E. Cragoe

发表

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives.

B. E. Evans, W. F. Hoffman, A. Deana, 1985, Journal of Medicinal Chemistry.

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.

W. F. Hoffman, P. Anderson, J. Hirshfield, 1986, Journal of Medicinal Chemistry.

(Acylaryloxy)acetic acid diuretics. 2. (2-Alkyl-2-aryl-1-oxo-5-indanyloxy)acetic acids.

E. Cragoe, G. Fanelli, S. J. Desolms, 1978, Journal of medicinal chemistry.

(ACYLARYLOXY)ACETIC ACID DIURETICS. 1. (2-ALKYL- AND 2,2-DIALKYL-1-OXO-5-INDANYLOXY)ACETIC ACIDS

E. Cragoe, S. J. Desolms, O. W. Woltersdorf, 1978 .

Agents for the treatment of brain injury. 1. (Aryloxy)alkanoic acids.

N. Sedransk, H. Kimelberg, A. Popp, 1982, Journal of medicinal chemistry.

2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS. 5. FUSED-RING ANALOGS

A. Deana, Robert L. Smith, G. Stokker, 1983 .

2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogues.

A. Deana, R. Smith, G. Stokker, 1983, Journal of medicinal chemistry.

2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution

A. Deana, C. Sweet, Robert L. Smith, 1981 .

The Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism.

E. Cragoe, S. Harguindey, 1992, Medical hypotheses.

Quantitative structure-activity relationships involving the inhibition of glycolic acid oxidase by derivatives of glycolic and glyoxylic acids.

P. Anderson, E. Eichler, W. Randall, 1979, Journal of medicinal chemistry.

Inhibitors of glycolic acid oxidase. 4-substituted 2,4-dioxobutanoic acid derivatives.

A. Patchett, E. Eichler, W. Randall, 1983, Journal of medicinal chemistry.

Cyclic amidine inhibitors of indolamine N-methyltransferase.

N. R. Hunter, P. Anderson, J. Rokach, 1979, Journal of medicinal chemistry.

2-(Aminomethyl)phenols, a new class of saluretic agents. 3. Effects of functional group reorientation and modification.

A. Deana, G. Stokker, E. Cragoe, 1981, Journal of Medicinal Chemistry.

2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution.

A. Deana, C. Sweet, G. Stokker, 1980, Journal of medicinal chemistry.

THE SYNTHESIS OF 3-HYDROXYCINCHONINIC ACID AND CERTAIN OF ITS DERIVATIVES

E. Cragoe, C. M. Robb, Mark D. Bealor, 1953 .

Proton, carbon-13, and nitrogen-15 nuclear magnetic resonance and CNDO/2 studies on the tautomerism and conformation of amiloride, a novel acylguanidine

P. Gund, Robert L. Smith, E. Cragoe, 1979 .

The Syntheses of 7-Sulphamylpyrido[2,3-e]-1,2,4-Thiadiazine-1,1-Dioxide, 5,Sulphamylpyrido[4,3-e]-1,2,4-Thiadiazine-1,1-Dioxide and Certain of Their Derivatives

J. Sprague, J. Nicholson, E. Cragoe, 1961 .

Inhibitors of gastric acid secretion: antisecretory 2-pyridylurea derivatives.

C. N. Habecker, A. Deana, R. Hirschmann, 1983, Journal of medicinal chemistry.

Inhibitors of indoleethylamine N-methyltransferase. Derivatives of 3-methyl-2-thiazolidinimine. In vitro, in vivo, and metabolic studies.

J. Rokach, P. Hamel, Y. Girard, 1980, Journal of medicinal chemistry.

2-(Aminomethyl)phenols, a new class of saluretic agents. 4. Effects of oxygen and/or nitrogen substitution.

A. Deana, G. Stokker, E. Cragoe, 1982, Journal of medicinal chemistry.

(Vinylaryloxy)acetic acids. A new class of diuretic agents. 1. (Diacylvinylaryloxy)acetic acids.

E. Cragoe, W. J. Holtz, J. Bicking, 1976, Journal of medicinal chemistry.

2-Aminomethylphenols: A New Class of Saluretic Agents

G. Stokker, E. Cragoe, E. Schultz, 1978 .

6-Substituted 5-chloro-1,3-dihydro-2H-imidazo(4,5-b)pyrazin-2-ones with hypotensive activity.

