R. van Elk

发表

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms

A. Smit, C. Ulens, R. Kini, 2015, Toxins.

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

D. Bertrand, T. Sixma, I. D. de Esch, 2009, Journal of medicinal chemistry.

Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

Ruud L. E. G. Aspers, S. Wijmenga, A. Smit, 2014, Biology.

Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein*

Timothy Gallagher, August B. Smit, Titia K. Sixma, 2012, The Journal of Biological Chemistry.

A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors

A. Smit, C. Ulens, J. Yakel, 2011, PLoS biology.

Quantification of proteins in the subnanogram and nanogram range: comparison of the AuroDye, FerriDye, and India ink staining methods.

W. Geraerts, R. van Elk, K. W. Li, 1989, Analytical biochemistry.

Fixation increases sensitivity of India ink staining of proteins and peptides on nitrocellulose paper.

W. Geraerts, R. van Elk, K. W. Li, 1988, Analytical biochemistry.

Evolutionary conservation of the insulin gene structure in invertebrates: cloning of the gene encoding molluscan insulin-related peptide III from Lymnaea stagnalis.

W. Geraerts, J. Bogerd, A. Smit, 1993, Journal of molecular endocrinology.

Trichobilharzia ocellata: physiological characterization of giant growth, glycogen depletion, and absence of reproductive activity in the intermediate snail host, Lymnaea stagnalis.

R. van Elk, J. Joosse, 1986, Experimental parasitology.

The effects of starvation and refeeding on egg laying and the synthetic activity of the albumen gland in Bulinus truncatus, a snail vector of urinary schistosomiasis.

R. van Elk, M. Bayomy, J. Joosse, 1987, Comparative biochemistry and physiology. A, Comparative physiology.

Expression and characterization of molluscan insulin-related peptide VII from the mollusc Lymnaea stagnalis.

S. Spijker, W. Geraerts, F. de Winter, 1996, Neuroscience.

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.

I. D. de Esch, O. Zuiderveld, R. Leurs, 2012, Bioorganic & medicinal chemistry letters.

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis.

Rob Leurs, Iwan J P de Esch, Ewald Edink, 2011, Journal of the American Chemical Society.

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

I. D. de Esch, R. Leurs, A. Smit, 2010, Journal of medicinal chemistry.

Structural basis of ligand recognition in 5-HT3 receptors

A. Smit, C. Ulens, A. J. Thompson, 2012, EMBO reports.

α‐Conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californica and some neuronal subtypes of nicotinic acetylcholine receptors

A. Smit, Y. Utkin, V. Tsetlin, 2006 .

Crystal Structure of Acetylcholine-binding Protein from Bulinus truncatus Reveals the Conserved Structural Scaffold and Sites of Variation in Nicotinic Acetylcholine Receptors*

T. Sixma, A. Smit, R. Klaassen, 2005, Journal of Biological Chemistry.

Effects of two gonadotropic hormones on polysaccharide synthesis in the albumen gland of Lymnaea stagnalis, studied with the organ culture technique.

J. Wijdenes, R. van Elk, J. Joosse, 1983, General and comparative endocrinology.

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

T. Sixma, A. Smit, C. Schroeder, 2007, The EMBO Journal.

Dot immunobinding assay of high-performance liquid chromatographic fractions on poly(vinylidene difluoride) membranes.

W. Geraerts, R. van Elk, K. W. Li, 1989, Journal of chromatography.

Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein

D. Bertrand, A. Smit, C. Ulens, 2012, Proceedings of the National Academy of Sciences.

Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein*

A. Smit, J. Tytgat, C. Ulens, 2010, The Journal of Biological Chemistry.

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

August B. Smit, Titia K. Sixma, Alexander Fish, 2013, Nature Communications.

Biosynthesis of tooth germ proteins in vitro: a fast quantitative extraction of amelogenins from intact hamster molar tooth germs.

A. Bronckers, R. van Elk, D. Lyaruu, 1984, Journal de biologie buccale.

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

T. Sixma, C. Schroeder, C. Ulens, 2007, The EMBO Journal.

Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.

I. D. de Esch, R. Leurs, A. Smit, 2010, Journal of medicinal chemistry.

Family of prohormone convertases in Lymnaea: characterization of two alternatively spliced furin-like transcripts and cell-specific regulation of their expression.

A. Kurosky, S. Spijker, W. Geraerts, 1999, Journal of neurobiology.