Theodore W Randolph

发表

Microflow Imaging Analyses Reflect Mechanisms of Aggregate Formation: Comparing Protein Particle Data Sets Using the Kullback-Leibler Divergence.

Nathaniel R Maddux, Austin L Daniels, Theodore W Randolph, 2017, Journal of pharmaceutical sciences.

Machine learning and statistical analyses for extracting and characterizing “fingerprints” of antibody aggregation at container interfaces from flow microscopy images

Austin L Daniels, Theodore W Randolph, Christopher P Calderon, 2020, Biotechnology and bioengineering.

Long‐Term Storage of Proteins

Theodore W Randolph, John F Carpenter, Mark C Manning, 2002, Current protocols in protein science.

Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations.

Austin L Daniels, Theodore W Randolph, Christopher P Calderon, 2017, Journal of pharmaceutical sciences.

Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin.

Theodore W Randolph, Gerhard Winter, John F Carpenter, 2010, Journal of pharmaceutical sciences.

Electrostatic Interactions Influence Protein Adsorption (but Not Desorption) at the Silica-Aqueous Interface.

Theodore W Randolph, D. K. Schwartz, T. Randolph, 2015, The journal of physical chemistry letters.

Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2016, Journal of pharmaceutical sciences.

Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2016, Journal of pharmaceutical sciences.

Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation.

Theodore W Randolph, Hasige A Sathish, John F Carpenter, 2010, Journal of pharmaceutical sciences.

Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2009, Biochemistry.

Particles shed from syringe filters and their effects on agitation-induced protein aggregation.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2012, Journal of pharmaceutical sciences.

Selective domain stabilization as a strategy to reduce fusion protein aggregation.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2012, Journal of pharmaceutical sciences.

Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions.

Chikako Yomota, Theodore W Randolph, John F Carpenter, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics.

Theodore W Randolph, Brent S Kendrick, John F Carpenter, 2008, Journal of pharmaceutical sciences.

Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants.

Theodore W Randolph, C Russell Middaugh, Lilia A. Rabia, 2015, Journal of pharmaceutical sciences.

Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2008, Journal of pharmaceutical sciences.

Protein aggregation and particle formation in prefilled glass syringes.

Theodore W Randolph, John F Carpenter, Jared S. Bee, 2014, Journal of pharmaceutical sciences.

Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2010, Journal of pharmaceutical sciences.

Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations.

Theodore W Randolph, John F Carpenter, S. Golledge, 2002, Journal of pharmaceutical sciences.

Aggregation of a monoclonal antibody induced by adsorption to stainless steel

Theodore W Randolph, Erwin Freund, John F Carpenter, 2010, Biotechnology and bioengineering.

High-pressure studies on protein aggregates and amyloid fibrils.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2006, Methods in Enzymology.

Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2018, Journal of pharmaceutical sciences.

Protein-solute interactions affect the outcome of ultrafiltration/diafiltration operations.

Theodore W Randolph, Brent S Kendrick, T. Randolph, 2004, Journal of pharmaceutical sciences.

Aggregation of recombinant human botulinum protein antigen serotype C in varying solution conditions: implications of conformational stability for aggregation kinetics.

Theodore W Randolph, John F Carpenter, Shujun Bai, 2011, Journal of pharmaceutical sciences.

Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor

Theodore W Randolph, Brent S Kendrick, Eva Y Chi, 2003, Protein science : a publication of the Protein Society.

Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2016, Journal of pharmaceutical sciences.

Buffer-dependent fragmentation of a humanized full-length monoclonal antibody.

Theodore W Randolph, Hasige A Sathish, John F Carpenter, 2010, Journal of pharmaceutical sciences.

Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations.

Theodore W Randolph, John P. Gabrielson, John F Carpenter, 2011, Analytical biochemistry.

The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study.

Theodore W Randolph, John F Carpenter, D. K. Schwartz, 2013, Journal of pharmaceutical sciences.

UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.

Amber Haynes Fradkin, Theodore W Randolph, John F Carpenter, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2013, Journal of pharmaceutical sciences.

Freezing-induced perturbation of tertiary structure of a monoclonal antibody.

Theodore W Randolph, Wei Wang, John F Carpenter, 2014, Journal of pharmaceutical sciences.

IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles.

Theodore W Randolph, John F Carpenter, A. Tyagi, 2009, Journal of pharmaceutical sciences.

Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition.

Theodore W Randolph, Mark C Manning, Eva Y Chi, 2002, Biochemistry.

Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist.

Theodore W Randolph, Brent S Kendrick, Eva Y Chi, 2005, Journal of pharmaceutical sciences.

The effect of protein PEGylation on physical stability in liquid formulation.

Theodore W Randolph, J. E. Rasmussen, M. van de Weert, 2014, Journal of pharmaceutical sciences.

Selective domain stabilization as a strategy to reduce human serum albumin-human granulocyte colony stimulating factor aggregation rate.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2012, Journal of pharmaceutical sciences.

Physical stability of albinterferon-α(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation.

Theodore W Randolph, John F Carpenter, Danny K Chou, 2012, Journal of pharmaceutical sciences.

Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2012, Journal of pharmaceutical sciences.

Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway.

Theodore W Randolph, John F Carpenter, S. Singh, 2011, Journal of pharmaceutical sciences.

High hydrostatic pressure as a tool to study protein aggregation and amyloidosis.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2002, Biochimica et biophysica acta.

Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions.

Theodore W Randolph, Hanns-Christian Mahler, Christine Wurth, 2012, Journal of pharmaceutical sciences.

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.

Steven Kozlowski, Theodore W Randolph, C Russell Middaugh, 2009, Journal of pharmaceutical sciences.

Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2003, Journal of pharmaceutical sciences.

Supercritical fluid crystallization of griseofulvin: crystal habit modification with a selective growth inhibitor.

Theodore W Randolph, Kristi S Anseth, K. Anseth, 2005, Journal of pharmaceutical sciences.

Precipitation of a monoclonal antibody by soluble tungsten.

Theodore W Randolph, Erwin Freund, John F Carpenter, 2009, Journal of pharmaceutical sciences.

Immunogenicity of aggregates of recombinant human growth hormone in mouse models.

Amber Haynes Fradkin, Theodore W Randolph, John F Carpenter, 2009, Journal of pharmaceutical sciences.

Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation.

Theodore W Randolph, Donn Sederstrom, Erwin Freund, 2015, Journal of pharmaceutical sciences.

Adsorption of monoclonal antibodies to glass microparticles.

Theodore W Randolph, Hanns-Christian Mahler, Christine Wurth, 2011, Journal of pharmaceutical sciences.

Challenges in Predicting Protein-Protein Interactions from Measurements of Molecular Diffusivity.

Theodore W Randolph, D. K. Schwartz, T. Randolph, 2016, Biophysical journal.

Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution.

Theodore W Randolph, John F Carpenter, D. Brems, 2009, Journal of pharmaceutical sciences.

Rational design of stable lyophilized protein formulations: theory and practice.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2002, Pharmaceutical biotechnology.

Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes.

Theodore W Randolph, John F Carpenter, D. K. Schwartz, 2015, Journal of pharmaceutical sciences.

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.

Theodore W Randolph, Brent S Kendrick, Eva Y Chi, 2003, Biochemistry.

Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release.

Theodore W Randolph, C Russell Middaugh, Wim Jiskoot, 2012, Journal of pharmaceutical sciences.

Surfactant-protein interactions.

Theodore W Randolph, T. Randolph, L. Jones, 2002, Pharmaceutical biotechnology.

Effect of the siliconization method on particle generation in a monoclonal antibody formulation in pre-filled syringes.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2015, Journal of pharmaceutical sciences.