J. Heering

发表

Caspase‐2 is an initiator caspase responsible for pore‐forming toxin‐mediated apoptosis

D. Green, V. Dötsch, F. G. van der Goot, 2012, The EMBO journal.

A selective modulator of peroxisome proliferator-activated receptor γ with unprecedented binding mode.

S. Knapp, O. Werz, M. Windbergs, 2020, Journal of medicinal chemistry.

Cyclic Di-GMP Regulates Type IV Pilus-Dependent Motility in Myxococcus xanthus

L. Søgaard-Andersen, M. Hoppert, V. Kaever, 2015, Journal of bacteriology.

Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries

E. Proschak, D. Merk, J. Heering, 2022, ChemMedChem.

Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms

A. Chaikuad, D. Merk, J. Heering, 2020, International journal of molecular sciences.

Mutation in SAM domain of TP63 is associated with nonsyndromic cleft lip and palate and cleft palate

V. Dötsch, P. Kantaputra, A. R. Vieira, 2011, American journal of medical genetics. Part A.

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

M. Schubert-Zsilavecz, E. Proschak, D. Merk, 2018, Scientific Reports.

Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.

S. Knapp, D. Steinhilber, E. Proschak, 2021, Journal of medicinal chemistry.

Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics

A. Chaikuad, D. Merk, J. Heering, 2020, International journal of molecular sciences.

Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

D. Steinhilber, M. Schubert-Zsilavecz, Franca-Maria Klingler, 2011, ChemMedChem.

Structure optimization of a new class of PPARγ antagonists.

D. Steinhilber, M. Schubert-Zsilavecz, M. Wurglics, 2019, Bioorganic & medicinal chemistry.

L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ.

S. Knapp, D. Steinhilber, M. Schubert-Zsilavecz, 2020, Journal of medicinal chemistry.

Phenotypic analysis of Arg227 mutations of TP63 with emphasis on dental phenotype and micturition difficulties in EEC syndrome

R. Hennekam, V. Dötsch, P. Tanpaiboon, 2011, American journal of medical genetics. Part A.

Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.

Sandra K. Wittmann, D. Steinhilber, S. George, 2020, Journal of medicinal chemistry.

Thermodynamic properties of leukotriene A4 hydrolase inhibitors.

Sandra K. Wittmann, S. Knapp, D. Steinhilber, 2016, Bioorganic & medicinal chemistry.

A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity.

Sandra K. Wittmann, J. Lausen, E. Proschak, 2018, Analytical biochemistry.

Compilation and Evaluation of Fatty Acid Mimetics Screening Library.

D. Steinhilber, M. Schubert-Zsilavecz, E. Proschak, 2022, Biochemical pharmacology.

Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2

V. Dötsch, S. Kehrloesser, B. Thiede, 2017, EMBO reports.

Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.

H. Schwalbe, A. Chaikuad, D. Merk, 2022, ACS chemical biology.

Botanical and agronomic evaluation of a collection of Sesbania sesban and related perennial species

J. Heering, 1995 .

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.

Sandra K. Wittmann, D. Steinhilber, B. Brüne, 2016, Journal of medicinal chemistry.

Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.

E. Proschak, D. Merk, J. Heering, 2019, Journal of medicinal chemistry.

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype.

E. Proschak, D. Merk, Pascal Heitel, 2019, ACS medicinal chemistry letters.

Nonacidic Farnesoid X Receptor Modulators.

Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk, 2017, Journal of medicinal chemistry.

Design of a Potent TLX Agonist by Rational Fragment Fusion.

S. Knapp, A. Chaikuad, D. Merk, 2022, Journal of medicinal chemistry.

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.

S. Knapp, H. Stark, V. Dötsch, 2021, Journal of medicinal chemistry.

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

M. Schubert-Zsilavecz, E. Proschak, D. Merk, 2018, Scientific Reports.

Closantel is an allosteric inhibitor of human Taspase1.

S. Knapp, E. Proschak, R. Marschalek, 2021, iScience.

The reproductive biology of three perennial Sesbania species (Leguminosae)

J. Heering, 2004, Euphytica.

Karyotype analysis and interspecific hybridisation in three perennial Sesbania species (Leguminosae)

J. Heering, J. Hanson, 2004, Euphytica.

The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells

Marcel H. Schulz, D. Steinhilber, R. Brandes, 2020, Basic Research in Cardiology.

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.

Gerd Geisslinger, Ewgenij Proschak, Daniel Merk, 2017, Journal of medicinal chemistry.

Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.

S. Knapp, A. Chaikuad, D. Merk, 2022, Bioorganic chemistry.

The classification of a Sesbania sesban (ssp. sesban) collection. 1. Morphological attributes and their taxonomic significance.

S. Nokoe, J. Heering, J. Mohammed, 1996 .

The classification of a Sesbania sesban (ssp. sesban) collection. II. Agronomic attributes and their relation to biomass estimation.

S. Nokoe, J. Heering, J. Mohammed, 1996 .

Induction of Cellular Differentiation and Single Cell Imaging of Vibrio parahaemolyticus Swimmer and Swarmer Cells.

S. Ringgaard, A. Alvarado, J. Heering, 2017, Journal of visualized experiments : JoVE.

Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions.

S. Knapp, S. Lorkowski, O. Werz, 2021, Cell chemical biology.

First structure-activity relationship study of potent BLT2 agonists as potential wound healing promoters.

D. Steinhilber, M. Windbergs, M. Schubert-Zsilavecz, 2020, Journal of medicinal chemistry.

Nurr1 Modulation Mediates Neuroprotective Effects of Statins

J. Heering, Giuseppe Faudone, Whitney Kilu, 2021, bioRxiv.

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ

Sandra K. Wittmann, D. Steinhilber, M. Schubert-Zsilavecz, 2019, Front. Pharmacol..

FAM96A is a novel pro‐apoptotic tumor suppressor in gastrointestinal stromal tumors

R. Penzel, K. Zatloukal, V. Dötsch, 2015, International journal of cancer.

Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain.

Sandra K. Wittmann, S. Knapp, D. Steinhilber, 2019, Journal of medicinal chemistry.

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

Ste, Sandra K. Wittmann, S. Knapp, 2019 .

Hybrid Reporter Gene Assays: Versatile In Vitro Tools to Characterize Nuclear Receptor Modulators.

D. Merk, J. Heering, 2019, Methods in molecular biology.

Development and Characterization of a Fluorescent Ligand for Leukotriene B4 Receptor 2 in Cells and Tissues.

D. Steinhilber, E. Proschak, I. Fleming, 2022, Journal of medicinal chemistry.

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ

D. Steinhilber, E. Proschak, D. Merk, 2021, The Journal of biological chemistry.

The effect of cutting height and frequency on the forage, wood and seed production of sixSesbania sesban accessions

J. Heering, 1995, Agroforestry Systems.

Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.

D. Merk, J. Heering, S. Schierle, 2021, Journal of medicinal chemistry.

The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs

S. Knapp, A. Chaikuad, D. Merk, 2020, Communications Chemistry.

Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR).

D. Trauner, D. Merk, Johannes Morstein, 2020, Journal of medicinal chemistry.

Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR‐1) Reveals Inverse NOR‐1 Agonists

D. Merk, J. Marschner, J. Heering, 2022, ChemMedChem.

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

G. Höfner, S. Knapp, E. Proschak, 2023, Journal of the American Chemical Society.

Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms.

D. Merk, J. Heering, Whitney Kilu, 2021, Journal of Medicinal Chemistry.

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.

Sandra K. Wittmann, D. Steinhilber, M. Wurglics, 2017, Journal of medicinal chemistry.

Caspase‐2 is an initiator caspase responsible for pore‐forming toxin‐mediated apoptosis

D. Green, V. Dötsch, F. G. van der Goot, 2012, The EMBO journal.

Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain

H. Schwalbe, V. Dötsch, F. Löhr, 2016, Protein science : a publication of the Protein Society.

The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Caffeine and Istradefylline

H. Schwalbe, S. Knapp, M. Schubert-Zsilavecz, 2021 .

International user identification and platform creation : user requirements study for remote sensing based spatial information for the sustainable management of forests : also as open access e-book

Wietske Bijker, J. Heering, C. de Pater, 1999 .

Design of the user needs assessment study : user requirements study for remote sensing based spatial information for the sustainable management of forests : also as open access e-book

Wietske Bijker, J. Heering, E. Westinga, 1999 .

Genetic resources of Stylosanthes species

J. Heering, J. Hanson, 1994 .

The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines.

H. Schwalbe, S. Knapp, M. Schubert-Zsilavecz, 2021, ACS pharmacology & translational science.

Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

D. Steinhilber, M. Schubert-Zsilavecz, Franca-Maria Klingler, 2011, ChemMedChem.