G. Porto

发表

G. Porto, M. Sousa, Graça Porto, 2010 .

Low serum levels of prohepcidin, but not hepcidin-25, are related to anemia in familial amyloidosis TTR V30M.

D. Swinkels, S. Almeida, C. Freitas, 2008, Blood cells, molecules & diseases.

Liver transplantation and anemia in familial amyloidosis ATTR V30M

A. Cabrita, G. Porto, I. Beirão, 2007, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Kidney and anemia in familial amyloidosis type I.

A. Cabrita, G. Porto, I. Beirão, 2004, Kidney international.

Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype.

M. Cancela, P. Gavaia, G. Porto, 2019, BioFactors.

Zinc activates neutrophils’ oxidative burst

E. Fernandes, J. Lima, M. Freitas, 2010, BioMetals.

Increased capacity of lymphocytes from hereditary hemochromatosis patients homozygous for the C282Y HFE mutation to respond to the genotoxic effect of diepoxybutane.

G. Porto, Raquel Vieira, B. Porto, 2009, Mutation research.

Nickel induces oxidative burst, NF-κB activation and interleukin-8 production in human neutrophils

E. Fernandes, M. Freitas, G. Porto, 2010, JBIC Journal of Biological Inorganic Chemistry.

Hepcidin messenger RNA expression in human lymphocytes

F. Carvalho, H. Zoller, H. Carmo, 2010, Immunology.

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis

M. Cancela, M. Cohen-Solal, G. Porto, 2018, PloS one.

The importance of the general practitioner as an information source for patients with hereditary haemochromatosis.

D. Swinkels, P. Brissot, Mayka Sánchez, 2014, Patient education and counseling.

Optimization of experimental settings for the analysis of human neutrophils oxidative burst in vitro.

E. Fernandes, J. Lima, M. Freitas, 2009, Talanta.

The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis

M. Zimmermann, F. Vallelian, B. M. Frey, 2022, European Journal of Nutrition.

Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils.

E. Fernandes, F. Carvalho, V. M. Costa, 2013, Toxicology letters.

The immunological system in hemochromatosis.

G. Porto, M. de Sousa, 1998, Journal of hepatology.

Metal-induced oxidative burst in isolated human neutrophils

E. Fernandes, J. Lima, M. Freitas, 2010 .

Trihydroxyflavones with antioxidant and anti-inflammatory efficacy.

J. Duarte, E. Fernandes, Diana Couto, 2012, BioFactors.

Invariant Natural Killer T Cells are Reduced in Hereditary Hemochromatosis Patients

M. Exley, G. Porto, C. Pereira, 2014, Journal of Clinical Immunology.

Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes.

G. Porto, Fernando A. Arosa, K. Uchida, 2001, Blood.

Protective effect of an ERAP 1 haplotype in ankylosing spondylitis : investigating non-MHC genes in HLA-B 27-positive individuals

Jaime, J. Caetano-Lopes, M. Lima, 2013 .

Iron Administration, Infection, and Anemia Management in CKD: Untangling the Effects of Intravenous Iron Therapy on Immunity and Infection Risk

W. Winkelmayer, I. Macdougall, T. Ganz, 2020, Kidney medicine.

iron overload: identification of a novel TfR2 mutation Transferrin receptor 2 (TfR2) and HFEmutational analysis in non-C282Y

M. Marra, D. Huntsman, Steven P. Jones, 2013 .

Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation.

M. Marra, Y. Butterfield, D. Huntsman, 2002, Blood.

Expansions of CD8+CD28- and CD8+TcRVbeta5.2+ T cells in peripheral blood of heavy alcohol drinkers.

B. Justiça, H. Alves, G. Porto, 2000, Alcoholism, clinical and experimental research.

EASL Clinical Practice Guidelines on haemochromatosis.

A. Vanclooster, J. Ryan, H. Zoller, 2022, Journal of hepatology.

Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways

E. Fernandes, F. Carvalho, J. Rivas, 2015, Archives of Toxicology.

G. Porto, M. de Sousa, M. J. Teles, 2019, Pharmaceuticals.

Hemochromatosis and pregnancy: iron stores in the Hfe-/- mouse are not reduced by multiple pregnancies.

I. Olsson, G. Porto, J. Neves, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Iron MetabolismResearch Paper

M. Brandão, G. Porto, I. Garrido, 2005 .

The soluble transferrin receptor as a marker of iron homeostasis in normal subjects and in HFE-related hemochromatosis.

