D. Bur

发表

Metabolic products of microorganisms. Part 262. The absolute configuration of sphydrofuran, a widespread metabolite from streptomycetes

U. Séquin, A. Zeeck, T. Henkel, 1991 .

Structure-Based Ligand Design

Klaus Gubernator, Paul R. Gerber, Clemens Broger, 1995 .

Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?

F. Winkler, A. D'arcy, C. Oefner, 1999, Chemistry & biology.

Loss-of-function point mutations associated with renal tubular dysgenesis provide insights about renin function and cellular trafficking.

L. Muller, O. Gribouval, M. Gubler, 2011, Human molecular genetics.

Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site.

C. Oefner, A. Binggeli, H. Märki, 1999, Bioorganic & medicinal chemistry letters.

Piperidine-renin inhibitors compounds with improved physicochemical properties.

M. Kansy, C. Oefner, A. Binggeli, 1999, Bioorganic & medicinal chemistry letters.

Design and optimization of new piperidines as renin inhibitors.

L. Prade, A. Treiber, D. Bur, 2010, Bioorganic & medicinal chemistry letters.

Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.

L. Prade, A. Treiber, S. Delahaye, 2009, Journal of medicinal chemistry.

New classes of potent and bioavailable human renin inhibitors.

L. Prade, A. Treiber, S. Delahaye, 2009, Bioorganic & medicinal chemistry letters.

Exploring the Flap Pocket of the Antimalarial Target Plasmepsin II: The “55 % Rule” Applied to Enzymes

F. Diederich, D. Bur, M. Zürcher, 2008, ChemMedChem.

Adaptation of the behaviour of an aspartic proteinase inhibitor by relocation of a lysine residue by one helical turn

Colin Berry, D. M. Wyatt, J. Kay, 2006, Biological chemistry.

Cloning and characterization of marmoset renin: comparison with human renin.

V. Breu, D. Bur, W. Fischli, 1999, Journal of cardiovascular pharmacology.

Inhibitors of Plasmepsin II-potential antimalarial agents.

L. Prade, G. Dunet, R. Brun, 2004, Bioorganic & medicinal chemistry letters.

On the effect on specificity of Thr246----Gly mutation in L-lactate dehydrogenase of Bacillus sterothermophilus.

H. Wilks, K. Hart, J. Holbrook, 1989, Biochemical and biophysical research communications.

Human renin in complex with remikiren

L. Prade, D. Bur, W. Fischli, 2008 .

Mapping of proteinase active sites by projection of surface‐derived correlation vectors

G. Schneider, M. Stahl, D. Bur, 1999 .

Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2

S. Krähenbühl, B. Stieger, M. Török, 2008, Cellular and Molecular Life Sciences.

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans

Pitter F. Huesgen, A. Wlodawer, B. Manadas, 2016, Scientific Reports.

NMR studies of DNA duplexes singly cross-linked by different synthetic linkers.

M. Billeter, K. Wüthrich, A. Labhardt, 1995, Nucleic acids research.

Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes.

F. Diederich, W. Schweizer, R. Brun, 2013, Chemistry.

New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates.

F. Diederich, W. Schweizer, L. Hardegger, 2009, Organic & biomolecular chemistry.

Key Features Determining the Specificity of Aspartic Proteinase Inhibition by the Helix-forming IA3 Polypeptide*

D. M. Wyatt, J. Kay, L. H. Phylip, 2007, Journal of Biological Chemistry.

Different Resistance Mechanisms for Cadazolid and Linezolid in Clostridium difficile Found by Whole-Genome Sequencing Analysis

P. Caspers, D. Ritz, H. Locher, 2017, Antimicrobial Agents and Chemotherapy.

Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic

P. Caspers, D. Boehringer, M. Leibundgut, 2019, Scientific Reports.

Characterization of Recombinant CDR1, an Arabidopsis Aspartic Proteinase Involved in Disease Resistance*

I. Simões, C. Faro, Rosário Faro, 2007, Journal of Biological Chemistry.

Functional and structural characterization of synthetic cardosin B-derived rennet

J. Manso, B. Manadas, I. Simões, 2017, Applied Microbiology and Biotechnology.

Human Aspartic Proteinases

J. Kay, D. Bur, 2011 .

Distinct ETA Receptor Binding Mode of Macitentan As Determined by Site Directed Mutagenesis

M. Bolli, O. Nayler, D. Bur, 2014, PloS one.

The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.

M. Bolli, M. Iglarz, M. Clozel, 2012, Journal of medicinal chemistry.

The Mechanisms of Action and Inhibition of Pancreatic Lipase and Acetylcholinesterase: A Comparative Modeling Study

P. Gerber, C. Broger, T. Schaumann, 1993 .

Piperidine renin inhibitors: from leads to drug candidates.

T Hartung, F C Luft, M. Kansy, 2001, Farmaco.

