthi, 1994, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

The anionic conjugates of bilirubin and bile acids stimulate ATP hydrolysis by S‐(dinitrophenyl)glutathione ATPase of human erythrocyte

Y. Awasthi, R. Lester, P. Zimniak, 1991, FEBS letters.

Purification and characterization of an ATPase from human liver which catalyzes ATP hydrolysis in the presence of the conjugates of bilirubin bile acids and glutathione.

Y. Awasthi, R. Lester, R. Sharma, 1991, Biochemical and biophysical research communications.

A specific, sensitive, and rapid method for the determination of glutathione and its application in ocular tissues.

M. Saxena, Y. Awasthi, S. Singhal, 1992, Experimental eye research.

Targeting p 53-Null Neuroblastomas through RLIP 76

R. Vatsyayan, S. Awasthi, S. Singhal, 2011 .

Targeting p53-Null Neuroblastomas through RLIP76

R. Vatsyayan, S. Awasthi, S. Singhal, 2011, Cancer Prevention Research.

A Central Role of RLIP76 in Regulation of Glycemic Control

R. Vatsyayan, Y. Awasthi, S. Awasthi, 2009, Diabetes.

Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2002, Acta biochimica Polonica.

Cells Preconditioned with Mild, Transient UVA Irradiation Acquire Resistance to Oxidative Stress and UVA-induced Apoptosis

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2003, Journal of Biological Chemistry.

Purification and Characterization of Glutathione S-Transferases of Eoreuma loftini and Diatraea saccharalis (Lepidoptera: Pyralidae)

Y. Awasthi, Rajendra K. Sharma, R. Meagher, 1991 .

Accelerated Metabolism and Exclusion of 4-Hydroxynonenal through Induction of RLIP76 and hGST5.8 Is an Early Adaptive Response of Cells to Heat and Oxidative Stress*

Shivendra V. Singh, Y. Awasthi, Abha Sharma, 2001, The Journal of Biological Chemistry.

Synergistic efficacy of RLIP inhibition and 2′‐hydroxyflavanone against DMBA‐induced mammary carcinogenesis in SENCAR mice

R. Salgia, S. Awasthi, S. Vonderfecht, 2019, Molecular carcinogenesis.

Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells

S. Awasthi, C. Bose, P. Palade, 2021, Cancers.

Novel human ocular glutathione S-transferases with high activity toward 4-hydroxynonenal.

Y. Awasthi, S. Awasthi, N. Ansari, 1995, Investigative ophthalmology & visual science.

RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer.

D. Stuckler, Y. Awasthi, S. Awasthi, 2005, Cancer research.

RLIP 76 Transports Vinorelbine and Mediates Drug Resistance in Non – Small Cell Lung Cancer

D. Stuckler, Y. Awasthi, S. Awasthi, 2005 .

Effects of mGST A4 transfection on 4-hydroxynonenal-mediated apoptosis and differentiation of K562 human erythroleukemia cells.

F. V. van Kuijk, Y. Awasthi, S. Awasthi, 1999, Archives of biochemistry and biophysics.

Transfection of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme, mouse GSTA4-4, confers doxorubicin resistance to Chinese hamster ovary cells.

S. Srivastava, Y. Awasthi, S. Awasthi, 1996, Archives of biochemistry and biophysics.

Determinants of differential doxorubicin sensitivity between SCLC and NSCLC

Y. Awasthi, S. Awasthi, S. Singhal, 2006, FEBS letters.

Modulation of cisplatin cytotoxicity by sulphasalazine.

Y. Awasthi, S. Awasthi, R. Sharma, 1994, British Journal of Cancer.

RLIP: A necessary transporter protein for translating oxidative stress into pro-obesity and pro-carcinogenic signaling.

S. Awasthi, R. Garg, S. Singhal, 2022, Biochimica et biophysica acta. Reviews on cancer.

Addressing Drug Resistance in Cancer: A Team Medicine Approach

F. M. Stewart, S. Ramisetty, A. Merla, 2022, Journal of clinical medicine.

Role of Glutathione S-Transferases in Protection against Lipid Peroxidation OVEREXPRESSION OF hGSTA2-2 IN K562 CELLS PROTECTS AGAINST HYDROGEN PEROXIDE-INDUCED APOPTOSIS AND INHIBITS JNK AND CASPASE 3 ACTIVATION*

Y. Awasthi, S. Awasthi, S. Singhal, 2001 .

Novel Flavonoid Didymin Inhibits Neuroblastomas—Response

S. Singhal, 2012, Cancer Prevention Research.

Didymin Induces Apoptosis by Inhibiting N-Myc and Upregulating RKIP in Neuroblastoma

Ashutosh, R. Vatsyayan, S. Awasthi, 2011, Cancer Prevention Research.