M. Brandão, G. Porto, I. Garrido, 2005, Haematologica.

Comparative study between Hfe‐/‐ and β2m‐/‐ mice: progression with age of iron status and liver pathology

P. Arosio, G. Porto, M. Sousa, 2006, International journal of experimental pathology.

The CD8+ T-lymphocyte profile as a modifier of iron overload in HFE hemochromatosis: an update of clinical and immunological data from 70 C282Y homozygous subjects.

S. Almeida, G. Porto, G. Melo, 2006, Blood cells, molecules & diseases.

A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload

S. Almeida, H. Alves, G. Porto, 2006, BMC Medical Genetics.

Involvement of the major histocompatibility complex region in the genetic regulation of circulating CD8 T-cell numbers in humans.

H. Alves, G. Porto, R. Lacerda, 2004, Tissue antigens.

Clinical and genetic heterogeneity in hereditary haemochromatosis: association between lymphocyte counts and expression of iron overload

V. Gordeuk, B. Justiça, V. Moyo, 2001, European journal of haematology.

T-cell receptor repertoire in hereditary hemochromatosis: a study of 32 hemochromatosis patients and 274 healthy subjects.

B. Justiça, G. Porto, F. Bravo, 2001, Human immunology.

Decreased CD8‐p561ck Activity in Peripheral Blood T‐Lymphocytes from Patients with Hereditary Haemochromatosis

C. Rudd, G. Porto, M. Sousa, 1994, Scandinavian journal of immunology.

Haemochromatosis as a window into the study of the immunological system: A novel correlation between CD8+ lymphocytes and iron overload

B. Justiça, G. Porto, M. Sousa, 1994, European journal of haematology.

Iron overload in beta 2-microglobulin-deficient mice.

S. Kaufmann, G. Porto, P. Hugo, 1994, Immunology letters.

Stability of CD4/CD8 ratios in man: new correlation between CD4/CD8 profiles and iron overload in idiopathic haemochromatosis patients.

G. Porto, R. Reimão, M. D. de Sousa, 1991, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Hereditary Hemochromatosis (HH) in the North of Portugal

G. Porto, M. Sousa, J. Soares, 1988 .

Hereditary Hemochromatosis (HH) in the North of Portugal

G. Porto, M. Sousa, R. Lacerda, 1988 .

The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis

M. Zimmermann, F. Vallelian, B. M. Frey, 2022, European Journal of Nutrition.

Hemochromatosis and Xeroderma Pigmentosum: Two (Un)Suspicious Neighbors

G. Porto, J. Reis, I. Pedroto, 2021, GE - Portuguese Journal of Gastroenterology.

Two novel mutations in the tmprss6 gene associated with iron‐refractory iron‐deficiency anaemia (irida) and partial expression in the heterozygous form

G. Saglio, G. Zecchina, A. Roetto, 2012, British journal of haematology.

Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8(+) T lymphocyte numbers.

G. Porto, M. de Sousa, M. F. Macedo, 2005, Blood cells, molecules & diseases.

Comparative study of the two more frequent HFE mutations (C282Y and H63D): significant different allelic frequencies between the North and South of Portugal

C. Oberkanins, G. Porto, M. Sousa, 2001, European Journal of Human Genetics.

Iron overload in β2-microglobulin-deficient mice

S. Kaufmann, R. Reimão, G. Porto, 1994 .

A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis

G. Porto, C. Whittington, R. Lacerda, 2008, BMC Medical Genetics.

Iron and Lymphocytes: Reciprocal Regulatory Interactions1

M. Hilgartner, R. Grady, P. Giardina, 1991 .

Iron and lymphocytes: reciprocal regulatory interactions.

M. Hilgartner, R. Grady, P. Giardina, 1991, Current studies in hematology and blood transfusion.

Major histocompatibility complex class I associations in iron overload: evidence for a new link between the HFE H63D mutation, HLA-A29, and non-classical forms of hemochromatosis

R. Wolff, B. Justiça, H. Alves, 1998, Immunogenetics.

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα

F. Carvalho, H. Pontes, D. Tosh, 2008, Blood.

Non-Transferrin-Bound Iron (NTBI) Uptake by T Lymphocytes: Evidence for the Selective Acquisition of Oligomeric Ferric Citrate Species

M. Vos, Xiaole Kong, R. Hider, 2013, PloS one.

Red blood cells upregulate cytoprotective proteins and the labile iron pool in dividing human T cells despite a reduction in oxidative stress.

