H. Ottenheijm

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Solid-phase organic reactions: A review of the recent literature

Harry C. J. Ottenheijm, D. Rees, David C. Rees, 1996 .

Solid-phase organic reactions II: A review of the literature Nov 95–Nov 96

Harry C. J. Ottenheijm, D. Rees, David C. Rees, 1997 .

Tetrahedron report number 476Solid-phase organic reactions III: A review of the literature Nov 96–Dec 97

Harry C. J. Ottenheijm, D. Rees, David C. Rees, 1998 .

Solid‐Phase Organic Reactions. Part 3. A Review of the Literature Nov 96—Dec 97

D. Rees, P. Hermkens, H. Ottenheijm, 1999 .

Solid-Phase Organic Reactions: A Review of the Recent Literature

Harry C. J. Ottenheijm, D. Rees, David C. Rees, 1996 .

Solid Phase Synthesis

D. Rees, P. Hermkens, H. Ottenheijm, 1998 .

Solid-phase synthesis of heterocyclic aromates: applicability towards combinatorial chemistry; a review.

H. Timmerman, H. Ottenheijm, E. Gelensa, 2003, Combinatorial chemistry & high throughput screening.

Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes.

R. Garrett, B. Porse, H. Ottenheijm, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Crystal and molecular structure of 2-(7-cyanonorcaran-7-yl)-5-(ethoxycarbonyl)-4,5,6,11b-tetrahydro(Δ4-1,2,4-oxadiazolino)-[2,3-a]-β-carboline, C23H24N4O3

J. Smits, P. Beurskens, H. Ottenheijm, 1988 .

Crystal and molecular structure of 1,6-dimethyl-3,6-dimethoxy-3-[(N-methylindol-3-yl)methyl] piperazine-2,5-dione, C18H23N3O4

J. Smits, P. Beurskens, H. Ottenheijm, 1986 .

Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.

S. Rensen, W. Blankesteijn, J. Smits, 2010, Cardiovascular research.

Structure-activity relationships of sparsomycin and its analogues. Inhibition of peptide bond formation in cell-free systems and of L1210 and bacterial cell growth.

J. Ballesta, M. Remacha, R. Liskamp, 1987, Journal of medicinal chemistry.

The role of the hydroxymethyl function on the biological activity of the antitumor antibiotic sparsomycin

J. Ballesta, H. Ottenheijm, L. V. D. Broek, 1989 .

Biochemical and kinetic characteristics of the interaction of the antitumor antibiotic sparsomycin with prokaryotic and eukaryotic ribosomes.

J. Ballesta, H. Ottenheijm, L. V. D. van den Broek, 1991, Biochemistry.

Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction

M. V. van Zandvoort, B. Janssen, W. Blankesteijn, 2011, Circulation.

Pharmacokinetics and toxicology of sparsomycin in beagle dogs

T. Vree, H. Rennes, Z. Żylicz, 2004, Cancer Chemotherapy and Pharmacology.

Application of an isoxazolidine in a stereoselective approach to the fumitremorgin series

P. Hermkens, H. Ottenheijm, H. Behm, 1987 .

Antitumour activity and retinotoxicity of ethyldeshydroxy-sparsomycin in mice.

D. Wagener, W. D. de Grip, H. Ottenheijm, 1995, European journal of cancer.

Correlation of the in vitro cytotoxicity of ethyldeshydroxysparsomycin and cisplatin with the in vivo antitumour activity in murine L1210 leukaemia and two resistant L1210 sublcones

D. Wagener, V. Valk-Bakker, H. Rennes, 2004, Cancer Chemotherapy and Pharmacology.

Heart Failure After Myocardial Infarction Wnt 3 a / Wnt 5 a Reduces Infarct Expansion and Prevents the Development of Blocking of Frizzled Signaling With a Homologous Peptide Fragment of

B. Janssen, J. Smits, M. Zandvoort, 2011 .

SYNTHESIS OF SPARSOMYCIN DERIVATIVES, ADDRESSING ITS BINDING TO THE LARGE RIBOSOMAL SUBUNIT

J. Ballesta, H. Ottenheijm, L. V. D. Broek, 2010 .

Flexible and Convergent Total Synthesis of Cyclotheonamide B.