RLIP76 and Cancer

Y. Awasthi, S. Awasthi, A. Frankel, 2008, Clinical Cancer Research.

RLIP 76 and Cancer

Y. Awasthi, A. Frankel, C. Cunningham, 2008 .

RLIP76 Knockdown Attenuates Obesity Due to High-Fat Diet*

R. Natarajan, S. Awasthi, S. Singhal, 2013 .

Induction of glutathione S-transferase hGST 5.8 is an early response to oxidative stress in RPE cells.

B. Godley, Y. Awasthi, S. Awasthi, 1999, Investigative ophthalmology & visual science.

Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76

M. Sahu, S. Awasthi, S. Singhal, 2008, FEBS letters.

RLIP76: A novel glutathione-conjugate and multi-drug transporter.

S. Singhal, Sushma Yadav, J. Singhal, 2009, Biochemical pharmacology.

Hsf-1 and POB1 Induce Drug Sensitivity and Apoptosis by Inhibiting Ralbp1*

S. Awasthi, S. Singhal, Sushma Yadav, 2008, Journal of Biological Chemistry.

RLIP76 (RALBP1)‐mediated transport of leukotriene C4 (LTC4) in cancer cells: Implications in drug resistance

Y. Awasthi, Rajendra K. Sharma, S. Awasthi, 2004, International journal of cancer.

Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling.

Y. Awasthi, S. Awasthi, A. Sharma, 2001, Archives of biochemistry and biophysics.

A Central Role of RLIP 76 in Regulation of Glycemic Control Running Title : Mechanisms of Insulin Resistance

R. Vatsyayan, Y. Awasthi, S. Awasthi, 2009 .

Lipid Peroxidation Products in Human Health and Disease

K. Ramana, S. Srivastava, Sharad S. Singhal, 2013, Oxidative medicine and cellular longevity.

Glutathione S-transferase 8-8 is localized in smooth muscle cells of rat aorta and is induced in an experimental model of atherosclerosis.

S. Srivastava, P. Boor, Y. Awasthi, 1995, Toxicology and applied pharmacology.

Regression of Lung Cancer by Hypoxia-Sensitizing Ruthenium Polypyridyl Complexes

S. Awasthi, S. Singhal, F. MacDonnell, 2013, Molecular Cancer Therapeutics.

Lipid Peroxidation Products in Human Health and Disease 2016

K. Ramana, S. Srivastava, S. Singhal, 2017, Oxidative medicine and cellular longevity.

Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver.

Y. Awasthi, S. Awasthi, S. Singhal, 1998, The international journal of biochemistry & cell biology.

Prognostic significance of natural products against multidrug tumor resistance.

S. Awasthi, R. Garg, S. Singhal, 2023, Cancer letters.

The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells.

Y. Awasthi, S. Awasthi, J. Cheng, 1999, Toxicology letters.

Therapeutic resistance in lung cancer

S. Awasthi, S. Singhal, Ewa Zając, 2006, Expert opinion on drug metabolism & toxicology.

Rlip Depletion Suppresses Growth of Breast Cancer

S. Rehman, Jihyun Lee, S. Awasthi, 2020, Cancers.

Targeting RLIP with CRISPR/Cas9 controls tumor growth.

R. Salgia, S. Awasthi, S. Singhal, 2020, Carcinogenesis.

SOX9: The Master Regulator of Cell Fate in Breast Cancer.

R. Salgia, S. Awasthi, S. Singhal, 2020, Biochemical pharmacology.

Didymin: an orally active citrus flavonoid for targeting neuroblastoma

David Horne, Sanjay Awasthi, S. Awasthi, 2017, Oncotarget.

Notch Signaling in Breast Cancer: From Pathway Analysis to Therapy.