J. Jones, E. Cragoe, W. J. Holtz, 1973, Journal of medicinal chemistry.

(Vinylaryloxy)acetic acids. A new class of diuretic agents. 4. Various ((2-substituted and 2,2-disubstituted vinyl)aryloxy)acetic acids.

E. Cragoe, O. W. Woltersdorf, L. Watson, 1976, Journal of medicinal chemistry.

SYNTHESIS OF SULFONYLHYDRAZINE DERIVATIVES WITH MONOAMINE OXIDASE INHIBITORY ACTIVITY.

J. Sprague, C. Rooney, E. Cragoe, 1962, Journal of medicinal and pharmaceutical chemistry.

THE SYNTHESIS OF α,α-DISUBSTITUTED SUCCINIC ACIDS FROM ETHYL ALKYLIDENECYANOACETATES

J. Sprague, E. Cragoe, C. M. Robb, 1950 .

Agents for the treatment of brain edema. 2. [(2,3,9,9a-Tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]+ ++alkanoi c acids and some of their analogues.

P. Anderson, H. Kimelberg, G. Stokker, 1986, Journal of medicinal chemistry.

Potential diuretic-.beta.-adrenergic blocking agents: synthesis of 3-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,4-dioxino[2,3-g]quinolines

A. K. Willard, Robert L. Smith, E. Cragoe, 1981 .

Inhibitors of glycolic acid oxidase. 4-Substituted 3-hydroxy-1H-pyrrole-2,5-dione derivatives.

E. Eichler, W. Randall, E. Ulm, 1983, Journal of medicinal chemistry.

Chapter 7. Diuretics

Robert L. Smith, E. Cragoe, O. W. Woltersdorf, 1978 .

ALPHA, BETA-UNSATURATED KETONE DERIVATIVES OF ARYLOXYACETIC ACIDS, A NEW CLASS OF DIURETICS.

J. Sprague, E. Cragoe, E. Schultz, 1962, Journal of medicinal and pharmaceutical chemistry.

Ethacrynic acid--an inhibitor of L-asparagine synthetase.

D. Cooney, E. Cragoe, H. Jayaram, 1975, Biochemical pharmacology.

3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE INHIBITORS. I. STRUCTURAL MODIFICATION OF 5-SUBSTITUTED 3,5-DIHYDROXYPENTANOIC ACIDS AND THEIR LACTONE DERIVATIVES

W. F. Hoffman, A. Deana, A. Alberts, 1985 .

Chapter 7. Diuretic Agents

J. Sprague, E. Cragoe, 1966 .

Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.

E. Cragoe, N. P. Gould, R. Smith, 1977, Journal of medicinal chemistry.

2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS. 3. EFFECTS OF FUNCTIONAL GROUP REORIENTATION AND MODIFICATION

A. Deana, Robert L. Smith, G. Stokker, 1982 .

Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides.

J. Jones, E. Cragoe, O. W. Woltersdorf, 1967, Journal of medicinal chemistry.

Drugs for the treatment of traumatic brain injury

E. Cragoe, E. Cragoe, 1987, Medicinal research reviews.

Pyrazine Diuretics. I. N-Amidino-3-amino-6-halopyrazinecarboxamides

E. Cragoe, O. W. Woltersdorf, James H. Jones, 1965 .

Activated esters of substituted pyrazinecarboxylic acids

K. Shepard, E. Cragoe, W. Halczenko, 1976 .

Pyrazine diuretics. V. N-Amidino-3-aminopyrazinecarboxamidines and analogous 2,4-diaminopteridines.

J. Jones, E. Cragoe, 1968, Journal of medicinal chemistry.

Pyrazine diuretics. 8. N-Amidino-3-aminopyrazinecarboxamide 4-oxides.

J. Jones, E. Cragoe, 1970, Journal of medicinal chemistry.

Pyrazine diuretics. VI. (Pyrazinecarboxamido)guanidines.

K. Shepard, J. Jones, E. Cragoe, 1969, Journal of medicinal chemistry.

Pyrazine diuretics. VII. N-amidino-3-substituted pyrazinecarboxamides.