H. Ottenheijm, H. Bastiaans, J. L. V. D. Baan, 1997 .

CASE HISTORIES OF PEPTIDOMIMETICS : PROGRESSION FROM PEPTIDES TO DRUGS

Harry C. J. Ottenheijm, J. Linders, Pedro H. H. Hermkens, 1994 .

Total synthesis of cyclotheonamide B, a facile route towards analogues

H. Ottenheijm, H. Bastiaans, J. L. V. D. Baan, 1995 .

Lipophilic analogues of sparsomycin as strong inhibitors of protein synthesis and tumor growth: a structure-activity relationship study.

J. Ballesta, Z. Żylicz, H. Ottenheijm, 1989, Journal of medicinal chemistry.

A Facile Synthesis of N-Substituted Pyrroles

Y. Fang, H. Ottenheijm, D. Leysen, 1995 .

Survey of Solid‐Phase Organic Reactions

C. Dreef‐Tromp, J. de Man, H. Ottenheijm, 1999 .

A Practical Synthesis of N-Hydroxy-α-amino Acid Derivatives

H. Ottenheijm, J. Herscheid, M. Tijhuis, 1980 .

Stereoselective synthesis of verruculogen TR-2 featuring the mild formation of a dihydro-.beta.-carboline as an intermediate

H. W. Scheeren, P. Hermkens, H. Ottenheijm, 1992 .

Synthesis of dehydroamino acids and didehydrodioxopiperazines and their conversion into α‐mercapto‐α‐amino acid derivatives

H. Ottenheijm, J. Herscheid, M. Tijhuis, 2010 .

.alpha.-Functionalized amino acid derivatives. A synthetic approach of possible biogenetic importance

H. Ottenheijm, J. Herscheid, R. Nivard, 1980 .

Sulphur in the Strategy of Natural Products Synthesis

H. Ottenheijm, 1985 .

Approaches to analogs of anhydrogliotoxin. 3.1,2-Synthesis of a desthiomethylene analog.

H. Ottenheijm, R. Nivard, J. Hulshof, 1975, The Journal of organic chemistry.

Synthesis of 2-(alkylthio)indoles

H. Ottenheijm, R. Plate, 1986 .

Chemical and biological aspects of sparsomycin, an antibiotic from Streptomyces.

J. Ballesta, Z. Żylicz, H. Ottenheijm, 1986, Progress in medicinal chemistry.

Sulfoxide configuration in sparsomycin determines time-dependent and competitive inhibition of peptidyl transferase.

R. Liskamp, H. Ottenheijm, G. Flynn, 1984, Biochemical and biophysical research communications.

Chemical, biochemical and genetic endeavours characterizing the interaction of sparsomycin with the ribosome.

J. Ballesta, H. Ottenheijm, L. V. D. van den Broek, 1991, Biochimie.

Structure-activity relationships of sparsomycin: modification at the hydroxyl group.

J. Ballesta, H. Ottenheijm, L. V. D. van den Broek, 1987, Biochimie.

Total synthesis and absolute configuration of the natural dipeptide .gamma.-glutamylmarasmine

R. Liskamp, H. Ottenheijm, L. V. D. Broek, 1987 .

Syntheses of 1,3-disubstituted N-oxy-β-carbolines by the Pictet-Spengler reactions of N-oxy-tryptophan and -tryptamine derivatives

P. Hermkens, H. Ottenheijm, J. Maarseveen, 1990 .

Synthesis of 2-hydroxy-3-(ethoxycarbonyl)-1,2,3,4-tetrahydro-.beta.-carbolines from N-hydroxytryptophans. An approach to the eudistomin series