R. Salgia, S. Awasthi, S. Singhal, 2019, Cancer letters.

2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer

R. Salgia, S. Awasthi, Hongzhi Li, 2018, Oncotarget.

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells.

K. Ramana, S. Srivastava, R. Tammali, 2006, Cancer research.

Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer.

S. Awasthi, D. Jain, S. Singhal, 2017, Biochimica et biophysica acta. Reviews on cancer.

Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer.

R. Roby, R. Vatsyayan, S. Awasthi, 2011, Biochemical pharmacology.

RALBP1/RLIP76 mediates multidrug resistance.

S. Awasthi, S. Singhal, Sushma Yadav, 2007, International journal of oncology.

Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells.

P. Boor, Y. Awasthi, Abha Sharma, 2003, Investigative ophthalmology & visual science.

Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2008, Free radical biology & medicine.

Ral-Binding Protein is Required for the Maturation and Function of Dendritic Cells

Y. Awasthi, M. Sahu, S. Awasthi, 2010 .

Novel Anti-cancer Compounds for Developing Combinatorial Therapies to Target Anoikis-Resistant Tumors

S. Awasthi, S. Singhal, L. Nagaprashantha, 2012, Pharmaceutical Research.

Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76).

Shivendra V. Singh, Y. Awasthi, Rajendra K. Sharma, 2002, Acta biochimica Polonica.

ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter.

Y. Awasthi, S. Awasthi, P. Zimniak, 1999, Toxicology and applied pharmacology.

Translational opportunities for broad‐spectrum natural phytochemicals and targeted agent combinations in breast cancer

S. Awasthi, S. Singhal, Shireen Chikara, 2018, International journal of cancer.

Therapeutic targeting of miRNA-216b in cancer.

R. Salgia, S. Awasthi, S. Singhal, 2020, Cancer letters.

Glutathione S-transferases of rabbit lung macrophages.

S. Awasthi, A. Bidani, T. Heming, 1998, Toxicology and Applied Pharmacology.

Bioenergetic modulation with the mitochondria uncouplers SR4 and niclosamide prevents proliferation and growth of treatment-naïve and vemurafenib-resistant melanomas

A. Riggs, J. Kusari, S. Singhal, 2018, Oncotarget.

Rlip depletion prevents spontaneous neoplasia in TP53 null mice

Zheng Liu, Meenakshi Awasthi, Sanjay Awasthi, 2018, Proceedings of the National Academy of Sciences.

Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression.

S. Awasthi, S. Rahbar, S. Singhal, 2013, Biochemical pharmacology.

RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis.

R. Salgia, S. Awasthi, S. Singhal, 2020, Biochimica et biophysica acta. Reviews on cancer.

2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention.

A. Riggs, S. Awasthi, S. Singhal, 2015, Biochemical pharmacology.

RLIP76 Targeted Therapy for Kidney Cancer

S. Awasthi, S. Singhal, J. Figarola, 2015, Pharmaceutical Research.

A Systems Biology Approach for Addressing Cisplatin Resistance in Non-Small Cell Lung Cancer

S. Ramisetty, J. Malhotra, Supriyo Bhattacharya, 2023, Journal of clinical medicine.

RLIP Depletion Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells.

Prakash Kulkarni, R. Salgia, S. Awasthi, 2021, Carcinogenesis.

Regression of prostate cancer xenografts by RLIP76 depletion.

S. Awasthi, S. Singhal, Kathryn L. Leake, 2009, Biochemical pharmacology.

Glutathione-Conjugate Transport and Stress-Response Signaling: Role of RLIP76

S. Awasthi, S. Singhal, 2006 .

Nutlin‐3 enhances sorafenib efficacy in renal cell carcinoma

R. Vatsyayan, S. Awasthi, S. Singhal, 2013, Molecular carcinogenesis.

Role of 4-hydroxynonenal in stress-mediated apoptosis signaling.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2003, Molecular aspects of medicine.

Apoptosis and Differentiation of K562 Cells by Targeting GST-O1 to Inhibit 4-HNE Metabolism

S. Awasthi, S. Singhal, Kathryn L. Leake, 2014 .

2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma.

R. Vatsyayan, L. Prokai, S. Awasthi, 2011, Carcinogenesis.

Iron-induced lipid peroxidation in rat liver is accompanied by preferential induction of glutathione S-transferase 8-8 isozyme.