C. Pereira, G. Porto, Fernando A. Arosa, 2003, Free radical biology & medicine.

A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron.

T. Ganz, C. Camaschella, S. Almeida, 2005, Blood.

Effects of Highly Conserved Major Histocompatibility Complex (MHC) Extended Haplotypes on Iron and Low CD8+ T Lymphocyte Phenotypes in HFE C282Y Homozygous Hemochromatosis Patients from Three Geographically Distant Areas

C. Vieira, J. Barton, B. M. da Silva, 2013, PloS one.

Growth hormone (GH)‐induced reconstitution of CD8+ CD28+ T lymphocytes in a rare case of severe lymphopenia associated with Juvenile Haemochromatosis and Turner's syndrome

A. Roetto, G. Porto, F. Daraio, 2004, Clinical endocrinology.

Hemochromatosis: T-lymphocyte expression and function in hemochromatosis

G. Porto, M. Sousa, J. Cabeda, 2000 .

Idiopathic haemochromatosis in north Portugal: association with haplotype A3B7.

B. M. da Silva, G. Porto, M. D. de Sousa, 1989, Journal of clinical pathology.

Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin

P. Klenerman, C. Willberg, J. Hughes, 2019, Nature Metabolism.

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications

André M. N. Silva, E. Hawkins, S. Vervoort, 2020, bioRxiv.

Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype

D. Girelli, D. Swinkels, N. Milman, 2018, Hepatology International.

Chromosome 6p SNP microhaplotypes and IgG3 levels in hemochromatosis probands with HFE p.C282Y homozygosity.

J. Barton, J. Guimarães, G. Porto, 2019, Blood cells, molecules & diseases.

WITHDRAWN: Chromosome 6p SNP microhaplotypes and IgG3 levels in hemochromatosis probands with HFE p.C282Y homozygosity

J. Barton, J. Guimarães, G. Porto, 2019, Blood Cells, Molecules, and Diseases.

Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways

E. Fernandes, F. Carvalho, J. Rivas, 2015, Archives of Toxicology.

A novel mutation in the CUB sequence of matriptase‐2 (TMPRSS6) is implicated in iron‐resistant iron deficiency anaemia – response to Jaspers et al

A. Roetto, G. Porto, 2013, British journal of haematology.

Polyacrylic acid coated and non-coated iron oxide nanoparticles are not genotoxic to human T lymphocytes.

E. Fernandes, F. Carvalho, J. Rivas, 2015, Toxicology letters.

Low Erythropoietin Production in Familial Amyloidosis TTR V30M Is Not Related with Renal Congophilic Amyloid Deposition

A. Cabrita, G. Porto, I. Beirão, 2008, Nephron Clinical Practice.

Hemochromatosis: Variation of hemochromatosis prevalence and genotype in national groups

G. Porto, M. Sousa, 2000 .

HFE mutations in the pathobiology of hemophilic arthropathy.

G. Porto, M. de Sousa, M. Campos, 2005, Blood.

Inhibition of LOX by flavonoids: a structure-activity relationship study.

E. Fernandes, E. Cabrita, Artur M. S. Silva, 2014, European journal of medicinal chemistry.

Iron homeostasis in breast cancer.

C. Lopes, B. M. da Silva, G. Porto, 2014, Cancer letters.

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.

M. Hentze, M. Muckenthaler, F. Vinchi, 2019, European heart journal.

Iron overload and immunity.

G. Porto, M. de Sousa, M. D. de Sousa, 2007, World journal of gastroenterology.

Protective role of calreticulin in HFE hemochromatosis

S. Rivella, M. Michalak, P. Ramos, 2008, Free radical biology & medicine.

T cell numbers relate to bone involvement in Gaucher disease.

A. Fortuna, O. Amaral, G. Porto, 1999, Blood cells, molecules & diseases.

The EHA Research Roadmap: Anemias

S. Rivella, D. Girelli, M. Muckenthaler, 2021, HemaSphere.

Isolation and activation of human neutrophils in vitro. The importance of the anticoagulant used during blood collection.

