N. Sabha

发表

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

Joydeep Mukherjee, Cynthia Hawkins, C. Hawkins, 2011, The Journal of experimental medicine.

Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway

M. Berens, S. Croul, S. Byron, 2014, Oncotarget.

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

Andrey Korshunov, Nada Jabado, David T. W. Jones, 2012, Acta Neuropathologica.

CELL BIOLOGY AND SIGNALING

V. P. Collins, Michael A. Koldobskiy, R. Spang, 2010 .

Study of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected under fluorescein fluorescence guidance.

J. Rutka, C. Hawkins, G. Zadeh, 2015, Journal of neurosurgery.

Metabolic , Endocrine and Genitourinary Pathobiology Mammalian Target of Rapamycin ( mTOR ) Induces Proliferation and De-Differentiation Responses to Three Coordinate Pathophysiologic Stimuli ( Mechanical Strain , Hypoxia , and Extracellular Matrix Remodeling ) in Rat Bladder Smooth Muscle

D. Bägli, T. Panchal, A. Lorenzo, 2010 .

MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma.

K. Hynynen, J. Rutka, S. Alli, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Expression in a Transgenic Mouse Glioma Model Loss or Mutant Epidermal Growth Factor Receptor High-Grade Glioma Formation Results from Postnatal Pten

R. Henkelman, Laura Clarke, N. Bock, 2006 .

Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.

D. Gutmann, P. Shannon, A. Guha, 2005, The American journal of pathology.

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery

K. Hynynen, J. Rutka, M. O’Reilly, 2018, Journal of controlled release : official journal of the Controlled Release Society.

X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition

R. Weksberg, F. Muntoni, J. Dowling, 2022, Acta Neuropathologica.

The role of drebrin in glioma migration and invasion.

S. Croul, J. Rutka, S. Agnihotri, 2013, Experimental cell research.

Conditional knockout of pik3c3 causes a murine muscular dystrophy.

J. Dowling, A. Reifler, N. Sabha, 2014, The American journal of pathology.

Characterization of a Clival Chordoma Xenograft Model Reveals Tumor Genomic Instability.

J. Rutka, M. Remke, R. Diaz, 2018, The American journal of pathology.

The Role of Signal Transducer and Activator of Transcription 3 (Stat3) in Stretch Injury to Bladder Smooth Muscle Cells

S. Halachmi, A. Lorenzo, K. Aitken, 2007 .

Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells

S. Halachmi, M. Szybowska, A. Lorenzo, 2006, Cell and Tissue Research.

Matrix metalloproteinase-7 and epidermal growth factor receptor mediate hypoxia-induced extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase activation and subsequent proliferation in bladder smooth muscle cells

M. Szybowska, D. Bägli, A. Lorenzo, 2006, In Vitro Cellular & Developmental Biology - Animal.

Mouse model of severe recessive RYR1-related myopathy.

J. Dowling, A. Michelucci, M. García-Castañeda, 2019, Human molecular genetics.

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Aaron S. Gajadhar, J. Rutka, C. Hawkins, 2014, Cancer discovery.

A role for activated Cdc42 in glioblastoma multiforme invasion

Erwin G. Van Meir, A. Marcus, J. Rutka, 2016, Oncotarget.

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.

R. Henkelman, Laura Clarke, N. Bock, 2006, Cancer research.

Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma.

G. Zadeh, M. Remke, Michael D. Taylor, 2013, Journal of neurosurgery.

Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas.

T. Kiehl, M. Bernstein, T. Mak, 2014, Neuro-oncology.

Targeting the Tie2/Tek receptor in astrocytomas.

G. Zadeh, A. Guha, C. Kontos, 2004, The American journal of pathology.

Conditional Astroglial Rictor Overexpression Induces Malignant Glioma in Mice

A. Guha, C. Cloninger, B. Holmes, 2012, PloS one.

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

S. Croul, L. Ermini, M. Kool, 2015, Cancer research.

Biallelic loss-of-function variants in RABGAP1 cause a novel neurodevelopmental syndrome.

Michael D. Wilson, H. Fuchs, J. Dowling, 2022, Genetics in medicine : official journal of the American College of Medical Genetics.

Inhibition of TRPM7 with waixenicin A reduces glioblastoma cellular functions.

J. Rutka, A. Fleig, Zhong-Ping Feng, 2020, Cell calcium.

Natural history of a mouse model of X-linked myotubular myopathy

J. Dowling, P. Onofre-Oliveira, H. Gonorazky, 2021, bioRxiv.

Tamoxifen therapy in a murine model of myotubular myopathy

Arun K. Ramani, M. Brudno, J. Dowling, 2018, Nature Communications.

PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.

J. Dowling, E. Feldman, A. Reifler, 2016, The Journal of clinical investigation.

Mechanotransduction of extracellular signal-regulated kinases 1 and 2 mitogen-activated protein kinase activity in smooth muscle is dependent on the extracellular matrix and regulated by matrix metalloproteinases.

M. Szybowska, D. Bägli, A. Lorenzo, 2006, The American journal of pathology.

CASCADES, a novel SOX2 super-enhancer associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma multiforme

R. Verhaak, J. Rutka, M. Gallo, 2020, bioRxiv.

Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells

A. Petronis, D. Bägli, T. Panchal, 2011, Laboratory Investigation.

X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition

R. Weksberg, F. Muntoni, J. Dowling, 2022, Acta Neuropathologica.

A preclinical study demonstrating the efficacy of nilotinib in inhibiting the growth of pediatric high-grade glioma

C. Hawkins, G. Zadeh, A. Huang, 2015, Journal of Neuro-Oncology.

Investigation of the In Vitro Therapeutic Efficacy of Nilotinib in Immortalized Human NF2-Null Vestibular Schwannoma Cells

G. Zadeh, A. Guha, S. Agnihotri, 2012, PloS one.

Biallelic pathogenic variants in the mitochondrial form of phosphoenolpyruvate carboxykinase cause peripheral neuropathy

J. Dowling, Dahai Wang, M. Shy, 2023, HGG advances.

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Aaron S. Gajadhar, J. Rutka, C. Hawkins, 2014, Cancer Discovery.

Mammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle.

D. Bägli, A. Lorenzo, M. Hassouna, 2010, The American journal of pathology.

J. Rutka, C. Hawkins, G. Zadeh, 2015, Journal of neurosurgery.