G. Ansari, S. Srivastava, D. Petersen, 1995, Toxicology and applied pharmacology.

RLIP76 in defense of radiation poisoning.

Sumihiro Suzuki, D. Armstrong, P. Dent, 2008, International journal of radiation oncology, biology, physics.

Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters

S. Awasthi, S. Singhal, Sushma Yadav, 2007, Cancer and Metastasis Reviews.

RLIP76 is a major determinant of radiation sensitivity.

P. Dent, A. Yacoub, P. Boor, 2005, Cancer research.

RLIP76 Regulates PI3K/Akt Signaling and Chemo-Radiotherapy Resistance in Pancreatic Cancer

S. Awasthi, S. Singhal, Kathryn L. Leake, 2012, PloS one.

Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer

R. Vatsyayan, M. Sahu, S. Awasthi, 2009, International journal of cancer.

RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics.

Y. Awasthi, Rajendra K. Sharma, S. Awasthi, 2002, Drug metabolism and disposition: the biological fate of chemicals.

RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes.

Y. Awasthi, S. Awasthi, R. Sharma, 2001, Archives of biochemistry and biophysics.

Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu.

B. Van Houten, J. Horton, S. Mitra, 1999, Biochemical pharmacology.

Role of RLIP 76 in doxorubicin resistance in lung cancer ( Review )

R. Vatsyayan, Y. Awasthi, P. Chaudhary, 2022 .

Doxorubicin transport by RALBP 1 and ABCG 2 in lung and breast cancer

Y. Awasthi, S. Awasthi, A. Lacko, 2022 .

Lipid Peroxidation Products in Human Health and Disease 2019

K. Ramana, S. Srivastava, S. Singhal, 2019, Oxidative medicine and cellular longevity.

RLIP: An existential requirement for breast carcinogenesis.

R. Salgia, S. Awasthi, S. Singhal, 2019, Biochimica et biophysica acta. Reviews on cancer.

Activating p53 function by targeting RLIP.

R. Salgia, S. Awasthi, S. Singhal, 2021, Biochimica et biophysica acta. Reviews on cancer.

Association of TGF-β1 Polymorphisms with Breast Cancer Risk: A Meta-Analysis of Case–Control Studies †

R. Salgia, S. Awasthi, S. Singhal, 2020, Cancers.

Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines

S. Batra, Prakash Kulkarni, R. Salgia, 2020, International journal of oncology.

2'-Hydroxyflavanone: A novel strategy for targeting breast cancer

S. Awasthi, S. Singhal, Shireen Chikara, 2017, Oncotarget.

Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1).

P. Boor, Y. Awasthi, S. Awasthi, 2007, Cancer research.

Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties.

S. Srivastava, S. Srivastava, B. Nanduri, 1994, European journal of biochemistry.

Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses.

Y. Awasthi, S. Awasthi, S. Singhal, 1996, The American journal of clinical nutrition.

hSET1: a novel approach for colon cancer therapy.

S. Awasthi, S. Singhal, Sushma Yadav, 2009, Biochemical pharmacology.

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells

S. Awasthi, S. Rahbar, S. Singhal, 2014, Apoptosis.

2'-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells.

R. Salgia, S. Awasthi, S. Singhal, 2019, Journal of proteomics.

Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer

S. Batra, Prakash Kulkarni, R. Salgia, 2021, Molecular Cancer Therapeutics.

Human glutathione S-transferases.

Y. Awasthi, R. Sharma, Y C Awasthi, 1994, The International journal of biochemistry.

Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin.

Y. Awasthi, S. Awasthi, S. Singhal, 2005, Biochemical pharmacology.

RLIP76: a versatile transporter and an emerging target for cancer therapy.

R. Vatsyayan, S. Awasthi, S. Singhal, 2010, Biochemical pharmacology.

Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76 and identification of ATP binding sequences.

Y. Awasthi, S. Awasthi, R. Sharma, 2001, Biochemistry.

Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis

Yate-Ching Yuan, Jihyun Lee, S. Awasthi, 2021, Cancers.

Anticancer activity of 2’-hydroxyflavanone towards lung cancer

Yate-Ching Yuan, V. Tonk, Y. Awasthi, 2018, Oncotarget.

RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.