J. Jones, E. Cragoe, W. J. Holtz, 1969, Journal of medicinal chemistry.

Pyrazine diuretics. IV. N-amidino-3-amino-6-substituted pyrazinecarboxamides.

J. Jones, E. Cragoe, J. Bicking, 1967, Journal of medicinal chemistry.

Pyrazine diuretics. 3. 5- and 6-alkyl, -cycloalkyl, and -aryl derivatives of n-amidino-3-aminopyrazinecarboxamides.

E. Cragoe, J. Bicking, C. M. Robb, 1967, Journal of medicinal chemistry.

3,5-Diamino-6-chloropyrazinecarboxylic acid “active esters” and their reactions

K. Shepard, E. Cragoe, W. Halczenko, 1969 .

Synthesis and biological activity of 3-amino-5-(3,5-diamino-6-chloropyrazin-2-yl)-1,2,4-oxadiazole: an amiloride prodrug.

M. Bock, E. Cragoe, E. H. Blaine, 1986, Journal of Medicinal Chemistry.

(ACYLARYLOXY)ACETIC ACID DIURETICS. 3. 2,3-DIHYDRO-5-ACYL-2-BENZOFURANCARBOXYLIC ACIDS, A NEW CLASS OF URICOSURIC DIURETICS

W. F. Hoffman, J. Springer, E. Cragoe, 1981 .

(Acylaryloxy)acetic acid diuretics. 1. (2-Alkyl- and 2,2-dialkyl-1-oxo-5-indanyloxy)acetic acids.

E. Cragoe, S. J. Desolms, O. W. Woltersdorf, 1977, Journal of medicinal chemistry.

(Acylaryloxy)acetic acid diuretics. 3. 2,3-Dihydro-5-acyl-2-benzofurancarboxylic acids, a new class of uricosuric diuretics.

W. F. Hoffman, J. Springer, E. Cragoe, 1981, Journal of medicinal chemistry.

SYNTHESIS AND DIURETIC ACTIVITY OF 3,3-SPIRO-SUBSTITUTED HYDROTHIAZIDES.

J. Sprague, E. Cragoe, O. W. Woltersdorf, 1962, Journal of medicinal and pharmaceutical chemistry.

(Acylaryloxy)acetic acid diuretics. 4. Indeno[5,4-b]furan-2-carboxylic acids.

E. Cragoe, S. J. Desolms, O. W. Woltersdorf, 1981, Journal of medicinal chemistry.

(ACYLARYLOXY)ACETIC ACID DIURETICS. 4. INDENO(5,4-B)FURAN-2-CARBOXYLIC ACIDS

E. Cragoe, S. J. Desolms, O. W. Woltersdorf, 1981 .

THE SYNTHESIS OF 3-HYDROXY-2-PHENYLQUINOLINE-4,8-DICARBOXYLIC ACID AND CERTAIN OF ITS DERIVATIVES

J. Sprague, C. Ziegler, E. Cragoe, 1953 .

Synthesis of the sultam analog of 11-deoxy PGE2.

J. Jones, E. Cragoe, J. Bicking, 1979, Prostaglandins.

Design, synthesis, and testing of potential antisickling agents. 7. Ethacrynic acid analogues.

D. Abraham, E. Cragoe, O. W. Woltersdorf, 1989, Journal of medicinal chemistry.

Diuretics--chemistry, pharmacology, and medicine

E. Cragoe, 1983 .

Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.

M. Bock, R. M. Dipardo, J. Springer, 1983, Journal of medicinal chemistry.

11,12-secoprostaglandins. 4. 7-(N-alkylmethanesulfonamido) heptanoic acids.

J. Jones, E. Cragoe, W. J. Holtz, 1977, Journal of medicinal chemistry.

A deuterium isotope effect on the inhibition of gastric secretion by N,N-dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea. Synthesis of metabolites.

C. N. Habecker, R. Hirschmann, J. Hoffman, 1983, Journal of medicinal chemistry.

3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. Part 3.

W. F. Hoffman, P. Anderson, J. Hirshfield, 1986 .

11,12-Secoprostaglandins. 1. Acylhydroxyalkanoic acids and related compounds.

E. Cragoe, J. Bicking, C. M. Robb, 1977, Journal of medicinal chemistry.