Characterization of a Human Angiotensinogen Cleaved in Its Reactive Center Loop by a Proteolytic Activity from Chinese Hamster Ovary Cells*

X. Jeunemaître, J. L. Le Caer, P. Corvol, 2000, The Journal of Biological Chemistry.

Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists.

J. Marfurt, M. Bolli, É. Thorin, 2004, Journal of medicinal chemistry.

A new class of inhibitors for the malarial aspartic protease plasmepsin II based on a central 11-azatricyclo[6.2.1.02,7]undeca-2,4,6-triene scaffold

F. Diederich, H. Märki, A. Dorn, 2003 .

Development of a New Class of Inhibitors for the Malarial Aspartic Protease Plasmepsin II Based on a Central 7‐Azabicyclo[2.2.1]heptane Scaffold

F. Diederich, H. Märki, P. Seiler, 2003 .

A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP).

C. Oefner, G. Dale, D. Bur, 2001, Protein engineering.

Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes.

M. Bolli, Stefan Abele, A. Treiber, 2013, Journal of medicinal chemistry.

The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan

W. Neidhart, K. Burri, V. Breu, 1996, CHIMIA.

C-terminal Elements Control Location, Activation Threshold, and p38 Docking of Ribosomal S6 Kinase B (RSKB)*

W. Lesslauer, J. Mary, D. Bur, 2001, The Journal of Biological Chemistry.

Purification and characterization of active recombinant human napsin A.

V. Schauer-Vukašinović, E. Kitas, D. Schlatter, 2000, European journal of biochemistry.

Single and double asymmetric induction in Diels-Alder cycloadditions with chiral acylnitroso dienophiles

D. Bur, A. Defoin, J. Streith, 1991 .

L-Phenylalanine Cyclohexylamide: A Simple and Convenient Auxiliary for the Synthesis of Optically Pure α,α-Disubstituted (R)- and (S)-Amino Acids.

C. Broger, D. Obrecht, D. Bur, 1995 .

Tris-benzimidazole derivatives: design, synthesis and DNA sequence recognition.

M. Waring, C. Bailly, R. Hochstrasser, 2001, Bioorganic & medicinal chemistry.

Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.

D. Ritz, H. Locher, P. Seiler, 2017, Journal of medicinal chemistry.

Shewasin A, an active pepsin homolog from the bacterium Shewanella amazonensis

J. Kay, I. Simões, C. Faro, 2011, The FEBS journal.

Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.

L. Prade, D. Ritz, P. Seiler, 2017, Journal of medicinal chemistry.

Piperidine-based renin inhibitors: upper chain optimization.

L. Prade, A. Treiber, D. Bur, 2010, Bioorganic & medicinal chemistry letters.

Conformational Analysis of Open-Chain 1,2:3,4-Diepoxides: Comparison of crystal structures, NMR data, and molecular-orbital calculations†

M. Neuburger, D. Bur, M. Zehnder, 1993 .

Optically Active Bipyridines in Asymmetric Catalysis

C. Bolm, D. Bur, M. Zehnder, 1990 .

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

M. Bolli, Stefan Abele, A. Treiber, 2010, Journal of medicinal chemistry.

2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.

D. Banner, H. Locher, F. Marlin, 2001, Journal of medicinal chemistry.

Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.

M. Page, D. Banner, G. Rosse, 2000, Journal of medicinal chemistry.

Asymmetric Synthesis of Diazepino‐β‐lactams by [2 + 2] Cycloaddition of an ‘Evans‐Sjogven’ Ketene with 1H‐1,2‐Diazepines

D. Bur, M. Muller, J. Streith, 1991 .

Synthesis of exo‐3‐Amino‐7‐azabicyclo[2.2.1]heptanes as a Class of Malarial Aspartic Protease Inhibitors: Exploration of Two Binding Pockets

Luzi J. Barandun, F. Diederich, W. Schweizer, 2009 .

Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.

Wolfgang Keck, Christopher Kohl, Daniel Ritz, 2013, Journal of medicinal chemistry.

Imidazole-analogues of 6-epicastanospermine and of 3,7a-diepialexine

D. Bur, J. Streith, A. Frankowski, 1991 .

1,4-Addition of azide to trans-diepoxycyclopentane with solvent participation

D. Bur, M. Zehnder, U. Séquin, 1992 .

X-ray Structure of Plasmepsin II Complexed with a Potent Achiral Inhibitor*

L. Prade, D. Bur, S. Richard-Bildstein, 2005, Journal of Biological Chemistry.

An evaluation of the substrate specificity, and of its modification by site-directed mutagenesis, of the cloned L-lactate dehydrogenase from Bacillus stearothermophilus

J. B. Jones, J. Friesen, D. Bur, 1989 .

Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines.

