A. Spaltenstein

发表

Discovery of next generation inhibitors of HIV protease.

W. Kazmierski, V. Samano, A. Spaltenstein, 2005, Current topics in medicinal chemistry.

Chapter 7 – Peptide antagonists of neuropeptide Y: Design, structure and pharmacological characterization

A. Spaltenstein, A. Daniels, D. Heyer, 1997 .

Blockade of X4-Tropic HIV-1 Cellular Entry by GSK812397, a Potent Noncompetitive CXCR4 Receptor Antagonist

S. Jenkinson, David C McCoy, K. Gudmundsson, 2009, Antimicrobial Agents and Chemotherapy.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties.

E. Furfine, W. Kazmierski, A. Spaltenstein, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of Aldose Sugars from Half-Protected Dialdehydes Using Rabbit Muscle Aldolase.

G. Whitesides, C. Borysenko, A. Spaltenstein, 1990 .

In Vitro Antiviral Activity of the Novel, Tyrosyl-Based Human Immunodeﬁciency Virus (HIV) Type 1 Protease Inhibitor Brecanavir (GW640385) in Combination with Other Antiretrovirals and against a Panel of Protease Inhibitor-Resistant HIV (cid:1)

E. Furfine, L. Boone, P. Yates, 2007 .

High-affinity neuropeptide Y receptor antagonists.

J. Leban, O. H. Viveros, A. Spaltenstein, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of novel protease inhibitors. Tripeptide α′,β′-epoxyketones as nanomolar inactivators of the proteasome

J. Leban, O. H. Viveros, R. Crouch, 1996 .

764 IN VITRO PROFILING OF GSK2336805, A POTENT AND SELECTIVE INHIBITOR OF HCV NS5A

R. Hamatake, J. Vamathevan, W. Kazmierski, 2011 .

Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1.

S. Jenkinson, K. Gudmundsson, D. Minick, 2010, Bioorganic & medicinal chemistry letters.

Hemodynamic characterization of a novel neuropeptide Y receptor antagonist.

J. Leban, A. Spaltenstein, A. Daniels, 1996, Journal of cardiovascular pharmacology.

Design and Synthesis of Novel Protease Inhibitors. Tripeptide α′, β′-Epoxyketones as Nanomolar Inactivators of the Proteasome.

J. Leban, O. H. Viveros, R. Crouch, 1996 .

Dietary fat alters HIV protease inhibitor-induced metabolic changes in mice.

E. Furfine, J. Weiel, D. Reynolds, 2000, The Journal of nutrition.

Synthesis of C2-symmetric HIV-protease inhibitors with sulfur-containing central units

E. Furfine, J. Leban, A. Spaltenstein, 1993 .

Hepatitis C replication inhibitors that target the viral NS4B protein.

D. J. Price, R. Hamatake, Z. Hong, 2014, Journal of medicinal chemistry.

Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1.

Stephen Jenkinson, S. Jenkinson, K. Gudmundsson, 2009, Bioorganic & medicinal chemistry letters.

Potent inhibitors of the HIV-1 protease incorporating cyclic urea P1-P2 scaffold.

E. Furfine, W. Kazmierski, A. Spaltenstein, 2004, Bioorganic & medicinal chemistry letters.

Novel inhibitors of HIV protease: design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds.

F. Salituro, E. Furfine, W. Kazmierski, 2000, Bioorganic & medicinal chemistry letters.

Amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines as CXCR4 antagonists with potent activity against HIV-1.

Stephen Jenkinson, S. Jenkinson, P. Sebahar, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and structure reassignment of mercaptohistidines of marine origin: syntheses of L-ovothiols A and C

R. Klevit, B. Shapiro, A. Spaltenstein, 1987 .

Substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection.

Pamela L. Golden, K. Romines, K. Gudmundsson, 2010, Bioorganic & medicinal chemistry letters.

Synthesis, structure and stability of novel dimeric peptide-disulfides.

J. Leban, A. Aulabaugh, A. Spaltenstein, 2009, International journal of peptide and protein research.

Novel N-substituted benzimidazole CXCR4 antagonists as potential anti-HIV agents.

S. Jenkinson, K. Gudmundsson, A. Spaltenstein, 2010, Bioorganic & medicinal chemistry letters.

Optimization of pyrrolidinone based HIV protease inhibitors.

E. Furfine, Ronda G. Davis-Ward, C. W. Andrews, 2005, Bioorganic & medicinal chemistry letters.

Tetrahydrocarbazole amides with potent activity against human papillomaviruses.

Pamela L. Golden, P. Sebahar, K. Romines, 2009, Bioorganic & medicinal chemistry letters.

Substituted tetrahydrocarbazoles with potent activity against human papillomaviruses.

P. Sebahar, K. Romines, K. Gudmundsson, 2009, Bioorganic & medicinal chemistry letters.

In Vitro Antiviral Activity of the Novel, Tyrosyl-Based Human Immunodeficiency Virus (HIV) Type 1 Protease Inhibitor Brecanavir (GW640385) in Combination with Other Antiretrovirals and against a Panel of Protease Inhibitor-Resistant HIV

M. Hanlon, E. Furfine, P. Yates, 2007, Antimicrobial Agents and Chemotherapy.

Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors.

E. Furfine, R. Hazen, David J. Reynolds, 2005, Bioorganic & medicinal chemistry letters.

Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir

E. Furfine, Dan Todd, Eric S. Furfine, 2004, Antimicrobial Agents and Chemotherapy.

A randomized, double blind, dose escalation, first time in human study to assess the safety, tolerability, pharmacokinetics, and antiviral activity of single doses of GSK2485852 in chronically infected hepatitis C subjects

D. Wilfret, K. Adkison, A. Spaltenstein, 2014, Clinical pharmacology in drug development.

Synthesis of C2‐Symmetric HIV‐Protease Inhibitors with Sulfur‐ Containing Central Units.

J. Leban, A. Spaltenstein, Furfine Eric Steven, 1993 .

New, potent P1/P2-morpholinone-based HIV-protease inhibitors.

E. Furfine, W. Kazmierski, A. Spaltenstein, 2006, Bioorganic & medicinal chemistry letters.

Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile.

Brian A. Chauder, W. Kazmierski, B. Chauder, 2011, Journal of medicinal chemistry.

Formation and isolation of simple, stable, acyclic di- and tripeptide hemiacetals

A. Spaltenstein, John F. Miller, 1996 .

Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.

M. Hanlon, E. Furfine, R. Xu, 2006, Bioorganic & medicinal chemistry letters.

Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains.

J. A. Ray, M. Hanlon, E. Furfine, 2004, Bioorganic & medicinal chemistry letters.

Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles.

Michael Brieger, E. Furfine, R. Hazen, 2005, Bioorganic & medicinal chemistry letters.

Discovery of N-benzyl-N'-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (II): modification of the acyl portion.

W. Kazmierski, R. Ferris, A. Spaltenstein, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activity.

S. Jenkinson, K. Gudmundsson, A. Spaltenstein, 2010, Bioorganic & medicinal chemistry letters.

Novel spirocyclic pyrrolidones as P2/P1 mimetics in potent inhibitors of HIV-1 protease.

E. Furfine, W. Kazmierski, A. Spaltenstein, 2002, Bioorganic & medicinal chemistry letters.

Inhibition of wild-type and mutant human immunodeficiency virus type 1 proteases by GW0385 and other arylsulfonamides.

M. Hanlon, E. Furfine, A. Shu, 2004, Biochemistry.

Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir

E. Furfine, Michael R. Hale, David J. Reynolds, 2004, Antimicrobial Agents and Chemotherapy.