S. Awasthi, Seunghyung Lee, L. Goldfinger, 2012, Cancer research.

Mitogenic and drug-resistance mediating effects of PKCα require RLIP76

Y. Awasthi, S. Awasthi, S. Singhal, 2006 .

Regression of melanoma in a murine model by RLIP76 depletion.

Y. Awasthi, S. Awasthi, S. Singhal, 2006, Cancer research.

The role of PKCα and RLIP76 in transport‐mediated doxorubicin‐resistance in lung cancer

Y. Awasthi, S. Awasthi, S. Singhal, 2005, FEBS letters.

POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis.

Y. Awasthi, S. Awasthi, S. Singhal, 2005, Biochemical and biophysical research communications.

Is a Major Determinant of Radiation Sensitivity

P. Dent, A. Yacoub, P. Boor, 2005 .

Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes.

Y. Awasthi, S. Awasthi, R. Sharma, 2001, Acta biochimica Polonica.

Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2α Expression

R. Vatsyayan, Jia Guo, L. Prokai, 2013, PloS one.

Therapeutic Potential of Natural Pharmacological Agents in the Treatment of Human Diseases

K. Ramana, S. Singhal, Aramati B. M. Reddy, 2014, BioMed research international.

Lipid Peroxidation Products in Human Health and Disease 2014

K. Ramana, S. Srivastava, S. Singhal, 2014, Oxidative medicine and cellular longevity.

SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells*

A. Riggs, S. Awasthi, G. Rogers, 2015, The Journal of Biological Chemistry.

Interactions of melphalan with glutathione and the role of glutathione S-transferase.

G. Ansari, Y. Awasthi, S. Awasthi, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Rabbit aorta glutathione S-transferases and their role in bioactivation of trinitroglycerin.

Y. Awasthi, S. Awasthi, S. Singhal, 1996, Toxicology and applied pharmacology.

Glutathione S-transferase-catalyzed conjugation of 9,10-epoxystearic acid with glutathione.

G. Ansari, Y. Awasthi, R. Sharma, 1991, Journal of biochemical toxicology.

Targeting the mercapturic acid pathway for the treatment of melanoma.

R. Salgia, S. Awasthi, T. Mirzapoiazova, 2021, Cancer letters.

Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.

Shivendra V. Singh, Y. Awasthi, Rajendra K. Sharma, 2003, International journal of oncology.

Purification and characterization of glutathione S-transferase from sugarcane leaves

S. Srivastava, Y. Awasthi, S. Singhal, 1991 .

RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma

S. Awasthi, S. Singhal, P. Singhal, 2017, Pharmaceutical Research.

Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis.

R. Vatsyayan, P. Chaudhary, S. Awasthi, 2009, Cancer letters.

Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer.

Y. Awasthi, S. Awasthi, A. Lacko, 2007, International journal of oncology.

Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates.

M. Sahu, S. Awasthi, S. Singhal, 2009, International journal of oncology.

RLIP76 Protein Knockdown Attenuates Obesity Due to a High-fat Diet*

R. Natarajan, S. Awasthi, S. Singhal, 2013, The Journal of Biological Chemistry.

M. Saxena, Y. Awasthi, S. Awasthi, 1992, Biochimica et biophysica acta.

RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.

S. Awasthi, Seunghyung Lee, M. Ginsberg, 2015, Biochemical and biophysical research communications.

Recent Advancement in Breast Cancer Research: Insights from Model Organisms—Mouse Models to Zebrafish

R. Soldi, P. Garg, R. Garg, 2023, Cancers.

Therapeutic Potential of Natural Antioxidants

K. Ramana, S. Singhal, Aramati B. M. Reddy, 2018, Oxidative medicine and cellular longevity.

RLIP76 Targeted Therapy for Kidney Cancer

S. Awasthi, S. Singhal, J. Figarola, 2015, Pharmaceutical Research.

A group of novel glutathione S-transferase isozymes showing high activity towards 4-hydroxy-2-nonenal are present in bovine ocular tissues.

S. Srivastava, Y. Awasthi, N. Ansari, 1994, Experimental eye research.

1 RALBP 1 / RLIP 76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization . Running title : RLIP 76 is essential for tumor angiogenesis

S. Awasthi, Seunghyung Lee, S. Singhal, 2012 .

Dinitrophenyl S-glutathione ATPase purified from human muscle catalyzes ATP hydrolysis in the presence of leukotrienes.

