S. Hecker

发表

Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin.

C. Hadley, C. Heathcock, T. Rosen, 1987, Journal of medicinal chemistry.

Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate

S. Hecker, L. Lefort, Angela Gonzalez‐de‐Castro, 2021, Organic Process Research & Development.

Synthesis of compounds designed to inhibit bacterial cell wall transglycosylation

K. Lackey, S. Hecker, Martha L. Minich, 1990 .

Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida.

C. Lipinski, J. McFarland, S. Hecker, 1997, Journal of medicinal chemistry.

Chapter 12. Antibacterial Agents

S. Hecker, J. Dirlam, M. Jefson, 1994 .

Chapter 12 - Antimicrobial Potentiation Approaches: Targets and Inhibitors

T. Renau, S. Hecker, V. Lee, 1998 .

In vitro microbiological characterization of novel macrolide CP-163,505 for animal health specific use.

M. Lemay, S. Hecker, J. Retsema, 1998, The Journal of antibiotics.

Expression of interest to the Superconducting Super Collider Laboratory by the L* Collaboration

Joseph A. Paradiso, R. T. Primm, B. C. Chakoumakos, 1990 .

Methodology for Monobactam Diversification: Syntheses and Studies of 4-Thiomethyl Substituted β-Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii.

Rui Liu, Marvin J. Miller, S. Hecker, 2017, Journal of medicinal chemistry.

Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546).

M. Dudley, S. Hecker, T. Glinka, 2003, Bioorganic & medicinal chemistry.

Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class.

C. Boojamra, S. Hecker, V. Lee, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of base-modified dihydropacidamycins.

S. Hecker, R. Lemoine, A. Magon, 2002, Bioorganic & medicinal chemistry letters.

QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics

M. Totrov, M. Dudley, Dongxu Sun, 2021, Frontiers in Microbiology.

Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin.

R. Leger, C. Boojamra, S. Hecker, 2001, Journal of the American Chemical Society.

Discovery of RWJ-54428 (MC-02,479), a new cephalosporin active against resistant gram-positive bacteria.

S. Hecker, T. Glinka, A. Cho, 2000, The Journal of antibiotics.

SAR studies of anti-MRSA non-zwitterionic 3-heteroarylthiocephems.

M. Dudley, S. Hecker, T. Glinka, 2000, The Journal of antibiotics.

N-Linked solid phase peptide synthesis

S. Hecker, V. Lee, R. Yen, 1998 .

Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.

M. Erion, P. D. van Poelje, M. Maccoss, 2007, Journal of medicinal chemistry.

Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.

M. Erion, Wenyu Li, E. Cable, 2008, Journal of medicinal chemistry.

Prodrugs of phosphates and phosphonates.

M. Erion, S. Hecker, 2008, Journal of medicinal chemistry.

Chapter 13. Antibacterial Agents

S. Hecker, J. Dirlam, B. H. Jaynes, 1996 .

A tandem decarboxylation and inverse electron-demand Diels–Alder reaction of amino-thiophenecarboxylic acids with 1,3,5-triazines

Q. Dang, Wenyu Li, F. Tian, 2009 .

Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.

T. Renau, K. Nakayama, S. Hecker, 1999, Journal of medicinal chemistry.

Application of hygromycin a structure activity relationships to the antibiotic A201A.

S. Hecker, Martha L. Minich, S. Lilley, 1993 .

Total synthesis of (.+-.)-leuhistin

S. Hecker, K. M. Werner, Kim M. Werner, 1993 .

New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position.

M. Wang, S. Hecker, T. Glinka, 2001, Bioorganic & medicinal chemistry letters.

Repromicin derivatives with potent antibacterial activity against Pasteurella multocida.

J. McFarland, S. Hecker, C. Vu, 1997, Journal of medicinal chemistry.

Prodrugs of Cephalosporin RWJ-333441 (MC-04,546) with Improved Aqueous Solubility

M. Dudley, S. Hecker, T. Glinka, 2003, Antimicrobial Agents and Chemotherapy.

Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy

Angela Lee, M. Lee, M. S. Warren, 2001, Antimicrobial Agents and Chemotherapy.