H. Ottenheijm, H. Behm, R. Plate, 1987 .

First total synthesis of (−)-Verruculogen tr-2

P. Hermkens, H. Ottenheijm, R. Plate, 1988 .

First Total Synthesis of (-)-Fumitremorgin C

P. Hermkens, H. Ottenheijm, R. Plate, 1988 .

Conversion of indole into 3-s-(cysteinyl)indoles and 2-s-(cysteinyl) tryptophans. an approach to tryptathionines

H. Ottenheijm, R. Plate, R. Nivard, 1986 .

C(2)-Functionalized tryptophans from 3-acetoxyindoles and their possible implication in indole alkaloid biosynthesis

H. Ottenheijm, R. Plate, A. W. Theunisse, 1987 .

Flash vacuum thermolysis of functionalized .gamma.-sultines

H. Blom, R. Liskamp, H. Ottenheijm, 1983 .

Nitrone cycloaddition in the stereoselective synthesis of .beta.-carbolines from N-hydroxytryptophan

J. Smits, P. Hermkens, H. Ottenheijm, 1986 .

On the conformation and dimerization of a 2‐mercapto‐5‐methylenepiperazine‐3,6‐dione

H. Ottenheijm, J. Noordik, Koos D. M. Herscheid, 2010 .

Crystal and molecular structure of cyclo-(S-prolyl-R-N-hydroxyphenylglycyl), C13H14O3

J. Smits, P. Beurskens, H. Ottenheijm, 1986 .

A practical synthesis of N-hydroxy-α-amino acid esters

H. Ottenheijm, J.D.M. Heracheid, 1979 .

Interconversion of (R) and (S)-α-hydroxy esters: precursors of (S) and (R)-o-benzyl-α-hydroxylamino acid esters of high optical purity

H. Ottenheijm, E. Stokkingreef, R. Feenstra, 1988 .

An efficient synthesis of N-hydroxy-α-amino acid derivatives of high optical purity

H. Ottenheijm, E. Stokkingreef, R. Feenstra, 1987 .

N-hydroxy .alpha.-amino acids in organic chemistry

H. Ottenheijm, J. Herscheid, 1986 .

Approaches to analogues of anhydrogliotoxin V Syntheses of monodesthio‐secogliotoxin analogues

H. Ottenheijm, P. Biessels, J. Hoffmann, 2010 .

Conversion of N-hydroxytryptophans into α,β-dehydrotryptophan. An approach to the neoechinulin series

H. Ottenheijm, R. Plate, R. Nivard, 1987 .

Flexible and Convergent Total Synthesis of Cyclotheonamide B

Harry C. J. Ottenheijm, H. Ottenheijm, Harold M. M. Bastiaans, 1997 .

Syntheses of α-Keto Acid Chlorides

J. de Man, H. Ottenheijm, J. Man, 1975 .

Total synthesis of the antibiotic sparsomycin, a modified uracil amino acid monoxodithioacetal

R. Liskamp, H. Ottenheijm, M. Tijhuis, 1981 .

Solid Phase Synthesis

D. Rees, P. Hermkens, H. Ottenheijm, 1998 .

CCK-A AGONISTS : ENDEAVOURS INVOLVING STRUCTURE-ACTIVITY RELATIONSHIP STUDIES

P. Hermkens, H. Ottenheijm, T. Boer, 2010 .

A one-pot N-protection of L-arginine.

