S. Nadanaciva

发表

Investigating mitochondrial dysfunction to increase drug safety in the pharmaceutical industry.

Yvonne Will, Y. Will, S. Nadanaciva, 2011, Current drug targets.

The molecular mechanism of ATP synthesis by F1F0-ATP synthase.

J. Weber, A. E. Senior, Joachim Weber, 2002, Biochimica et biophysica acta.

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Vinal V. Lakhani, P. Watkins, M. Aleo, 2019, Pharmacology research & perspectives.

High throughput glutathione and Nrf2 assays to assess chemical and biological reactivity of cysteine-reactive compounds

K. Leach, R. Naven, T. Schroeter, 2013 .

The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo

P. Oliveira, Y. Will, S. Nadanaciva, 2012, Expert opinion on drug metabolism & toxicology.

Interstitial Lung Disease Associated With Crizotinib in Patients With Advanced Non-Small Cell Lung Cancer: Independent Review of Four PROFILE Trials.

N. Stollenwerk, K. Yoneda, K. Wilner, 2017, Clinical lung cancer.

A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays.

J. Hynes, Y. Will, S. Nadanaciva, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone.

J. Xu, L. Marroquin, J. Dykens, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death.

Y. Will, J. Cali, A. Niles, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.

Y. Will, L. Jones, S. Nadanaciva, 2016, Bioorganic & medicinal chemistry letters.

Distribution of Aβ peptide in whole blood

R. Motter, P. Seubert, C. Painter, 2007 .

Prediction of metabolism-induced hepatotoxicity on three-dimensional hepatic cell culture and enzyme microarrays

Dong Woo Lee, J. Dordick, Y. Will, 2018, Archives of Toxicology.

The Catalytic Transition State in ATP Synthase

J. Weber, A. E. Senior, S. Nadanaciva, 2000, Journal of bioenergetics and biomembranes.

Binding of the Transition State Analog MgADP-fluoroaluminate to F1-ATPase*

J. Weber, A. E. Senior, S. Nadanaciva, 1999, The Journal of Biological Chemistry.

Rate acceleration of ATP hydrolysis by F(1)F(o)-ATP synthase.

J. Weber, A. E. Senior, S. Nadanaciva, 2000, The Journal of experimental biology.

ATP‐driven rotation of the γ subunit in F1‐ATPase

J. Weber, A. E. Senior, S. Nadanaciva, 2000 .

Assessment of Fatty Acid Beta Oxidation in Cells and Isolated Mitochondria

Ajit S. Divakaruni, G. Rogers, Y. Will, 2014, Current protocols in toxicology.

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes.

Donald B Stedman, Yvonne Will, Christopher J Strock, 2013, Toxicology and applied pharmacology.

A high content screening assay for identifying lysosomotropic compounds.

Yvonne Will, W. Pennie, Shuyan Lu, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays.

Yvonne Will, Robert Aggeler, R. Aggeler, 2007, Toxicology in vitro : an international journal published in association with BIBRA.

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

P. Watkins, S. Siler, Y. Will, 2014, Pharmaceutical Research.

Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells.

B. Jessen, L. Marroquin, J. Hynes, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis.

J. Willis, R. Capaldi, Y. Will, 2009, Journal of immunological methods.

Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial.

Ying Cheng, T. Mok, Yi-long Wu, 2017, The Lancet. Oncology.

Current Concepts in Drug‐Induced Mitochondrial Toxicity

Y. Will, S. Nadanaciva, 2009, Current protocols in toxicology.

A pyrophosphate synthase gene: molecular cloning and sequencing of the cDNA encoding the inorganic pyrophosphate synthase from Rhodospirillum rubrum.

M. Baltscheffsky, S. Nadanaciva, A. Schultz, 1998, Biochimica et biophysica acta.

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.

