P. Ahring

J. Hanrahan, Navnath S. Gavande, A. Clarkson, 2019, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

A pharmacological assessment of agonists and modulators at α4β2γ2 and α4β2δ GABAA receptors: The challenge in comparing apples with oranges.

N. Absalom, D. Strøbæk, P. Ahring, 2016, Pharmacological research.

Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface

N. Absalom, A. Clarkson, P. Ahring, 2016, Scientific Reports.

New Ligands with Affinity for the α4β2 Subtype of Nicotinic Acetylcholine Receptors. Synthesis, Receptor Binding, and 3D-QSAR Modeling

T. Liljefors, K. Audouze, E. Nielsen, 2006 .

The de novo GABRA4 p.Thr300Ile variant found in a patient with early‐onset intractable epilepsy and neurodevelopmental abnormalities displays gain‐of‐function traits

N. Absalom, R. Møller, Susan Lin, 2022, Epilepsia.

The beta subunit determines the ion selectivity of the GABAA receptor.

A. Schousboe, T. H. Johansen, P. Ahring, 2002, The Journal of biological chemistry.

Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists

Jianguo Ji, T. Dyhring, C. Surowy, 2007 .

Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies

P. Striano, J. Jacobs, N. Absalom, 2022, Nature Communications.

NS383 Selectively Inhibits Acid‐Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats

T. Dyhring, G. Munro, P. Ahring, 2016, CNS neuroscience & therapeutics.

Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors

D. Peters, K. Harpsøe, P. Ahring, 2011, The Journal of Neuroscience.

Modulation of the Ca2+-dependent K+ Channel, hslo, by the Substituted Diphenylurea NS 1608, Paxilline and Internal Ca2+

D. Strøbæk, P. Christophersen, T. Johansen, 1996, Neuropharmacology.

Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain.

D. Strøbæk, J. Tseng-Crank, T. Johansen, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.

T. Dyhring, K. Marsh, C. Faltynek, 2007, Biochemical pharmacology.

Kainate induces various domain closures in AMPA and kainate receptors

J. Kastrup, M. Gajhede, K. Frydenvang, 2012, Neurochemistry International.

Charge selectivity of the Cys‐loop family of ligand‐gated ion channels

A. Schousboe, P. Ahring, M. Jensen, 2005, Journal of neurochemistry.

Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors

J. Kastrup, M. Gajhede, P. Ahring, 2014, PloS one.

Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.

R. Henry, T. Dyhring, C. Surowy, 2006, Journal of medicinal chemistry.

Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors.

U. Kristiansen, B. Frølund, P. Ahring, 2016, Biochemical pharmacology.

Pharmacological characterization of small‐conductance Ca2+‐activated K+ channels stably expressed in HEK 293 cells

D. Strøbæk, P. Christophersen, S. Olesen, 2000, British journal of pharmacology.

Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station.

C. Briggs, M. Håkerud, H. Ween, 2009, Assay and drug development technologies.

The Delta-Subunit Selective GABAA Receptor Modulator, DS2, Improves Stroke Recovery via an Anti-inflammatory Mechanism

A. Clarkson, P. Ahring, S. Young, 2019, Front. Neurosci..

A Mosaic of Functional Kainate Receptors in Hippocampal Interneurons

J. Lerma, P. Ahring, S. Selak, 2004, The Journal of Neuroscience.

Functional genomics of epilepsy-associated mutations in the GABAA receptor subunits reveal that one mutation impairs function and two are catastrophic

N. Absalom, I. McGregor, J. Arnold, 2019, The Journal of Biological Chemistry.

Concatenated nicotinic acetylcholine receptors: A gift or a curse?

V. Liao, P. Ahring, T. Balle, 2018, The Journal of general physiology.

Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at α4β2 Nicotinic Acetylcholine Receptors*

J. Kastrup, M. Gajhede, P. Ahring, 2014, The Journal of Biological Chemistry.

In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

C. Briggs, E. Nielsen, Jinhe Li, 2010, Journal of Pharmacology and Experimental Therapeutics.

Characterization of AN317, a novel selective agonist of α6β2-containing nicotinic acetylcholine receptors.

P. Christophersen, T. Dyhring, D. Peters, 2019, Biochemical pharmacology.

Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs

P. Ahring, T. Balle, Ali S Kusay, 2020, British journal of pharmacology.

Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists.

E. Nielsen, J. Kastrup, M. Gajhede, 2013, Journal of medicinal chemistry.

Ligand Binding at the α4-α4 Agonist-Binding Site of the α4β2 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State

N. Absalom, T. Lewis, D. Indurthi, 2016, PloS one.

pH Dependency and Desensitization Kinetics of Heterologously Expressed Combinations of Acid-sensing Ion Channel Subunits*

P. Ahring, D. Timmermann, Mette Hesselager, 2004, Journal of Biological Chemistry.

Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets.

N. Mirza, G. Munro, P. Ahring, 2009, Trends in pharmacological sciences.

Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.