H. Ottenheijm, J. W. Nispen, M. Jetten, 1991 .

Employment of nitriles in the stereoselective cycloaddition to nitrones

J. Smits, P. Hermkens, H. Ottenheijm, 1987 .

Acid Chlorides from α‐Keto Acids with α,α‐Dichloromethyl Methyl Ether: Pyruvoyl Chloride

H. Ottenheijm, M. Tijhuis, 2003 .

Biosynthesis of gliotoxin. Synthesis of sulfur-bridged dioxopiperazines from N-hydroxyamino acids

H. Ottenheijm, J. Herscheid, R. Nivard, 1980 .

Intramolecular Pictet-Spengler reaction of N-alkoxytryptamines. 3. Stereoselective synthesis of (-)-debromoeudistomin L and (-)-O-methyldebromoeudistomin E and their stereoisomers

H. W. Scheeren, P. Hermkens, H. Ottenheijm, 1990 .

Oxidative preparation of optically active n-hydroxy-α-amino acid amides

H. Schoemaker, J. Kamphuis, H. Ottenheijm, 1990 .

Conversion of N-hydroxytryptophan into α-functionalised tryptophans. An approach to the sporidesmin series

J. Smits, H. Ottenheijm, R. Plate, 1987 .

N-Hydroxytryptophan in the synthesis of natural products containing oxidized dioxopiperazines. An approach to the neoechinulin and sporidesmin series

H. Ottenheijm, J. Noordik, R. Plate, 1982 .

In vivo antitumor activity of sparsomycin and its analogues in eight murine tumor models

H. Rennes, Z. Żylicz, H. Ottenheijm, 1988, Investigational New Drugs.

In vitro and in vivo anticancer activity of mitozolomide and sparsomycin in human tumor xenografts, murine tumors and human bone marrow

H. Fiebig, Z. Żylicz, D. Berger, 2005, Journal of Cancer Research and Clinical Oncology.

Application of a ligand‐based theoretical approach to derive conversion paths and ligand conformations in CYP11B2‐mediated aldosterone formation

Peter A. J. Hilbers, Marcel de Gooyer, Luc Roumen, 2011, J. Comput. Chem..

Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics

Peter A. J. Hilbers, Paj Peter Hilbers, Marcel de Gooyer, 2007, J. Comput. Aided Mol. Des..

A new cleavage strategy for the solid-phase synthesis of secondary amines

H. Ottenheijm, P. Conti, D. Leysen, 1997 .

DESULFURIZATION OF EPIDITHIODIOXOPIPERAZINES. A MECHANISTIC AND CHIROPTICAL STUDY

H. Ottenheijm, J. Noordik, J. Herscheid, 1979 .

Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.

H. van Essen, M. D. de Gooyer, P. Hilbers, 2008, Endocrinology.

Preclinical antitumor activity of ethyldeshydroxysparsomycin in combination with cisplatin

D. Wagener, V. Valk-Bakker, H. Rennes, 2007, Investigational New Drugs.

In vitro modulation of cisplatin cytotoxicity by sparsomycin inhibition of protein synthesis.

Z. Żylicz, W. D. de Grip, H. Ottenheijm, 1987, Journal of the National Cancer Institute.

Synthesis of 2-Hydroxy-3-(ethoxycarbonyl)-1,2,3,4-tetrahydro-β-carbolines from N-Hydroxytryptophans. An Approach to the Eudistomin Series.

H. Ottenheijm, H. Behm, R. Plate, 1987 .

Molecular and electronic structure of the dehydroalanine derivatives: The cyclic dipeptide of dehydrophenylalanine

R. Bertoncello, M. Casarin, H. Ottenheijm, 1985 .

Structure of ethyl (Z)‐N‐acetyldehydrophenylalaninate, C13H15NO3

D. Ajó, H. Ottenheijm, R. Plate, 1984 .

Conformational and electronic effects in dehydroaminoacid derivatives

M. Casarin, D. Ajó, A. Vittadini, 1986 .

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

M. D. de Gooyer, P. Hilbers, H. Janssen, 2010, Journal of medicinal chemistry.

Crystal Structure Determination of 8-(16-hydroxy-16-methylpropyl)-7,8,14,14a -tetrahydro-pyrrolidino-[1,2-c]piperazino-[1′, 6′-2,3]-β-carboline -(5aHα, 8Hβ,14aHα)-1,6-dione, C21H25N3O3