L. Marroquin, J. Dykens, J. Jamieson, 2008, Toxicology and applied pharmacology.

Efficacy and safety of palbociclib in combination with letrozole as first-line treatment of ER-positive, HER2-negative, advanced breast cancer: expanded analyses of subgroups from the randomized pivotal trial PALOMA-1/TRIO-18

R. Finn, Marcus Schmidt, I. Bondarenko, 2016, Breast Cancer Research.

High-Content Screening for Compounds That Affect mtDNA-Encoded Protein Levels in Eukaryotic Cells

Y. Will, S. Nadanaciva, A. Shrikhande, 2010, Journal of biomolecular screening.

The Inorganic Pyrophosphate Synthase from Rhodospirillum Rubrum and its Gene

M. Baltscheffsky, S. Nadanaciva, A. Schultz, 1999 .

Assessing Hepatoxicants based on High-throughput Quantitative SILAC Proteomics and Causal Biological Networks

A. Lamond, K. Leach, Ahmed Enayetallah, 2015 .

Quantitative Determination of Direct Binding of b Subunit to F1 in Escherichia coli F1F0-ATP Synthase*

J. Weber, A. E. Senior, S. Wilke-Mounts, 2004, Journal of Biological Chemistry.

Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

I. Schuppe-Koistinen, W. Mattes, H. Kamp, 2013, BioMed research international.

Human A53T α-Synuclein Causes Reversible Deficits in Mitochondrial Function and Dynamics in Primary Mouse Cortical Neurons

A. Milici, J. Schwartz, Z. Berger, 2013, PloS one.

Isolation of the Catalytic (β) Subunit of the Chloroplast ATP Synthase in a Hydrolytically Active Form

D. Harris, S. Nadanaciva, 1990 .

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms.

P. Oliveira, Y. Will, S. Nadanaciva, 2012, Toxicology and applied pharmacology.

Mitochondrial membrane potential measurement of H9c2 cells grown in high-glucose and galactose-containing media does not provide additional predictivity towards mitochondrial assessment.

Y. Will, S. Nadanaciva, Payal Rana, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration.

R. Capaldi, J. Dykens, Y. Will, 2007, Toxicology and applied pharmacology.

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

Yvonne Will, David A Ferrick, Payal Rana, 2012, Journal of Bioenergetics and Biomembranes.

Importance of F1-ATPase residue alpha-Arg-376 for catalytic transition state stabilization.

J. Weber, A. E. Senior, S. Wilke-Mounts, 1999, Biochemistry.

Analysis of protein fragmentation inhibition by an MMP-inhibitor in an in vivo model of heart failure using automated chromatography.

M. Heron, C. Painter, J. Slemmon, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

New insights in drug-induced mitochondrial toxicity.

Y. Will, S. Nadanaciva, 2011, Current pharmaceutical design.

Impact of a planned dose interruption of dacomitinib in the treatment of advanced non-small-cell lung cancer (ARCHER 1042).

M. Lacouture, Dong-Wan Kim, B. Cho, 2017, Lung cancer.

Distribution of Abeta peptide in whole blood.

R. Motter, P. Seubert, C. Painter, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial.

Ying Cheng, T. Mok, Yi-long Wu, 2017, The Lancet. Oncology.

Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays.

R. Aggeler, R. Capaldi, Y. Will, 2007, Toxicology in vitro : an international journal published in association with BIBRA.

High‐Content Imaging Assays for Identifying Compounds that Generate Superoxide and Impair Mitochondrial Membrane Potential in Adherent Eukaryotic Cells

Yvonne Will, Y. Will, S. Nadanaciva, 2014, Current protocols in toxicology.

A phase II study (ARCHER 1042) to evaluate prophylactic treatment of dacomitinib-induced dermatologic and gastrointestinal adverse events in advanced non-small-cell lung cancer.

M. Lacouture, A. Jatoi, S. Sonis, 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

High‐Throughput Assays for Assessing Mitochondrial Dysfunction Caused by Compounds that Impair mtDNA‐Encoded Protein Levels in Eukaryotic Cells

Y. Will, J. Murray, S. Nadanaciva, 2011, Current protocols in toxicology.

Prediction of metabolism-induced hepatotoxicity on three-dimensional hepatic cell culture and enzyme microarrays

Dong Woo Lee, J. Dordick, Y. Will, 2017, Archives of Toxicology.

The role of mitochondrial dysfunction and drug safety.

Y. Will, S. Nadanaciva, 2009, IDrugs : the investigational drugs journal.