T. Liljefors, J. Kastrup, M. Gajhede, 2009, Journal of molecular biology.

Partial Agonism and Antagonism of the Ionotropic Glutamate Receptor iGLuR5

T. Liljefors, A. Schousboe, P. Naur, 2007, Journal of Biological Chemistry.

Thyrotropin internalization is directed by a highly conserved motif in the seventh transmembrane region of its receptor

S. Al-Sedairy, M. Zou, N. Farid, 1995, Endocrine.

Comparison of the Novel Subtype-Selective GABAA Receptor-Positive Allosteric Modulator NS11394 [3′-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with Diazepam, Zolpidem, Bretazenil, and Gaboxadol in Rat Models of Inflammatory and Neuropathic Pain

E. Nielsen, J. Lopez-Garcia, N. Mirza, 2008, Journal of Pharmacology and Experimental Therapeutics.

Probing the molecular basis for affinity/potency‐ and efficacy‐based subtype‐selectivity exhibited by benzodiazepine‐site modulators at GABAA receptors

P. Ahring, T. Balle, P. C. Söderhielm, 2018, Biochemical pharmacology.

NS11394 [3′-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy

C. Mathiasen, E. Nielsen, N. Mirza, 2008, Journal of Pharmacology and Experimental Therapeutics.

Characterization of a novel high-potency positive modulator of K(v)7 channels.

Palle Christophersen, D. Strøbæk, C. Hougaard, 2013, European journal of pharmacology.

Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal Kv7 Channels

D. Strøbæk, M. Korsgaard, N. Mirza, 2005, Journal of Pharmacology and Experimental Therapeutics.

Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.

A. Silahtaroglu, P. Christophersen, C. Hansen, 1998, The American journal of physiology.

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

P. Christophersen, S. Olesen, R. S. Hansen, 2004, Biochimica et biophysica acta.

Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.

A. Silahtaroglu, D. Strøbæk, P. Christophersen, 1998, American journal of physiology. Cell physiology.

Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry

N. Absalom, T. Lewis, D. Indurthi, 2019, Pharmacological research.

A pharmacological characterization of GABA, THIP and DS2 at binary α4β3 and β3δ receptors: GABA activates β3δ receptors via the β3(+)δ(−) interface

J. Hanrahan, N. Absalom, P. Ahring, 2016, Brain Research.

GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085.

J. Lopez-Garcia, N. Mirza, G. Munro, 2015, Biochemical pharmacology.

The β Subunit Determines the Ion Selectivity of the GABAA Receptor*

A. Schousboe, T. H. Johansen, P. Ahring, 2002, The Journal of Biological Chemistry.

Mutational studies using a cation‐conducting GABAA receptor reveal the selectivity determinants of the Cys‐loop family of ligand‐gated ion channels

A. Schousboe, P. Ahring, D. Timmermann, 2005, Journal of neurochemistry.

Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

J. Kastrup, M. Gajhede, C. Krintel, 2015, Molecular Pharmacology.

Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors

K. Harpsøe, P. Ahring, T. Balle, 2012, The Journal of Biological Chemistry.

The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies

E. Nielsen, C. Vinkers, B. Olivier, 2010, Psychopharmacology.

In Vitro Characterization of 5-Carboxyl-2,4-di-benzamidobenzoic Acid (NS3763), a Noncompetitive Antagonist of GLUK5 Receptors

E. Nielsen, P. Ahring, T. Varming, 2004, Journal of Pharmacology and Experimental Therapeutics.

Molecular Determinants of Subtype-selective Efficacies of Cytisine and the Novel Compound NS3861 at Heteromeric Nicotinic Acetylcholine Receptors*

E. Nielsen, J. Kastrup, M. Gajhede, 2012, The Journal of Biological Chemistry.

Functional Characterization of a Cloned Human Intermediate‐Conductance Ca2+‐Activated K+ Channel

P. Christophersen, S. Olesen, B. Jensen, 1999, Annals of the New York Academy of Sciences.

Gain-of-function variants in GABRD reveal a novel pathway for neurodevelopmental disorders and epilepsy.

E. Eichler, H. Lerche, R. Møller, 2021, Brain : a journal of neurology.

GABAA receptors in epilepsy: Elucidating phenotypic divergence through functional analysis of genetic variants.

N. Absalom, R. Møller, V. Liao, 2023, Journal of neurochemistry.

Augmentation of cognitive function by NS9283, a stoichiometry‐dependent positive allosteric modulator of α2‐ and α4‐containing nicotinic acetylcholine receptors

E. Nielsen, T. Dyhring, D. Peters, 2012, British journal of pharmacology.

Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets.

N. Mirza, G. Munro, P. Ahring, 2009, Trends in pharmacological sciences.

P. Ahring, H. K. Erichsen, C. Mathiasen, 2008, Journal of Pharmacology and Experimental Therapeutics.

Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity

N. Absalom, R. Møller, A. Keramidas, 2023, Brain : a journal of neurology.

Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4–α4 interface

E. Nielsen, J. Kastrup, M. Gajhede, 2015, Neuropharmacology.

Vinpocetine improved neuropsychiatric and epileptic outcomes in a patient with a GABRA1 loss‐of‐function variant

G. Rubboli, R. Møller, E. Gardella, 2023, Annals of clinical and translational neurology.