P. Beurskens, H. Ottenheijm, H. Behm, 1986 .

Crystal structure determination of 1‐[N‐benzyloxycarbonyl‐1‐amino‐(S‐4‐methoxybenzyl)‐2‐thio‐ethyl] ‐2‐hydroxy‐3‐ethoxycarbonyl‐1,2,3,4 ‐tetrahydro‐β‐carboline, C32H35N3O6S

P. Beurskens, H. Ottenheijm, H. Behm, 1986 .

The Chemistry of Functional Groups. Supplement S: The Chemistry Sulphur‐containing Functional Groups S. Patai and Z. Rappoport, eds. John Wiley, Chichester, 1993 xiv + 1122 pp., £320.00 ISBN 0‐471‐93046‐6

H. Ottenheijm, L. V. D. Broek, 2010 .

Syntheses of 1,3‐Disubstituted N‐Oxy‐β‐carbolines by the Pictet‐Spengler Reactions of N‐Oxy‐tryptophan and ‐tryptamine Derivatives.

H. W. Scheeren, P. Hermkens, H. Ottenheijm, 1990 .

Conversion of N-Hydroxytryptophans into α,β-Dehydrotryptophan. An Approach to the Neoechinulin Series.

H. Ottenheijm, R. Plate, R. Nivard, 1988 .

Crystal and molecular structure of (exo)-1-carboxymethyl-5-ethoxycarbonyl-4,5,6,11b-tetrahydroisoxazolidmo-[2,3-a]-β-carboline, C18H20N2O5

J. Smits, P. Beurskens, H. Ottenheijm, 1986 .

Crystal and molecular structure of (endo)-1-methoxycarbonyl-5-ethoxycarbonyl-4,5,6,11b-tetrahydroisoxazolidino-[2,3-a]-β-carboline, C18H20N205

J. Smits, P. Beurskens, H. Ottenheijm, 1986 .

Crystal and molecular structure of (exo)-2-phenyl-5-ethoxycarbonyl-4,5,6,11b-tetrahydroisoxazolidino-[2,3-a]-β-carboline, C22H22N2O3

J. Smits, P. Beurskens, H. Ottenheijm, 1986 .

Crystal and molecular structure ofN-(S)-α-bromophenylacetyl-(S)-proline methyl ester, C14H16NO3Br

J. Smits, P. Beurskens, H. Ottenheijm, 1986 .

Nitrone Cycloaddition in the Stereoselective Synthesis of β-Carbolines from N-Hydroxytryptophan.

J. Smits, P. Hermkens, H. Ottenheijm, 1986 .

Crystal and Molecular Structure of Ethyl‐α((E)‐hydroxyimino)‐β‐(2(α,α‐dimethylallyl) indol‐3‐yl)propanoate, C18H22N2O3.1/6 CH2CL2

J. Smits, P. Beurskens, H. Ottenheijm, 2010 .

Determination of sparsomycin in plasma and urine of the dog by means of reversed-phase high-performance liquid chromatography and first pharmacokinetic results.

R. Liskamp, B. Winograd, H. Ottenheijm, 1983, Journal of chromatography.

Synthesis of 2-(dimethylallyl)-N-hydroxytryptophans from indole

H. Ottenheijm, R. Plate, 1986 .

Total synthesis of enantiomeric sparsomycin

R. Liskamp, H. Ottenheijm, M. Tijhuis, 1979 .

Approaches to the antibiotic sparsomycin. An efficient synthesis of the cysteinol mono-oxodithioacetal moiety

R. Liskamp, H. Ottenheijm, 1978 .

Synthesis of C(2)Halomethyl Substituted Derivatives of 2,3-Dihydro-1,3-benzoxaz-4-ones

H. Ottenheijm, D. Leysen, Y. Fang, 1993 .