M. Saxena, Y. Awasthi, S. Awasthi, 1992, Archives of biochemistry and biophysics.

ATP-Dependent human erythrocyte glutathione-conjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity.

S. Srivastava, Y. Awasthi, S. Awasthi, 1998, Biochemistry.

ATP-Dependent human erythrocyte glutathione-conjugate transporter. II. Functional reconstitution of transport activity.

S. Srivastava, Y. Awasthi, S. Awasthi, 1998, Biochemistry.

Identification of membrane-anchoring domains of RLIP76 using deletion mutant analyses.

T. Albrecht, Y. Awasthi, S. Awasthi, 2004, Biochemistry.

Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity.

Y. Awasthi, S. Awasthi, P. Zimniak, 2003, International journal of oncology.

Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76.

Y. Awasthi, S. Awasthi, P. Zimniak, 2003, International journal of oncology.

Glutathione S-transferases of human lung: characterization and evaluation of the protective role of the alpha-class isozymes against lipid peroxidation.

M. Saxena, Y. Awasthi, S. Awasthi, 1992, Archives of biochemistry and biophysics.

Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

Yate-Ching Yuan, Xiwei Wu, D. Wheeler, 2023, iScience.

Energy dependent transport of xenobiotics and its relevance to multidrug resistance.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2003, Current cancer drug targets.

RLIP76 and Cancer

Y. Awasthi, S. Awasthi, A. Frankel, 2008, Clinical Cancer Research.

Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer.

S. Awasthi, D. Jain, S. Singhal, 2017, Biochimica et biophysica acta. Reviews on cancer.

The Potential of 3,6 Dihydroxyflavone Embedded Gold Nanoparticles for Inhibition of Tumor Growth in Presence of Dietary Supplements

S. Singhal, Pankaj Garg, 2022, Current Trends in Internal Medicine.

The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS

D. Armstrong, S. Awasthi, Eranda Wanigasekara, 2008, Analytical and bioanalytical chemistry.

The sensors and regulators of cell–matrix surveillance in anoikis resistance of tumors

R. Vatsyayan, S. Awasthi, S. Singhal, 2011, International journal of cancer.

Regression of ovarian cancer xenografts by depleting or inhibiting RLIP.

S. Ramisetty, T. Mirzapoiazova, S. Singhal, 2023, Biochemical pharmacology.

RLIP inhibition suppresses breast-to-lung metastasis.

R. Salgia, S. Awasthi, S. Singhal, 2019, Cancer letters.

Glutathione-Conjugate Transport by RLIP76 Is Required for Clathrin-Dependent Endocytosis and Chemical Carcinogenesis

Sumihiro Suzuki, R. Vatsyayan, Y. Awasthi, 2011, Molecular Cancer Therapeutics.

The innate effects of plant secondary metabolites in preclusion of gynecologic cancers: Inflammatory response and therapeutic action.

P. Garg, S. Awasthi, S. Singhal, 2023, Biochimica et biophysica acta. Reviews on cancer.

Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer

Yanan He, R. Soldi, Maneesh Jain, 2023, Science advances.

Synergistic efficacy of RLIP inhibition and 2′‐hydroxyflavanone against DMBA‐induced mammary carcinogenesis in SENCAR mice

R. Salgia, S. Awasthi, S. Vonderfecht, 2019, Molecular carcinogenesis.

A glutathione S-transferases isozyme (bGST 5.8) involved in the metabolism of 4-hydroxy-2-trans-nonenal is localized in bovine lens epithelium.

S. Srivastava, Y. Awasthi, S. Awasthi, 1996, Experimental eye research.

POLYCLONAL ANTIBODIES SPECIFIC TO HUMAN GLUTATHIONE S-TRANSFERASE 5.8 (HGST 5.8)

Y. Awasthi, S. Awasthi, P. Zimniak, 1995 .

PHYSIOLOGICAL ROLE OF GLUTATHIONE S-TRANSFERASES IN PROTECTION MECHANISMS AGAINST LIPID PEROXIDATION; A COMMENTARY

S. Awasthi, P. Zimniak, S. Singhal, 1995 .

Qualitative and quantitative sex-related differences in glutathione S-transferases of mouse kidney

S. Srivastava, Y. Awasthi, S. Singhal, 1993 .