R. de Kanter, M. Bolli, Stefan Abele, 2014, Journal of medicinal chemistry.

Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic

P. Caspers, D. Boehringer, M. Leibundgut, 2019, Scientific reports.

Conformational Analysis of 1,2:3,4-Diepoxides: Ab Initio and semiempirical molecular-orbital calculations

D. Bur, H. Huber, U. Séquin, 1992 .

The Influence of Endoproteolytic Processing of Familial Alzheimer's Disease Presenilin 2 on Aβ42 Amyloid Peptide Formation*

H. Loetscher, M. Brockhaus, H. Jacobsen, 1999, The Journal of Biological Chemistry.

Stereoselective partial hydrogenation of the triple bond in methyl 2-ethyl-6,6-dimethylhept-2-en-4-ynoate: A comparison of lindlar and montmorillonite catalysts

D. Bur, U. Séquin, M. Nikles, 1990 .

Novel S1P(1) receptor agonists--part 2: from bicyclo[3.1.0]hexane-fused thiophenes to isobutyl substituted thiophenes.

R. de Kanter, M. Bolli, C. Kohl, 2014, Journal of medicinal chemistry.

Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues

S. Krähenbühl, D Bur, S. Hebeisen, 2008, British journal of pharmacology.

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.

L. Prade, D. Ritz, R. Lange, 2012, Bioorganic & medicinal chemistry letters.

The Potency and Specificity of the Interaction between the IA3 Inhibitor and Its Target Aspartic Proteinase fromSaccharomyces cerevisiae *

Alexander Wlodawer, Mi Li, Jakob R. Winther, 2001, The Journal of Biological Chemistry.

Transthyretin is a metallopeptidase with an inducible active site.

L. Juliano, M. Sousa, M. Saraiva, 2012, The Biochemical journal.

Molecular modelling contributions to serine protease and serine esterase inhibitor design

Klaus Gubernator, Paul R. Gerber, Clemens Broger, 1993 .

Expression and characterisation of plasmepsin I from Plasmodium falciparum.

U. Certa, B. Dunn, J. Kay, 1997, European journal of biochemistry.

Cathepsin E. The best laid plans of mice and men.

J. Kay, W. E. Lees, D. Bur, 1998, Advances in experimental medicine and biology.

De Novo Design, Synthesis, and In Vitro Evaluation of a New Class of Nonpeptidic Inhibitors of the Malarial Enzyme Plasmepsin II

F. Diederich, H. Märki, A. Dorn, 2002, Chembiochem : a European journal of chemical biology.

Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV.

F. Diederich, Jun Liu, D. Goldberg, 2006, Angewandte Chemie.

Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.

D. Ritz, H. Locher, P. Seiler, 2015, Journal of medicinal chemistry.

Glycosylation of Asn-632 and Asn-651 is important for functional expression of endothelin-converting enzyme-1.

B. Löffler, D. Bur, M. Fuchs, 1998, Journal of cardiovascular pharmacology.

Single and Double Asymmetric Induction in Diels‐Alder Cycloadditions with Chiral Acylnitroso Dienophiles.

D. Bur, A. Defoin, J. Streith, 1992 .

Tetrahydroisoquinolines as orexin receptor antagonists: Strategies for lead optimization by solution-phase chemistry

M. Clozel, A. Treiber, O. Nayler, 2003 .

Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus.

A. Wlodawer, B. Dunn, A. Gustchina, 1996, European journal of biochemistry.

Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro

S. Krähenbühl, K. Brecht, A. Zahno, 2010, British journal of pharmacology.

Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets.

U. Certa, J. Kay, A. D'arcy, 1998, Advances in experimental medicine and biology.

Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV

L. Prade, D. Bur, W. Fischli, 2006, ChemMedChem.

Molecular analysis of the interaction between cardosin A and phospholipase Dα

A. Otto, I. Simões, C. Faro, 2005, The FEBS journal.

A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum

U. Certa, J. Kay, D. Bur, 1999, FEBS letters.

Human napsin A: expression, immunochemical detection, and tissue localization

V. Schauer-Vukašinović, D. Kling, D. Bur, 1999, FEBS letters.

The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum

D. Bur, C. Berry, R. Ridley, 1999, FEBS letters.

Functional and structural characterization of synthetic cardosin B-derived rennet

J. Manso, B. Manadas, I. Simões, 2017, Applied Microbiology and Biotechnology.

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

M. Bolli, Stefan Abele, A. Treiber, 2010, Journal of medicinal chemistry.

Enantiomerically Pure and Highly Substituted Alicyclic α,α‐Difluoro Ketones: Potential Inhibitors for Malarial Aspartic Proteases, the Plasmepsins

F. Diederich, L. Hardegger, D. Bur, 2010 .

New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates.

F. Diederich, L. Hardegger, D. Bur, 2009, Organic & biomolecular chemistry.

Shewasin A, an active pepsin homolog from the bacterium Shewanella amazonensis

J. Kay, I. Simões, C. Faro, 2011, The FEBS journal.

CAFCA: a Novel Tool for the Calculation of Amphiphilic Properties of Charged Drug Molecules

M. Kansy, H. Fischer, D. Bur, 2000, CHIMIA.

Mapping of proteinase active sites by projection of surface-derived correlation vectors

Gisbert Schneider, Martin Stahl, Daniel Bur, 1999, J. Comput. Chem..