Brent A. McLean

发表

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease

B. Vanhaesebroeck, Manish Paul, Mousumi Hazra, 2018, Nature Communications.

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity

J. Penninger, M. Grant, G. Lopaschuk, 2015, Diabetes.

Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.

B. Yusta, D. Drucker, Holly Bates, 2017, Cell metabolism.

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice

R. Seeley, D. Drucker, S. Heximer, 2017, Molecular metabolism.

Glucagon-Like Peptide-1 Receptor Agonists in Adult Patients With Type 2 Diabetes: Review of Cardiovascular Outcome Trials.

J. Lovshin, Brent A. McLean, E. Varin, 2019, Canadian journal of diabetes.

Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide

R. Seeley, D. Drucker, Brent A. McLean, 2021, JCI insight.

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation.

R. Seeley, B. Yusta, D. Drucker, 2022, Cell metabolism.

Role of autoimmunity in heart disease: is Chagas heart disease the definitive proof?

G. Oudit, Brent A. McLean, 2014, The Canadian journal of cardiology.

Genetic disruption of the Gipr in Apoe−/− mice promotes atherosclerosis

D. Drucker, L. Baggio, Brent A. McLean, 2022, Molecular metabolism.

Regulators of G-Protein Signaling 10 and Heart Failure: The Importance of Negative Regulators of Heart Disease.

G. Oudit, Vaibhav B. Patel, Xueyi Chen, 2016, Hypertension.

Dual loss of PI3Kα and PI3Kγ signaling leads to an age-dependent cardiomyopathy.

G. Oudit, T. Ramprasath, P. Zhabyeyev, 2014, Journal of molecular and cellular cardiology.

Glucagon-like Peptide-1 receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction

D. Drucker, M. G. Kabir, Brent A. McLean, 2022, Molecular metabolism.

PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction

B. Vanhaesebroeck, G. Oudit, P. Zhabyeyev, 2019, Journal of the American Heart Association.

PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction

B. Vanhaesebroeck, G. Oudit, P. Zhabyeyev, 2019, Journal of the American Heart Association.

Review Article PI3K Inhibitors as Novel Cancer Therapies: Implications for Cardiovascular Medicine

M. Haykowsky, E. Pituskin, G. Oudit, 2013 .

PI3K inhibitors as novel cancer therapies: implications for cardiovascular medicine.

M. Haykowsky, E. Pituskin, I. Paterson, 2013, Journal of cardiac failure.

Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts.

B. Vanhaesebroeck, G. Oudit, P. Zhabyeyev, 2019, Journal of molecular and cellular cardiology.

PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.

B. Vanhaesebroeck, G. Oudit, N. Parajuli, 2015, Cardiovascular research.

Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling.

Petra C. Kienesberger, J. Dyck, P. Kienesberger, 2013, Journal of molecular and cellular cardiology.

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System

J. Vederas, Manish Paul, G. Oudit, 2016, Hypertension.

Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy

J. Dyck, R. Hajjar, G. Oudit, 2015, Scientific Reports.

Revisiting the complexity of GLP-1 action-from sites of synthesis to receptor activation.

D. Drucker, D. Hodson, Jonathan E. Campbell, 2020, Endocrine reviews.

Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

Josef M. Penninger, John C. Vederas, J. Vederas, 2013, Journal of the American Heart Association.

Hydrogen sulfide: an old gas with new cardioprotective effects.

G. Oudit, Vaibhav B. Patel, Xueyi Chen, 2015, Clinical science.

Letter by McLean and Oudit regarding article, "myostatin regulates energy homeostasis in the heart and prevents heart failure".

G. Oudit, Brent A. McLean, 2015, Circulation research.

Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation: A Metabolic Contribution to Heart Failure With Normal Ejection Fraction

G. Lopaschuk, G. Oudit, Z. Kassiri, 2012, Circulation. Heart failure.

Review Article PI3K Inhibitors as Novel Cancer Therapies: Implications for Cardiovascular Medicine

M. Haykowsky, E. Pituskin, G. Oudit, 2013 .

Breast Cancer Patients Receiving Anthracycline Chemotherapy and Trastuzumab Have Biventricular Dysfunction and Reduced Heart Mass.

James A. White, G. Oudit, Brent A. McLean, 2018, Journal of the American College of Cardiology.