A. Dorn

发表

Evaluation of a High-Throughput Fluorescence Assay Method for hERG Potassium Channel Inhibition

Andreas Ebneth, Gerhard Trube, G. Trube, 2005, Journal of biomolecular screening.

Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?

F. Winkler, A. D'arcy, C. Oefner, 1999, Chemistry & biology.

Haematin (haem) polymerization and its inhibition by quinoline antimalarials

J. Vennerstrom, A. Dorn, S. Vippagunta, 1997 .

Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.

J. Karle, H. Matile, A. Bhattacharjee, 1999, Journal of medicinal chemistry.

Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines.

L. Gerena, W. Milhous, J. Vennerstrom, 1998, Journal of medicinal chemistry.

Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.

J. Karle, J. Chollet, S. Charman, 2007, Bioorganic & medicinal chemistry letters.

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

C. Benoist, D. Mathis, M. L. Meur, 1987, Proceedings of the National Academy of Sciences of the United States of America.

B-cell control region at the 5' end of a major histocompatibility complex class II gene: sequences and factors

C. Benoist, D. Mathis, P. Gerlinger, 1988, Molecular and cellular biology.

B-Cell Control Region atthe5'Endofa MajorHistocompatibili ty ComplexClass II Gene:Sequences andFactors

C. Benoist, D. Mathis, M. Lemeur, 1988 .

New B-lymphocyte-specific enhancer-binding protein

C. Benoist, D. Mathis, A. Dorn, 1989, Molecular and cellular biology.

8-Aminoquinolines Active against Blood Stage Plasmodium falciparum In Vitro Inhibit Hematin Polymerization

L. Gerena, W. Milhous, Robert E. Miller, 1999, Antimicrobial Agents and Chemotherapy.

A new class of inhibitors for the malarial aspartic protease plasmepsin II based on a central 11-azatricyclo[6.2.1.02,7]undeca-2,4,6-triene scaffold

F. Diederich, H. Märki, A. Dorn, 2003 .

Development of a New Class of Inhibitors for the Malarial Aspartic Protease Plasmepsin II Based on a Central 7‐Azabicyclo[2.2.1]heptane Scaffold

F. Diederich, H. Märki, P. Seiler, 2003 .

SEAP expression in transiently transfected mammalian cells grown in serum-free suspension culture

E. Schlaeger, E. Kitas, A. Dorn, 2003, Cytotechnology.

Tris-benzimidazole derivatives: design, synthesis and DNA sequence recognition.

M. Waring, C. Bailly, R. Hochstrasser, 2001, Bioorganic & medicinal chemistry.

Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine.

J. Vennerstrom, A. Dorn, S. Vippagunta, 1999, Biochemical pharmacology.

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

J. Karle, J. Chollet, S. Charman, 2005, Journal of medicinal chemistry.

Properties of a CCAAT box-binding protein.

C. Benoist, D. Mathis, R. Hooft van Huijsduijnen, 1987, Nucleic acids research.

Subclasses of simian-virus-40 large tumor antigen. Partial purification and DNA-binding properties of two subclasses of tumor antigen from productively infected cells.

E. Fanning, R. Knippers, A. Dorn, 2005, European journal of biochemistry.

Haem polymerization in malaria

M. Kansy, H. Matile, A. Dorn, 1995, Nature.

4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

H. Matile, W. Huber, S. Jolidon, 1996, Antimicrobial agents and chemotherapy.

Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores

M. Kansy, H. Shimada, H. Matile, 2000, Antimicrobial Agents and Chemotherapy.

The enhancer in an MHC class II gene, in vitro and in mouso.

C. Benoist, D. Mathis, C. Waltzinger, 1988, Biochimie.

Short report: floxacrine analog WR 243251 inhibits hematin polymerization.

H. Matile, J. Vennerstrom, A. Dorn, 2001, The American journal of tropical medicine and hygiene.

Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth.

S. Maiti, Srinivas Cheruku, A. Bhattacharjee, 2003, Journal of medicinal chemistry.

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

J. Chollet, S. Charman, W. Charman, 2010, Journal of medicinal chemistry.

A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro.

H. Matile, J. Vennerstrom, A. Dorn, 1998, Biochemical pharmacology.

An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials.

H. Matile, J. Vennerstrom, A. Dorn, 1998, Biochemical pharmacology.

Identification of an antimalarial synthetic trioxolane drug development candidate

Christian Scheurer, Jonathan L. Vennerstrom, Susan A. Charman, 2004, Nature.

Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein

H. Matile, R. Stoffel, A. Dorn, 1995, Nature.

Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry.

J. Vennerstrom, A. Dorn, S. Vippagunta, 2000, Biochimica et biophysica acta.

Short Optimally Capped Duplex DNA as Conformationally Restricted Analogue of B‐DNA

W. Bannwarth, A. Dorn, P. Iaiza, 1994 .

Distamycin‐induced inhibition of homeodomain‐DNA complexes.

W. Gehring, M. Affolter, M. Müller, 1992, The EMBO journal.

A multiplicity of CCAAT box-binding proteins

C. Benoist, D. Mathis, A. Dorn, 1987, Cell.

The Regulation of Ia Gene Transcription

C. Benoist, D. Mathis, M. Lemeur, 1986 .

Homeodomain proteins in development and therapy.

W. Gehring, M. Affolter, A. Dorn, 1994, Pharmacology & therapeutics.

NF-X, a transcription factor implicated in MHC class II gene regulation.

V. Kouskoff, C. Benoist, C. Griscelli, 1991, Journal of immunology.

Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737

F. Theil, H. Matile, A. Guenzi, 1997, Antimicrobial agents and chemotherapy.

De Novo Design, Synthesis, and In Vitro Evaluation of a New Class of Nonpeptidic Inhibitors of the Malarial Enzyme Plasmepsin II

F. Diederich, H. Märki, A. Dorn, 2002, Chembiochem : a European journal of chemical biology.

In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum.

S. Charman, R. Brun, H. Matile, 2006, The Journal of antimicrobial chemotherapy.

The comparative antimalarial properties of weak base and neutral synthetic ozonides.

J. Chollet, S. Charman, W. Charman, 2010, Bioorganic & medicinal chemistry letters.

Haematin (haem) polymerization and its inhibition by quinoline antimalarials.

J. Vennerstrom, A. Dorn, S. Vippagunta, 1997, Annals of tropical medicine and parasitology.

Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets.

U. Certa, J. Kay, A. D'arcy, 1998, Advances in experimental medicine and biology.