E. Fernandes, J. Lima, M. Freitas, 2008, Clinical biochemistry.

A putative gene located at the MHC class I region around the D6S105 marker contributes to the setting of CD8+ T‐lymphocyte numbers in humans

P. Brazdil, S. Almeida, H. Alves, 2007, International journal of immunogenetics.

Invariant Natural Killer T Cells are Reduced in Hereditary Hemochromatosis Patients

M. Exley, G. Porto, C. Pereira, 2014, Journal of Clinical Immunology.

Local iron homeostasis in the breast ductal carcinoma microenvironment

M. Gomez-Lazaro, C. Lopes, F. Faria, 2016, BMC Cancer.

HFE Variants and the Expression of Iron-Related Proteins in Breast Cancer-Associated Lymphocytes and Macrophages

C. Lopes, P. Faustino, G. Porto, 2016, Cancer Microenvironment.

Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation

M. Guerreiro, A. Mendonça, A. Verdelho, 2014, Neurobiology of Aging.

EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH)

D. Swinkels, S. Patton, P. Brissot, 2015, European Journal of Human Genetics.

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

S. Rivella, P. Olinga, M. Muckenthaler, 2017, Nature Communications.

Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds.

C. Pereira, G. Porto, Fernando A. Arosa, 2003, Cellular immunology.

Physiological implications of NTBI uptake by T lymphocytes

M. Vos, Y. Rikers, M. Rangel, 2014, Front. Pharmacol..

Co-selection of the H63D mutation and the HLA-A29 allele: a new paradigm of linkage disequilibrium?

H. Alves, G. Porto, C. Cardoso, 2002, Immunogenetics.

Expression of iron-related proteins in feline and canine mammary gland reveals unexpected accumulation of iron

A. Cañadas, A. Gama, I. Amorim, 2017, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Lymphocyte Gene Expression Signatures from Patients and Mouse Models of Hereditary Hemochromatosis Reveal a Function of HFE as a Negative Regulator of CD8+ T-Lymphocyte Activation and Differentiation In Vivo

V. Beneš, M. Muckenthaler, M. Lima, 2015, PloS one.

Low numbers of CD8+ T lymphocytes in hereditary haemochromatosis are explained by a decrease of the most mature CD8+ effector memory T cells

G. Porto, M. F. Macedo, B. Rocha, 2010, Clinical and experimental immunology.

EPOR signalling and regulation of C/EBP{alpha} Erythropoietin mediates hepcidin expression in hepatocytes through

F. Carvalho, H. Pontes, D. Tosh, 2010 .

Human red blood cells have an enhancing effect on the relative expansion of CD8+ T lymphocytes in vitro

G. Porto, Fernando A. Arosa, A. M. Fonseca, 2001, Cell Proliferation.

Anomalies of the CD8+ T cell pool in haemochromatosis: HLA‐A3‐linked expansions of CD8+CD28− T cells

B. M. da Silva, W. Kruijer, J. Veltman, 1997, Clinical and experimental immunology.

Modulation of human neutrophils' oxidative burst by flavonoids.

E. Fernandes, Artur M. S. Silva, M. Freitas, 2013, European journal of medicinal chemistry.

Long-term treatment of anemia with recombinant human erythropoietin in familial amyloidosis TTR V30M

A. Cabrita, G. Porto, I. Beirão, 2008, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Relative impact of HLA phenotype and CD4‐CD8 ratios on the clinical expression of hemochromatosis

B. Justiça, H. Alves, G. Porto, 1997, Hepatology.

Interaction of polyacrylic acid coated and non-coated iron oxide nanoparticles with human neutrophils.

José Rivas, Eduarda Fernandes, E. Fernandes, 2014, Toxicology letters.

Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis

J. Lopes, C. Caldas, G. Porto, 2016, Redox biology.

A structure-activity relationship study of flavonoids as dual inhibitors of LOX and COX

E. Fernandes, Artur M. S. Silva, M. Freitas, 2013 .

Hemochromatosis classification: update and recommendations by the BIOIRON Society.

D. Girelli, M. Muckenthaler, P. Brissot, 2021, Blood.

Importance of establishing appropriate local reference values for the screening of hemochromatosis: a study of three different control populations and 136 hemochromatosis family members. Hemochromatosis Clinical and Research Group.

B. M. da Silva, G. Porto, J. Fraga, 1992, The Journal of laboratory and clinical medicine.