Cu-Catalyzed Decarboxylative Borylation

D. Blackmond, P. Baran, Tian Qin, 2018, ACS catalysis.

Total synthesis of (+)-dihydromevinolin

C. Heathcock, S. Hecker, 1986 .

Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate

P. Poechlauer, T. Pabst, S. Hecker, 2019, Organic Process Research & Development.

An approach to the synthesis of mevinolin based on intramolecular Diels-Alder cycloaddition

C. Heathcock, S. Hecker, 1985 .

Discovery of Cyclic Boronic Acid QPX7728, an Ultra-broad-spectrum Inhibitor of Serine and Metallo Beta-lactamases.

M. Totrov, Yu Chen, K. R. Reddy, 2020, Journal of medicinal chemistry.

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.

M. Totrov, K. R. Reddy, J. Loutit, 2015, Journal of medicinal chemistry.

, Jorge Agents for Combination Therapy : Novel Pseudomonas aeruginosa Pumps in Inhibitors of Multidrug Resistance Efflux Identification and Characterization of

Angela Lee, M. Lee, M. S. Warren, 2000 .

Broad-spectrum cyclic boronate β-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.

M. Totrov, S. Hecker, O. Lomovskaya, 2022, Bioorganic & medicinal chemistry.

Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

M. Erion, P. D. van Poelje, M. Maccoss, 2009, Antimicrobial Agents and Chemotherapy.

Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions

Christopher P. Breen, Yuan-Qing Fang, S. Hecker, 2021 .

A tour of recent patent applications addressing antibacterial resistance

A. Boggs, S. Hecker, 2002 .

Semisynthetic modification of hygromycin A. 2. synthesis and antibacterial activity of aryl analogs.

Christopher B. Cooper, C. Cooper, S. Hecker, 1993 .

Hygromycin A: preparation of aminocyclitol analogs defining the minimum functionality required for biological activity

S. Hecker, S. Lilley, K. M. Werner, 1992 .

Semisynthetic modification of hygromycin A. 3. synthesis and antibacterial activity of aminocyclitol analogs.

S. Hecker, Martha L. Minich, S. Lilley, 1992 .

Semisynthetic modification of hygromycin A. 1. Synthesis and antibacterial activity of vinyl methyl and amide analogs.

S. Hecker, Martha L. Minich, K. M. Werner, 1992 .

Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C4′ aryl position

Christopher B. Cooper, C. Cooper, S. Hecker, 1993 .

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

N. Voelcker, J. Li, R. Nation, 2022, Nature Communications.

A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis.

M. Erion, Q. Dang, P. D. van Poelje, 2010, ACS medicinal chemistry letters.

In vitro Microbiological Characterization of Novel Macrolide CP‐163,505 for Animal Health Specific Use.

M. Lemay, S. Hecker, J. Retsema, 1998 .

Selection of QPX7831, an Orally Bioavailable Prodrug of Boronic Acid β-Lactamase Inhibitor QPX7728.

K. R. Reddy, M. Dudley, S. Hecker, 2021, Journal of medicinal chemistry.

An Efficient Synthesis of 5-Bromopyridine-2-carbonitrile

T. Renau, S. Hecker, David Y. Markevitch, 2003 .

SYNTHESIS OF C(6)-CARBOXYLATE ANALOGUES OF N-ACETYLMURAMIC ACID

S. Hecker, Martha L. Minich, 1990 .

Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant Staphylococcus aureus.

C. Chan, F. Malouin, A. Boggs, 1998, The Journal of antibiotics.

Discovery of MC‐02,331, a New Cephalosporin Exhibiting Potent Activity Against Methicillin‐Resistant Staphylococcus aureus.

S. Hecker, 1999 .

New total synthesis of (.+-.)-indolmycin

S. Hecker, J. Dirlam, D. Clark, 1986 .

New Total Synthesis of (.+-.)-Indolmycin.

S. Hecker, J. Dirlam, D. Clark, 1987 .