Y. Yamaguchi

发表

Newly established in vitro system with fluorescent proteins shows that abnormal expression of downstream prion protein-like protein in mice is probably due to functional disconnection between splicing and 3' formation of prion protein pre-mRNA.

S. Katamine, D. Yoshikawa, J. Kopáček, 2007, Gene.

Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesis.

J. Halpert, Y. Yamaguchi, K. K. Khan, 2004, Drug metabolism and disposition: the biological fate of chemicals.

TOPOLOGICAL CHANGES IN THE CYP 3 A 4 ACTIVE SITE PROBED WITH PHENYLDIAZENE : EFFECT OF INTERACTION WITH NADPH-CYTOCHROME P 450 REDUCTASE AND CYTOCHROME B 5 AND OF SITE-DIRECTED MUTAGENESIS

J. Halpert, Y. Yamaguchi, K. K. Khan, 2003 .

Increased levels of UV‐induced protease activity in human UVAP‐1 cells exposed to gravity‐changing stress: involvement of E‐64‐sensitive proteases in suppression of UV mutagenicity

Shunji Takahashi, K. Kita, S. Sugaya, 2003, Cell biology international.

Model for the drug–drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans

T. Kanazu, N. Okamura, T. Baba, 2004, Xenobiotica; the fate of foreign compounds in biological systems.

Mutagenicity of bisphenol A and its suppression by interferon-α in human RSa cells

Shunji Takahashi, K. Kita, S. Sugaya, 2001 .

Mouse-Hamster Chimeric Prion Protein (PrP) Devoid of N-Terminal Residues 23-88 Restores Susceptibility to 22L Prions, but Not to RML Prions in PrP-Knockout Mice

K. Uchiyama, M. Imamura, Masashi Yano, 2014, PloS one.

Dominant-negative Effects of the N-terminal Half of Prion Protein on Neurotoxicity of Prion Protein-like Protein/Doppel in Mice*

S. Katamine, Tsuyoshi Mori, D. Yoshikawa, 2008, Journal of Biological Chemistry.

Biological and Biochemical Characterization of Mice Expressing Prion Protein Devoid of the Octapeptide Repeat Region after Infection with Prions

A. Ootsuyama, S. Katamine, K. Uchiyama, 2012, PloS one.

Contribution of CYP4A8 to the formation of 20-hydroxyeicosatetraenoic acid from arachidonic acid in rat kidney.

S. Imaoka, Y. Funae, H. Hasegawa, 2002, Drug metabolism and pharmacokinetics.

Induction of uPA release in human peripheral blood lymphocytes by [deamino-Cysl,D-Arg8]-vasopressin (dDAVP).

Shunji Takahashi, K. Kita, N. Suzuki, 2004, American journal of physiology. Endocrinology and metabolism.

Effects of a Brain-Engraftable Microglial Cell Line Expressing Anti-Prion scFv Antibodies on Survival Times of Mice Infected with Scrapie Prions

A. Ootsuyama, R. Kaji, K. Fujita, 2011, Cellular and Molecular Neurobiology.

Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug–drug interaction model rats

T. Kanazu, N. Okamura, T. Baba, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Model for the drug–drug interaction responsible for CYP3A enzyme inhibition. II: establishment and evaluation of dexamethasone-pretreated female rats

T. Kanazu, N. Okamura, T. Baba, 2004, Xenobiotica; the fate of foreign compounds in biological systems.

Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice.

Tsuyoshi Mori, N. Yamaguchi, D. Ishibashi, 2011, Vaccine.

Immunization with recombinant bovine but not mouse prion protein delays the onset of disease in mice inoculated with a mouse-adapted prion.

S. Katamine, D. Yoshikawa, N. Yamaguchi, 2007, Vaccine.

Possible involvement of urokinase-type plasminogen activator release from human peripheral blood lymphocytes in the pathophysiology of chronic allograft nephropathy.

N. Suzuki, K. Yamada, Y. Yamaguchi, 2005, Transplantation proceedings.

Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91–106

K. Uchiyama, M. Imamura, G. Kondoh, 2020, International journal of molecular sciences.

2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.

H. Kai, T. Yoshikawa, T. Baba, 2007, Bioorganic & medicinal chemistry letters.

Species differences in β-oxidative metabolism of a thromboxane A2-receptor antagonist [(+)-S-145] in rat, dog and monkey

T. Baba, Y. Yamaguchi, T. Matsubara, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

Induction and regulation of cytochrome P450 K-5 (lauric acid hydroxylase) in rat renal microsomes by starvation.

S. Imaoka, Y. Funae, Y. Yamaguchi, 1990, Biochimica et biophysica acta.

Investigation of drug–drug interaction via mechanism‐based inhibition of cytochrome P450 3A by macrolides in dexamethasone‐treated female rats

T. Kanazu, T. Baba, Y. Yamaguchi, 2012, Biopharmaceutics & drug disposition.

Using improved serial blood sampling method of mice to study pharmacokinetics and drug-drug interaction.

K. Nezasa, Y. Yamaguchi, Yukari Tanaka, 2015, Journal of pharmaceutical sciences.

Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management

Y. Yamaguchi, Gang Wu, D. Kyle, 2014, Journal of medicinal chemistry.

In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans

H. Yamazaki, T. Kanazu, Y. Yamaguchi, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Sex differences in the metabolism of (+)-S-145, a novel thromboxane A2 receptor antagonist in rat.

K. Mizojiri, T. Baba, Y. Yamaguchi, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Presence of Sarcocystis sybillensis in Japanese sika deer (Cervus nippon) captured in its native territory and its phylogenetic relationship with Sarcocystis nipponi

Y. Sugita‐Konishi, K. Taira, Y. Kamata, 2020, Parasitology Research.

The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites

N. Tamaki, K. Nishijima, Songji Zhao, 2015, Scientific Reports.

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.

L. Tritsmans, K. Kusakabe, M. Timmers, 2021, Journal of medicinal chemistry.

MicroRNA-150 suppresses p27Kip1 expression and promotes cell proliferation in HeLa human cervical cancer cells

Takehiro Nakamura, Y. Yamaguchi, Wataru Oboshi, 2020, Oncology letters.

Non-clinical evaluation of the metabolism, pharmacokinetics and excretion of S-777469, a new cannabinoid receptor 2 selective agonist

T. Kanazu, H. Hasegawa, Y. Yamaguchi, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Mutagenicity of bisphenol A and its suppression by interferon-alpha in human RSa cells.

K. Kita, S. Sugaya, N. Suzuki, 2001, Mutation research.

IDENTIFICATION OF RAT AND HUMAN CYTOCHROME P 450 FORMS INVOLVED IN THE METABOLISM OF THE THROMBOXANE A 2 RECEPTOR ANTAGONIST

R. Tukey, F. Guengerich, T. Baba, 1997 .

Identification of rat and human cytochrome P450 forms involved in the metabolism of the thromboxane A2 receptor antagonist (+)-S-145.

R. Tukey, F. Guengerich, T. Baba, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism.

Y. Sugiyama, Kiyomi Ito, Y. Ohno, 2002, Drug metabolism and pharmacokinetics.

A high-sensitivity and rapid enzymatic method using a biochemical automated analyzer to detect inorganic pyrophosphate generated by nucleic acid sequence-based amplification.

S. Sakasegawa, Y. Yamaguchi, Masanori Seimiya, 2020, Clinica chimica acta; international journal of clinical chemistry.

Biological and Biochemical Characterization of Mice Expressing Prion Protein Devoid of the Octapeptide Repeat Region after Infection with Prions

A. Ootsuyama, S. Katamine, K. Uchiyama, 2012, PloS one.